JP2012526727A - 皮膚および爪の真菌感染症の局所治療に適した組成物 - Google Patents
皮膚および爪の真菌感染症の局所治療に適した組成物 Download PDFInfo
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- JP2012526727A JP2012526727A JP2012510077A JP2012510077A JP2012526727A JP 2012526727 A JP2012526727 A JP 2012526727A JP 2012510077 A JP2012510077 A JP 2012510077A JP 2012510077 A JP2012510077 A JP 2012510077A JP 2012526727 A JP2012526727 A JP 2012526727A
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- 230000008020 evaporation Effects 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
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- 150000004665 fatty acids Chemical class 0.000 description 1
- 210000004905 finger nail Anatomy 0.000 description 1
- RFHAOTPXVQNOHP-UHFFFAOYSA-N fluconazole Chemical compound C1=NC=NN1CC(C=1C(=CC(F)=CC=1)F)(O)CN1C=NC=N1 RFHAOTPXVQNOHP-UHFFFAOYSA-N 0.000 description 1
- 229960004884 fluconazole Drugs 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 235000019249 food preservative Nutrition 0.000 description 1
- 239000005452 food preservative Substances 0.000 description 1
- 230000002538 fungal effect Effects 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 239000003349 gelling agent Substances 0.000 description 1
- 229960002518 gentamicin Drugs 0.000 description 1
- 239000001087 glyceryl triacetate Substances 0.000 description 1
- 235000013773 glyceryl triacetate Nutrition 0.000 description 1
- 239000007952 growth promoter Substances 0.000 description 1
- 229960001906 haloprogin Drugs 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 229920013821 hydroxy alkyl cellulose Polymers 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 230000002458 infectious effect Effects 0.000 description 1
- 235000015110 jellies Nutrition 0.000 description 1
- 239000003410 keratolytic agent Substances 0.000 description 1
- 229960004125 ketoconazole Drugs 0.000 description 1
- 238000011866 long-term treatment Methods 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 230000003211 malignant effect Effects 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 238000002483 medication Methods 0.000 description 1
- 229940041616 menthol Drugs 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 1
- 229960002216 methylparaben Drugs 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000036562 nail growth Effects 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
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- 229960001257 oxyquinoline sulfate Drugs 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 229960003742 phenol Drugs 0.000 description 1
- 229960000969 phenyl salicylate Drugs 0.000 description 1
- FVZVCSNXTFCBQU-UHFFFAOYSA-N phosphanyl Chemical group [PH2] FVZVCSNXTFCBQU-UHFFFAOYSA-N 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920006254 polymer film Polymers 0.000 description 1
