JP2012529463A5 - - Google Patents

Info

Publication number

JP2012529463A5

JP2012529463A5 JP2012514442A JP2012514442A JP2012529463A5 JP 2012529463 A5 JP2012529463 A5 JP 2012529463A5 JP 2012514442 A JP2012514442 A JP 2012514442A JP 2012514442 A JP2012514442 A JP 2012514442A JP 2012529463 A5 JP2012529463 A5 JP 2012529463A5

Authority

JP

Japan

Prior art keywords

ethoxy

compound

fgf21

glp

group

Prior art date

2010-06-08

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Withdrawn

Links

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• 150000001875 compounds Chemical class 0.000 claims 12
• -1 GLP-1 compound Chemical class 0.000 claims 11
• 108090000376 Fibroblast growth factor 21 Proteins 0.000 claims 10
• 102000003973 Fibroblast growth factor 21 Human genes 0.000 claims 8
• 125000002252 acyl group Chemical group 0.000 claims 7
• 102000009027 Albumins Human genes 0.000 claims 6
• 108010088751 Albumins Proteins 0.000 claims 6
• 101710198884 GATA-type zinc finger protein 1 Proteins 0.000 claims 6
• 102400000322 Glucagon-like peptide 1 Human genes 0.000 claims 6
• 150000003839 salts Chemical class 0.000 claims 6
• 101800004266 Glucagon-like peptide 1(7-37) Proteins 0.000 claims 4
• 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 claims 4
• 125000003275 alpha amino acid group Chemical group 0.000 claims 4
• 108090000765 processed proteins & peptides Proteins 0.000 claims 3
• RUVRGYVESPRHSZ-UHFFFAOYSA-N 2-[2-(2-azaniumylethoxy)ethoxy]acetate Chemical compound NCCOCCOCC(O)=O RUVRGYVESPRHSZ-UHFFFAOYSA-N 0.000 claims 2
• DTHNMHAUYICORS-KTKZVXAJSA-N Glucagon-like peptide 1 Chemical class C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 DTHNMHAUYICORS-KTKZVXAJSA-N 0.000 claims 2
• OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 claims 2
• 238000007792 addition Methods 0.000 claims 2
• 125000000217 alkyl group Chemical group 0.000 claims 2
• 150000001408 amides Chemical class 0.000 claims 2
• 235000001014 amino acid Nutrition 0.000 claims 2
• 125000003277 amino group Chemical group 0.000 claims 2
• 125000004432 carbon atom Chemical group C* 0.000 claims 2
• 125000002843 carboxylic acid group Chemical group 0.000 claims 2
• 230000037430 deletion Effects 0.000 claims 2
• 238000012217 deletion Methods 0.000 claims 2
• 235000014113 dietary fatty acids Nutrition 0.000 claims 2
• 150000002148 esters Chemical class 0.000 claims 2
• 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims 2
• 229930195729 fatty acid Natural products 0.000 claims 2
• 239000000194 fatty acid Substances 0.000 claims 2
• 150000004665 fatty acids Chemical class 0.000 claims 2
• 125000000404 glutamine group Chemical group N[C@@H](CCC(N)=O)C(=O)* 0.000 claims 2
• 229920001184 polypeptide Polymers 0.000 claims 2
• 102000004196 processed proteins & peptides Human genes 0.000 claims 2
• 238000006467 substitution reaction Methods 0.000 claims 2
• 125000003396 thiol group Chemical group [H]S* 0.000 claims 2
• 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 2
• 229940126062 Compound A Drugs 0.000 claims 1
• NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 claims 1
• 101000846529 Homo sapiens Fibroblast growth factor 21 Proteins 0.000 claims 1
• XCHARIIIZLLEBL-UHFFFAOYSA-N Medicagenic acid 3-O-beta-D-glucoside Chemical compound C12CC(C)(C)CCC2(C(O)=O)CCC(C2(CCC3C4(C)C(O)=O)C)(C)C1=CCC2C3(C)CC(O)C4OC1OC(CO)C(O)C(O)C1O XCHARIIIZLLEBL-UHFFFAOYSA-N 0.000 claims 1
• 125000000729 N-terminal amino-acid group Chemical group 0.000 claims 1
• 101100395023 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) his-7 gene Proteins 0.000 claims 1
• GYDJEQRTZSCIOI-UHFFFAOYSA-N Tranexamic acid Chemical compound NCC1CCC(C(O)=O)CC1 GYDJEQRTZSCIOI-UHFFFAOYSA-N 0.000 claims 1
• 125000000738 acetamido group Chemical group [H]C([H])([H])C(=O)N([H])[*] 0.000 claims 1
• NKLCHDQGUHMCGL-UHFFFAOYSA-N cyclohexylidenemethanone Chemical group O=C=C1CCCCC1 NKLCHDQGUHMCGL-UHFFFAOYSA-N 0.000 claims 1
• 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 102000056713 human FGF21 Human genes 0.000 claims 1
• 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 1
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
• 238000002360 preparation method Methods 0.000 claims 1
• GYDJEQRTZSCIOI-LJGSYFOKSA-N tranexamic acid Chemical group NC[C@H]1CC[C@H](C(O)=O)CC1 GYDJEQRTZSCIOI-LJGSYFOKSA-N 0.000 claims 1
• 229960000401 tranexamic acid Drugs 0.000 claims 1