JP2012527522A5 - - Google Patents

Download PDF

Info

Publication number
JP2012527522A5
JP2012527522A5 JP2012512013A JP2012512013A JP2012527522A5 JP 2012527522 A5 JP2012527522 A5 JP 2012527522A5 JP 2012512013 A JP2012512013 A JP 2012512013A JP 2012512013 A JP2012512013 A JP 2012512013A JP 2012527522 A5 JP2012527522 A5 JP 2012527522A5
Authority
JP
Japan
Prior art keywords
alkyl
independently
group
integer
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2012512013A
Other languages
English (en)
Japanese (ja)
Other versions
JP2012527522A (ja
JP5684798B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2010/035495 external-priority patent/WO2010135481A1/en
Publication of JP2012527522A publication Critical patent/JP2012527522A/ja
Publication of JP2012527522A5 publication Critical patent/JP2012527522A5/ja
Application granted granted Critical
Publication of JP5684798B2 publication Critical patent/JP5684798B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2012512013A 2009-05-22 2010-05-20 化学線架橋性シロキサン含有コポリマー Expired - Fee Related JP5684798B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US18045309P 2009-05-22 2009-05-22
US61/180,453 2009-05-22
PCT/US2010/035495 WO2010135481A1 (en) 2009-05-22 2010-05-20 Actinically-crosslinkable siloxane-containing copolymers

Publications (3)

Publication Number Publication Date
JP2012527522A JP2012527522A (ja) 2012-11-08
JP2012527522A5 true JP2012527522A5 (https=) 2014-07-24
JP5684798B2 JP5684798B2 (ja) 2015-03-18

Family

ID=43124974

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2012512013A Expired - Fee Related JP5684798B2 (ja) 2009-05-22 2010-05-20 化学線架橋性シロキサン含有コポリマー

Country Status (5)

