JP2012518649A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2012518649A5 JP2012518649A5 JP2011551274A JP2011551274A JP2012518649A5 JP 2012518649 A5 JP2012518649 A5 JP 2012518649A5 JP 2011551274 A JP2011551274 A JP 2011551274A JP 2011551274 A JP2011551274 A JP 2011551274A JP 2012518649 A5 JP2012518649 A5 JP 2012518649A5
- Authority
- JP
- Japan
- Prior art keywords
- subject
- substituted
- unsubstituted
- pharmaceutical composition
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000003839 salts Chemical class 0.000 claims description 6
- -1 9-methoxynonyl Chemical group 0.000 claims description 4
- LXBIFEVIBLOUGU-UHFFFAOYSA-N Deoxymannojirimycin Natural products OCC1NCC(O)C(O)C1O LXBIFEVIBLOUGU-UHFFFAOYSA-N 0.000 claims description 4
- LXBIFEVIBLOUGU-JGWLITMVSA-N duvoglustat Chemical compound OC[C@H]1NC[C@H](O)[C@@H](O)[C@@H]1O LXBIFEVIBLOUGU-JGWLITMVSA-N 0.000 claims description 4
- 206010012310 Dengue fever Diseases 0.000 claims description 3
- 208000025729 dengue disease Diseases 0.000 claims description 3
- 241000710815 Dengue virus 2 Species 0.000 claims description 2
- 241000124008 Mammalia Species 0.000 claims description 2
- 208000036142 Viral infection Diseases 0.000 claims description 2
- 230000009385 viral infection Effects 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 150000001875 compounds Chemical class 0.000 description 5
- 229910052739 hydrogen Inorganic materials 0.000 description 4
- 125000004430 oxygen atom Chemical group O* 0.000 description 4
- 239000001257 hydrogen Substances 0.000 description 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 2
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 2
- OLYHECNPMKMYII-LXTVHRRPSA-N (2r,3r,4r,5s)-2-(hydroxymethyl)-1-(6-propoxyhexyl)piperidine-3,4,5-triol Chemical compound CCCOCCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO OLYHECNPMKMYII-LXTVHRRPSA-N 0.000 description 1
- 0 C*CNc(c(*)c1*)c(*)c(***C)c1I Chemical compound C*CNc(c(*)c1*)c(*)c(***C)c1I 0.000 description 1
- 208000001490 Dengue Diseases 0.000 description 1
- 125000002252 acyl group Chemical group 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 125000003435 aroyl group Chemical group 0.000 description 1
- 125000001188 haloalkyl group Chemical group 0.000 description 1
- 150000002431 hydrogen Chemical class 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20236709P | 2009-02-23 | 2009-02-23 | |
| US61/202,367 | 2009-02-23 | ||
| US27225509P | 2009-09-04 | 2009-09-04 | |
| US61/272,255 | 2009-09-04 | ||
| PCT/US2010/024920 WO2010096764A1 (en) | 2009-02-23 | 2010-02-22 | Iminosugars and methods of treating viral diseases |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014165290A Division JP5940607B2 (ja) | 2009-02-23 | 2014-08-14 | イミノ糖およびウイルス性疾患を治療する方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012518649A JP2012518649A (ja) | 2012-08-16 |
| JP2012518649A5 true JP2012518649A5 (https=) | 2014-04-17 |
| JP5600329B2 JP5600329B2 (ja) | 2014-10-01 |
Family
ID=42634239
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011551274A Expired - Fee Related JP5600329B2 (ja) | 2009-02-23 | 2010-02-22 | イミノ糖およびウイルス性疾患を治療する方法 |
| JP2014165290A Expired - Fee Related JP5940607B2 (ja) | 2009-02-23 | 2014-08-14 | イミノ糖およびウイルス性疾患を治療する方法 |
| JP2016099696A Pending JP2016175937A (ja) | 2009-02-23 | 2016-05-18 | イミノ糖およびウイルス性疾患を治療する方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014165290A Expired - Fee Related JP5940607B2 (ja) | 2009-02-23 | 2014-08-14 | イミノ糖およびウイルス性疾患を治療する方法 |
