JP2012525127A5 - - Google Patents
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- Publication number
- JP2012525127A5 JP2012525127A5 JP2012507692A JP2012507692A JP2012525127A5 JP 2012525127 A5 JP2012525127 A5 JP 2012525127A5 JP 2012507692 A JP2012507692 A JP 2012507692A JP 2012507692 A JP2012507692 A JP 2012507692A JP 2012525127 A5 JP2012525127 A5 JP 2012525127A5
- Authority
- JP
- Japan
- Prior art keywords
- ghb
- sample
- cofactor
- enzyme
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 15
- SJZRECIVHVDYJC-UHFFFAOYSA-N 4-hydroxybutyric acid Chemical compound OCCCC(O)=O SJZRECIVHVDYJC-UHFFFAOYSA-N 0.000 claims 8
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 claims 6
- 102000004190 Enzymes Human genes 0.000 claims 5
- 108090000790 Enzymes Proteins 0.000 claims 5
- 238000011534 incubation Methods 0.000 claims 4
- UIUJIQZEACWQSV-UHFFFAOYSA-N succinic semialdehyde Chemical compound OC(=O)CCC=O UIUJIQZEACWQSV-UHFFFAOYSA-N 0.000 claims 4
- 101710088194 Dehydrogenase Proteins 0.000 claims 2
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims 2
- 102000004316 Oxidoreductases Human genes 0.000 claims 2
- 108090000854 Oxidoreductases Proteins 0.000 claims 2
- 238000005259 measurement Methods 0.000 claims 2
- 235000006408 oxalic acid Nutrition 0.000 claims 2
- 102100028443 Aflatoxin B1 aldehyde reductase member 2 Human genes 0.000 claims 1
- 101710149128 Aflatoxin B1 aldehyde reductase member 2 Proteins 0.000 claims 1
- 108010053754 Aldehyde reductase Proteins 0.000 claims 1
- 102100027265 Aldo-keto reductase family 1 member B1 Human genes 0.000 claims 1
- AEMOLEFTQBMNLQ-AQKNRBDQSA-N D-glucopyranuronic acid Chemical compound OC1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-AQKNRBDQSA-N 0.000 claims 1
- IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 claims 1
- 230000002068 genetic effect Effects 0.000 claims 1
- 229940097043 glucuronic acid Drugs 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09005884.3A EP2253711B1 (en) | 2009-04-28 | 2009-04-28 | Methods, compositions and a kit suitable for determining the concentration of gamma-hydroxy butyric acid (GHB) in a sample |
| EP09005884.3 | 2009-04-28 | ||
| PCT/EP2010/055436 WO2010124999A1 (en) | 2009-04-28 | 2010-04-23 | Methods, compositions and a kit suitable for determining the concentration of gamma-hydroxy butyric acid (ghb) in a sample |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012525127A JP2012525127A (ja) | 2012-10-22 |
| JP2012525127A5 true JP2012525127A5 (enExample) | 2013-06-13 |
| JP5711216B2 JP5711216B2 (ja) | 2015-04-30 |
Family
ID=40740184
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012507692A Active JP5711216B2 (ja) | 2009-04-28 | 2010-04-23 | サンプル中のγ−ヒドロキシ酪酸（ＧＨＢ）の濃度決定に適した方法、組成物およびキット |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8609359B2 (enExample) |
| EP (1) | EP2253711B1 (enExample) |
| JP (1) | JP5711216B2 (enExample) |
| KR (1) | KR20120015327A (enExample) |
| CN (1) | CN102405294A (enExample) |
| CA (1) | CA2757686C (enExample) |
| WO (1) | WO2010124999A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2649443A2 (en) | 2010-12-06 | 2013-10-16 | Ramot at Tel-Aviv University Ltd | Methods and kits for detection of drugs |
| GB201116420D0 (en) * | 2011-09-23 | 2011-11-02 | Univ Strathclyde | GHB detection |
| CN104111253A (zh) * | 2014-06-20 | 2014-10-22 | 武汉高丰生物科技有限公司 | 一种抗抗坏血酸和色素干扰的4-羟基丁酸检测试纸的制备方法 |
| CN104713874B (zh) * | 2015-03-05 | 2016-08-31 | 杭州欣叶生物科技有限公司 | 乳腺癌尿液检测试剂和检测试剂盒及其制备和检测方法 |
| CN104897667B (zh) * | 2015-06-19 | 2017-10-03 | 公安部物证鉴定中心 | Smith试剂在检测液体检材中GHB中的应用 |
| CN107014939B (zh) * | 2017-02-27 | 2018-06-08 | 南京市公安局刑事侦查局 | 离子排斥-离子交换柱切换联用测定尿液中的γ-羟基丁酸的方法 |
| CN111208247A (zh) * | 2020-01-08 | 2020-05-29 | 浙江工业大学 | 在线热辅助甲基化-气相色谱质谱法测定人体毛发中γ-羟基丁酸含量的方法 |
| KR20210091996A (ko) | 2020-01-15 | 2021-07-23 | 금오공과대학교 산학협력단 | 감마-히드록시뷰티릭산 감지 물질이 도포된 섬유를 포함하는 감지키트 및 이의 제조방법 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6091998A (ja) * | 1983-10-27 | 1985-05-23 | Yukio Shigeta | 体液及び尿中のｄ―３―ヒドロキシ酪酸の測定法並びにそのための測定試薬 |
| US6153147A (en) * | 1998-10-06 | 2000-11-28 | Craig; James J. | Beverage analysis sample |
| US20050233459A1 (en) * | 2003-11-26 | 2005-10-20 | Melker Richard J | Marker detection method and apparatus to monitor drug compliance |
| US20010046710A1 (en) * | 2000-02-04 | 2001-11-29 | Cutler Charlyne E. | Narcotics detector test strips for a beverage |
| US6617123B1 (en) * | 2000-06-29 | 2003-09-09 | Jack V. Smith | Method for detection of 4-hydroxybutyric acid and its precursor(s) in fluids |
| US6703216B2 (en) * | 2002-03-14 | 2004-03-09 | The Regents Of The University Of California | Methods, compositions and apparatuses for detection of gamma-hydroxybutyric acid (GHB) |
| CN1962876A (zh) * | 2006-11-13 | 2007-05-16 | 于永光 | 酶法测定d－3－羟基丁酸试剂盒 |
-
2009
- 2009-04-28 EP EP09005884.3A patent/EP2253711B1/en active Active
-
2010
- 2010-04-23 CA CA2757686A patent/CA2757686C/en active Active
- 2010-04-23 US US13/318,054 patent/US8609359B2/en active Active
- 2010-04-23 WO PCT/EP2010/055436 patent/WO2010124999A1/en not_active Ceased
- 2010-04-23 JP JP2012507692A patent/JP5711216B2/ja active Active
- 2010-04-23 CN CN2010800174446A patent/CN102405294A/zh active Pending
- 2010-04-23 KR KR1020117027687A patent/KR20120015327A/ko not_active Withdrawn
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