JP2012528137A - 複素環式尿素誘導体およびそれらの使用方法 - Google Patents

複素環式尿素誘導体およびそれらの使用方法 Download PDF

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Publication number
JP2012528137A
JP2012528137A JP2012512460A JP2012512460A JP2012528137A JP 2012528137 A JP2012528137 A JP 2012528137A JP 2012512460 A JP2012512460 A JP 2012512460A JP 2012512460 A JP2012512460 A JP 2012512460A JP 2012528137 A JP2012528137 A JP 2012528137A
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Japan
Prior art keywords
alkyl
infection
pharmaceutically acceptable
substituted
acceptable salt
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English (en)
Japanese (ja)
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JP2012528137A5 (OSRAM
Inventor
ビフルコ，ニール
チョイ，アリソン・ローラ
クイロガ，オルガ
シャーラー，ブライアン
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AstraZeneca AB
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AstraZeneca AB
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Publication of JP2012528137A publication Critical patent/JP2012528137A/ja
Publication of JP2012528137A5 publication Critical patent/JP2012528137A5/ja
Withdrawn legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Oncology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Communicable Diseases (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)
JP2012512460A 2009-05-29 2010-05-28 複素環式尿素誘導体およびそれらの使用方法 Withdrawn JP2012528137A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US18237309P 2009-05-29 2009-05-29
US61/182,373 2009-05-29
US28501709P 2009-12-09 2009-12-09
US61/285,017 2009-12-09
PCT/GB2010/050908 WO2010136817A1 (en) 2009-05-29 2010-05-28 Heterocyclic urea derivatives and methods of use thereof

Publications (2)

Publication Number Publication Date
JP2012528137A true JP2012528137A (ja) 2012-11-12
JP2012528137A5 JP2012528137A5 (OSRAM) 2013-06-20

Family

ID=42635508

Family Applications (1)

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JP2012512460A Withdrawn JP2012528137A (ja) 2009-05-29 2010-05-28 複素環式尿素誘導体およびそれらの使用方法

Country Status (8)

Country Link
US (1) US8569484B2 (OSRAM)
EP (1) EP2435434A1 (OSRAM)
JP (1) JP2012528137A (OSRAM)
CN (1) CN102448962A (OSRAM)
AR (1) AR076899A1 (OSRAM)
TW (1) TW201102065A (OSRAM)
UY (1) UY32674A (OSRAM)
WO (1) WO2010136817A1 (OSRAM)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018174288A1 (ja) * 2017-03-24 2018-09-27 大正製薬株式会社 ２（１ｈ）－キノリノン誘導体
JP2020512372A (ja) * 2017-03-30 2020-04-23 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 細菌感染の治療及び予防のための新規ピリド［２，３−ｂ］インドール化合物
JP2022501391A (ja) * 2018-09-26 2022-01-06 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft 細菌感染症の治療及び予防のための、置換ピリドインドール

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011121555A1 (en) 2010-03-31 2011-10-06 Actelion Pharmaceuticals Ltd Antibacterial isoquinolin-3-ylurea derivatives
AR088729A1 (es) 2011-03-29 2014-07-02 Actelion Pharmaceuticals Ltd Derivados de 3-ureidoisoquinolin-8-ilo y una composicion farmaceutica
JP2020527593A (ja) * 2017-07-18 2020-09-10 ニューベイション・バイオ・インコーポレイテッドＮｕｖａｔｉｏｎ Ｂｉｏ Ｉｎｃ． １，８−ナフチリジノン化合物およびその使用
CN107445981B (zh) * 2017-08-25 2018-06-22 牡丹江医学院 一种用于防治宫颈炎的活性化合物
CN113939291A (zh) 2019-01-18 2022-01-14 诺维逊生物股份有限公司 1,8-萘啶酮化合物及其用途
MX2021008650A (es) 2019-01-18 2021-11-03 Nuvation Bio Inc Compuestos heterociclicos como antagonistas de adenosina.
WO2021083936A1 (en) 2019-11-01 2021-05-06 Syngenta Crop Protection Ag Pesticidally active fused bicyclic heteroaromatic compounds

