JP2012521194A5 - - Google Patents
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- Publication number
- JP2012521194A5 JP2012521194A5 JP2012500979A JP2012500979A JP2012521194A5 JP 2012521194 A5 JP2012521194 A5 JP 2012521194A5 JP 2012500979 A JP2012500979 A JP 2012500979A JP 2012500979 A JP2012500979 A JP 2012500979A JP 2012521194 A5 JP2012521194 A5 JP 2012521194A5
- Authority
- JP
- Japan
- Prior art keywords
- receptor
- tnf
- extracellular domain
- nucleic acid
- immunoglobulin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 102000005962 receptors Human genes 0.000 claims 55
- 108020003175 receptors Proteins 0.000 claims 55
- 150000007523 nucleic acids Chemical class 0.000 claims 24
- 108020004707 nucleic acids Proteins 0.000 claims 21
- 102000039446 nucleic acids Human genes 0.000 claims 21
- 230000004927 fusion Effects 0.000 claims 17
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 16
- 102100040247 Tumor necrosis factor Human genes 0.000 claims 16
- 230000001588 bifunctional effect Effects 0.000 claims 15
- 108700015048 receptor decoy activity proteins Proteins 0.000 claims 15
- 108060003951 Immunoglobulin Proteins 0.000 claims 14
- 125000003275 alpha amino acid group Chemical group 0.000 claims 14
- 102000018358 immunoglobulin Human genes 0.000 claims 14
- 238000000034 method Methods 0.000 claims 10
- 208000015114 central nervous system disease Diseases 0.000 claims 9
- 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 claims 8
- 108010019476 Immunoglobulin Heavy Chains Proteins 0.000 claims 8
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 claims 8
- 102000013275 Somatomedins Human genes 0.000 claims 8
- 230000006907 apoptotic process Effects 0.000 claims 8
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 8
- 102000013463 Immunoglobulin Light Chains Human genes 0.000 claims 7
- 108010065825 Immunoglobulin Light Chains Proteins 0.000 claims 7
- 102000003746 Insulin Receptor Human genes 0.000 claims 7
- 108010001127 Insulin Receptor Proteins 0.000 claims 7
- 239000003446 ligand Substances 0.000 claims 6
- 230000000295 complement effect Effects 0.000 claims 5
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 claims 4
- 102000050554 Eph Family Receptors Human genes 0.000 claims 4
- 108091008815 Eph receptors Proteins 0.000 claims 4
- 102000010781 Interleukin-6 Receptors Human genes 0.000 claims 4
- 108010038501 Interleukin-6 Receptors Proteins 0.000 claims 4
- 102000011965 Lipoprotein Receptors Human genes 0.000 claims 4
- 108010061306 Lipoprotein Receptors Proteins 0.000 claims 4
- 102000046283 TNF-Related Apoptosis-Inducing Ligand Human genes 0.000 claims 4
- 102000007238 Transferrin Receptors Human genes 0.000 claims 4
- 108010033576 Transferrin Receptors Proteins 0.000 claims 4
- 108060008683 Tumor Necrosis Factor Receptor Proteins 0.000 claims 4
- 101710097160 Tumor necrosis factor ligand superfamily member 10 Proteins 0.000 claims 4
- 239000000411 inducer Substances 0.000 claims 4
- 230000001939 inductive effect Effects 0.000 claims 4
- 102000005861 leptin receptors Human genes 0.000 claims 4
- 108010019813 leptin receptors Proteins 0.000 claims 4
- 102000003298 tumor necrosis factor receptor Human genes 0.000 claims 4
- 239000013598 vector Substances 0.000 claims 4
- 101000852815 Homo sapiens Insulin receptor Proteins 0.000 claims 3
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 3
- 210000004027 cell Anatomy 0.000 claims 3
- 239000013604 expression vector Substances 0.000 claims 3
- 102000047882 human INSR Human genes 0.000 claims 3
- 201000006474 Brain Ischemia Diseases 0.000 claims 2
- 206010008120 Cerebral ischaemia Diseases 0.000 claims 2
- 108010024777 Mating Factor Receptors Proteins 0.000 claims 2
- 108091008605 VEGF receptors Proteins 0.000 claims 2