Country Link
US (2) US8642712B2 (https=)
EP (1) EP2432821B1 (https=)
JP (1) JP5684798B2 (https=)
CA (1) CA2761218C (https=)
WO (1) WO2010135481A1 (https=)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8083348B2 (en) * 2009-06-16 2011-12-27 Bausch & Lomb Incorporated Biomedical devices
EP2510051A1 (en) * 2009-12-07 2012-10-17 Novartis AG Methods for increasing the ion permeability of contact lenses
TWI483996B (zh) 2009-12-08 2015-05-11 Novartis Ag 具有共價貼合塗層之聚矽氧水凝膠鏡片
US9005492B2 (en) * 2009-12-14 2015-04-14 Novartis Ag Methods for making silicone hydrogel lenses from water-based lens formulations
US9522980B2 (en) 2010-05-06 2016-12-20 Johnson & Johnson Vision Care, Inc. Non-reactive, hydrophilic polymers having terminal siloxanes and methods for making and using the same
KR101564490B1 (ko) 2010-07-30 2015-10-29 노파르티스 아게 Uv―흡수 안과용 렌즈의 제조 방법
US8480227B2 (en) 2010-07-30 2013-07-09 Novartis Ag Silicone hydrogel lenses with water-rich surfaces
JP5852659B2 (ja) 2010-10-06 2016-02-03 ノバルティス アーゲー 水処理可能なシリコーン含有プレポリマー及びその使用
US9170349B2 (en) 2011-05-04 2015-10-27 Johnson & Johnson Vision Care, Inc. Medical devices having homogeneous charge density and methods for making same
US20130203813A1 (en) 2011-05-04 2013-08-08 Johnson & Johnson Vision Care, Inc. Medical devices having homogeneous charge density and methods for making same
CN106896422B (zh) * 2011-06-09 2021-03-23 爱尔康公司 具有纳米纹理化表面的硅氧烷水凝胶透镜
HUE029018T2 (en) 2011-10-12 2017-02-28 Novartis Ag A method for producing UV absorbing contact lenses by coating
KR20140136988A (ko) 2012-03-22 2014-12-01 모멘티브 퍼포먼스 머티리얼즈 인크. 친수성 매크로머 및 이를 함유하는 하이드로겔
JP6429242B2 (ja) * 2012-03-22 2018-11-28 モメンティブ パフォーマンス マテリアルズ インコーポレイテッド 有機変性シリコーンポリマーおよびそれを含むハイドロゲル
JP5881059B2 (ja) * 2012-04-02 2016-03-09 東洋ゴム工業株式会社 ゴム又はプラスチック用補強剤、ゴム組成物及びプラスチック組成物の製造方法
CN104220447B (zh) * 2012-04-02 2017-09-01 东洋橡胶工业株式会社 硅化合物及其制造方法以及其应用
US10073192B2 (en) 2012-05-25 2018-09-11 Johnson & Johnson Vision Care, Inc. Polymers and nanogel materials and methods for making and using the same
US9244196B2 (en) 2012-05-25 2016-01-26 Johnson & Johnson Vision Care, Inc. Polymers and nanogel materials and methods for making and using the same
US9297929B2 (en) 2012-05-25 2016-03-29 Johnson & Johnson Vision Care, Inc. Contact lenses comprising water soluble N-(2 hydroxyalkyl) (meth)acrylamide polymers or copolymers
US9395468B2 (en) 2012-08-27 2016-07-19 Ocular Dynamics, Llc Contact lens with a hydrophilic layer
SG11201501266UA (en) * 2012-08-28 2015-03-30 Coopervision Int Holding Co Lp Contact lenses made with hema-compatible polysiloxane macromers
DE102012109685A1 (de) * 2012-10-11 2014-04-17 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verfahren zur Umwandlung reaktiver Gruppen an Si-C-gebundenen Resten von Silanen unter gleichzeitiger Vergrößerung von deren räumlichem Abstand zueinander
CA3030638C (en) 2012-12-14 2020-09-15 Novartis Ag Amphiphilic siloxane-containing vinylic monomers and uses thereof
CA2889925C (en) 2012-12-14 2017-07-04 Novartis Ag Tris(trimethyl siloxy)silane vinylic monomers and uses thereof
EP2931767B1 (en) 2012-12-14 2017-11-08 Novartis AG Amphiphilic siloxane-containing (meth)acrylamides and uses thereof
