CA2789941A1 - Infertility associated defb-126 deletion polymorphism - Google Patents

Infertility associated defb-126 deletion polymorphism Download PDF

Info

Publication number
CA2789941A1
CA2789941A1 CA2789941A CA2789941A CA2789941A1 CA 2789941 A1 CA2789941 A1 CA 2789941A1 CA 2789941 A CA2789941 A CA 2789941A CA 2789941 A CA2789941 A CA 2789941A CA 2789941 A1 CA2789941 A1 CA 2789941A1
Authority
CA
Canada
Prior art keywords
defb
seq
polypeptide
sperm
individual
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2789941A
Other languages
English (en)
French (fr)
Inventor
Charles L. Bevins
Tsang Lau
Gary N. Cherr
Ashley I. Yudin
Theodore L. Tollner
James W. Overstreet
Scott Venners
Xiping Xu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California, San Diego
University of Illinois System
Original Assignee
University of California, San Diego
University of Illinois System
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of California, San Diego, University of Illinois System filed Critical University of California, San Diego
Publication of CA2789941A1 publication Critical patent/CA2789941A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/689—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to pregnancy or the gonads
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/14—Peptides containing saccharide radicals; Derivatives thereof, e.g. bleomycin, phleomycin, muramylpeptides or vancomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4721—Cationic antimicrobial peptides, e.g. defensins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2400/00—Assays, e.g. immunoassays or enzyme assays, involving carbohydrates
    • G01N2400/02—Assays, e.g. immunoassays or enzyme assays, involving carbohydrates involving antibodies to sugar part of glycoproteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/36—Gynecology or obstetrics
    • G01N2800/367—Infertility, e.g. sperm disorder, ovulatory dysfunction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/50—Determining the risk of developing a disease

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Wood Science & Technology (AREA)
  • Pathology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Reproductive Health (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Biophysics (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
CA2789941A 2009-02-26 2010-02-26 Infertility associated defb-126 deletion polymorphism Abandoned CA2789941A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US15580709P 2009-02-26 2009-02-26
US61/155,807 2009-02-26
PCT/US2010/025626 WO2010099468A2 (en) 2009-02-26 2010-02-26 Infertility associated defb-126 deletion polymorphism

Publications (1)

Publication Number Publication Date
CA2789941A1 true CA2789941A1 (en) 2010-09-02

Family

ID=42666247

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2789941A Abandoned CA2789941A1 (en) 2009-02-26 2010-02-26 Infertility associated defb-126 deletion polymorphism

Country Status (5)

Country Link
US (1) US20120077758A1 (enExample)
EP (1) EP2401407A4 (enExample)
JP (1) JP2012519003A (enExample)
CA (1) CA2789941A1 (enExample)
WO (1) WO2010099468A2 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020052946A1 (en) 2018-09-11 2020-03-19 Universita' Degli Studi Di Foggia Method for identifying the predisposition to male infertility based on polymorphisms of the vitamin d receptor gene
CN114606310A (zh) * 2022-03-23 2022-06-10 上海市生物医药技术研究院 人defb126基因移码突变检测方法和试剂盒

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140087395A1 (en) * 2011-03-31 2014-03-27 Hiroshima University Method for distinguishing between species within the genus staphilococcus
CN103468807B (zh) * 2013-09-12 2015-07-15 上海惠宝生物科技有限公司 用于检测男性生育力的引物、探针及其试剂盒
JP6852397B2 (ja) * 2016-12-28 2021-03-31 株式会社島津製作所 分析用試料の調製方法および分析方法
CN114175175A (zh) 2019-07-31 2022-03-11 纺壳株式会社 报告装置、报告方法、报告程序以及报告系统

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI118265B (fi) * 2004-01-15 2007-09-14 Jurilab Ltd Oy Menetelmä akuutin sydäninfarktin ja sepelvaltimotaudin riskin havaitsemiseksi

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020052946A1 (en) 2018-09-11 2020-03-19 Universita' Degli Studi Di Foggia Method for identifying the predisposition to male infertility based on polymorphisms of the vitamin d receptor gene
CN114606310A (zh) * 2022-03-23 2022-06-10 上海市生物医药技术研究院 人defb126基因移码突变检测方法和试剂盒

Also Published As

Publication number Publication date
WO2010099468A3 (en) 2010-11-18
US20120077758A1 (en) 2012-03-29
EP2401407A2 (en) 2012-01-04
JP2012519003A (ja) 2012-08-23
WO2010099468A2 (en) 2010-09-02
EP2401407A4 (en) 2012-10-03

Similar Documents

Publication Publication Date Title
JP5650876B2 (ja) 子癇前症または子癇の診断方法および治療方法
US9433642B2 (en) TRPC6 involved in glomerulonephritis
US20120077758A1 (en) Infertility associated defb-126 deletion polymorphism
JP2003513655A (ja) ２１個のヒト分泌タンパク質
KR101617497B1 (ko) Slit3의 lrr2 유전자 또는 그 발현 단백질을 유효성분으로 함유하는 골절 또는 골다공증 예방 또는 치료용 약학적 조성물
Fant et al. PLAC1 (Placenta‐specific 1): a novel, X‐linked gene with roles in reproductive and cancer biology
JP2003514541A (ja) １８個のヒト分泌タンパク質
JP2003513622A (ja) １９個のヒト分泌タンパク質
WO2005072049A2 (en) Novel nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis of endometriosis
JP2003520049A (ja) ヒトタンパク質であるチロシンホスファターゼのポリヌクレオチド、ポリペプチド、および抗体
CA2514971C (en) Regeneration and neogenesis of retinal photoreceptor cell using otx2 gene
JPH10509581A (ja) トロフィニンおよびトロフィニン補助タンパク質
US7407753B2 (en) Methods, kits and pharmaceutical compositions for diagnosing, delaying onset of, preventing and/or treating osteoporosis
JP2003527841A (ja) 三つ葉ドメイン含有ポリヌクレオチド、ポリペプチドおよび抗体
JP2003510074A (ja) ２６個のヒト分泌タンパク質
KR101029004B1 (ko) 염증성 관절염 마커로서의 ｐｒｄｍ10 단백질 및 이를 포함하는 염증성 관절염 진단키트
JP2003530109A (ja) エルビンをコードする遺伝子及びその診断及び治療的使用
JP2003520032A (ja) ２４個のヒト分泌タンパク質
US20030143601A1 (en) Methods and compositions for the detection of bovine pregnancy which utilize members of the 1-8 family of interferon inducible genes
JPWO2005092383A1 (ja) 呼吸器疾患の予防・治療剤
Scobie et al. Cloning, sequencing and site of origin of the rat sperm receptor protein, ZP3
JP2005505267A (ja) 癌において差次的に発現する膜貫通タンパク質
KR101598899B1 (ko) 골격근 이완 장애 관련 질환의 예방, 진단 또는 치료용 조성물
JP4445291B2 (ja) 新規タンパク質およびそのｄｎａ
US20090018071A1 (en) Epididymis-specific receptor protein

Legal Events

Date Code Title Description
FZDE Discontinued

Effective date: 20160226