JP2012523853A5 - - Google Patents
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- JP2012523853A5 JP2012523853A5 JP2011505170A JP2011505170A JP2012523853A5 JP 2012523853 A5 JP2012523853 A5 JP 2012523853A5 JP 2011505170 A JP2011505170 A JP 2011505170A JP 2011505170 A JP2011505170 A JP 2011505170A JP 2012523853 A5 JP2012523853 A5 JP 2012523853A5
- Authority
- JP
- Japan
- Prior art keywords
- hydroxyapatite
- crystallinity
- less
- range
- estimated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 229910052588 hydroxylapatite Inorganic materials 0.000 description 6
- DVRWARBRQNDOAJ-UHFFFAOYSA-N (3,4-dihydroxyphenyl)methyl 6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylate Chemical compound C1=C(O)C(O)=CC=C1COC(=O)C1C2=CC(O)=C(O)C=C2CCN1 DVRWARBRQNDOAJ-UHFFFAOYSA-N 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- 239000002105 nanoparticle Substances 0.000 description 3
- 210000000988 Bone and Bones Anatomy 0.000 description 2
- QORWJWZARLRLPR-UHFFFAOYSA-H Tricalcium phosphate Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 2
- 229910000389 calcium phosphate Inorganic materials 0.000 description 2
- 239000001506 calcium phosphate Substances 0.000 description 2
- 235000011010 calcium phosphates Nutrition 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 210000004369 Blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 239000012503 blood component Substances 0.000 description 1
- 239000002639 bone cement Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000001009 osteoporotic Effects 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Description
本発明の第一の局面のさらに他の態様において、薬学的に許容される液体は、水、生理食塩液、リン酸緩衝液、生物学的液体、特に血液または血液成分を含む液体、およびグリセロールから選択される。本方法にはまた、流動可能な骨セメントを2つ以上の椎体に注入する段階が含まれる。加えて、椎体は、骨折した骨または骨粗鬆症の骨であってもよい。他の態様において、リン酸カルシウム材料は30〜80 nm(たとえば、30〜50 nm)の範囲内の結晶を有するか、またはヒドロキシアパタイトと比較して60%未満(好ましくは50%未満、およびより好ましくは40%未満)の結晶化度の値を有する。
本発明の第二の局面のさらに他の態様において、リン酸カルシウムは、30〜80 nm(たとえば、30〜50 nm)の範囲内で結晶を有するか、またはヒドロキシアパタイトと比較して60%未満(好ましくは50%未満、より好ましくは40%未満)の結晶化度の値を有する。
本実施例において、産生されたNCAの結晶化度は、ナノサイズ結晶範囲30〜80 nmでおよそ60%であると推定される(ヒドロキシアパタイトと比較することによって)。
本実施例において、産生されたNLCAの結晶化度は、ナノサイズ結晶範囲30〜50 nmでおよそ50%であると推定される(ヒドロキシアパタイトと比較することによって)。
本実施例において、産生されたNLCAの結晶化度は、ナノサイズ結晶範囲30〜50 nmでおよそ40%であると推定される(ヒドロキシアパタイトと比較することによって)。
本実施例において、産生されたNLCAの結晶化度は、ナノサイズ結晶範囲30〜50 nmでおよそ40%であると推定される(ヒドロキシアパタイトと比較することによって)。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4518108P | 2008-04-15 | 2008-04-15 | |
PCT/US2009/040680 WO2009129316A2 (en) | 2008-04-15 | 2009-04-15 | Minimally invasive treatment of vertebra (mitv) using a calcium phosphate combination bone cement |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2016101062A Division JP2016209599A (ja) | 2016-05-20 | 2016-05-20 | リン酸カルシウム配合骨セメントを用いる脊椎骨の最小侵襲治療(mitv) |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2012523853A JP2012523853A (ja) | 2012-10-11 |
JP2012523853A5 true JP2012523853A5 (ja) | 2015-02-19 |
JP6324653B2 JP6324653B2 (ja) | 2018-05-16 |
Family
ID=41199709
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2011505170A Active JP6324653B2 (ja) | 2008-04-15 | 2009-04-15 | リン酸カルシウム配合骨セメントを用いる脊椎骨の最小侵襲治療(mitv) |
Country Status (8)
Country | Link |
---|---|
US (3) | US9314545B2 (ja) |
EP (1) | EP2276512A4 (ja) |
JP (1) | JP6324653B2 (ja) |
KR (2) | KR101692911B1 (ja) |
CN (2) | CN107737367A (ja) |
AU (1) | AU2009236216B2 (ja) |
CA (1) | CA2721608A1 (ja) |
WO (1) | WO2009129316A2 (ja) |
Families Citing this family (40)
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TWI579007B (zh) | 2010-07-02 | 2017-04-21 | 艾格諾福斯保健公司 | 骨再生材料之用途 |
ES2379329B1 (es) * | 2010-09-29 | 2013-03-20 | Instituto Científico Y Tecnológico De Navarra, S.A. | Uso de carboximetilquitosanos como aditivos en composiciones conglomerantes. |
US9549760B2 (en) * | 2010-10-29 | 2017-01-24 | Kyphon Sarl | Reduced extravasation of bone cement |