WO2014093756A1 (en) 2012-12-14 2014-06-19 Novartis Ag Actinically-crosslinkable amphiphilic prepolymers
HUE031702T2 (en) 2012-12-17 2017-07-28 Novartis Ag A method for producing improved UV absorbing ophthalmic lenses
WO2014121030A2 (en) 2013-01-31 2014-08-07 Momentive Performance Materials Inc. Water soluble silicone material
WO2014140599A1 (en) * 2013-03-15 2014-09-18 Coopervision International Holding Company, Lp Silicone hydrogel contact lenses
AU2014348502B2 (en) 2013-11-15 2019-08-15 Tangible Science, Inc. Contact lens with a hydrophilic layer
HUE038809T2 (hu) 2013-12-17 2018-11-28 Novartis Ag Térhálósított hidrofíl bevonattal ellátott szilikon hidrogél lencse
JP6405647B2 (ja) * 2014-03-05 2018-10-17 Dic株式会社 重合性樹脂、活性エネルギー線硬化性組成物及び物品。
CN103865014B (zh) * 2014-03-21 2016-01-06 东华大学 两亲性共聚网络的制备方法
WO2015164582A1 (en) 2014-04-25 2015-10-29 Novartis Ag Hydrophilized carbosiloxane vinylic monomers
CA2940203C (en) 2014-04-25 2019-08-06 Novartis Ag Carbosiloxane vinylic monomers
MY183678A (en) 2014-08-26 2021-03-08 Alcon Inc Method for applying stable coating on silicone hydrogel contact lenses
AU2015321646B2 (en) 2014-09-26 2017-11-30 Alcon Inc. Polymerizable polysiloxanes with hydrophilic substituents
JP6305324B2 (ja) * 2014-11-28 2018-04-04 信越化学工業株式会社 共重合体および眼科デバイス
CN107206119B (zh) 2014-12-09 2021-01-29 实体科学公司 具有生物相容性层的医疗设备涂层
US9851472B2 (en) 2015-03-27 2017-12-26 Momentive Performance Materials Inc. Silicone-based hydrophilic copolymer and hydrogel compositions comprising the same
US10160854B1 (en) * 2015-08-03 2018-12-25 Gl Chemtec Vision Inc. Hydrogel materials
WO2017103792A1 (en) 2015-12-15 2017-06-22 Novartis Ag Amphiphilic branched polydiorganosiloxane macromers
KR102604468B1 (ko) 2015-12-15 2023-11-22 알콘 인코포레이티드 실리콘 하이드로겔 콘택트 렌즈 상에 안정한 코팅을 적용하기 위한 방법
EP3419966B1 (en) 2016-02-22 2020-03-25 Alcon Inc. Uv-absorbing vinylic monomers and uses thereof
WO2017145022A1 (en) 2016-02-22 2017-08-31 Novartis Ag Uv/visible-absorbing vinylic monomers and uses thereof
KR101995725B1 (ko) * 2016-03-11 2019-07-03 주식회사 엘지화학 경화성 조성물
EP3676082A1 (en) 2017-08-29 2020-07-08 Alcon Inc. Cast-molding process for producing contact lenses
CN117492228A (zh) 2017-12-13 2024-02-02 爱尔康公司 周抛和月抛水梯度接触镜片
HUE059157T2 (hu) 2018-01-22 2022-10-28 Alcon Inc Formaöntéses eljárás UV-t elnyelõ kontaktlencse elõállítására
MY208061A (en) 2018-12-03 2025-04-11 Alcon Inc Method for making coated silicone hydrogel contact lenses
WO2020115569A1 (en) 2018-12-03 2020-06-11 Alcon Inc. Method for coated silicone hydrogel contact lenses
US11433630B2 (en) 2018-12-14 2022-09-06 Alcon Inc. Method for making silicone hydrogel contact lenses
WO2020208576A1 (en) 2019-04-10 2020-10-15 Alcon Inc. Method for producing coated contact lenses
MY206069A (en) 2019-05-28 2024-11-27 Alcon Inc Pad transfer printing method for making colored contact lenses
WO2023225332A1 (en) * 2022-05-20 2023-11-23 Duke University Tri-arm star bottlebrush polymer with defined viscosity and optical properties for use in a novel intraocular lens
US12600820B2 (en) 2022-12-06 2026-04-14 Canon Kabushiki Kaisha Photocurable composition with high silicon content