- 239000011736 potassium bicarbonate Substances 0.000 description 1
- 229910000028 potassium bicarbonate Inorganic materials 0.000 description 1
- 235000015497 potassium bicarbonate Nutrition 0.000 description 1
- WFIZEGIEIOHZCP-UHFFFAOYSA-M potassium formate Chemical compound [K+].[O-]C=O WFIZEGIEIOHZCP-UHFFFAOYSA-M 0.000 description 1
- TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 description 1
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- 239000000843 powder Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 229940095574 propionic acid Drugs 0.000 description 1
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
- 229960003415 propylparaben Drugs 0.000 description 1
- 239000003586 protic polar solvent Substances 0.000 description 1
- MCJGNVYPOGVAJF-UHFFFAOYSA-N quinolin-8-ol Chemical compound C1=CN=C2C(O)=CC=CC2=C1 MCJGNVYPOGVAJF-UHFFFAOYSA-N 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 229960001755 resorcinol Drugs 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 229960004599 sodium borate Drugs 0.000 description 1
- 229960005480 sodium caprylate Drugs 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 229940001593 sodium carbonate Drugs 0.000 description 1
- BYKRNSHANADUFY-UHFFFAOYSA-M sodium octanoate Chemical compound [Na+].CCCCCCCC([O-])=O BYKRNSHANADUFY-UHFFFAOYSA-M 0.000 description 1
- 235000010339 sodium tetraborate Nutrition 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 229960005349 sulfur Drugs 0.000 description 1
- 235000001508 sulfur Nutrition 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 235000015523 tannic acid Nutrition 0.000 description 1
- 229940033123 tannic acid Drugs 0.000 description 1
- LRBQNJMCXXYXIU-NRMVVENXSA-N tannic acid Chemical compound OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-NRMVVENXSA-N 0.000 description 1
- 229920002258 tannic acid Polymers 0.000 description 1
- 229940111630 tea tree oil Drugs 0.000 description 1
- 239000010677 tea tree oil Substances 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 210000003813 thumb Anatomy 0.000 description 1
- 229960000790 thymol Drugs 0.000 description 1
- 210000004906 toe nail Anatomy 0.000 description 1
- ANJNOJFLVNXCHT-UHFFFAOYSA-N tolindate Chemical compound C=1C=C2CCCC2=CC=1OC(=S)N(C)C1=CC=CC(C)=C1 ANJNOJFLVNXCHT-UHFFFAOYSA-N 0.000 description 1
- 229950007633 tolindate Drugs 0.000 description 1
- 239000012049 topical pharmaceutical composition Substances 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 229960002622 triacetin Drugs 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- BSVBQGMMJUBVOD-UHFFFAOYSA-N trisodium borate Chemical compound [Na+].[Na+].[Na+].[O-]B([O-])[O-] BSVBQGMMJUBVOD-UHFFFAOYSA-N 0.000 description 1
- 229940075466 undecylenate Drugs 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
