JP2013521761A5 - - Google Patents
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- JP2013521761A5 JP2013521761A5 JP2012541252A JP2012541252A JP2013521761A5 JP 2013521761 A5 JP2013521761 A5 JP 2013521761A5 JP 2012541252 A JP2012541252 A JP 2012541252A JP 2012541252 A JP2012541252 A JP 2012541252A JP 2013521761 A5 JP2013521761 A5 JP 2013521761A5
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- Prior art keywords
- amino acid
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- acid sequence
- Prior art date
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- 108090000765 processed proteins & peptides Proteins 0.000 claims 28
- 150000001413 amino acids Chemical class 0.000 claims 20
- 229940024606 amino acid Drugs 0.000 claims 12
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 claims 9
- 102000004196 processed proteins & peptides Human genes 0.000 claims 9
- 239000002157 polynucleotide Substances 0.000 claims 7
- 102000040430 polynucleotide Human genes 0.000 claims 7
- 108091033319 polynucleotide Proteins 0.000 claims 7
- 239000000427 antigen Substances 0.000 claims 5
- 108091007433 antigens Proteins 0.000 claims 5
- 102000036639 antigens Human genes 0.000 claims 5
- 230000001939 inductive effect Effects 0.000 claims 5
- 238000000034 method Methods 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims 3
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 210000001744 T-lymphocyte Anatomy 0.000 claims 3
- 210000000612 antigen-presenting cell Anatomy 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 239000012634 fragment Substances 0.000 claims 3
- 238000000338 in vitro Methods 0.000 claims 3
- 229930182817 methionine Natural products 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 2
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims 2
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims 2
- 108091008874 T cell receptors Proteins 0.000 claims 2
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims 2
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims 2
- 238000012258 culturing Methods 0.000 claims 2
- 210000001808 exosome Anatomy 0.000 claims 2
- 108091005601 modified peptides Proteins 0.000 claims 2
- 239000002773 nucleotide Substances 0.000 claims 2
- 125000003729 nucleotide group Chemical group 0.000 claims 2
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims 2
- 125000001433 C-terminal amino-acid group Chemical group 0.000 claims 1
- 238000009007 Diagnostic Kit Methods 0.000 claims 1
- 108010074032 HLA-A2 Antigen Proteins 0.000 claims 1
- 102000025850 HLA-A2 Antigen Human genes 0.000 claims 1
- 108010013476 HLA-A24 Antigen Proteins 0.000 claims 1
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 1
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical group CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims 1
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims 1
- 238000007792 addition Methods 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 238000012217 deletion Methods 0.000 claims 1
- 230000037430 deletion Effects 0.000 claims 1
- 239000013604 expression vector Substances 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 239000000411 inducer Substances 0.000 claims 1
- 229960000310 isoleucine Drugs 0.000 claims 1
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims 1
- 125000001909 leucine group Chemical group [H]N(*)C(C(*)=O)C([H])([H])C(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- 238000001356 surgical procedure Methods 0.000 claims 1
- 230000008685 targeting Effects 0.000 claims 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims 1
- 239000004474 valine Substances 0.000 claims 1
- 239000013598 vector Substances 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31293110P | 2010-03-11 | 2010-03-11 | |
| US61/312,931 | 2010-03-11 | ||
| US31532010P | 2010-03-18 | 2010-03-18 | |
| US61/315,320 | 2010-03-18 | ||