Family Cites Families (90)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4182822A (en) 1976-11-08 1980-01-08 Chang Sing Hsiung Hydrophilic, soft and oxygen permeable copolymer composition
US4343927A (en) 1976-11-08 1982-08-10 Chang Sing Hsiung Hydrophilic, soft and oxygen permeable copolymer compositions
US4136250A (en) 1977-07-20 1979-01-23 Ciba-Geigy Corporation Polysiloxane hydrogels
US4153641A (en) 1977-07-25 1979-05-08 Bausch & Lomb Incorporated Polysiloxane composition and contact lens
US4189546A (en) 1977-07-25 1980-02-19 Bausch & Lomb Incorporated Polysiloxane shaped article for use in biomedical applications
US4261875A (en) 1979-01-31 1981-04-14 American Optical Corporation Contact lenses containing hydrophilic silicone polymers
US4254248A (en) 1979-09-13 1981-03-03 Bausch & Lomb Incorporated Contact lens made from polymers of polysiloxane and polycyclic esters of acrylic acid or methacrylic acid
US4276402A (en) 1979-09-13 1981-06-30 Bausch & Lomb Incorporated Polysiloxane/acrylic acid/polcyclic esters of methacrylic acid polymer contact lens
US4260725A (en) 1979-12-10 1981-04-07 Bausch & Lomb Incorporated Hydrophilic contact lens made from polysiloxanes which are thermally bonded to polymerizable groups and which contain hydrophilic sidechains
US4259467A (en) 1979-12-10 1981-03-31 Bausch & Lomb Incorporated Hydrophilic contact lens made from polysiloxanes containing hydrophilic sidechains
US4355147A (en) 1981-02-26 1982-10-19 Bausch & Lomb Incorporated Polysiloxane with polycyclic modifier composition and biomedical devices
US4327203A (en) 1981-02-26 1982-04-27 Bausch & Lomb Incorporated Polysiloxane with cycloalkyl modifier composition and biomedical devices
US4341889A (en) 1981-02-26 1982-07-27 Bausch & Lomb Incorporated Polysiloxane composition and biomedical devices
US4444711A (en) 1981-12-21 1984-04-24 Husky Injection Molding Systems Ltd. Method of operating a two-shot injection-molding machine
US4661575A (en) 1982-01-25 1987-04-28 Hercules Incorporated Dicyclopentadiene polymer product
US4460534A (en) 1982-09-07 1984-07-17 International Business Machines Corporation Two-shot injection molding
US4486577A (en) 1982-10-12 1984-12-04 Ciba-Geigy Corporation Strong, silicone containing polymers with high oxygen permeability
US4543398A (en) 1983-04-28 1985-09-24 Minnesota Mining And Manufacturing Company Ophthalmic devices fabricated from urethane acrylates of polysiloxane alcohols
US4605712A (en) 1984-09-24 1986-08-12 Ciba-Geigy Corporation Unsaturated polysiloxanes and polymers thereof
US4833218A (en) 1984-12-18 1989-05-23 Dow Corning Corporation Hydrophilic silicone-organic copolymer elastomers containing bioactine agent
US4711943A (en) 1985-04-26 1987-12-08 Sola U.S.A. Inc. Hydrophilic siloxane monomers and dimers for contact lens materials, and contact lenses fabricated therefrom
US4684538A (en) 1986-02-21 1987-08-04 Loctite Corporation Polysiloxane urethane compounds and adhesive compositions, and method of making and using the same
DE3708308A1 (de) 1986-04-10 1987-10-22 Bayer Ag Kontaktoptische gegenstaende
DE3710343A1 (de) 1987-03-28 1988-10-06 Basf Lacke & Farben Verzweigtes acrylatcopolymerisat mit polisierbaren doppelbindungen und verfahren zur herstellung des acrylatcopolymerisats
US4837289A (en) 1987-04-30 1989-06-06 Ciba-Geigy Corporation UV- and heat curable terminal polyvinyl functional macromers and polymers thereof
US5070170A (en) 1988-02-26 1991-12-03 Ciba-Geigy Corporation Wettable, rigid gas permeable, substantially non-swellable contact lens containing block copolymer polysiloxane-polyoxyalkylene backbone units, and use thereof
US4954587A (en) 1988-07-05 1990-09-04 Ciba-Geigy Corporation Dimethylacrylamide-copolymer hydrogels with high oxygen permeability
