JP2012520085A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2012520085A5 JP2012520085A5 JP2011554275A JP2011554275A JP2012520085A5 JP 2012520085 A5 JP2012520085 A5 JP 2012520085A5 JP 2011554275 A JP2011554275 A JP 2011554275A JP 2011554275 A JP2011554275 A JP 2011554275A JP 2012520085 A5 JP2012520085 A5 JP 2012520085A5
- Authority
- JP
- Japan
- Prior art keywords
- sequence
- polynucleotide
- expression vector
- cell
- promoter
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16028709P | 2009-03-13 | 2009-03-13 | |
| US16028809P | 2009-03-13 | 2009-03-13 | |
| US61/160,287 | 2009-03-13 | ||
| US61/160,288 | 2009-03-13 | ||
| PCT/US2010/027365 WO2010105277A1 (en) | 2009-03-13 | 2010-03-15 | Compositions and methods for the delivery of biologically active rnas |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012520085A JP2012520085A (ja) | 2012-09-06 |
| JP2012520085A5 true JP2012520085A5 (enExample) | 2013-02-21 |
Family
ID=42728852
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011554275A Pending JP2012520085A (ja) | 2009-03-13 | 2010-03-15 | 生物活性ｒｎａの送達のための組成物及び方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US8569065B2 (enExample) |
| EP (1) | EP2406379A4 (enExample) |
| JP (1) | JP2012520085A (enExample) |
| KR (1) | KR20110128345A (enExample) |
| CN (1) | CN102625842A (enExample) |
| AU (1) | AU2010223888A1 (enExample) |
| CA (1) | CA2755245A1 (enExample) |
| WO (1) | WO2010105277A1 (enExample) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5863670B2 (ja) | 2010-01-19 | 2016-02-17 | ノースウェスタン ユニバーシティ | 核酸および／または他の構成要素を含有している合成ナノ構造体 |
| WO2011113054A2 (en) * | 2010-03-12 | 2011-09-15 | Aurasense Llc | Crosslinked polynucleotide structure |
| US9593347B2 (en) | 2010-04-16 | 2017-03-14 | University of Pittsburgh—of the Commonwealth System of Higher Education | Identification of mutations in herpes simplex virus envelope glycoproteins that enable or enhance vector retargeting to novel non-HSV receptors |
| CA2807552A1 (en) | 2010-08-06 | 2012-02-09 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| ES3005233T3 (en) | 2010-10-01 | 2025-03-14 | Modernatx Inc | Modified nucleosides, nucleotides, and nucleic acids, and uses thereof |
| JP2014511687A (ja) | 2011-03-31 | 2014-05-19 | モデルナ セラピューティクス インコーポレイテッド | 工学操作された核酸の送達および製剤 |
| WO2012159164A1 (en) * | 2011-05-23 | 2012-11-29 | Phylogica Limited | Method of determining, identifying or isolating cell-penetrating peptides |
| US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| EP2763701B1 (en) | 2011-10-03 | 2018-12-19 | Moderna Therapeutics, Inc. | Modified nucleosides, nucleotides, and nucleic acids, and uses thereof |
| JP2015501844A (ja) | 2011-12-16 | 2015-01-19 | モデルナ セラピューティクス インコーポレイテッドＭｏｄｅｒｎａ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． | 修飾ヌクレオシド、ヌクレオチドおよび核酸組成物 |
| KR20140123054A (ko) * | 2011-12-23 | 2014-10-21 | 씨엘에스엔 래버러토리스, 인코퍼레이티드 | 생물학적 활성 ｒｎａ의 전달을 위한 조성물 및 방법 |
| WO2013101690A1 (en) * | 2011-12-29 | 2013-07-04 | modeRNA Therapeutics | Modified mrnas encoding cell-penetrating polypeptides |
| US9254311B2 (en) | 2012-04-02 | 2016-02-09 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of proteins |
| US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
| US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
| WO2013151663A1 (en) | 2012-04-02 | 2013-10-10 | modeRNA Therapeutics | Modified polynucleotides for the production of membrane proteins |
| ES2921623T3 (es) | 2012-11-26 | 2022-08-30 | Modernatx Inc | ARN modificado terminalmente |
| US9909123B2 (en) * | 2013-03-15 | 2018-03-06 | Techulon Inc. | Antisense molecules for treatment of Staphylococcus aureus infection |
| US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
