JP2011511006A5 - 肺病態に対する医薬組成物 - Google Patents
肺病態に対する医薬組成物 Download PDFInfo
- Publication number
- JP2011511006A5 JP2011511006A5 JP2010545245A JP2010545245A JP2011511006A5 JP 2011511006 A5 JP2011511006 A5 JP 2011511006A5 JP 2010545245 A JP2010545245 A JP 2010545245A JP 2010545245 A JP2010545245 A JP 2010545245A JP 2011511006 A5 JP2011511006 A5 JP 2011511006A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- citrulline
- patient
- plasma
- hypoxia
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000008194 pharmaceutical composition Substances 0.000 title claims 8
- 210000004072 Lung Anatomy 0.000 title 1
- 230000001575 pathological Effects 0.000 title 1
- RHGKLRLOHDJJDR-BYPYZUCNSA-N L-citrulline zwitterion Chemical group NC(=O)NCCC[C@H]([NH3+])C([O-])=O RHGKLRLOHDJJDR-BYPYZUCNSA-N 0.000 claims 11
- 229960002173 citrulline Drugs 0.000 claims 11
- 235000013477 citrulline Nutrition 0.000 claims 11
- 210000002381 Plasma Anatomy 0.000 claims 6
- MWUXSHHQAYIFBG-UHFFFAOYSA-N nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 claims 4
- OZAIFHULBGXAKX-UHFFFAOYSA-N precursor Substances N#CC(C)(C)N=NC(C)(C)C#N OZAIFHULBGXAKX-UHFFFAOYSA-N 0.000 claims 4
- 206010006475 Bronchopulmonary dysplasia Diseases 0.000 claims 3
- 206010021143 Hypoxia Diseases 0.000 claims 3
- 208000002815 Pulmonary Hypertension Diseases 0.000 claims 3
- 230000001146 hypoxic Effects 0.000 claims 3
- 239000004475 Arginine Substances 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
Claims (6)
- 一酸化窒素前駆体及び薬学的に許容可能な担体から成る、気管支肺異形成症又は低酸素症誘発性肺高血圧症を治療するための医薬組成物。
- 前記一酸化窒素前駆体が、シトルリン、in vivoにおいてシトルリンを産生する前駆体、アルギニン、in vivoにおいてアルギニンを産生する前駆体、及びこれらの組合せからなる群から選択される請求項１に記載の医薬組成物。
- 患者における気管支肺異形成症又は低酸素症誘発性肺高血圧症を治療するために血漿シトルリンレベルを上昇させるのに有効量のシトルリン及び薬学的に許容可能な担体から成る医薬組成物であって、該血漿シトルリンレベルが、治療すべき患者の血漿シトルリンレベルを、気管支肺異形成症又は低酸素症誘発性肺高血圧症を羅患してない患者の血漿シトルリンレベルと比較して決定されることを特徴とする医薬組成物。
- 前記シトルリン量が、患者における血漿シトルリンレベルを少なくとも5μmol/liter上昇させるに有効である請求項３に記載の医薬組成物。
- 前記シトルリン量が、患者における血漿シトルリンレベルを少なくとも37μmol/liter上昇させるに有効である請求項３に記載の医薬組成物。
- 前記医薬組成物が、経静脈投与又は経口投与のために適合している請求項１〜５のいずれか一項に記載の医薬組成物。
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2515708P | 2008-01-31 | 2008-01-31 | |
| PCT/US2009/032824 WO2009099998A2 (en) | 2008-01-31 | 2009-02-02 | Therapeutic treatment for lung conditions |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014225734A Division JP2015044846A (ja) | 2008-01-31 | 2014-11-06 | 肺病態に対する治療 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011511006A JP2011511006A (ja) | 2011-04-07 |
| JP2011511006A5 true JP2011511006A5 (ja) | 2012-03-22 |
Family
ID=40952648
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010545245A Pending JP2011511006A (ja) | 2008-01-31 | 2009-02-02 | 肺病態に対する治療 |
| JP2014225734A Pending JP2015044846A (ja) | 2008-01-31 | 2014-11-06 | 肺病態に対する治療 |
| JP2017121841A Pending JP2017200940A (ja) | 2008-01-31 | 2017-06-22 | 肺病態に対する医薬組成物 |
| JP2019044416A Pending JP2019112439A (ja) | 2008-01-31 | 2019-03-12 | 肺病態に対する医薬組成物 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014225734A Pending JP2015044846A (ja) | 2008-01-31 | 2014-11-06 | 肺病態に対する治療 |
| JP2017121841A Pending JP2017200940A (ja) | 2008-01-31 | 2017-06-22 | 肺病態に対する医薬組成物 |
| JP2019044416A Pending JP2019112439A (ja) | 2008-01-31 | 2019-03-12 | 肺病態に対する医薬組成物 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20090312423A1 (ja) |
| EP (1) | EP2247297B1 (ja) |
| JP (4) | JP2011511006A (ja) |
| KR (3) | KR20100135729A (ja) |
| CN (2) | CN101969974A (ja) |
| AU (1) | AU2009212692B2 (ja) |