JPH0651795B2 (ja) 1988-09-16 1994-07-06 信越化学工業株式会社 メタクリル官能性ジメチルポリシロキサン
US4954586A (en) 1989-01-17 1990-09-04 Menicon Co., Ltd Soft ocular lens material
US5034461A (en) 1989-06-07 1991-07-23 Bausch & Lomb Incorporated Novel prepolymers useful in biomedical devices
US5010141A (en) 1989-10-25 1991-04-23 Ciba-Geigy Corporation Reactive silicone and/or fluorine containing hydrophilic prepolymers and polymers thereof
US5079319A (en) 1989-10-25 1992-01-07 Ciba-Geigy Corporation Reactive silicone and/or fluorine containing hydrophilic prepolymers and polymers thereof
US5244981A (en) 1990-04-10 1993-09-14 Permeable Technologies, Inc. Silicone-containing contact lens polymers, oxygen permeable contact lenses and methods for making these lenses and treating patients with visual impairment
US5314960A (en) 1990-04-10 1994-05-24 Permeable Technologies, Inc. Silicone-containing polymers, oxygen permeable hydrophilic contact lenses and methods for making these lenses and treating patients with visual impairment
JPH0450814A (ja) * 1990-06-15 1992-02-19 Asahi Chem Ind Co Ltd ソフトコンタクトレンズ
US5314961A (en) 1990-10-11 1994-05-24 Permeable Technologies, Inc. Silicone-containing polymers, compositions and improved oxygen permeable hydrophilic contact lenses
JP2947915B2 (ja) * 1990-10-31 1999-09-13 ノバルティス アクチエンゲゼルシャフト 酸素透過性高分子材料の製造方法
EP0603268B1 (en) 1991-09-12 1996-12-18 BAUSCH & LOMB INCORPORATED Wettable silicone hydrogel compositions and methods
US5310779A (en) * 1991-11-05 1994-05-10 Bausch & Lomb Incorporated UV curable crosslinking agents useful in copolymerization
DE69211152T2 (de) 1991-11-05 1997-01-02 Bausch & Lomb Zusammensetzungen von benetzbaren siliconhydrogels und verfahren zu deren herstellung
US5358995A (en) 1992-05-15 1994-10-25 Bausch & Lomb Incorporated Surface wettable silicone hydrogels
JP3195662B2 (ja) 1992-08-24 2001-08-06 株式会社メニコン 眼用レンズ材料
JP2774233B2 (ja) 1992-08-26 1998-07-09 株式会社メニコン 眼用レンズ材料
TW328535B (en) 1993-07-02 1998-03-21 Novartis Ag Functional photoinitiators and their manufacture
US6800225B1 (en) 1994-07-14 2004-10-05 Novartis Ag Process and device for the manufacture of mouldings and mouldings manufactured in accordance with that process
TW272976B (https=) 1993-08-06 1996-03-21 Ciba Geigy Ag
US5712356A (en) 1993-11-26 1998-01-27 Ciba Vision Corporation Cross-linkable copolymers and hydrogels
US5894002A (en) 1993-12-13 1999-04-13 Ciba Vision Corporation Process and apparatus for the manufacture of a contact lens
US5843346A (en) 1994-06-30 1998-12-01 Polymer Technology Corporation Method of cast molding contact lenses
US5760100B1 (en) 1994-09-06 2000-11-14 Ciba Vision Corp Extended wear ophthalmic lens
US5665840A (en) 1994-11-18 1997-09-09 Novartis Corporation Polymeric networks from water-soluble prepolymers
TW349967B (en) 1995-02-03 1999-01-11 Novartis Ag Process for producing contact lenses and a cross-linkable polyvinylalcohol used therefor
ATE178414T1 (de) 1995-02-03 1999-04-15 Novartis Ag Vernetzte polymere enthaltend ester- oder amidgruppen
AUPN354595A0 (en) 1995-06-14 1995-07-06 Ciba-Geigy Ag Novel materials
JP2001502734A (ja) 1996-10-21 2001-02-27 ノバルティス アクチエンゲゼルシャフト 架橋性ポリマー
TW425403B (en) 1997-02-04 2001-03-11 Novartis Ag Branched polyurethane (meth)acrylate prepolymers, opthal-mic mouldings derived therefrom and processes for their manufacture
EP0867456A1 (de) 1997-02-04 1998-09-30 Novartis AG Ophthalmischer Formkörper
ATE216501T1 (de) 1997-02-21 2002-05-15 Novartis Erfind Verwalt Gmbh Opthalmische formmasse
EP1017734B1 (en) 1997-09-16 2002-08-28 Novartis AG Crosslinkable polyurea polymers
TW429327B (en) 1997-10-21 2001-04-11 Novartis Ag Single mould alignment
US5981669A (en) 1997-12-29 1999-11-09 Bausch & Lomb Incorporated Silicone-containing prepolymers and low water materials
