JP2012523437A - 認知障害の治療のための5−ht4受容体アゴニスト化合物 - Google Patents

認知障害の治療のための5−ht4受容体アゴニスト化合物 Download PDF

Info

Publication number
JP2012523437A
JP2012523437A JP2012504924A JP2012504924A JP2012523437A JP 2012523437 A JP2012523437 A JP 2012523437A JP 2012504924 A JP2012504924 A JP 2012504924A JP 2012504924 A JP2012504924 A JP 2012504924A JP 2012523437 A JP2012523437 A JP 2012523437A
Authority
JP
Japan
Prior art keywords
compound
methyl
isopropyl
amino
carboxylic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2012504924A
Other languages
English (en)
Japanese (ja)
Other versions
JP2012523437A5 (enExample
Inventor
デイビッド ビーティ,
フェイ シェン,
ジャクリーン エー. エム. スミス,
ロバート マレー マッキンネル,
レイ チャン,
Original Assignee
セラヴァンス, インコーポレーテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by セラヴァンス, インコーポレーテッド filed Critical セラヴァンス, インコーポレーテッド
Publication of JP2012523437A publication Critical patent/JP2012523437A/ja
Publication of JP2012523437A5 publication Critical patent/JP2012523437A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2012504924A 2009-04-13 2010-04-12 認知障害の治療のための5−ht4受容体アゴニスト化合物 Pending JP2012523437A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US16874109P 2009-04-13 2009-04-13
US61/168,741 2009-04-13
US29255910P 2010-01-06 2010-01-06
US61/292,559 2010-01-06
PCT/US2010/030760 WO2010120695A2 (en) 2009-04-13 2010-04-12 5-ht4 receptor agonist compounds for treatment of cognitive disorders

Publications (2)

Publication Number Publication Date
JP2012523437A true JP2012523437A (ja) 2012-10-04
JP2012523437A5 JP2012523437A5 (enExample) 2013-04-11

Family

ID=42237213

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2012504924A Pending JP2012523437A (ja) 2009-04-13 2010-04-12 認知障害の治療のための5−ht4受容体アゴニスト化合物

Country Status (24)

Country Link
US (2) US8404711B2 (enExample)
EP (1) EP2419104B1 (enExample)
JP (1) JP2012523437A (enExample)
KR (1) KR20120017421A (enExample)
CN (2) CN102395371A (enExample)
AU (1) AU2010236734B2 (enExample)
BR (1) BRPI1013777A8 (enExample)
CA (1) CA2758321A1 (enExample)
CY (1) CY1119800T1 (enExample)
DK (1) DK2419104T3 (enExample)
ES (1) ES2654930T3 (enExample)
HR (1) HRP20180018T1 (enExample)
HU (1) HUE038141T2 (enExample)
IL (1) IL215660A0 (enExample)
LT (1) LT2419104T (enExample)
MX (1) MX2011010782A (enExample)
NO (1) NO2419104T3 (enExample)
PL (1) PL2419104T3 (enExample)
PT (1) PT2419104T (enExample)
RU (1) RU2569056C2 (enExample)
SI (1) SI2419104T1 (enExample)
SM (1) SMT201800036T1 (enExample)
WO (1) WO2010120695A2 (enExample)
ZA (1) ZA201107490B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11951092B2 (en) 2017-06-02 2024-04-09 Fujifilm Toyama Chemical Co., Ltd. Agent for preventing or treating brain atrophy

