JP2012522488A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2012522488A5 JP2012522488A5 JP2011542381A JP2011542381A JP2012522488A5 JP 2012522488 A5 JP2012522488 A5 JP 2012522488A5 JP 2011542381 A JP2011542381 A JP 2011542381A JP 2011542381 A JP2011542381 A JP 2011542381A JP 2012522488 A5 JP2012522488 A5 JP 2012522488A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- peptide
- group
- detecting
- gene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 47
- 238000000034 method Methods 0.000 claims description 23
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 21
- 150000001413 amino acids Chemical class 0.000 claims description 17
- 101000977257 Homo sapiens Protein MMS22-like Proteins 0.000 claims description 16
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 claims description 15
- 229940024606 amino acid Drugs 0.000 claims description 14
- 210000000612 antigen-presenting cell Anatomy 0.000 claims description 14
- 108091033319 polynucleotide Proteins 0.000 claims description 14
- 239000002157 polynucleotide Substances 0.000 claims description 14
- 102000040430 polynucleotide Human genes 0.000 claims description 14
- 206010028980 Neoplasm Diseases 0.000 claims description 13
- 201000011510 cancer Diseases 0.000 claims description 13
- 108090000623 proteins and genes Proteins 0.000 claims description 12
- 239000000427 antigen Substances 0.000 claims description 10
- 108091007433 antigens Proteins 0.000 claims description 10
- 102000036639 antigens Human genes 0.000 claims description 10
- 230000014509 gene expression Effects 0.000 claims description 10
- 239000012634 fragment Substances 0.000 claims description 9
- 239000003153 chemical reaction reagent Substances 0.000 claims description 8
- 230000001939 inductive effect Effects 0.000 claims description 8
- 102000004169 proteins and genes Human genes 0.000 claims description 8
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims description 6
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims description 6
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims description 6
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 6
- 108020004999 messenger RNA Proteins 0.000 claims description 6
- 229930182817 methionine Natural products 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 6
- 239000008194 pharmaceutical composition Substances 0.000 claims description 6
- 108010075704 HLA-A Antigens Proteins 0.000 claims description 4
- 102000011786 HLA-A Antigens Human genes 0.000 claims description 4
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims description 4
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims description 4
- 206010041067 Small cell lung cancer Diseases 0.000 claims description 4
- 208000005718 Stomach Neoplasms Diseases 0.000 claims description 4
- 108091008874 T cell receptors Proteins 0.000 claims description 4
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims description 4
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims description 4
- 230000004071 biological effect Effects 0.000 claims description 4
- 239000012472 biological sample Substances 0.000 claims description 4
- 238000012258 culturing Methods 0.000 claims description 4
- 206010017758 gastric cancer Diseases 0.000 claims description 4
- 238000000338 in vitro Methods 0.000 claims description 4
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims description 4
- 239000002773 nucleotide Substances 0.000 claims description 4
- 125000003729 nucleotide group Chemical group 0.000 claims description 4
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims description 4
- 208000000587 small cell lung carcinoma Diseases 0.000 claims description 4
- 206010041823 squamous cell carcinoma Diseases 0.000 claims description 4
- 201000011549 stomach cancer Diseases 0.000 claims description 4
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims description 4
- 125000001433 C-terminal amino-acid group Chemical group 0.000 claims description 3
- 108010074032 HLA-A2 Antigen Proteins 0.000 claims description 3
- 102000025850 HLA-A2 Antigen Human genes 0.000 claims description 3
- 230000028993 immune response Effects 0.000 claims description 3
- 208000010507 Adenocarcinoma of Lung Diseases 0.000 claims description 2
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 claims description 2
- 206010005003 Bladder cancer Diseases 0.000 claims description 2