| BR (1) | BRPI0906606A2 (ja) |
| CA (1) | CA2714272C (ja) |
| DK (1) | DK2247297T3 (ja) |
| ES (1) | ES2719530T3 (ja) |
| HU (1) | HUE043235T2 (ja) |
| PL (1) | PL2247297T3 (ja) |
| PT (1) | PT2247297T (ja) |
| RU (1) | RU2557048C2 (ja) |
| TR (1) | TR201903753T4 (ja) |
| WO (1) | WO2009099998A2 (ja) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9486429B2 (en) * | 1999-06-01 | 2016-11-08 | Vanderbilt University | Therapeutic methods employing nitric oxide precursors |
| US6346382B1 (en) | 1999-06-01 | 2002-02-12 | Vanderbilt University | Human carbamyl phosphate synthetase I polymorphism and diagnostic methods related thereto |
| KR101932831B1 (ko) | 2008-01-31 | 2018-12-27 | 반더빌트유니버시티 | 관상과 동맥의 동맥류성 지주막하출혈의 치료를 위한 조성물 및 방법 |
| JP5666161B2 (ja) * | 2010-04-05 | 2015-02-12 | 森永製菓株式会社 | ヘチマ及び一酸化窒素産生物質を含有する飲食物 |
| JP6876632B2 (ja) | 2015-06-29 | 2021-05-26 | バンダービルト・ユニバーシティＶａｎｄｅｒｂｉｌｔ Ｕｎｉｖｅｒｓｉｔｙ | 手術中のシトルリン静脈内投与 |
| US10265286B2 (en) * | 2016-12-28 | 2019-04-23 | Vanderbilt University | Sequelae of cardiopulmonary bypass-induced pulmonary injury |
| AR111082A1 (es) | 2017-02-27 | 2019-05-29 | Univ Vanderbilt | Citrulina para el tratamiento de la crisis de células falciformes |
| WO2019046415A1 (en) * | 2017-08-30 | 2019-03-07 | Bellerophon Pulse Technologies Llc | USE OF INHALED NITRIC OXIDE FOR THE TREATMENT OF PULMONARY HYPERTENSION ASSOCIATED WITH PULMONARY DISEASE |
| CN111714478B (zh) * | 2020-07-14 | 2023-08-04 | 江南大学 | 丙酸钠在制备治疗支气管肺发育不良药物中的应用 |
| US20220401396A1 (en) * | 2021-06-22 | 2022-12-22 | Asklepion Pharmaceuticals, Llc | Action of l-citrulline to prevent or treat endothelial dysfunction |
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-
2009
- 2009-02-02 HU HUE09707788A patent/HUE043235T2/hu unknown
- 2009-02-02 JP JP2010545245A patent/JP2011511006A/ja active Pending
- 2009-02-02 BR BRPI0906606-3A patent/BRPI0906606A2/pt not_active Application Discontinuation
- 2009-02-02 CA CA2714272A patent/CA2714272C/en active Active
- 2009-02-02 PT PT09707788T patent/PT2247297T/pt unknown
- 2009-02-02 TR TR2019/03753T patent/TR201903753T4/tr unknown
- 2009-02-02 KR KR1020107019292A patent/KR20100135729A/ko active Search and Examination
- 2009-02-02 CN CN2009801091503A patent/CN101969974A/zh active Pending
- 2009-02-02 PL PL09707788T patent/PL2247297T3/pl unknown
- 2009-02-02 AU AU2009212692A patent/AU2009212692B2/en active Active
- 2009-02-02 DK DK09707788.7T patent/DK2247297T3/en active
- 2009-02-02 CN CN201410300705.5A patent/CN104083352A/zh active Pending
- 2009-02-02 RU RU2010132581/14A patent/RU2557048C2/ru not_active Application Discontinuation
- 2009-02-02 EP EP09707788.7A patent/EP2247297B1/en active Active
- 2009-02-02 US US12/364,078 patent/US20090312423A1/en not_active Abandoned
- 2009-02-02 WO PCT/US2009/032824 patent/WO2009099998A2/en active Application Filing
- 2009-02-02 KR KR1020167036905A patent/KR20170005155A/ko active Application Filing
- 2009-02-02 KR KR1020187015021A patent/KR20180059582A/ko not_active Application Discontinuation
- 2009-02-02 ES ES09707788T patent/ES2719530T3/es active Active
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2014
- 2014-11-06 JP JP2014225734A patent/JP2015044846A/ja active Pending
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2017
- 2017-06-22 JP JP2017121841A patent/JP2017200940A/ja active Pending
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2019
- 2019-03-12 JP JP2019044416A patent/JP2019112439A/ja active Pending
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