| PCT/JP2011/001407 WO2011111392A1 (en) | 2010-03-11 | 2011-03-10 | Hjurp peptides and vaccines including the same |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013521761A JP2013521761A (ja) | 2013-06-13 |
| JP2013521761A5 true JP2013521761A5 (enExample) | 2014-04-24 |
| JP5838482B2 JP5838482B2 (ja) | 2016-01-06 |
Family
ID=44563223
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012541252A Active JP5838482B2 (ja) | 2010-03-11 | 2011-03-10 | Ｈｊｕｒｐペプチドおよびそれを含むワクチン |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US8933014B2 (enExample) |
| EP (1) | EP2545171B1 (enExample) |
| JP (1) | JP5838482B2 (enExample) |
| KR (1) | KR101872284B1 (enExample) |
| CN (2) | CN102884190B (enExample) |
| AU (1) | AU2011225577B2 (enExample) |
| BR (1) | BR112012022641A2 (enExample) |
| CA (1) | CA2792910A1 (enExample) |
| IL (1) | IL221474A0 (enExample) |
| MX (1) | MX344579B (enExample) |
| RU (1) | RU2570560C2 (enExample) |
| SG (2) | SG183500A1 (enExample) |
| TW (1) | TWI565473B (enExample) |
| WO (1) | WO2011111392A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201322034D0 (en) | 2013-12-12 | 2014-01-29 | Almac Diagnostics Ltd | Prostate cancer classification |
| MX2019008878A (es) | 2017-01-25 | 2020-02-13 | Ose Immunotherapeutics | Metodo para fabricar una emulsion estable para suministro de peptidos. |
| CN111944018B (zh) * | 2020-08-28 | 2022-12-23 | 深圳市乐土生物医药有限公司 | 诱导肝癌特异性细胞毒性t淋巴细胞的抗原多肽及其应用 |
Family Cites Families (43)
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| US4722848A (en) | 1982-12-08 | 1988-02-02 | Health Research, Incorporated | Method for immunizing animals with synthetically modified vaccinia virus |
| JPS60217905A (ja) | 1984-04-13 | 1985-10-31 | のむら産業株式会社 | 自動包装機 |
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
| US5108921A (en) | 1989-04-03 | 1992-04-28 | Purdue Research Foundation | Method for enhanced transmembrane transport of exogenous molecules |
| US6150584A (en) | 1990-01-12 | 2000-11-21 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| CA2089661C (en) | 1990-08-29 | 2007-04-03 | Nils Lonberg | Transgenic non-human animals capable of producing heterologous antibodies |
| US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| US6607727B1 (en) * | 1991-08-26 | 2003-08-19 | The Scripps Research Institute | Peptides for inducing cytotoxic T lymphocyte responses to hepatitus B virus |
| US5804566A (en) | 1993-08-26 | 1998-09-08 | The Regents Of The University Of California | Methods and devices for immunizing a host through administration of naked polynucleotides with encode allergenic peptides |
| US5679647A (en) | 1993-08-26 | 1997-10-21 | The Regents Of The University Of California | Methods and devices for immunizing a host against tumor-associated antigens through administration of naked polynucleotides which encode tumor-associated antigenic peptides |
| US5739118A (en) | 1994-04-01 | 1998-04-14 | Apollon, Inc. | Compositions and methods for delivery of genetic material |
| US5736524A (en) | 1994-11-14 | 1998-04-07 | Merck & Co.,. Inc. | Polynucleotide tuberculosis vaccine |
| US5922687A (en) | 1995-05-04 | 1999-07-13 | Board Of Trustees Of The Leland Stanford Junior University | Intracellular delivery of nucleic acids using pressure |
| US20030198642A1 (en) | 1995-08-03 | 2003-10-23 | Johannes J. Geuze | Cell derived antigen presenting vesicles |
| US5853719A (en) | 1996-04-30 | 1998-12-29 | Duke University | Methods for treating cancers and pathogen infections using antigen-presenting cells loaded with RNA |
| JP2000516090A (ja) | 1996-07-26 | 2000-12-05 | スローン―ケッタリング インスティチュート フォー キャンサー リサーチ | 遺伝子的免疫化のための方法と試薬 |
| FR2766205B1 (fr) | 1997-07-16 | 2002-08-30 | Inst Nat Sante Rech Med | Nouveau procede de sensibilisation de cellules presentatrices d'antigene et nouveaux moyens pour la mise en oeuvre du procede |
| JP4413429B2 (ja) | 1998-06-25 | 2010-02-10 | 株式会社グリーンペプタイド | サイクロフィリンｂ由来の腫瘍抗原ペプチド |
| ES2747357T3 (es) | 2001-03-14 | 2020-03-10 | Dako Denmark As | Construcciones de moléculas MHC y sus usos para el diagnóstico y terapia |