- 206010008342 Cervix carcinoma Diseases 0.000 claims description 2
- 238000009007 Diagnostic Kit Methods 0.000 claims description 2
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims description 2
- 208000008839 Kidney Neoplasms Diseases 0.000 claims description 2
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims description 2
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims description 2
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims description 2
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 2
- 206010025323 Lymphomas Diseases 0.000 claims description 2
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims description 2
- 208000002151 Pleural effusion Diseases 0.000 claims description 2
- 206010036790 Productive cough Diseases 0.000 claims description 2
- 102100023475 Protein MMS22-like Human genes 0.000 claims description 2
- 206010038389 Renal cancer Diseases 0.000 claims description 2
- 206010068771 Soft tissue neoplasm Diseases 0.000 claims description 2
- 208000024313 Testicular Neoplasms Diseases 0.000 claims description 2
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims description 2
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims description 2
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims description 2
- 208000009956 adenocarcinoma Diseases 0.000 claims description 2
- 238000001574 biopsy Methods 0.000 claims description 2
- 210000004369 blood Anatomy 0.000 claims description 2
- 239000008280 blood Substances 0.000 claims description 2
- 201000010881 cervical cancer Diseases 0.000 claims description 2
- 208000006990 cholangiocarcinoma Diseases 0.000 claims description 2
- 230000002596 correlated effect Effects 0.000 claims description 2
- 238000003745 diagnosis Methods 0.000 claims description 2
- 201000004101 esophageal cancer Diseases 0.000 claims description 2
- 210000001808 exosome Anatomy 0.000 claims description 2
- 238000009396 hybridization Methods 0.000 claims description 2
- 229960000310 isoleucine Drugs 0.000 claims description 2
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims description 2
- 201000010982 kidney cancer Diseases 0.000 claims description 2
- 210000004072 lung Anatomy 0.000 claims description 2
- 201000005249 lung adenocarcinoma Diseases 0.000 claims description 2
- 201000005202 lung cancer Diseases 0.000 claims description 2
- 208000020816 lung neoplasm Diseases 0.000 claims description 2
- 239000000463 material Substances 0.000 claims description 2
- 201000008968 osteosarcoma Diseases 0.000 claims description 2
- 229920001184 polypeptide Polymers 0.000 claims description 2
- 239000000523 sample Substances 0.000 claims description 2
- 210000003802 sputum Anatomy 0.000 claims description 2
- 208000024794 sputum Diseases 0.000 claims description 2
- 238000001356 surgical procedure Methods 0.000 claims description 2
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims description 2
- 201000005112 urinary bladder cancer Diseases 0.000 claims description 2
- 210000002700 urine Anatomy 0.000 claims description 2
- 239000004474 valine Substances 0.000 claims description 2
- 210000004027 cell Anatomy 0.000 claims 2
- 239000000411 inducer Substances 0.000 claims 1
- 230000006698 induction Effects 0.000 claims 1
- 208000025189 neoplasm of testis Diseases 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 201000003120 testicular cancer Diseases 0.000 claims 1
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 108010013476 HLA-A24 Antigen Proteins 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21170009P | 2009-04-01 | 2009-04-01 | |
| US61/211,700 | 2009-04-01 | ||
| PCT/JP2010/002352 WO2010113495A1 (en) | 2009-04-01 | 2010-03-31 | C6orf167 peptides and vaccines containing the same |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012522488A JP2012522488A (ja) | 2012-09-27 |
| JP2012522488A5 true JP2012522488A5 (enExample) | 2013-05-16 |
| JP5728759B2 JP5728759B2 (ja) | 2015-06-03 |
Family
ID=42827803
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011542381A Expired - Fee Related JP5728759B2 (ja) | 2009-04-01 | 2010-03-31 | C6orf167ペプチドおよびそれを含むワクチン |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20120128705A1 (enExample) |
| EP (1) | EP2414383A4 (enExample) |
| JP (1) | JP5728759B2 (enExample) |
| KR (1) | KR20120034605A (enExample) |