| JP2016099696A Pending JP2016175937A (ja) | 2009-02-23 | 2016-05-18 | イミノ糖およびウイルス性疾患を治療する方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (4) | US8450345B2 (https=) |
| EP (1) | EP2398321B1 (https=) |
| JP (3) | JP5600329B2 (https=) |
| KR (2) | KR101755133B1 (https=) |
| CN (2) | CN106420740A (https=) |
| CA (1) | CA2753195C (https=) |
| ES (1) | ES2579628T3 (https=) |
| WO (1) | WO2010096764A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20150035767A (ko) | 2012-06-06 | 2015-04-07 | 유니터 바이롤로지, 엘엘씨 | 신규 이미노당 및 그의 용도 |
| JP2016513729A (ja) * | 2013-03-15 | 2016-05-16 | ユニザー ヴィロロジー，エルエルシー | 抗菌化合物 |
| JP6456393B2 (ja) | 2013-09-16 | 2019-01-23 | エマージェント バイロロジー エルエルシー | デオキシノジリマイシン誘導体およびその使用方法 |
| BR112017008898B1 (pt) | 2014-11-05 | 2022-11-29 | Emergent Virology Llc | Compostos de iminoaçúcares, suas composições farmacêuticas e usos dos mesmos para tratar doenças virais |
| WO2017201052A1 (en) * | 2016-05-16 | 2017-11-23 | Emergent Virology Llc | Methods of treating zika virus infection |
| KR101942757B1 (ko) | 2017-08-23 | 2019-01-28 | 주식회사 유앤아이미트 | 마이크로웨이브를 이용한 n-노닐데옥시노지리마이신의 제조방법 |
| CN113425720A (zh) * | 2020-04-03 | 2021-09-24 | 深圳前海诺贝尔奖科学家技术转移转化有限公司 | 亚胺糖化合物在制备抗SARS-CoV-2病毒的药物中的用途 |
| CN119841765B (zh) * | 2025-01-09 | 2025-10-10 | 中南大学 | Dnj衍生物、药物组合物及其应用 |
Family Cites Families (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1555654A (en) * | 1977-06-25 | 1979-11-14 | Exxon Research Engineering Co | Agricultural burner apparatus |
| NO154918C (no) * | 1977-08-27 | 1987-01-14 | Bayer Ag | Analogifremgangsmaate til fremstilling av terapeutisk aktive derivater av 3,4,5-trihydroksypiperidin. |
| DE2834122A1 (de) * | 1978-08-03 | 1980-02-14 | Bayer Ag | Verfahren zur herstellung von 6-amino-6-desoxy-l-sorbose |
| DE2839309A1 (de) * | 1978-09-09 | 1980-03-27 | Bayer Ag | 3,4,5-trihydroxypiperidin-derivate |
| DE2853573A1 (de) * | 1978-12-12 | 1980-07-03 | Bayer Ag | Herstellung von n-substituierten derivaten des l-desoxynojirimycins |
| DE3038901A1 (de) * | 1980-10-15 | 1982-05-06 | Bayer Ag, 5090 Leverkusen | Verfahren zur herstellung von n-substituierten derivaten des 1-desoxynojirimycins |
| DE3611841A1 (de) * | 1986-04-09 | 1987-10-15 | Bayer Ag | Verfahren zur herstellung von 1-desoxynojirimycin und dessen n-derivaten |
| US5043273A (en) * | 1989-08-17 | 1991-08-27 | Monsanto Company | Phosphorylated glycosidase inhibitor prodrugs |
| US5103008A (en) * | 1989-08-17 | 1992-04-07 | Monsanto Company | Compound, N-butyl-deoxynojirimycin-6-phosphate |
| US4994572A (en) * | 1989-10-12 | 1991-02-19 | Monsanto Company | Synthesis of nojirimycin derivatives |
| US5030638A (en) * | 1990-02-26 | 1991-07-09 | G. D. Searle & Co. | Method of antiviral enhancement |
| US5200523A (en) * | 1990-10-10 | 1993-04-06 | Monsanto Company | Synthesis of nojirimycin derivatives |
| US5206251A (en) * | 1992-04-01 | 1993-04-27 | G. D. Searle & Co. | 2- and 3- amino and azido derivatives of 1,5-iminosugars |
| US5399567A (en) * | 1993-05-13 | 1995-03-21 | Monsanto Company | Method of treating cholera |
| AU1876095A (en) * | 1994-02-25 | 1995-09-11 | G.D. Searle & Co. | Use of 1-deoxynojirimycin and its derivatives for treating mammals infected with respiratory syncytial virus |
| KR20010033028A (ko) * | 1997-12-11 | 2001-04-25 | 더 챈슬러 마스터즈 앤드 스칼라스 오브 더 유니버시티 오브 옥스포드 | 막-관련 바이러스 복제의 억제 |
| DE69932154T2 (de) | 1998-02-12 | 2007-05-31 | G.D. Searle Llc, Chicago | Verwendung von n-substituirten-1,5-dideoxy-1,5-imino-d-glucitolen zur behandlung von hepatitis infektionen |
