JP2014503593A5 - - Google Patents
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- JP2014503593A5 JP2014503593A5 JP2013551354A JP2013551354A JP2014503593A5 JP 2014503593 A5 JP2014503593 A5 JP 2014503593A5 JP 2013551354 A JP2013551354 A JP 2013551354A JP 2013551354 A JP2013551354 A JP 2013551354A JP 2014503593 A5 JP2014503593 A5 JP 2014503593A5
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- 239000008194 pharmaceutical composition Substances 0.000 claims 13
- 230000037165 Serum Concentration Effects 0.000 claims 6
- RVOLLAQWKVFTGE-UHFFFAOYSA-N Pyridostigmine Chemical compound CN(C)C(=O)OC1=CC=C[N+](C)=C1 RVOLLAQWKVFTGE-UHFFFAOYSA-N 0.000 claims 4
- 229960002290 Pyridostigmine Drugs 0.000 claims 4
- 208000001797 Obstructive Sleep Apnea Diseases 0.000 claims 2
- 238000010521 absorption reaction Methods 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000002496 gastric Effects 0.000 claims 1
- 239000006186 oral dosage form Substances 0.000 claims 1
Claims (12)
- 有効量のピリドスチグミンを含む、閉塞性睡眠時無呼吸（ＯＳＡ）を処置するための医薬組成物であって、有効量のピリドスチグミンが、睡眠前に必要とする被験者に投与する際に、睡眠中の少なくとも１時間にわたり、２〜１５０ng/mlの範囲で被験者にピリドスチグミンの標的血清濃度をもたらすように選択される、医薬組成物。
- 標的血清濃度が３〜６０ng/mlの範囲である、請求項１記載の医薬組成物。
- 標的血清濃度が３〜４５ng/mlの範囲である、請求項１記載の医薬組成物。
- 標的血清濃度が３〜３０ng/mlの範囲である、請求項１記載の医薬組成物。
- 標的血清濃度が３〜１５ng/mlの範囲である、請求項１記載の医薬組成物。
- 標的血清濃度が睡眠中の少なくとも３時間維持される、請求項１記載の医薬組成物。
- ３０〜３６０mgのピリドスチグミンを含む、請求項１記載の医薬組成物。
- 被験者に、睡眠前の２時間以内に投与される、請求項１記載の医薬組成物。
- 被験者に、単回投与で投与される、請求項１記載の医薬組成物。
- さらに、医薬的に許容可能な担体又は希釈剤を含む、請求項１記載の医薬組成物。
- 被験者に、経口投与形態で投与される、請求項１記載の医薬組成物。
- 被験者に、胃腸吸収のために投与される、請求項１記載の医薬組成物。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161437272P | 2011-01-28 | 2011-01-28 | |
| US61/437,272 | 2011-01-28 | ||
| PCT/US2012/022825 WO2012103398A2 (en) | 2011-01-28 | 2012-01-27 | Methods for treating obstructive sleep apnea |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017000145A Division JP6342525B2 (ja) | 2011-01-28 | 2017-01-04 | 閉塞性睡眠時無呼吸を処置するための方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014503593A JP2014503593A (ja) | 2014-02-13 |
| JP2014503593A5 true JP2014503593A5 (ja) | 2015-03-19 |
Family
ID=46577943
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013551354A Pending JP2014503593A (ja) | 2011-01-28 | 2012-01-27 | 閉塞性睡眠時無呼吸を処置するための方法 |
| JP2017000145A Active JP6342525B2 (ja) | 2011-01-28 | 2017-01-04 | 閉塞性睡眠時無呼吸を処置するための方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017000145A Active JP6342525B2 (ja) | 2011-01-28 | 2017-01-04 | 閉塞性睡眠時無呼吸を処置するための方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US8753327B2 (ja) |
| EP (1) | EP2672972B1 (ja) |
| JP (2) | JP2014503593A (ja) |
| CN (2) | CN103458899A (ja) |
| CA (1) | CA2825309C (ja) |
| WO (1) | WO2012103398A2 (ja) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2672972B1 (en) * | 2011-01-28 | 2020-11-04 | Pfantastic Medical Research Institute, LLC | Methods for treating obstructive sleep apnea |
| WO2015131222A1 (en) * | 2014-03-03 | 2015-09-11 | Sleep Innovations Pty Ltd | Device and method for sleep apnoea treatment |