| WO2015002956A1 (en) * | 2013-07-01 | 2015-01-08 | Ohio State Innovation Foundation | Exosome delivery system |
| KR20160042917A (ko) | 2013-07-25 | 2016-04-20 | 엑시큐어, 인크. | 예방 및 치료 용도를 위한 면역자극제로서의 구형 핵산-기재 구축물 |
| WO2015023797A1 (en) | 2013-08-13 | 2015-02-19 | Northwestern University | Lipophilic nanoparticles for drug delivery |
| WO2015048744A2 (en) | 2013-09-30 | 2015-04-02 | Moderna Therapeutics, Inc. | Polynucleotides encoding immune modulating polypeptides |
| KR20160067219A (ko) | 2013-10-03 | 2016-06-13 | 모더나 세라퓨틱스, 인코포레이티드 | 저밀도 지단백질 수용체를 암호화하는 폴리뉴클레오타이드 |
| KR102490462B1 (ko) | 2013-10-28 | 2023-01-19 | 유니버시티 오브 피츠버그-오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션 | 종양분해성 hsv 벡터 |
| WO2015120541A1 (en) * | 2014-02-14 | 2015-08-20 | Symvivo Corporation | Nucleic acid vectors and uses thereof |
| EP3164113B1 (en) | 2014-06-04 | 2019-03-27 | Exicure, Inc. | Multivalent delivery of immune modulators by liposomal spherical nucleic acids for prophylactic or therapeutic applications |
| WO2016028940A1 (en) | 2014-08-19 | 2016-02-25 | Northwestern University | Protein/oligonucleotide core-shell nanoparticle therapeutics |
| EA201790802A1 (ru) | 2014-10-06 | 2017-08-31 | Экзикьюр, Инк. | Соединения против tnf |
| US9816080B2 (en) * | 2014-10-31 | 2017-11-14 | President And Fellows Of Harvard College | Delivery of CAS9 via ARRDC1-mediated microvesicles (ARMMs) |
| US10078092B2 (en) | 2015-03-18 | 2018-09-18 | Northwestern University | Assays for measuring binding kinetics and binding capacity of acceptors for lipophilic or amphiphilic molecules |
| ES2919953T3 (es) | 2016-01-27 | 2022-07-29 | Oncorus Inc | Vectores víricos oncolíticos y usos de los mismos |
| US11639371B2 (en) * | 2016-02-17 | 2023-05-02 | The Chinese University Of Hong Kong | Peptidylic inhibitors of nucleolin (NCL) targeting CAG-repeat RNA toxicity and methods for reducing polyQ-mediated toxicity in polyQ diseases |
| WO2017161043A1 (en) | 2016-03-16 | 2017-09-21 | The J. David Gladstone Institutes | Methods and compositions for treating obesity and/or diabetes and for identifying candidate treatment agents |
| CN109983121A (zh) | 2016-06-30 | 2019-07-05 | 昂克诺斯公司 | 治疗性多肽的假型化溶瘤病毒递送 |
| RU2771110C2 (ru) | 2017-07-26 | 2022-04-26 | Онкорус, Инк. | Онколитические вирусные векторы и их применение |
| EP3731850A4 (en) | 2017-12-29 | 2021-12-01 | Oncorus, Inc. | ONCOLYTIC VIRUS DELIVERY OF THERAPEUTIC POLYPEPTIDES |
| WO2020010083A1 (en) * | 2018-07-05 | 2020-01-09 | The Regents Of The University Of California | Compositions and methods for delivery of rna to a cell |
| JP2022550130A (ja) | 2019-09-26 | 2022-11-30 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 最小アレスチンドメイン含有蛋白質１（ａｒｒｄｃ１）コンストラクト |
| WO2023244760A1 (en) * | 2022-06-15 | 2023-12-21 | Duke University | Protein library display systems and methods thereof |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5585263A (en) | 1994-05-20 | 1996-12-17 | University Of Alabama At Birmingham Research Foundation | Purified retroviral constitutive transport enhancer and its use to facilitate mRNA transport, and to produce recombinant, attenuated HIV |
| US6451592B1 (en) | 1996-04-05 | 2002-09-17 | Chiron Corporation | Recombinant alphavirus-based vectors with reduced inhibition of cellular macromolecular synthesis |
| US20040241845A1 (en) * | 1998-05-22 | 2004-12-02 | Luc Desgroseillers | Mammalian staufen and use thereof |
| US6899871B2 (en) * | 1998-10-01 | 2005-05-31 | University Of Southern California | Gene delivery system and methods of use |
| JP2002533128A (ja) * | 1998-12-31 | 2002-10-08 | アドバンスド リサーチ アンド テクノロジー インスティテュート | アデノ随伴ウイルス２による感染のためのコレセプターとしてのヒト線維芽細胞増殖因子レセプター１ |