- 229920003176 water-insoluble polymer Polymers 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
- CHJMFFKHPHCQIJ-UHFFFAOYSA-L zinc;octanoate Chemical compound [Zn+2].CCCCCCCC([O-])=O.CCCCCCCC([O-])=O CHJMFFKHPHCQIJ-UHFFFAOYSA-L 0.000 description 1
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- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
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Abstract
【解決手段】 この組成物の活性成分は複数の低分子量有機酸およびその塩からなり、2種又はそれ以上の酸の組合せにより相乗的効果を奏する。この活性成分の抗菌作用が不揮発性吸湿性溶媒の使用を介して更に向上するようになっている。
Description
本発明の抗真菌組成物の調合は当業者にとって公知の手段により実施することができる。本発明の2つの調合例(限定されない)、つまり液状処方およびゼリー状処方を以下に記載する。これらの調合例のほか、他の局所用調合(当業者にとって公知の方法を用いて製造される)も本発明の抗真菌組成物の投与のために利用することができる。
好ましい液状調合として以下の成分を含有する。
成分 重量%
プロピレングリコール 72
安息香酸ナトリウム 5
プロピオン酸カルシウム 5
プロピオン酸亜鉛 5
蟻酸ナトリウム 3
グリセロール 10
好ましいゼリー状調合として以下の成分を含有する。
成分 重量%
プロピレングリコール 80
安息香酸ナトリウム 5
プロピオン酸カルシウム 5
プロピオン酸亜鉛 5
蟻酸ナトリウム 3
ヒドロキシエチルセルロース 2
一般に、抗真菌製剤は例えば実施例1および2に記載した液状又はゼリー状製剤を感染部位に直接適用することにより皮膚および爪の真菌感染を治療するのに適したものである。液状製剤は皮膚のひだ又は狭い裂け目の下に、例えば爪床に拡散した感染を治療するのに特に有益である。ゼリー状製剤は開放した皮膚および爪の真菌感染を治療するのに特に有用であり、それを更に保護フィルム、例えば布、手袋、包帯、巻きつけテープなどで覆うことができる。
水虫の感染で、後に爪まで拡大したものの治療のための薬剤の開発途上において、本発明の抗菌効能が本発明者によって最初に実証された。本発明者を含め他のヒトについて本発明の抗真菌組成物のテストを行った結果、治療の完了後に再発を生じさせることなく感染の根絶がなされた。
本発明の抗真菌組成物の抗真菌活性を、侵襲性感染を生じさせる繊維状真菌の抗菌感受性の測定に使用される抗菌微量希釈法を用いてin vitroテストを介して確認した。真菌コロニーをジャガイモグルコース寒天(PGA)に成長させた。1つのコロニーを取り上げ、サブローグルコース液体培地(Sabouraud glucose broth)(SGB)を用い、テスト化合物の存在下24℃で3日間成長させた。微量希釈トレイは24℃で培養され、培養の5日後に読み込んだ。微量希釈ウェル内の濁り度は、読取りミラーを用いて評点をつけ、生育対照物のものと比較した。各ウェルに対し0から4の数値スコアを以下のスケールで与えた。すなわち、0=光学的に透明又は生育無し;1=僅かな生育(生育対照物の25%);2=生育の顕著な減少(生育対照物の50%);3=生育の僅かな減少(生育対照物の75%);4=生育減少が認められない。
純度(%) 0 0.625 1.25 2.5 5 10
実施例1の液状製剤 4 0 0 0 0 0
キャリア 4 4 4 4 2.67 1
純度(%) 0 0.625 1.25 2.5 5 10
実施例1の液状製剤 4 1 1 0.67 0 0
キャリア 4 4 4 4 3 2
Claims (47)
- 皮膚との適合性を有する非毒性組成物であって、2種又はそれ以上の低分子量有機酸、その塩又はその有機酸誘導体であって湿気の存在により有機酸に戻るものの組合せからなり、かつ、キャリアに溶解されたものからなり、ここで、
前記低分子量有機酸は、
飽和又は非飽和、環式又は非環式、分岐又は非分岐の脂肪族カルボン酸で炭素原子数が15未満であり、最長炭素鎖の長さが炭素原子数8未満のもの、
炭素原子数が15未満の芳香族カルボン酸、および
前記脂肪族又は芳香族カルボン酸の対応するスルホン酸誘導体およびホスホン酸誘導体、
の中から選択されたものであり;
これら有機酸の夫々は、アルキル、アルケニル、アルキニル、ハロゲン、ヒドロキシ、カルボニル、カルボン酸、アルデヒド、エステル、アミド、カーボネート、カルバメート、エーテル、アミノ、シアノ、イソシアノ、オキシ、オクソ、チア、アゾ、アジド、イミン、ニトロ、ニトレート、ニトロソ、ニトロソオキシ、シアナート、イソシアナート、チオシアナート、イソチオシアナート、スルフィニル、スルフヒドリル、スルホニル、ホスフィノ官能基などの内の1又はそれ以上で適宜置換されていてもよく、更に、アルキル、アルケニル、アルキニルおよびアミノ基の夫々はそれ自体で前述の官能基の1又はそれ以上で適宜、置換されていてもよく;
前記キャリアは1種又はそれ以上の不揮発性吸湿性溶媒からなり;
前記低分子量有機酸の組合せが該組成物に対し0.1重量%ないし50重量%であり、前記酸又は塩の如何なる1種も酸成分総量の75%よりも多くないことを特徴とする組成物。
- 前記有機酸の夫々は炭素原子数が10未満である請求項1に記載の組成物。
- 前記有機酸が、蟻酸、酢酸、プロピオン酸、酪酸、バレリアン酸、カプロン酸、エナント酸、カプリル酸、グリセル酸、グリコール酸、乳酸、酒石酸、グルコン酸、安息香酸、マンデル酸、サリチル酸、アクリル酸、アセト酢酸、ピルビン酸、アジピン酸、アルダル酸、フマル酸、グルタル酸、マレイン酸、ソルビン酸、リンゴ酸、マロン酸、シュウ酸、琥珀酸、タルトロン酸、クエン酸、イソクエン酸、アコニット酸、カルバリル酸およびそれらの誘導体又は置換誘導体であって湿気の存在により有機酸に戻るものから選択されたものである請求項1又は2に記載の組成物。
- 前記有機酸の1種又はそれ以上が塩の形態で使用される請求項1,2又は3に記載の組成物。
- 前記有機酸が金属塩の形態で使用される請求項1,2又は3に記載の組成物。
- 前記有機酸がアルカリ金属、アルカリ土類金属、アルミニウムおよび亜鉛から選択される塩の形態で使用される請求項1,2又は3に記載の組成物。