US5962548A (en) 1998-03-02 1999-10-05 Johnson & Johnson Vision Products, Inc. Silicone hydrogel polymers
US6822016B2 (en) 2001-09-10 2004-11-23 Johnson & Johnson Vision Care, Inc. Biomedical devices containing internal wetting agents
US6367929B1 (en) 1998-03-02 2002-04-09 Johnson & Johnson Vision Care, Inc. Hydrogel with internal wetting agent
US5959117A (en) 1998-08-10 1999-09-28 Bausch & Lomb Monomers useful for contact lens materials
US6039913A (en) 1998-08-27 2000-03-21 Novartis Ag Process for the manufacture of an ophthalmic molding
EP1002807A1 (en) 1998-11-20 2000-05-24 Novartis AG Functionalized resin derived from polyallylamine
US5981675A (en) 1998-12-07 1999-11-09 Bausch & Lomb Incorporated Silicone-containing macromonomers and low water materials
JP2002538236A (ja) * 1999-03-05 2002-11-12 ダウ・コーニング・コーポレイション 制御された重合反応用開始剤の使用方法
EP1637550B1 (en) 1999-03-23 2017-09-20 Carnegie Mellon University Catalytic processes for the controlled polymerization of free radically (co) polymerizable monomers and functional polymeric systems prepared thereby
HK1048331B (en) 1999-07-27 2004-08-13 Bausch & Lomb Incorporated Contact lens material
US6719929B2 (en) 2000-02-04 2004-04-13 Novartis Ag Method for modifying a surface
CA2682118A1 (en) 2000-03-24 2001-09-27 Novartis Ag Crosslinkable or polymerizable prepolymers
US6723814B2 (en) * 2000-05-16 2004-04-20 Biocure, Inc. Amphiphilic copolymer planar membranes
US6846892B2 (en) 2002-03-11 2005-01-25 Johnson & Johnson Vision Care, Inc. Low polydispersity poly-HEMA compositions
DE10227338B4 (de) 2002-06-19 2006-05-24 Byk-Chemie Gmbh Verwendung von Polyacrylat-modifizierten Polysiloxanen als Verlaufmittel in Beschichtungsmitteln
AU2003258609A1 (en) 2002-08-14 2004-03-03 Novartis Ag Radiation-curable prepolymers
US7387759B2 (en) 2002-12-17 2008-06-17 Novartis Ag System and method for curing polymeric moldings having a masking collar
US7384590B2 (en) 2002-12-17 2008-06-10 Novartis Ag System and method for curing polymeric moldings
US7977430B2 (en) 2003-11-25 2011-07-12 Novartis Ag Crosslinkable polyurea prepolymers
JP4765356B2 (ja) * 2005-03-18 2011-09-07 Jnc株式会社 シロキサンブロック共重合体およびその製造法
US7858000B2 (en) 2006-06-08 2010-12-28 Novartis Ag Method of making silicone hydrogel contact lenses
PT2038310E (pt) 2006-07-12 2010-08-25 Novartis Ag Copolímeros reticuláveis por via actínica para o fabrico de lentes de contacto
AR064286A1 (es) 2006-12-13 2009-03-25 Quiceno Gomez Alexandra Lorena Produccion de dispositivos oftalmicos basados en la polimerizacion por crecimiento escalonado fotoinducida
KR101482808B1 (ko) 2007-03-22 2015-01-14 노파르티스 아게 현수 폴리실록산-함유 중합체 사슬이 있는 예비중합체
WO2008124093A1 (en) 2007-04-04 2008-10-16 The University Of Akron Amphiphilic networks, process for producing same, and products made therefrom
CN101215363A (zh) 2008-01-08 2008-07-09 厦门大学 有机硅两嵌段共聚物的合成方法
US8845935B2 (en) 2008-03-12 2014-09-30 Novartis Ag Method for cast molding contact lenses
US20100069522A1 (en) * 2008-03-17 2010-03-18 Linhardt Jeffrey G Lenses comprising amphiphilic multiblock copolymers
RU2524946C2 (ru) * 2008-11-13 2014-08-10 Новартис Аг Сополимеры полисилоксана с гидрофильными полимерными концевыми цепочками

Similar Documents

Publication Publication Date Title
JP2012527522A5 (https=)
JP2015507065A5 (https=)
JP2018509503A5 (https=)
JP2015062072A5 (https=)
JP2015513788A5 (https=)
JP2015187276A5 (https=)
JP2015096949A5 (https=)
JP2010530919A5 (https=)
JP2012526907A5 (https=)
JP2013523975A5 (https=)
JP2006515382A5 (https=)
JP2012526906A5 (https=)
JP2013010096A5 (https=)
JP2017536332A5 (https=)
JP2009533534A5 (https=)
JP2012088699A5 (https=)
JP2018501086A5 (https=)
JP2016522282A5 (https=)
JP2017512670A5 (https=)
JP2013540864A5 (https=)
JP2012533675A5 (https=)
JP2013516413A5 (https=)
JP2013523912A5 (https=)
JP2016515648A5 (https=)
JP2017519077A5 (https=)