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GB201102468D0 (en) * | 2011-02-11 | 2011-03-30 | Univ Manchester | Biocompatible composite materials |
KR102199273B1 (ko) | 2012-03-26 | 2021-01-06 | 닛뽕 케미파 가부시키가이샤 | 뼈 및 연부에 발생하는 거대 세포성 종양 또는 연골 육종의 예방 및 치료제 |
KR20150023294A (ko) * | 2012-05-30 | 2015-03-05 | 클록스 테크놀로지스 인크. | 생체광자성 골 재건용 조성물 및 방법 |
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US9486483B2 (en) | 2013-10-18 | 2016-11-08 | Globus Medical, Inc. | Bone grafts including osteogenic stem cells, and methods relating to the same |
US9579421B2 (en) | 2014-02-07 | 2017-02-28 | Globus Medical Inc. | Bone grafts and methods of making and using bone grafts |
US9463264B2 (en) | 2014-02-11 | 2016-10-11 | Globus Medical, Inc. | Bone grafts and methods of making and using bone grafts |
US9707314B2 (en) * | 2014-03-26 | 2017-07-18 | DePuy Synthes Products, Inc. | Acrylic bone cement having a delayed release polymerization inhibitor such as an anti-oxidant for increased working time |
CN104056304B (zh) * | 2014-07-02 | 2015-09-02 | 昆明医科大学第一附属医院 | 负载生长因子壳聚糖微球的dbm支架修复关节软骨材料 |
US20160135435A1 (en) * | 2014-11-13 | 2016-05-19 | Valdosta State University, University System of Georgia | Nutrient Enriched Mineral Substrate for Propagating Marine Life |
JP6827960B2 (ja) * | 2015-03-03 | 2021-02-10 | ティーアールエス ホールディングス リミテッド ライアビリティ カンパニー | コーティングスキャフォールド |
CA2986702C (en) | 2015-05-21 | 2023-04-04 | David Wang | Modified demineralized cortical bone fibers |
US11426489B2 (en) | 2015-06-10 | 2022-08-30 | Globus Medical, Inc. | Biomaterial compositions, implants, and methods of making the same |
US10016529B2 (en) | 2015-06-10 | 2018-07-10 | Globus Medical, Inc. | Biomaterial compositions, implants, and methods of making the same |
US9642942B2 (en) * | 2015-07-16 | 2017-05-09 | Nova Southeastern University | Osteogenic regenerative scaffold matrix composition |
EP3228334A1 (en) | 2016-04-06 | 2017-10-11 | Graftys | Phosphocalcic cement composition comprising blood |
KR101978386B1 (ko) * | 2016-10-06 | 2019-05-15 | 순천향대학교 산학협력단 | 주입형 다공성 브루샤이트 골 충진재용 조성물 키트 및 골 충진재의 제조방법 |
CN107899072A (zh) * | 2017-04-01 | 2018-04-13 | 北京大学第三医院 | 一种可成孔的能够增加骨把持力的复合骨水泥及其制备方法和应用 |
JP6462822B2 (ja) * | 2017-10-12 | 2019-01-30 | 株式会社ソフセラ | 生分解性材料 |
CN108273128B (zh) * | 2018-02-09 | 2020-10-16 | 山东大学深圳研究院 | 自固化磷酸钙骨修复材料 |
CN108992707B (zh) * | 2018-09-27 | 2021-09-17 | 广东海洋大学 | 可注射壳聚糖牡蛎壳羟基磷灰石温敏性水凝胶的制备方法 |
CN110624136B (zh) * | 2019-10-08 | 2021-12-17 | 威高集团有限公司 | 一种可降解医用复合材料及其制备方法和应用 |
CN111084780A (zh) * | 2020-01-09 | 2020-05-01 | 昆明医科大学 | 老鹳草素在制备治疗骨质疏松合并骨折的药物中的用途 |
CN113694260B (zh) * | 2020-05-21 | 2022-12-02 | 上海交通大学医学院附属第九人民医院 | 一种用于椎体成形术的骨水泥水凝胶复合材料及其制备方法 |
US11896736B2 (en) | 2020-07-13 | 2024-02-13 | Globus Medical, Inc | Biomaterial implants and methods of making the same |
CN112107735A (zh) * | 2020-09-18 | 2020-12-22 | 成都理工大学 | 注射型可降解高矿化活性复合骨水泥及其制备方法 |
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-
2009
- 2009-04-15 CN CN201710961615.4A patent/CN107737367A/zh active Pending
- 2009-04-15 WO PCT/US2009/040680 patent/WO2009129316A2/en active Application Filing
- 2009-04-15 AU AU2009236216A patent/AU2009236216B2/en not_active Ceased
- 2009-04-15 JP JP2011505170A patent/JP6324653B2/ja active Active
- 2009-04-15 CA CA2721608A patent/CA2721608A1/en not_active Abandoned
- 2009-04-15 EP EP09731897.6A patent/EP2276512A4/en not_active Ceased
- 2009-04-15 KR KR1020107025648A patent/KR101692911B1/ko active IP Right Grant
- 2009-04-15 CN CN2009801220237A patent/CN102065914A/zh active Pending
- 2009-04-15 US US12/937,944 patent/US9314545B2/en not_active Expired - Fee Related
- 2009-04-15 KR KR1020167036894A patent/KR101815321B1/ko active IP Right Grant
-
2016
- 2016-04-18 US US15/131,801 patent/US9956313B2/en not_active Expired - Fee Related
-
2018
- 2018-04-25 US US15/962,111 patent/US20180311402A1/en not_active Abandoned
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