JP2012519003A - 不妊症関連defb−126欠失多型 - Google Patents

不妊症関連defb−126欠失多型 Download PDF

Info

Publication number
JP2012519003A
JP2012519003A JP2011552196A JP2011552196A JP2012519003A JP 2012519003 A JP2012519003 A JP 2012519003A JP 2011552196 A JP2011552196 A JP 2011552196A JP 2011552196 A JP2011552196 A JP 2011552196A JP 2012519003 A JP2012519003 A JP 2012519003A
Authority
JP
Japan
Prior art keywords
defb
polypeptide
seq
sperm
individual
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
JP2011552196A
Other languages
English (en)
Japanese (ja)
Other versions
JP2012519003A5 (enExample
Inventor
チャールズ エル. ベビンス
ツァン ラウ
ゲイリー エヌ. シェール
アシュレー アイ. ユージン
セオドア エル. トルナー
ジェイムス ダブリュ. オーバーストリート
スコット ベナーズ
シピン スー
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California
Original Assignee
University of California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of California filed Critical University of California
Publication of JP2012519003A publication Critical patent/JP2012519003A/ja
Publication of JP2012519003A5 publication Critical patent/JP2012519003A5/ja
Ceased legal-status Critical Current

Links

Images

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/689Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to pregnancy or the gonads
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/14Peptides containing saccharide radicals; Derivatives thereof, e.g. bleomycin, phleomycin, muramylpeptides or vancomycin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/156Polymorphic or mutational markers
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701Details
    • G01N2333/4721Cationic antimicrobial peptides, e.g. defensins
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2400/00Assays, e.g. immunoassays or enzyme assays, involving carbohydrates
    • G01N2400/02Assays, e.g. immunoassays or enzyme assays, involving carbohydrates involving antibodies to sugar part of glycoproteins
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/36Gynecology or obstetrics
    • G01N2800/367Infertility, e.g. sperm disorder, ovulatory dysfunction
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/50Determining the risk of developing a disease

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • Pathology (AREA)
  • Genetics & Genomics (AREA)
  • Physics & Mathematics (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
JP2011552196A 2009-02-26 2010-02-26 不妊症関連defb−126欠失多型 Ceased JP2012519003A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US15580709P 2009-02-26 2009-02-26
US61/155,807 2009-02-26
PCT/US2010/025626 WO2010099468A2 (en) 2009-02-26 2010-02-26 Infertility associated defb-126 deletion polymorphism

Publications (2)

Publication Number Publication Date
JP2012519003A true JP2012519003A (ja) 2012-08-23
JP2012519003A5 JP2012519003A5 (enExample) 2013-04-11

Family

ID=42666247

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2011552196A Ceased JP2012519003A (ja) 2009-02-26 2010-02-26 不妊症関連defb−126欠失多型

Country Status (5)

Country Link
US (1) US20120077758A1 (enExample)
EP (1) EP2401407A4 (enExample)
JP (1) JP2012519003A (enExample)
CA (1) CA2789941A1 (enExample)
WO (1) WO2010099468A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021020498A1 (ja) * 2019-07-31 2021-02-04 スピンシェル株式会社 レポーティング装置、レポーティング方法、レポーティングプログラム、及びレポーティングシステム

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2012133127A1 (ja) * 2011-03-31 2014-07-28 株式会社グライエンス ブドウ球菌属内の菌種を判別する方法
CN103468807B (zh) * 2013-09-12 2015-07-15 上海惠宝生物科技有限公司 用于检测男性生育力的引物、探针及其试剂盒
JP6852397B2 (ja) * 2016-12-28 2021-03-31 株式会社島津製作所 分析用試料の調製方法および分析方法
EP3850112A1 (en) 2018-09-11 2021-07-21 Università degli Studi di Foggia Method for identifying the predisposition to male infertility based on polymorphisms of the vitamin d receptor gene
CN114606310A (zh) * 2022-03-23 2022-06-10 上海市生物医药技术研究院 人defb126基因移码突变检测方法和试剂盒

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070299025A1 (en) * 2004-01-15 2007-12-27 Oy Jurilab Ltd Method for Detecting the Risk of Cardiovascular Diseases Such as Acute Myocardial Infarction and Coronary Heart Disease By Analysing Defesin

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070299025A1 (en) * 2004-01-15 2007-12-27 Oy Jurilab Ltd Method for Detecting the Risk of Cardiovascular Diseases Such as Acute Myocardial Infarction and Coronary Heart Disease By Analysing Defesin