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10164139A1 (de) 2001-12-27 2003-07-10 Bayer Ag 2-Heteroarylcarbonsäureamide
HUE026815T2 (en) 2008-11-19 2016-07-28 Forum Pharmaceuticals Inc Treatment of Cognitive Disorders with (R)-7-chloro-N-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide and pharmaceutically acceptable salts thereof
AU2010247835A1 (en) * 2009-05-11 2011-12-08 Envivo Pharmaceuticals, Inc. Treatment of cognitive disorders with certain alpha-7 nicotinic acid receptors in combination with acetylcholinesterase inhibitors
TWI519532B (zh) 2010-05-17 2016-02-01 艾維沃製藥公司 (R)-7-氯-N-(啶-3-基)苯並[b]噻吩-2-羧醯胺鹽酸鹽單水合物之結晶形體
RU2017136693A (ru) 2012-05-08 2019-02-08 Форум Фармасьютикалз, Инк. Способы поддержания, лечения или улучшения когнитивной функции
JP6009080B2 (ja) 2012-08-16 2016-10-19 ユニバーシティ−インダストリー コオペレーション グループ オブ キョン ヒ ユニバーシティUniversity−Industry Cooperation Group Of Kyung Hee University 老化及び認知症の予防及び/または治療活性を有する乳酸菌
US10874701B2 (en) 2012-08-16 2020-12-29 University-Industry Cooperation Group Of Kyung Hee University Lactic acid bacteria capable of preventing and/or treating senescence and dementia
RS61704B1 (sr) 2017-05-24 2021-05-31 H Lundbeck As Kombinacija antagonista 5-ht6 receptora i inhibitora acetilholinesteraze za upotrebu u lečenju alchajmerove bolesti kod subpopulacije pacijenata koji nose apoe4 alele
CN116585316A (zh) 2017-06-01 2023-08-15 卫材R&D管理有限公司 包含pde9抑制剂的药物组合物
CA3069989C (en) 2017-07-31 2025-05-06 Alfasigma S.P.A. METHODS FOR TREATING GASTROPARESIA SYMPTOMS USING VELUSETRAG

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007532546A (ja) * 2004-04-07 2007-11-15 セラヴァンス, インコーポレーテッド 5−ht4レセプターアゴニストとしてのキノリノン−カルボキサミド化合物
JP2008535848A (ja) * 2005-04-06 2008-09-04 セラヴァンス, インコーポレーテッド キノリン−カルボキサミド化合物の結晶形態物

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60124730T2 (de) * 2000-03-03 2007-10-04 Eisai R&D Management Co., Ltd. Neue methoden unter verwendung von cholinesteraseinhibitoren
US7598265B2 (en) * 2004-09-30 2009-10-06 Epix Delaware, Inc. Compositions and methods for treating CNS disorders
MY147756A (en) * 2005-05-25 2013-01-15 Theravance Inc Benzimidazole-carboxamide compounds as 5-ht4 receptor agonists

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007532546A (ja) * 2004-04-07 2007-11-15 セラヴァンス, インコーポレーテッド 5−ht4レセプターアゴニストとしてのキノリノン−カルボキサミド化合物
JP2008535848A (ja) * 2005-04-06 2008-09-04 セラヴァンス, インコーポレーテッド キノリン−カルボキサミド化合物の結晶形態物

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
JPN5012018155; FERRER E: 'TOWARDS EARLY DETECTION AND TREATMENT OF ALZHEIMER'S DISEASE: HIGHLIGHTS 以下備考' DRUGS OF THE FUTURE V33 N9, 20080901, P811-822 *
JPN5012018156; LAMIRAULT L: 'COMBINED TREATMENT WITH GALANTHAMINIUM BROMIDE, A NEW CHOLINESTERASE INHIBITOR, 以下備考' PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY V27 N1, 20030201, P185-195 *
JPN5012018157; MOHLER: 'VRX-03011, A NOVEL 5-HT4 AGONIST, ENHANCES MEMORY AND HIPPOCAMPAL ACETYLCHOLINE EFFLUX' NEUROPHARMACOLOGY V53 N4, 20070823, P563-573, PERGAMON PRESS *
JPN5012018158; CACHARD-CHASTEL: 'PRUCALOPRIDE AND DONEPEZIL ACT SYNERGISTICALLY TO REVERSE SCOPOLAMINE-INDUCED 以下備考' BEHAVIOURAL BRAIN RESEARCH V187 N2, 20071018, P455-461, ELSEVIER *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11951092B2 (en) 2017-06-02 2024-04-09 Fujifilm Toyama Chemical Co., Ltd. Agent for preventing or treating brain atrophy