| CN (2) | CN104774260A (enExample) |
| AU (1) | AU2010231381A1 (enExample) |
| BR (1) | BRPI1013384A2 (enExample) |
| CA (1) | CA2757210A1 (enExample) |
| IL (1) | IL215268A0 (enExample) |
| MX (1) | MX2011010191A (enExample) |
| RU (1) | RU2011144088A (enExample) |
| SG (2) | SG174998A1 (enExample) |
| TW (1) | TW201100090A (enExample) |
| WO (1) | WO2010113495A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101273144B (zh) | 2005-07-27 | 2011-12-28 | 肿瘤疗法科学股份有限公司 | 诊断食道癌的方法 |
| JP5838482B2 (ja) * | 2010-03-11 | 2016-01-06 | オンコセラピー・サイエンス株式会社 | Hjurpペプチドおよびそれを含むワクチン |
| JP2013542711A (ja) * | 2010-08-19 | 2013-11-28 | オンコセラピー・サイエンス株式会社 | がんの治療および診断の標的遺伝子としてのC6orf167 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2307320A1 (en) * | 1997-10-24 | 1999-05-06 | Human Genome Sciences, Inc. | 148 human secreted proteins |
| CN1351069A (zh) * | 2000-10-26 | 2002-05-29 | 上海博德基因开发有限公司 | 一种新的多肽——鼠的同ampa受体相互作用的蛋白grip12.54和编码这种多肽的多核苷酸 |
| US7919467B2 (en) * | 2000-12-04 | 2011-04-05 | Immunotope, Inc. | Cytotoxic T-lymphocyte-inducing immunogens for prevention, treatment, and diagnosis of cancer |
| EP1548032B9 (en) * | 2002-09-12 | 2009-10-28 | Oncotherapy Science, Inc. | Kdr peptides and vaccines comprising the same |
| JP4628208B2 (ja) * | 2004-08-10 | 2011-02-09 | オンコセラピー・サイエンス株式会社 | Cxadrl1またはgcud1タンパク質を発現する胃癌または結腸直腸癌の治療のためのペプチドワクチン |
| ES2459492T3 (es) * | 2005-02-25 | 2014-05-09 | Oncotherapy Science, Inc. | Vacunas de péptidos para cánceres de pulmón que expresan polipéptidos TTK, URLC10 o KOC1 |
| WO2007013665A2 (en) * | 2005-07-27 | 2007-02-01 | Oncotherapy Science, Inc. | Method of diagnosing small cell lung cancer |
| CN101273144B (zh) * | 2005-07-27 | 2011-12-28 | 肿瘤疗法科学股份有限公司 | 诊断食道癌的方法 |
| JP5409658B2 (ja) * | 2008-03-13 | 2014-02-05 | セレラ コーポレーション | 静脈血栓症に関連した遺伝子多型、その検出方法および使用 |
-
2010
- 2010-03-30 TW TW099109539A patent/TW201100090A/zh unknown
- 2010-03-31 EP EP10758274.4A patent/EP2414383A4/en not_active Withdrawn
- 2010-03-31 CN CN201510111822.1A patent/CN104774260A/zh active Pending
- 2010-03-31 KR KR1020117025871A patent/KR20120034605A/ko not_active Withdrawn
- 2010-03-31 JP JP2011542381A patent/JP5728759B2/ja not_active Expired - Fee Related
- 2010-03-31 CN CN201080024056.0A patent/CN102448980B/zh not_active Expired - Fee Related
- 2010-03-31 AU AU2010231381A patent/AU2010231381A1/en not_active Abandoned
- 2010-03-31 BR BRPI1013384A patent/BRPI1013384A2/pt not_active IP Right Cessation
- 2010-03-31 CA CA2757210A patent/CA2757210A1/en not_active Abandoned
- 2010-03-31 SG SG2011071370A patent/SG174998A1/en unknown
- 2010-03-31 SG SG2014011423A patent/SG2014011423A/en unknown
- 2010-03-31 MX MX2011010191A patent/MX2011010191A/es active IP Right Grant
- 2010-03-31 WO PCT/JP2010/002352 patent/WO2010113495A1/en not_active Ceased
- 2010-03-31 US US13/260,900 patent/US20120128705A1/en not_active Abandoned
- 2010-03-31 RU RU2011144088/10A patent/RU2011144088A/ru unknown
-
2011
- 2011-09-21 IL IL215268A patent/IL215268A0/en unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2464275C2 (ru) | Пептидные вакцины для раков, экспрессирующих опухолеспецифические антигены | |
| JP5339292B2 (ja) | Mphosph1またはdepdc1ポリペプチドを発現する癌に対するペプチドワクチン | |
| JP2012520659A5 (enExample) | ||
| JP2010523471A5 (enExample) | ||
| RU2016138428A (ru) | Пептиды neil3 и включающие их вакцины | |
| JP2019502360A5 (enExample) | ||
| JP2010519176A5 (enExample) | ||
| TW200413406A (en) | Peptides and drugs containing the same | |
| UA109891C2 (uk) | Композиція пухлиноасоційованих пептидів для лікування ракових захворювань | |
| WO2010032696A1 (ja) | がんの診断方法と治療方法 | |
| JP2012517799A5 (enExample) | ||
| Bertino et al. | [Retracted] The Immune System in Hepatocellular Carcinoma and Potential New Immunotherapeutic Strategies | |
| KR20160003141A (ko) | 암을 치료하는 방법 | |
| JP2011522777A5 (enExample) | ||
| JP2014533095A5 (enExample) | ||
| JP2011529683A5 (enExample) | ||
| Zhang et al. | MAGED4 expression in glioma and upregulation in glioma cell lines with 5-aza-2'-deoxycytidine treatment | |
| JP2013523084A5 (enExample) | ||
| JP2015529219A5 (enExample) | ||
| JP2012522488A5 (enExample) | ||
| JP2012526519A5 (enExample) | ||
| JP2012527867A5 (enExample) | ||
| RU2011120447A (ru) | Эпитопные пептиды rab6kifl/kif20a и содержащие их вакцины | |
| JP2014506114A5 (enExample) | ||
| RU2011144088A (ru) | ПЕПТИДЫ С6orf167 И СОДЕРЖАЩИЕ ИХ ВАКЦИНЫ |