- 前記低分子量有機酸の塩が蟻酸塩、プロピオン酸塩および安息香酸塩である請求項5に記載の組成物。
- 前記低分子量有機酸の塩が蟻酸ナトリウム、プロピオン酸カルシウム、プロピオン酸亜鉛および安息香酸ナトリウムである請求項5に記載の組成物。
- 前記有機酸又はその塩の夫々が3乃至7重量%の量で存在する請求項1ないし8のいずれかに記載の組成物。
- 前記キャリアが分子量500gmol-1未満のポリヒドロキシ化溶媒およびポリグリコールから選択される吸湿性溶媒からなる請求項1ないし9のいずれかに記載の組成物。
- 前記キャリアがグリセリン、ジグリセロール、エチレングリコール、プロピレングリコール、ソルビトール、キシリトール、マルチトール、低分子量ポリグリコール、例えば500gmol-1未満の分子量のポリエチレングリコール、ポリプロピレングリコール、からなる群から選択される吸湿性溶媒からなる請求項1ないし9のいずれかに記載の組成物。
- 前記キャリアがプロピレングリコールである請求項1ないし9のいずれかに記載の組成物。
- 前記キャリアが更にグリセロールを含む請求項12に記載の組成物。
- 前記キャリアが更に増粘剤を含む請求項1ないし12のいずれかに記載の組成物。
- 可溶性セルロース誘導体、オリゴ糖類、多糖類、分子量1000 g/mol-1を超えるポリエチレングリコール又はポリプロピレングリコール、ヒュームドシリカまたは酸化アルミニウムからなる群から選択される増粘剤を更に含む請求項1ないし12のいずれかに記載の組成物。
- ヒドロキシエチルセルロースおよびヒュームドシリカから選択される増粘剤を更に含む請求項1ないし12のいずれかに記載の組成物。
- ヒドロキシエチルセルロースを増粘剤として更に含む請求項1ないし12のいずれかに記載の組成物。
- 前記有機酸の1種又はそれ以上が湿気の存在により酸に戻る誘導体として存在する請求項1又は2に記載の組成物。
- 皮膚又は爪の真菌感染の治療のための請求項1ないし18のいずれかに記載の組成物の使用。
- 前記真菌感染が爪の感染である請求項19に記載の使用。
- 前記真菌感染が皮膚の真菌感染である請求項19に記載の使用。
- 前記真菌感染が爪白癬、足部白癬、股部白癬、体幹白癬、でん風又はカンジダ症である請求項19に記載の使用。
- 前記真菌感染がTrichophyton rubrum又はTrichophyton interdigitaleによって発症するものである請求項19ないし22のいずれかに記載の使用。
- 真菌殺菌消毒剤としての請求項1ないし18のいずれかに記載の組成物の使用。
- 真菌により感染された皮膚又は爪に適用される包帯又はその他の材料に含浸ないし適用された請求項1ないし18のいずれかに記載の組成物。
- 皮膚との適合性を有する非毒性組成物であって、2種又はそれ以上の低分子量有機酸、その塩又はその有機酸誘導体であって湿気の存在により有機酸に戻るものの組合せからなり、かつ、キャリアに溶解されたものを、皮膚、爪の真菌感染の局所治療に使用することを目的として、皮膚との適合性を有する非毒性組成物の製造のための使用であって、ここで、
前記低分子量有機酸は、
飽和又は非飽和、環式又は非環式、分岐又は非分岐の脂肪族カルボン酸で炭素原子数が15未満であり、最長炭素鎖の長さが炭素原子数8未満のもの、
炭素原子数が15未満の芳香族カルボン酸、および
前記脂肪族又は芳香族カルボン酸の対応するスルホン酸誘導体およびホスホン酸誘導体、
の中から選択されたものであり;
これら有機酸の夫々は、アルキル、アルケニル、アルキニル、ハロゲン、ヒドロキシ、カルボニル、カルボン酸、アルデヒド、エステル、アミド、カーボネート、カルバメート、エーテル、アミノ、シアノ、イソシアノ、オキシ、オクソ、チア、アゾ、アジド、イミン、ニトロ、ニトレート、ニトロソ、ニトロソオキシ、シアナート、イソシアナート、チオシアナート、イソチオシアナート、スルフィニル、スルフヒドリル、スルホニル、ホスフィノ官能基などの内の1又はそれ以上で適宜置換されていてもよく、更に、アルキル、アルケニル、アルキニルおよびアミノ基の夫々はそれ自体で前述の官能基の1又はそれ以上で適宜、置換されていてもよく;
前記キャリアは1種又はそれ以上の不揮発性吸湿性溶媒からなり;
前記低分子量有機酸の組合せが該組成物に対し0.1重量%ないし50重量%であり、上記酸又は塩の如何なる1種も酸成分総量の75%よりも多くないことを特徴とする。
- 前記有機酸が蟻酸、プロピオン酸、安息香酸又はそれらの塩である請求項26に記載の使用。
- 前記有機酸の塩が蟻酸ナトリウム、プロピオン酸カルシウム、プロピオン酸亜鉛および安息香酸ナトリウムである請求項27に記載の使用。
- 前記キャリアがプロピレングリコールを含む請求項26ないし28のいずれかに記載の使用。
- 前記キャリアが更にグリセロールを含む請求項29に記載の使用。
- 前記組成物が更に増粘剤を含む請求項26ないし29のいずれかに記載の使用。
- 前記増粘剤がヒドロキシエチルセルロースである請求項31に記載の使用。
- 前記真菌感染が爪白癬、足部白癬、股部白癬、体幹白癬、でん風又はカンジダ症である請求項26ないし32のいずれかに記載の使用。
- 前記真菌感染がTrichophyton rubrum又はTrichophyton interdigitaleによって発症するものである請求項26ないし32のいずれかに記載の使用。
- 皮膚との適合性を有する非毒性抗真菌組成物であって、蟻酸、プロピオン酸および安息香酸の夫々の金属塩の組合せを含有してなり、かつ、これら金属塩がリチウム、ナトリウム、カリウム、マグネシウム、カルシウム、アルミニウムおよび亜鉛からなる群から選択されたものであり、更に該塩はプロピレングリコールおよびグリセロールから選択される1種又はそれ以上の吸湿性溶媒からなるキャリアに溶解されたものであり、更に前記金属塩の組合せは該組成物に対し0.1重量%ないし50重量%であり、上記塩の如何なる1種も酸成分総量の75%よりも多くないことを特徴とするもの。
- 各塩は該組成物に対し3重量%ないし7重量%含まれる請求項35に記載の抗真菌組成物。
- 前記塩が蟻酸ナトリウム、プロピオン酸カルシウム、プロピオン酸亜鉛および安息香酸ナトリウムである請求項35又は36に記載の抗真菌組成物。
- 前記キャリアがプロピレングリコールを含む請求項35又は36に記載の抗真菌組成物。
- 前記キャリアが更にグリセロールを含む請求項38に記載の抗真菌組成物。
