JP2011519821A5 - 動脈瘤性くも膜下出血及び血管痙攣に対する医薬組成物 - Google Patents
動脈瘤性くも膜下出血及び血管痙攣に対する医薬組成物 Download PDFInfo
- Publication number
- JP2011519821A5 JP2011519821A5 JP2010545246A JP2010545246A JP2011519821A5 JP 2011519821 A5 JP2011519821 A5 JP 2011519821A5 JP 2010545246 A JP2010545246 A JP 2010545246A JP 2010545246 A JP2010545246 A JP 2010545246A JP 2011519821 A5 JP2011519821 A5 JP 2011519821A5
- Authority
- JP
- Japan
- Prior art keywords
- citrulline
- pharmaceutical composition
- vasospasm
- plasma
- subarachnoid hemorrhage
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 title claims 8
- 206010042316 Subarachnoid haemorrhage Diseases 0.000 title claims 7
- 206010047163 Vasospasm Diseases 0.000 title claims 4
- RHGKLRLOHDJJDR-BYPYZUCNSA-N L-citrulline zwitterion Chemical compound NC(=O)NCCC[C@H]([NH3+])C([O-])=O RHGKLRLOHDJJDR-BYPYZUCNSA-N 0.000 claims 11
- 229960002173 citrulline Drugs 0.000 claims 11
- 235000013477 citrulline Nutrition 0.000 claims 11
- 210000002381 Plasma Anatomy 0.000 claims 6
- MWUXSHHQAYIFBG-UHFFFAOYSA-N nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 claims 4
- OZAIFHULBGXAKX-UHFFFAOYSA-N precursor Substances N#CC(C)(C)N=NC(C)(C)C#N OZAIFHULBGXAKX-UHFFFAOYSA-N 0.000 claims 3
- 239000003937 drug carrier Substances 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
Claims (6)
- 一酸化窒素前駆体及び薬学的に許容可能な担体から成る、動脈瘤性くも膜下出血（SAH）又は血管痙攣を治療するための医薬組成物。
- 前記一酸化窒素前駆体が、シトルリン、in vivoにおいてシトルリンを産生する前駆体、これらの薬学的に許容可能な塩、及びこれらの組合せの少なくとも１つから成る請求項１に記載の医薬組成物。
- 患者における動脈瘤性くも膜下出血（SAH）又は血管痙攣を治療するために血漿シトルリンレベルを上昇させるのに有効量のシトルリン及び薬学的に許容可能な担体から成る医薬組成物であって、該血漿シトルリンレベルが、治療すべき患者の血漿シトルリンレベルが、動脈瘤性くも膜下出血（SAH）又は血管痙攣に羅患してない患者の血漿シトルリンレベルと比較して決定されることを特徴とする医薬組成物。
- 前記シトルリン量が、患者における血漿シトルリンレベルを少なくとも5μmol/liter上昇させるに有効である請求項３に記載の医薬組成物。
- 前記シトルリン量が、患者における血漿シトルリンレベルを少なくとも37μmol/liter上昇させるに有効である請求項３に記載の医薬組成物。
- 前記医薬組成物が、経静脈投与又は経口投与のために適合している請求項１〜５のいずれか一項に記載の医薬組成物。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2517008P | 2008-01-31 | 2008-01-31 | |
| US61/025,170 | 2008-01-31 | ||
| PCT/US2009/032826 WO2009099999A2 (en) | 2008-01-31 | 2009-02-02 | Methods and compositions for treatment for coronary and arterial aneurysmal subarachnoid hemorrhage |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014195084A Division JP6042392B2 (ja) | 2008-01-31 | 2014-09-25 | 血管痙攣を治療するための医薬組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011519821A JP2011519821A (ja) | 2011-07-14 |
| JP2011519821A5 true JP2011519821A5 (ja) | 2012-03-22 |
| JP5623916B2 JP5623916B2 (ja) | 2014-11-12 |
Family
ID=40932329
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010545246A Active JP5623916B2 (ja) | 2008-01-31 | 2009-02-02 | 動脈瘤性くも膜下出血及び血管痙攣に対する医薬組成物 |
| JP2014195084A Active JP6042392B2 (ja) | 2008-01-31 | 2014-09-25 | 血管痙攣を治療するための医薬組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014195084A Active JP6042392B2 (ja) | 2008-01-31 | 2014-09-25 | 血管痙攣を治療するための医薬組成物 |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US20090197964A1 (ja) |
| EP (1) | EP2240170B1 (ja) |
| JP (2) | JP5623916B2 (ja) |
| KR (2) | KR101932831B1 (ja) |
| CN (2) | CN105106186A (ja) |
| AU (2) | AU2009212693B2 (ja) |
| BR (1) | BRPI0906608A2 (ja) |
| CA (1) | CA2715260C (ja) |
| DK (1) | DK2240170T3 (ja) |
| ES (1) | ES2732810T3 (ja) |