| EP1714676A3 (en) | 1998-02-12 | 2006-11-15 | G.D. Searle LLC. | Use of N-substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds for treating hepatitis virus infections |
| US6689759B1 (en) * | 1998-02-12 | 2004-02-10 | G. D. Searle & Co. | Methods of Treating hepatitis virus infections with N-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds in combination therapy |
| US6610703B1 (en) | 1998-12-10 | 2003-08-26 | G.D. Searle & Co. | Method for treatment of glycolipid storage diseases |
| GB9828474D0 (en) * | 1998-12-24 | 1999-02-17 | British Aerospace | Surface topology inspection |
| ATE402701T1 (de) * | 1999-02-12 | 2008-08-15 | United Therapeutics Corp | N-(8,8,8-trifluorooctyl)-1,5-dideoxy-1,5-imino- - glucitol zur behandlung von hepatitis-virus- infektionen |
| GB0100889D0 (en) * | 2001-01-12 | 2001-02-21 | Oxford Glycosciences Uk Ltd | Compounds |
| EP1196190B1 (en) * | 1999-07-26 | 2003-03-19 | G.D. SEARLE & CO. | Use of long-chain n-alkyl derivatives of deoxynojirimycin and a glucocerebrosidase enzyme for the manufacture of a medicament for the treatment of glycolipid storage diseases |
| US7256005B2 (en) * | 1999-08-10 | 2007-08-14 | The Chancellor, Masters And Scholars Of The University Of Oxford | Methods for identifying iminosugar derivatives that inhibit HCV p7 ion channel activity |
| CN1694696A (zh) * | 2002-09-23 | 2005-11-09 | 牛津大学校委会 | 亚氨基糖衍生物在抑制离子通道活性中的应用 |
| EP2857036B1 (en) * | 2003-01-31 | 2016-12-21 | Mount Sinai School of Medicine of New York University | Combination therapy for treating protein deficiency disorders |
| US7446098B2 (en) | 2003-02-18 | 2008-11-04 | Mount Sinai School Of Medicine Of New York University | Combination therapy for treating protein deficiencies |
| US20060211752A1 (en) * | 2004-03-16 | 2006-09-21 | Kohn Leonard D | Use of phenylmethimazoles, methimazole derivatives, and tautomeric cyclic thiones for the treatment of autoimmune/inflammatory diseases associated with toll-like receptor overexpression |
| US20050256168A1 (en) * | 2004-04-28 | 2005-11-17 | Block Timothy M | Compositions for oral administration for the treatment of interferon-responsive disorders |
| US7524829B2 (en) * | 2004-11-01 | 2009-04-28 | Avi Biopharma, Inc. | Antisense antiviral compounds and methods for treating a filovirus infection |
| GB0501352D0 (en) | 2005-01-21 | 2005-03-02 | Slingsby Jason H | Use of glycosylation modulators in combination with membrane fusion inhibitors for treatment of infections caused by viruses bearing glycosylated envelope |
| US7638488B2 (en) | 2005-03-08 | 2009-12-29 | Intermune, Inc. | Use of alpha-glucosidase inhibitors to treat alphavirus infections |
| CA2601797A1 (en) * | 2005-03-16 | 2006-09-21 | University Of Oxford | Mannose immunogens for hiv-1 |
| EP3782655A1 (en) * | 2005-05-17 | 2021-02-24 | Amicus Therapeutics, Inc. | A method for the treatment of pompe disease using 1-deoxynojirimycin and derivatives |
| KR20080031474A (ko) * | 2005-07-27 | 2008-04-08 | 유니버시티 오브 플로리다 리서치 파운데이션, 아이엔씨. | 안구 질환의 치료를 위한 열충격의 사용 |
| US20100004156A1 (en) * | 2005-07-27 | 2010-01-07 | Shalesh Kaushal | Small Compounds That Correct Protein Misfolding and Uses Thereof |
| US20070244184A1 (en) * | 2006-01-09 | 2007-10-18 | Simon Fraser University | Glycosidase inhibitors and methods of synthesizing same |
| DE602007008870D1 (de) * | 2006-04-24 | 2010-10-14 | Amc Amsterdam | Verbessertes verfahren zur behandlung von cystischer fibrose |
| CN104876855A (zh) * | 2006-05-24 | 2015-09-02 | 联合治疗公司 | 脱氧吉瑞霉素和d-阿拉伯胶素醇类似物及使用方法 |
| JP2009545621A (ja) | 2006-08-02 | 2009-12-24 | ユナイテッド セラピューティクス コーポレーション | ウィルス感染症のリポソーム処置 |