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0519449A1 (en) * 1991-06-21 1992-12-23 Boehringer Mannheim Italia S.P.A. 2-Amino-4-aryl thiazoles with antiasthmatic and antiinflammatory activities on the respiratory tract
TW538046B (en) 1998-01-08 2003-06-21 Hoechst Marion Roussel Inc Aromatic amides having antiobiotic activities and the preparation processes, intermediates and pharmaceutical composition thereof
WO2001052845A1 (en) 2000-01-18 2001-07-26 Vertex Pharmaceuticals Incorpoated Gyrase inhibitors and uses thereof
IL156031A0 (en) * 2000-12-15 2003-12-23 Vertex Pharma Fused heterocyclic derivatives and pharmaceutical compositions containing the same
TW200526626A (en) 2003-09-13 2005-08-16 Astrazeneca Ab Chemical compounds
CN101163674A (zh) 2005-02-18 2008-04-16 阿斯利康(瑞典)有限公司 作为dna促旋酶和拓扑异构酶抑制剂的吡咯衍生物
KR101422432B1 (ko) 2005-02-18 2014-07-22 아스트라제네카 아베 항균성 피페리딘 유도체
JP2008530192A (ja) 2005-02-18 2008-08-07 アストラゼネカ アクチボラグ Ｄｎａジャイレース及びトポイソメラーゼの阻害剤としてのピロール誘導体
US20090253671A1 (en) 2005-03-04 2009-10-08 Astrazeneca Ab Tricyclic derivatives of azetidine and pyrrole with antibacterial activity
JP2008531671A (ja) * 2005-03-04 2008-08-14 アストラゼネカ アクチボラグ 化合物
EP1991545A2 (en) 2005-12-23 2008-11-19 AstraZeneca AB Antibacterial pyrrolopyridines, pyrrolopyrimidines, and pyrroloazepines
RU2469034C2 (ru) * 2006-12-04 2012-12-10 Астразенека Аб Химические соединения
CA2711500A1 (en) 2008-01-07 2009-07-16 Huanming Chen Novel hiv integrase inhibitors and methods of use
TW200940537A (en) 2008-02-26 2009-10-01 Astrazeneca Ab Heterocyclic urea derivatives and methods of use thereof
EA201001858A1 (ru) * 2008-06-04 2011-08-30 Астразенека Аб Гетероциклические производные мочевины для лечения бактериальных инфекций

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018174288A1 (ja) * 2017-03-24 2018-09-27 大正製薬株式会社 ２（１ｈ）－キノリノン誘導体
JP2020512372A (ja) * 2017-03-30 2020-04-23 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 細菌感染の治療及び予防のための新規ピリド［２，３−ｂ］インドール化合物
JP7344125B2 (ja) 2017-03-30 2023-09-13 エフ． ホフマン－ラ ロシュ アーゲー 細菌感染の治療及び予防のための新規ピリド［２，３－ｂ］インドール化合物
JP2022501391A (ja) * 2018-09-26 2022-01-06 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft 細菌感染症の治療及び予防のための、置換ピリドインドール
JP7443351B2 (ja) 2018-09-26 2024-03-05 エフ． ホフマン－ラ ロシュ アーゲー 細菌感染症の治療及び予防のための、置換ピリドインドール

Also Published As

Publication number Publication date
UY32674A (es) 2010-12-31
AR076899A1 (es) 2011-07-13
WO2010136817A1 (en) 2010-12-02
CN102448962A (zh) 2012-05-09
US20120122817A1 (en) 2012-05-17
US8569484B2 (en) 2013-10-29
TW201102065A (en) 2011-01-16
EP2435434A1 (en) 2012-04-04

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