| HU (1) | HUE045571T2 (ja) |
| PL (1) | PL2240170T3 (ja) |
| PT (1) | PT2240170T (ja) |
| RU (1) | RU2528097C2 (ja) |
| SG (1) | SG196863A1 (ja) |
| WO (1) | WO2009099999A2 (ja) |
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| EP2669269B1 (en) | 2005-05-27 | 2019-05-22 | The University of North Carolina At Chapel Hill | Nitric oxide-releasing particles for nitric oxide therapeutics and biomedical applications |
| CA2715260C (en) | 2008-01-31 | 2017-07-04 | Vanderbilt University | Methods and compositions for treatment for coronary and arterial aneurysmal subarachnoid hemorrhage |
| PL2247297T3 (pl) * | 2008-01-31 | 2019-07-31 | Vanderbilt University | Działanie terapeutyczne w stanach chorobowych płuc |
| US9919072B2 (en) | 2009-08-21 | 2018-03-20 | Novan, Inc. | Wound dressings, methods of using the same and methods of forming the same |
| BR112012003792B1 (pt) | 2009-08-21 | 2020-05-19 | Novan Inc | composição tópica, e, uso da composição tópica |
| US8591876B2 (en) | 2010-12-15 | 2013-11-26 | Novan, Inc. | Methods of decreasing sebum production in the skin |
| ES2695173T3 (es) | 2011-02-28 | 2019-01-02 | Novan Inc | Partículas de sílice modificadas con S-nitrosotiol que liberan óxido nítrico y procedimientos de fabricación de las mismas |
| MX2017015664A (es) | 2015-06-29 | 2018-04-18 | Univ Vanderbilt | Administracion intravenosa de citrulina durante cirugia. |
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2009
- 2009-02-02 CA CA2715260A patent/CA2715260C/en active Active
- 2009-02-02 JP JP2010545246A patent/JP5623916B2/ja active Active
- 2009-02-02 KR KR1020167036885A patent/KR101932831B1/ko active IP Right Grant
- 2009-02-02 US US12/322,434 patent/US20090197964A1/en not_active Abandoned
- 2009-02-02 BR BRPI0906608-0A patent/BRPI0906608A2/pt not_active Application Discontinuation
- 2009-02-02 DK DK09708687.0T patent/DK2240170T3/da active
- 2009-02-02 KR KR1020107019291A patent/KR20100135728A/ko active Search and Examination
- 2009-02-02 HU HUE09708687A patent/HUE045571T2/hu unknown
- 2009-02-02 PL PL09708687T patent/PL2240170T3/pl unknown
- 2009-02-02 CN CN201510522527.5A patent/CN105106186A/zh active Pending
- 2009-02-02 AU AU2009212693A patent/AU2009212693B2/en active Active
- 2009-02-02 CN CN2009801091471A patent/CN102369006A/zh active Pending
- 2009-02-02 EP EP09708687.0A patent/EP2240170B1/en active Active
- 2009-02-02 PT PT09708687T patent/PT2240170T/pt unknown
- 2009-02-02 ES ES09708687T patent/ES2732810T3/es active Active
- 2009-02-02 WO PCT/US2009/032826 patent/WO2009099999A2/en active Application Filing
- 2009-02-02 RU RU2010132580/15A patent/RU2528097C2/ru not_active Application Discontinuation
- 2009-02-02 SG SG2014005458A patent/SG196863A1/en unknown
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2011
- 2011-12-20 US US13/331,678 patent/US9943494B2/en active Active
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2014
- 2014-07-18 AU AU2014204508A patent/AU2014204508B2/en active Active
- 2014-09-25 JP JP2014195084A patent/JP6042392B2/ja active Active
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2018
- 2018-04-17 US US15/955,370 patent/US10500181B2/en active Active
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