- 102000009484 Vascular Endothelial Growth Factor Receptors Human genes 0.000 claims 2
- 230000001154 acute effect Effects 0.000 claims 2
- 206010008118 cerebral infarction Diseases 0.000 claims 2
- 230000001684 chronic effect Effects 0.000 claims 2
- 230000003511 endothelial effect Effects 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 230000000626 neurodegenerative effect Effects 0.000 claims 2
- 230000002792 vascular Effects 0.000 claims 2
- 229940124676 vascular endothelial growth factor receptor Drugs 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 102000014461 Ataxins Human genes 0.000 claims 1
- 108010078286 Ataxins Proteins 0.000 claims 1
- 208000022526 Canavan disease Diseases 0.000 claims 1
- 206010008025 Cerebellar ataxia Diseases 0.000 claims 1
- 208000024412 Friedreich ataxia Diseases 0.000 claims 1
- 201000011240 Frontotemporal dementia Diseases 0.000 claims 1
- 208000023105 Huntington disease Diseases 0.000 claims 1
- 208000026072 Motor neurone disease Diseases 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- 208000000609 Pick Disease of the Brain Diseases 0.000 claims 1
- 201000007737 Retinal degeneration Diseases 0.000 claims 1
- 208000006289 Rett Syndrome Diseases 0.000 claims 1
- 208000009415 Spinocerebellar Ataxias Diseases 0.000 claims 1
- 208000030886 Traumatic Brain injury Diseases 0.000 claims 1
- 208000026911 Tuberous sclerosis complex Diseases 0.000 claims 1
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 1
- 201000004562 autosomal dominant cerebellar ataxia Diseases 0.000 claims 1
- 102000003675 cytokine receptors Human genes 0.000 claims 1
- 108010057085 cytokine receptors Proteins 0.000 claims 1
- 210000003527 eukaryotic cell Anatomy 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 claims 1
- 208000005264 motor neuron disease Diseases 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 208000001749 optic atrophy Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 230000004258 retinal degeneration Effects 0.000 claims 1
- 208000020431 spinal cord injury Diseases 0.000 claims 1
- 208000009174 transverse myelitis Diseases 0.000 claims 1
- 230000009529 traumatic brain injury Effects 0.000 claims 1
- 208000009999 tuberous sclerosis Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16132009P | 2009-03-18 | 2009-03-18 | |
| US61/161,320 | 2009-03-18 | ||
| PCT/US2010/027882 WO2010108048A2 (en) | 2009-03-18 | 2010-03-18 | Compositions and methods for blood-brain barrier delivery of igg-decoy receptor fusion proteins |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012521194A JP2012521194A (ja) | 2012-09-13 |
| JP2012521194A5 true JP2012521194A5 (cg-RX-API-DMAC7.html) | 2013-05-02 |
| JP5873003B2 JP5873003B2 (ja) | 2016-03-01 |
Family
ID=42740242
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012500979A Active JP5873003B2 (ja) | 2009-03-18 | 2010-03-18 | ＩｇＧデコイ受容体融合タンパク質の血液脳関門送達のための組成物および方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US9533055B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2408474B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP5873003B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2748889A1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2010108048A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8741260B2 (en) * | 2005-10-07 | 2014-06-03 | Armagen Technologies, Inc. | Fusion proteins for delivery of GDNF to the CNS |
| AU2007285763B2 (en) * | 2006-08-18 | 2011-12-15 | Armagen Technologies, Inc. | Agents for blood-brain barrier delivery |
| CA3184105A1 (en) * | 2007-07-27 | 2009-02-05 | Armagen Inc. | Methods and compositions for increasing alpha-l-iduronidase activity in the cns |
| WO2010108048A2 (en) | 2009-03-18 | 2010-09-23 | Armagen Technologies, Inc. | Compositions and methods for blood-brain barrier delivery of igg-decoy receptor fusion proteins |