- プロピレングリコールを少なくとも70重量%含む請求項39に記載の抗真菌組成物。
- 更に増粘剤を含む請求項35ないし38のいずれかに記載の抗真菌組成物。
- 前記増粘剤がヒドロキシエチルセルロースおよびヒュームドシリカから選択されるものである請求項41に記載の抗真菌組成物。
- 前記増粘剤がヒドロキシエチルセルロースである請求項42に記載の抗真菌組成物。
- 皮膚又は爪の真菌感染の治療のための請求項35ないし43のいずれかに記載の抗真菌組成物の使用。
- Trichophyton rubrum又はTrichophyton interdigitaleによって発症する前記真菌感染の治療における請求項35ないし43のいずれかに記載の抗真菌組成物の使用。
- 真菌殺菌消毒剤としての請求項35ないし43のいずれかに記載の抗真菌組成物の使用。
- 真菌により感染された皮膚又は爪に適用される包帯又はその他の材料に含浸ないし適用された請求項35ないし43のいずれかに記載の抗真菌組成物。
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US12/466,615 | 2009-05-15 | ||
CA2666063A CA2666063C (en) | 2009-05-15 | 2009-05-15 | Compositions suitable for the topical treatment of fungal infections of the skin and nails |
US12/466,615 US20100292333A1 (en) | 2009-05-15 | 2009-05-15 | Compositions suitable for the topical treatment of fungal infections of the skin and nails |
PCT/CA2010/000685 WO2010130028A1 (en) | 2009-05-15 | 2010-04-29 | Compositions suitable for the topical treatment of fungal infections of the skin and nails |
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RU2489170C2 (ru) * | 2011-04-27 | 2013-08-10 | Государственное научное учреждение Всероссийский научно-исследовательский институт ветеринарной санитарии, гигиены и экологии Российской академии сельскохозяйственных наук | Способ дезинфекции транспортных средств и контейнеров после перевозки животноводческих грузов |
ITRM20110278A1 (it) * | 2011-06-06 | 2012-12-07 | Cavallari Ivan | Composizione farmaceutica comprendente formaldeide, una fonte di ioni formili e suoi usi in campo medico. |
WO2014045961A1 (ja) * | 2012-09-21 | 2014-03-27 | Yoshizaki Shiro | 皮膚真菌症治療剤 |
AU2014232433A1 (en) * | 2013-03-15 | 2015-09-24 | Jeneil Biosurfactant Company, Llc | Antimicrobial compositions and related methods of use |
MX357998B (es) * | 2015-03-20 | 2018-07-11 | Antonio Hernandez Miramontes Jorge | Una mezcla de acidos carboxilicos, especificamente acido citrico, acido succinico, acido fumarico y acido malico para el tratamiento de pacientes con insuficiencia renal cronica, insuficiencia renal aguda, hepatopatias agudas o cronicas que cursen con hiperamonemia, enfermedades congenitas con alteraciones enzimaticas en el ciclo de la urea, asi como condiciones clínicas que cursen con balance nitrogenado negativo. |
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AU2010246847A1 (en) | 2011-11-17 |
RU2011146135A (ru) | 2013-06-20 |
BRPI1014488A2 (pt) | 2016-04-05 |
NZ595867A (en) | 2015-05-29 |
EP2429517A4 (en) | 2013-03-27 |
EP2429517A1 (en) | 2012-03-21 |
ZA201108335B (en) | 2013-01-30 |
MX2011012143A (es) | 2011-12-08 |
CU20110209A7 (es) | 2012-03-15 |
WO2010130028A1 (en) | 2010-11-18 |
JP5740393B2 (ja) | 2015-06-24 |
IL216323A0 (en) | 2012-01-31 |
CN102427811A (zh) | 2012-04-25 |
AU2010246847B2 (en) | 2014-04-17 |
KR20120015319A (ko) | 2012-02-21 |
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