| AU2001294872A1 (en) | 2000-09-28 | 2002-04-08 | Cellomics, Inc. | Methods and reagents for live-cell gene expression quantification |
| CU23225A1 (es) * | 2001-12-20 | 2007-08-30 | Ct Ingenieria Genetica Biotech | PéPTIDOS PARA EL TRATAMIENTO DEL CáNCER ASOCIADO AL VIRUS PAPILOMA HUMANO (VPH) Y DE OTROS TUMORES EPITELIALES |
| US20040005593A1 (en) * | 2002-03-06 | 2004-01-08 | Rigel Pharmaceuticals, Inc. | Novel method for delivery and intracellular synthesis of siRNA molecules |
| US20050074865A1 (en) * | 2002-08-27 | 2005-04-07 | Compound Therapeutics, Inc. | Adzymes and uses thereof |
| JP2006512906A (ja) | 2002-09-28 | 2006-04-20 | マサチューセッツ インスティチュート オブ テクノロジー | インフルエンザ治療剤 |
| GB0225788D0 (en) * | 2002-11-05 | 2002-12-11 | Glaxo Group Ltd | Vaccine |
| US20040147027A1 (en) * | 2003-01-28 | 2004-07-29 | Troy Carol M. | Complex for facilitating delivery of dsRNA into a cell and uses thereof |
| US20070036773A1 (en) * | 2005-08-09 | 2007-02-15 | City Of Hope | Generation and application of universal T cells for B-ALL |
| CN101415816A (zh) | 2006-02-02 | 2009-04-22 | 雷格内泰克公司 | 表征生物活性化合物的方法 |
| JP2009532017A (ja) * | 2006-02-10 | 2009-09-10 | ザ レジェンツ オブ ザ ユニヴァースティ オブ カリフォルニア | ＰＴＤ／ＣＰＰＳへのｄｓＲＮＡ結合ドメイン融合体によるｓｉＲＮＡの導入可能な送達 |
| US9085778B2 (en) * | 2006-05-03 | 2015-07-21 | VL27, Inc. | Exosome transfer of nucleic acids to cells |
| CN100549179C (zh) * | 2006-08-07 | 2009-10-14 | 汪运山 | 胃癌靶向AFP基因的siRNAs表达载体及其用途 |
| US20100112638A1 (en) * | 2007-02-15 | 2010-05-06 | Cornelis Maria Jacobus Sagt | Recombinant host cell for the production of a compound of interest |
| EP3023495B1 (en) | 2010-02-24 | 2019-05-08 | Arrowhead Pharmaceuticals, Inc. | Compositions for targeted delivery of sirna |
-
2010
- 2010-03-15 US US12/724,408 patent/US8569065B2/en active Active
- 2010-03-15 AU AU2010223888A patent/AU2010223888A1/en not_active Abandoned
- 2010-03-15 CA CA2755245A patent/CA2755245A1/en not_active Abandoned
- 2010-03-15 JP JP2011554275A patent/JP2012520085A/ja active Pending
- 2010-03-15 EP EP10751551A patent/EP2406379A4/en not_active Withdrawn
- 2010-03-15 WO PCT/US2010/027365 patent/WO2010105277A1/en not_active Ceased
- 2010-03-15 KR KR1020117024110A patent/KR20110128345A/ko not_active Ceased
- 2010-03-15 CN CN2010800210226A patent/CN102625842A/zh active Pending
-
2013
- 2013-03-11 US US13/793,961 patent/US20140005254A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2019524140A5 (enExample) | ||
| JP2018532705A5 (enExample) | ||
| JP2022516130A5 (enExample) | ||
| JP2018528237A5 (enExample) | ||
| RU2013152648A (ru) | Аденовирус обезьян и гибридные аденовирусные векторы | |
| HRP20230150T1 (hr) | Konstrukcija kimernog antigenskog receptora koji cilja cd20 antigen i identifikacija aktivnosti njegovih inženjerskih t-stanica | |
| EP2852407A1 (fr) | Cassettes d'expression procaryotes régulées par le stress. | |
| JP2011062217A5 (enExample) | ||
| WO2008084115A3 (en) | Lactococcus promoters and uses thereof | |
| JP2013530689A5 (enExample) | ||
| JP2020523983A5 (enExample) | ||
| JP2009528843A5 (enExample) | ||
| JP2011520424A5 (enExample) | ||
| JP2016503434A5 (enExample) | ||
| JP2023504826A5 (enExample) | ||
| CN116218904B (zh) | 一种可提高工程化细胞外泌体中特定核酸分子载量的方法及其应用 | |
| CN109929865A (zh) | 基于gal4-uas系统的crispr辅助反式增强子激活基因表达的方法及其应用 | |
| CN103266127B (zh) | 一种电击转化枯草芽孢杆菌的方法 | |
| WO2013052814A8 (en) | E1 enzyme mutants and uses thereof | |
| CN102702335A (zh) | 重组转录激活子样效应因子、转录激活子样效应因子核酸酶及其编码基因及应用 | |
| RU2008153051A (ru) | Способ направленной доставки днк в опухолевые и стволовые клетки | |
| CN102753687B (zh) | 用于遗传转化藻类的新型启动子 | |
| CN112888712A (zh) | 工程化的微生物及其制造和使用方法 | |
| AR102762A1 (es) | Secuencia de oligonucleótidos para uso en ingeniería de rutas metabólicas | |
| CA2752947A1 (en) | Foxp1 splice variants and methods and uses thereof |