| CA2399569A1 (en) | 2001-09-25 | 2003-03-25 | Yusuke Nakamura | Diagnostic markers and drug targets for treatment of cancer |
| JP2004000216A (ja) * | 2002-04-26 | 2004-01-08 | Kyogo Ito | 腫瘍抗原 |
| GB2392158B (en) | 2002-08-21 | 2005-02-16 | Proimmune Ltd | Chimeric MHC protein and oligomer thereof |
| CN101139392B (zh) | 2002-09-12 | 2012-12-26 | 肿瘤疗法科学股份有限公司 | Kdr肽和包括该肽的疫苗 |
| TW200413725A (en) | 2002-09-30 | 2004-08-01 | Oncotherapy Science Inc | Method for diagnosing non-small cell lung cancers |
| US20060024692A1 (en) | 2002-09-30 | 2006-02-02 | Oncotherapy Science, Inc. | Method for diagnosing non-small cell lung cancers |
| WO2004108948A2 (en) * | 2003-06-04 | 2004-12-16 | President And Fellows Of Harvard College | Systems, methods and kits for characterizing phosphoproteomes |
| JP4516916B2 (ja) * | 2003-07-11 | 2010-08-04 | 昇志 佐藤 | リビン由来のｈｌａ−ａ２４結合性癌抗原ペプチド |
| EP1691824B1 (en) * | 2003-11-19 | 2009-03-11 | Survac ApS | Proteins belonging to the bcl-2 family and fragments thereof, and their use in cancer patients |
| AU2005265182B2 (en) * | 2004-06-17 | 2012-06-21 | Mannkind Corporation | Epitope analogs |
| JP4628208B2 (ja) * | 2004-08-10 | 2011-02-09 | オンコセラピー・サイエンス株式会社 | Ｃｘａｄｒｌ１またはｇｃｕｄ１タンパク質を発現する胃癌または結腸直腸癌の治療のためのペプチドワクチン |
| US7915036B2 (en) | 2004-09-13 | 2011-03-29 | The United States Of America As Represented By The Secretary, Department Of Health And Human Services | Compositions comprising T cell receptors and methods of use thereof |
| JP5276846B2 (ja) | 2005-09-13 | 2013-08-28 | 国立大学法人三重大学 | Ｔ細胞レセプターをコードする核酸が挿入されてなるベクター及び該レセプターを発現する細胞 |
| CN100373575C (zh) | 2005-12-09 | 2008-03-05 | 北京北方微电子基地设备工艺研究中心有限责任公司 | 一种半导体设备中的工艺过程的异常监测方法 |
| WO2008020653A1 (en) * | 2006-08-18 | 2008-02-21 | Oncotherapy Science, Inc. | Use of holliday junction-recognizing protein related to cancer |
| TW201425333A (zh) * | 2007-04-11 | 2014-07-01 | Oncotherapy Science Inc | 腫瘤血管內皮標誌８胜肽及包含此胜肽之疫苗 |
| EP2342334A4 (en) | 2008-09-29 | 2012-03-14 | Univ Pennsylvania | VACCINES DIRECTED TO TUMOR VESSEL MARKERS |
| CN102227442B (zh) | 2008-11-28 | 2014-04-16 | 日油株式会社 | Sars冠状病毒的细胞毒性t细胞表位肽及其用途 |
| MX2011007963A (es) * | 2009-03-18 | 2011-08-17 | Oncotherapy Science Inc | Peptidos neil3 y vacunas que incluyen los mismos. |
| TW201100090A (en) * | 2009-04-01 | 2011-01-01 | Oncotherapy Science Inc | C6orf167 peptides and vaccines containing the same |
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2011
- 2011-03-10 CN CN201180023275.1A patent/CN102884190B/zh active Active
- 2011-03-10 BR BR112012022641A patent/BR112012022641A2/pt not_active IP Right Cessation
- 2011-03-10 KR KR1020127023860A patent/KR101872284B1/ko not_active Expired - Fee Related
- 2011-03-10 WO PCT/JP2011/001407 patent/WO2011111392A1/en not_active Ceased
- 2011-03-10 CN CN201610108328.4A patent/CN105601727B/zh active Active
- 2011-03-10 CA CA2792910A patent/CA2792910A1/en not_active Abandoned
- 2011-03-10 JP JP2012541252A patent/JP5838482B2/ja active Active
- 2011-03-10 US US13/583,195 patent/US8933014B2/en active Active
- 2011-03-10 MX MX2012010433A patent/MX344579B/es active IP Right Grant
- 2011-03-10 SG SG2012063277A patent/SG183500A1/en unknown
- 2011-03-10 EP EP11753055.0A patent/EP2545171B1/en active Active
- 2011-03-10 AU AU2011225577A patent/AU2011225577B2/en not_active Ceased
- 2011-03-10 SG SG10201501857YA patent/SG10201501857YA/en unknown
- 2011-03-10 RU RU2012143396/10A patent/RU2570560C2/ru not_active IP Right Cessation
- 2011-03-10 TW TW100108048A patent/TWI565473B/zh not_active IP Right Cessation
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2012
- 2012-08-15 IL IL221474A patent/IL221474A0/en unknown
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2014
- 2014-03-11 US US14/205,163 patent/US9403890B2/en active Active
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2016
- 2016-06-29 US US15/197,278 patent/US9896492B2/en active Active