| JP2013507131A (ja) | 2009-10-09 | 2013-03-04 | アーメイゲン・テクノロジーズ・インコーポレイテッド | Ｃｎｓにおけるイズロン酸２−スルファターゼ活性を増加させるための方法および組成物 |
| CN103443125B (zh) | 2010-11-30 | 2019-05-03 | 霍夫曼-拉罗奇有限公司 | 低亲和力血脑屏障受体抗体及其用途 |
| US8486399B2 (en) | 2011-12-02 | 2013-07-16 | Armagen Technologies, Inc. | Methods and compositions for increasing arylsulfatase A activity in the CNS |
| US20140050720A1 (en) | 2012-01-09 | 2014-02-20 | The Scripps Research Institute | Ultralong complementarity determining regions and uses thereof |
| PL2908837T3 (pl) * | 2012-10-19 | 2019-08-30 | Vect-Horus | Kompozycje do dostarczania leku |
| EP2943512A4 (en) | 2013-01-11 | 2016-06-01 | California Inst Biomedical Res | BOVINE FUSION ANTIBODY |
| EP2983721B2 (en) | 2013-04-12 | 2021-01-20 | Evox Therapeutics Limited | Therapeutic delivery vesicles |
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| HRP20210977T1 (hr) | 2014-02-10 | 2021-09-17 | Merck Patent Gmbh | Ciljano inhibiranje tgf beta |
| US10538589B2 (en) | 2015-01-14 | 2020-01-21 | Armagen Inc. | Methods and compositions for increasing N-acetylglucosaminidase (NAGLU) activity in the CNS using a fusion antibody comprising an anti-human insulin receptor antibody and NAGLU |
| US9553885B2 (en) * | 2015-06-08 | 2017-01-24 | Illusive Networks Ltd. | System and method for creation, deployment and management of augmented attacker map |
| MX2019007824A (es) | 2016-12-28 | 2019-09-09 | Japan Chem Res | Preparacion liofilizada. |
| WO2020014185A1 (en) | 2018-07-09 | 2020-01-16 | Regeneron Pharmaceuticals, Inc. | Tuning of release kinetics in hydrogels |
| WO2020146359A1 (en) * | 2019-01-08 | 2020-07-16 | Armagen, Inc. | Methods and compositions for increasing galactosidase beta-1 activity in the cns |
| CA3128035A1 (en) | 2020-08-13 | 2022-02-13 | Bioasis Technologies, Inc. | Combination therapies for delivery across the blood brain barrier |
| EP4359430A4 (en) * | 2021-06-23 | 2025-07-16 | Lycia Therapeutics Inc | BIFUNCTIONAL COMPOUNDS CONTAINING IGF-2 POLYPEPTIDES |
| JP2024524614A (ja) | 2021-07-14 | 2024-07-05 | ライシア セラピューティクス， インコーポレイテッド | Ａｓｇｐｒ細胞表面受容体結合化合物及びコンジュゲート |
| WO2024080843A1 (ko) * | 2022-10-14 | 2024-04-18 | 주식회사 아임뉴런 | 뇌혈관장벽 투과성 융합 단백질 및 이의 용도 |
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| WO2010108048A2 (en) | 2009-03-18 | 2010-09-23 | Armagen Technologies, Inc. | Compositions and methods for blood-brain barrier delivery of igg-decoy receptor fusion proteins |
| ES2618894T3 (es) | 2009-06-24 | 2017-06-22 | Curna, Inc. | Tratamiento de enfermedades relacionadas con el receptor del factor de necrosis tumoral 2 (tnfr2) por inhibición del transcrito natural antisentido para tnfr2 |
| JP2013507131A (ja) | 2009-10-09 | 2013-03-04 | アーメイゲン・テクノロジーズ・インコーポレイテッド | Ｃｎｓにおけるイズロン酸２−スルファターゼ活性を増加させるための方法および組成物 |
| JP6073783B2 (ja) | 2010-06-25 | 2017-02-01 | シャイアー ヒューマン ジェネティック セラピーズ インコーポレイテッド | ヘパランｎ−スルファターゼのｃｎｓ送達のための方法および組成物 |
| US8486399B2 (en) | 2011-12-02 | 2013-07-16 | Armagen Technologies, Inc. | Methods and compositions for increasing arylsulfatase A activity in the CNS |
| US20150023956A1 (en) | 2013-07-22 | 2015-01-22 | Armagen Technologies, Inc. | Methods and compositions for increasing enzyme activity in the cns |
-
2010
- 2010-03-18 WO PCT/US2010/027882 patent/WO2010108048A2/en not_active Ceased
- 2010-03-18 EP EP10754139.3A patent/EP2408474B1/en active Active
- 2010-03-18 JP JP2012500979A patent/JP5873003B2/ja active Active
- 2010-03-18 CA CA2748889A patent/CA2748889A1/en not_active Abandoned
- 2010-03-18 US US13/141,682 patent/US9533055B2/en not_active Expired - Fee Related
-
2016
- 2016-11-21 US US15/357,894 patent/US20170066832A1/en not_active Abandoned
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