| US10166268B2 (en) | 2014-07-25 | 2019-01-01 | The George Washington University | Oxytocin improves treatment of obstructive sleep apnea |
| EP4186548A1 (en) | 2015-04-02 | 2023-05-31 | Hill-Rom Services PTE. LTD. | Mask leakage detection for a respiratory device |
| US11944567B2 (en) * | 2016-12-23 | 2024-04-02 | Koninklijke Philips N.V. | System for treating snoring among at least two users |
| CA3061468A1 (en) * | 2017-04-28 | 2018-11-01 | The Brigham And Women's Hospital, Inc. | Methods and compositions for treating sleep apnea |
| US11911351B2 (en) | 2018-01-30 | 2024-02-27 | Apnimed, Inc. (Delaware) | Methods for treating sleep apnea with combinations of atomoxetine and (R)-oxybutynin |
| EP4056172A1 (en) * | 2018-06-18 | 2022-09-14 | Amneal Complex Products Research LLC | Extended release compositions comprising pyridostigmine |
| WO2020038900A1 (en) * | 2018-08-24 | 2020-02-27 | Koninklijke Philips N.V. | Providing sleep therapy with a pressure therapy system |
| US11654283B2 (en) | 2019-03-06 | 2023-05-23 | Medtronic Xomed, Inc. | Obstructive sleep apnea patient programmer for implantable devices |
| CN114504643B (zh) * | 2021-12-24 | 2024-03-26 | 北京大学第一医院 | 抗IgE抗体在用于治疗OSAS中的应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2247662B (en) | 1990-08-31 | 1994-11-02 | Instance Ltd David J | Labels and manufacture thereof |
| SE9504537D0 (sv) | 1995-12-19 | 1995-12-19 | Jan Hedner | Sätt att behandla och diagnosticera andningsstörningar under sömn och medel för utförande av sättet |
| US7297691B2 (en) * | 2003-08-13 | 2007-11-20 | Janssen Pharmaceutica N.V. | Treatment of sleep disorders with cholinesterase inhibitors |
| US20080261931A1 (en) * | 2005-09-16 | 2008-10-23 | Cereu-Science Ab | Method and Means of Preventing and Treating Sleep Disordered Breathing |
| US20080066739A1 (en) * | 2006-09-20 | 2008-03-20 | Lemahieu Edward | Methods and systems of delivering medication via inhalation |
| US7984714B2 (en) * | 2006-09-29 | 2011-07-26 | Nellcor Puritan Bennett Llc | Managing obstructive sleep apnea and/or snoring using local time released agents |
| EP2672972B1 (en) * | 2011-01-28 | 2020-11-04 | Pfantastic Medical Research Institute, LLC | Methods for treating obstructive sleep apnea |
-
2012
- 2012-01-27 EP EP12739245.4A patent/EP2672972B1/en active Active
- 2012-01-27 CA CA2825309A patent/CA2825309C/en active Active
- 2012-01-27 US US13/359,692 patent/US8753327B2/en active Active
- 2012-01-27 WO PCT/US2012/022825 patent/WO2012103398A2/en active Application Filing
- 2012-01-27 CN CN2012800065522A patent/CN103458899A/zh active Pending
- 2012-01-27 JP JP2013551354A patent/JP2014503593A/ja active Pending
- 2012-01-27 CN CN201610821591.8A patent/CN107007602A/zh active Pending
-
2014
- 2014-05-05 US US14/269,326 patent/US9295670B2/en active Active
-
2017
- 2017-01-04 JP JP2017000145A patent/JP6342525B2/ja active Active
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