| KR20090057035A (ko) * | 2006-08-21 | 2009-06-03 | 유나이티드 세러퓨틱스 코오포레이션 | 바이러스 감염의 치료를 위한 병용 요법 |
| WO2008068548A1 (en) | 2006-12-08 | 2008-06-12 | Institut Necker | Use of inhibitors of the glycosylation process for the prevention and treatment of genetic diseases |
| US8097728B2 (en) * | 2007-04-30 | 2012-01-17 | Philadelphia Health & Education Corporation | Iminosugar compounds with antiflavirus activity |
| KR20100127842A (ko) * | 2008-03-26 | 2010-12-06 | 유니버시티 오브 옥스퍼드 | 소포체 표적화 리포좀 |
| EP2400843B1 (en) | 2009-02-24 | 2015-11-11 | United Therapeutics Corporation | Iminosugars and methods of treating arenaviral infections |
| US8703744B2 (en) | 2009-03-27 | 2014-04-22 | The Chancellor, Masters And Scholars Of The University Of Oxford | Cholesterol level lowering liposomes |
| ES2524361T3 (es) | 2009-06-12 | 2014-12-05 | United Therapeutics Corporation | Iminoazúcares para su uso en el tratamiento de enfermedades por bunyavirus y togavirus |
| JP5653438B2 (ja) | 2009-09-04 | 2015-01-14 | ユナイテッド セラピューティクス コーポレイション | オルトミクソウイルス感染の治療方法 |
| CA2772813A1 (en) | 2009-09-04 | 2011-03-10 | The Chancellor, Masters And Scholars Of The University Of Oxford | Iminosugars and methods of treating filoviral diseases |
| CA2772807A1 (en) | 2009-09-04 | 2011-03-10 | The Chancellor, Masters And Scholars Of The University Of Oxford | Methods of treating poxviral infections |
-
2010
- 2010-02-22 EP EP10744432.5A patent/EP2398321B1/en not_active Not-in-force
- 2010-02-22 ES ES10744432.5T patent/ES2579628T3/es active Active
- 2010-02-22 KR KR1020157006783A patent/KR101755133B1/ko not_active Expired - Fee Related
- 2010-02-22 US US12/656,992 patent/US8450345B2/en not_active Expired - Fee Related
- 2010-02-22 KR KR1020117021770A patent/KR20120042716A/ko not_active Ceased
- 2010-02-22 JP JP2011551274A patent/JP5600329B2/ja not_active Expired - Fee Related
- 2010-02-22 WO PCT/US2010/024920 patent/WO2010096764A1/en not_active Ceased
- 2010-02-22 CN CN201610416182.XA patent/CN106420740A/zh active Pending
- 2010-02-22 CN CN201080017591.3A patent/CN102655746B/zh not_active Expired - Fee Related
- 2010-02-22 CA CA2753195A patent/CA2753195C/en not_active Expired - Fee Related
-
2013
- 2013-04-25 US US13/870,341 patent/US9044470B2/en not_active Expired - Fee Related
-
2014
- 2014-08-14 JP JP2014165290A patent/JP5940607B2/ja not_active Expired - Fee Related
-
2015
- 2015-04-27 US US14/696,686 patent/US9579334B2/en not_active Expired - Fee Related
-
2016
- 2016-05-18 JP JP2016099696A patent/JP2016175937A/ja active Pending
-
2017
- 2017-01-05 US US15/399,213 patent/US9943532B2/en not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2012518649A5 (https=) | ||
| JP2013503881A5 (https=) | ||
| JP2009504763A5 (https=) | ||
| JP2012092103A5 (https=) | ||
| JP2009536660A5 (https=) | ||
| JP2013503880A5 (https=) | ||
| JP2013512915A5 (https=) | ||
| JP2013032389A5 (https=) | ||
| JP2013507423A5 (https=) | ||
| EP1857457A3 (en) | Benzimidazole derivative and its use as AII receptor antagonist | |
| JP2013503846A5 (https=) | ||
| JP2008509166A5 (https=) | ||
| JP2014506907A5 (https=) | ||
| JP2011037841A5 (https=) | ||
| JP2013545785A5 (https=) | ||
| EA201201031A1 (ru) | Ингибиторы вируса гепатита с | |
| JP2013510120A5 (https=) | ||
| JP2013518107A5 (https=) | ||
| JP2008533007A5 (https=) | ||
| JP2019526596A5 (https=) | ||
| JP2015535847A5 (https=) | ||
| JP2014500861A5 (https=) | ||
| JP2015504081A5 (https=) | ||
| JP2012532883A5 (https=) | ||
| JP2010529994A5 (https=) |