Also Published As

Publication number Publication date
US20140057939A1 (en) 2014-02-27
CY1119800T1 (el) 2018-06-27
HRP20180018T1 (hr) 2018-02-09
BRPI1013777A2 (pt) 2016-04-05
US8404711B2 (en) 2013-03-26
KR20120017421A (ko) 2012-02-28
AU2010236734B2 (en) 2015-06-11
LT2419104T (lt) 2018-02-12
IL215660A0 (en) 2012-01-31
WO2010120695A3 (en) 2010-12-02
EP2419104B1 (en) 2017-11-08
NO2419104T3 (enExample) 2018-04-07
PT2419104T (pt) 2018-01-31
DK2419104T3 (en) 2018-02-05
AU2010236734A1 (en) 2011-11-03
RU2569056C2 (ru) 2015-11-20
WO2010120695A2 (en) 2010-10-21
BRPI1013777A8 (pt) 2017-09-19
EP2419104A2 (en) 2012-02-22
PL2419104T3 (pl) 2018-04-30
SMT201800036T1 (it) 2018-03-08
ZA201107490B (en) 2012-06-27
US20100261752A1 (en) 2010-10-14
AU2010236734A8 (en) 2012-02-16
RU2011146032A (ru) 2013-05-20
ES2654930T3 (es) 2018-02-15
CN105832735A (zh) 2016-08-10
HUE038141T2 (hu) 2018-10-29
SI2419104T1 (en) 2018-03-30
CA2758321A1 (en) 2010-10-21
MX2011010782A (es) 2012-01-20
CN102395371A (zh) 2012-03-28

Similar Documents

Publication Publication Date Title
US8404711B2 (en) 5-HT4 receptor agonist compounds for treatment of cognitive disorders
JP5647099B2 (ja) 認知症を治療するための使用及び組成物
KR102559354B1 (ko) 치매 치료
US20130045988A1 (en) Combination therapy
CA2898045C (en) Use of alpha 7 nicotinic acetylcholine receptor agonists
CN116940362A (zh) 在慢性ssri方案后使用苯二氮䓬增加对裸盖菇素的敏感性
EP2945626B1 (en) Use of alpha 7 nicotinic receptor agonists for the treatment of narcolepsy
US20220211679A1 (en) Alpha 7 nicotinic acetylcholine receptor agonists
EP0952826A1 (en) Idebenone containing combination agent for treating alzheimer's disease
HK1165722A (en) Combinations of 5-ht4 receptor agonists and acetylcholinesterase inhibitors for treatment of cognitive disorders
HK1165722B (en) Combinations of 5-ht4 receptor agonists and acetylcholinesterase inhibitors for treatment of cognitive disorders
JPH10259126A (ja) アルツハイマー病治療・予防剤
EP4217063A1 (en) Pharmaceutical combination for the treatment of human hypocholinergic disorders
CN105796582B (zh) 一种治疗老年痴呆的片剂
FR2916142A1 (fr) Forme pharmaceutique comprenant du (10-[(3s)-1-azabicyclo [2.2.2]oct-3-ylmethyl]-10h-phenothiazine se presentant sous une forme appropriee pour l'administration d'unde dose journaliere comprise entre 1 et 3 mg
JP2002517446A (ja) 精神障害の治療のためのnk−1受容体アンタゴニストの使用

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20130220

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20130220

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20140411

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20140630

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20140630

A711 Notification of change in applicant

Free format text: JAPANESE INTERMEDIATE CODE: A711

Effective date: 20140725

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20141202

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20150312

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20150319

A912 Re-examination (zenchi) completed and case transferred to appeal board

Free format text: JAPANESE INTERMEDIATE CODE: A912

Effective date: 20150410