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
JPN5012010090; GENBANK: 'HOMO SAPIENS MRNA FOR BETA DEFENSIN 126 PREPROPROTEIN VARIANT,CLONE: FCC111E11' [ONLINE] , 2006 *
JPN6014030798; Hum. Reprod., 2008, 23(11), pp.2523-2534 *
JPN6014030799; EMBO J., 2007, 26(9), pp.2327-2338 *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021020498A1 (ja) * 2019-07-31 2021-02-04 スピンシェル株式会社 レポーティング装置、レポーティング方法、レポーティングプログラム、及びレポーティングシステム
JPWO2021020498A1 (enExample) * 2019-07-31 2021-02-04
JP7304020B2 (ja) 2019-07-31 2023-07-06 スピンシェル株式会社 レポーティング装置、レポーティング方法、レポーティングプログラム、及びレポーティングシステム
JP2023107999A (ja) * 2019-07-31 2023-08-03 スピンシェル株式会社 レポーティング装置、レポーティング方法、レポーティングプログラム、及びレポーティングシステム
US12327621B2 (en) 2019-07-31 2025-06-10 Spinshell, Inc. Reporting device, reporting method, reporting program, and reporting system

Also Published As

Publication number Publication date
WO2010099468A2 (en) 2010-09-02
CA2789941A1 (en) 2010-09-02
EP2401407A2 (en) 2012-01-04
US20120077758A1 (en) 2012-03-29
EP2401407A4 (en) 2012-10-03
WO2010099468A3 (en) 2010-11-18

Similar Documents

Publication Publication Date Title
US20080113340A1 (en) Diagnosis and treatment of cervical cancer
JP6285472B2 (ja) 診断及び治療のための腫瘍関連マーカーの同定
JP2006511615A (ja) 子癇前症または子癇の診断方法および治療方法
JP2012519003A (ja) 不妊症関連defb−126欠失多型
CN104619840A (zh) Fgfr2融合基因
JP2003514541A (ja) 18個のヒト分泌タンパク質
WO2004069268A1 (ja) Otx2遺伝子を用いた網膜視細胞の再生と新生
JPH10509581A (ja) トロフィニンおよびトロフィニン補助タンパク質
JP2008237204A (ja) 疾患モデル動物、細胞、組織、精巣、交配用動物、生殖細胞生産方法、生殖細胞、培養細胞、スクリーニング方法、医薬組成物、妊孕性診断キット、検出方法、ポリヌクレオチド、ポリペプチド、及び抗体
JP2002543761A (ja) 結核症抗原およびそのための使用の方法
CN110713544B (zh) 融合基因plekha6-ntrk3及其在lch中的应用
JP2003510053A (ja) ヘパラナーゼ蛋白質ファミリーの1種、ヘパラナーゼ−2
KR101029004B1 (ko) 염증성 관절염 마커로서의 prdm10 단백질 및 이를 포함하는 염증성 관절염 진단키트
KR101700945B1 (ko) 선천성 녹내장, 유전성 혈관 석회화 또는 골격 이상증에 대한 원인 유전자로서의 ddx58 돌연변이 유전자 및 이를 이용한 상기 질병의 진단방법 및 진단용 조성물
US10213481B2 (en) Compositions and methods to treat inflammatory joint disease
JP2003530109A (ja) エルビンをコードする遺伝子及びその診断及び治療的使用
JP2010187556A (ja) 妊孕性診断方法、妊孕性診断キット、ポリヌクレオチド、ポリペプチド、及び抗体
JP2005505267A (ja) 癌において差次的に発現する膜貫通タンパク質
CN110452987A (zh) 一组肺腺癌诊断标记及其应用
JPWO2005092383A1 (ja) 呼吸器疾患の予防・治療剤
KR100983386B1 (ko) 난소암 진단을 위한 agr-2의 신규한 용도
CN108728523A (zh) Bcl-3作为诊断早期肾纤维化的标志物的应用
US20030104418A1 (en) Diagnostic markers for breast cancer
KR102015527B1 (ko) 데스모글레인 3의 유전적 변이 및 이의 용도
JP4445291B2 (ja) 新規タンパク質およびそのdna

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20130220

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20130220

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20140723

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20141020

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20141027

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20150122

A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20150603

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20150629

A045 Written measure of dismissal of application [lapsed due to lack of payment]

Free format text: JAPANESE INTERMEDIATE CODE: A045

Effective date: 20151022