CA2753195C - Iminosugars and methods of treating viral diseases - Google Patents
Iminosugars and methods of treating viral diseases Download PDFInfo
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- CA2753195C CA2753195C CA2753195A CA2753195A CA2753195C CA 2753195 C CA2753195 C CA 2753195C CA 2753195 A CA2753195 A CA 2753195A CA 2753195 A CA2753195 A CA 2753195A CA 2753195 C CA2753195 C CA 2753195C
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- dnj
- virus
- dengue
- iminosugar
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- 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 230000036961 partial effect Effects 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- JRKICGRDRMAZLK-UHFFFAOYSA-L peroxydisulfate Chemical compound [O-]S(=O)(=O)OOS([O-])(=O)=O JRKICGRDRMAZLK-UHFFFAOYSA-L 0.000 description 1
- 229940075930 picrate Drugs 0.000 description 1
- OXNIZHLAWKMVMX-UHFFFAOYSA-M picrate anion Chemical compound [O-]C1=C([N+]([O-])=O)C=C([N+]([O-])=O)C=C1[N+]([O-])=O OXNIZHLAWKMVMX-UHFFFAOYSA-M 0.000 description 1
- 229950010765 pivalate Drugs 0.000 description 1
- IUGYQRQAERSCNH-UHFFFAOYSA-N pivalic acid Chemical compound CC(C)(C)C(O)=O IUGYQRQAERSCNH-UHFFFAOYSA-N 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000002250 progressing effect Effects 0.000 description 1
- 230000002685 pulmonary effect Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000010076 replication Effects 0.000 description 1
- 230000001850 reproductive effect Effects 0.000 description 1
- 229940077952 ribavirin 100 mg Drugs 0.000 description 1
- AWUCVROLDVIAJX-GSVOUGTGSA-N sn-glycerol 3-phosphate Chemical compound OC[C@@H](O)COP(O)(O)=O AWUCVROLDVIAJX-GSVOUGTGSA-N 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- 230000004797 therapeutic response Effects 0.000 description 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000048 toxicity data Toxicity 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- 230000014599 transmission of virus Effects 0.000 description 1
- ZDPHROOEEOARMN-UHFFFAOYSA-N undecanoic acid Chemical compound CCCCCCCCCCC(O)=O ZDPHROOEEOARMN-UHFFFAOYSA-N 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 230000004580 weight loss Effects 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/665—Phosphorus compounds having oxygen as a ring hetero atom, e.g. fosfomycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20236709P | 2009-02-23 | 2009-02-23 | |
| US61/202,367 | 2009-02-23 | ||
| US27225509P | 2009-09-04 | 2009-09-04 | |
| US61/272,255 | 2009-09-04 | ||
| PCT/US2010/024920 WO2010096764A1 (en) | 2009-02-23 | 2010-02-22 | Iminosugars and methods of treating viral diseases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2753195A1 CA2753195A1 (en) | 2010-08-26 |
| CA2753195C true CA2753195C (en) | 2015-06-02 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| CA2753195A Expired - Fee Related CA2753195C (en) | 2009-02-23 | 2010-02-22 | Iminosugars and methods of treating viral diseases |
Country Status (8)
| Country | Link |
|---|---|
| US (4) | US8450345B2 (https=) |
| EP (1) | EP2398321B1 (https=) |
| JP (3) | JP5600329B2 (https=) |
| KR (2) | KR20120042716A (https=) |
| CN (2) | CN102655746B (https=) |
| CA (1) | CA2753195C (https=) |
| ES (1) | ES2579628T3 (https=) |
| WO (1) | WO2010096764A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IN2014MN02539A (https=) | 2012-06-06 | 2015-07-24 | Unither Virology Llc | |
| KR20150128899A (ko) * | 2013-03-15 | 2015-11-18 | 유니터 바이롤로지, 엘엘씨 | 항박테리아 화합물 |
| KR20160055916A (ko) * | 2013-09-16 | 2016-05-18 | 이머전트 바이롤로지 엘엘씨 | 데옥시노지리마이신 유도체 및 그의 이용 방법 |
| CA2966893C (en) | 2014-11-05 | 2023-10-24 | Emergent Virology Llc | Iminosugars |
| WO2017201052A1 (en) * | 2016-05-16 | 2017-11-23 | Emergent Virology Llc | Methods of treating zika virus infection |
| KR101942757B1 (ko) | 2017-08-23 | 2019-01-28 | 주식회사 유앤아이미트 | 마이크로웨이브를 이용한 n-노닐데옥시노지리마이신의 제조방법 |
| CN113425720A (zh) * | 2020-04-03 | 2021-09-24 | 深圳前海诺贝尔奖科学家技术转移转化有限公司 | 亚胺糖化合物在制备抗SARS-CoV-2病毒的药物中的用途 |
| CN119841765B (zh) * | 2025-01-09 | 2025-10-10 | 中南大学 | Dnj衍生物、药物组合物及其应用 |
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| DE2834122A1 (de) | 1978-08-03 | 1980-02-14 | Bayer Ag | Verfahren zur herstellung von 6-amino-6-desoxy-l-sorbose |
| DE2839309A1 (de) | 1978-09-09 | 1980-03-27 | Bayer Ag | 3,4,5-trihydroxypiperidin-derivate |
| DE2853573A1 (de) | 1978-12-12 | 1980-07-03 | Bayer Ag | Herstellung von n-substituierten derivaten des l-desoxynojirimycins |
| DE3038901A1 (de) | 1980-10-15 | 1982-05-06 | Bayer Ag, 5090 Leverkusen | Verfahren zur herstellung von n-substituierten derivaten des 1-desoxynojirimycins |
| DE3611841A1 (de) | 1986-04-09 | 1987-10-15 | Bayer Ag | Verfahren zur herstellung von 1-desoxynojirimycin und dessen n-derivaten |
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| KR20120059447A (ko) | 2009-03-27 | 2012-06-08 | 더 챈슬러 마스터즈 앤드 스칼라스 오브 더 유니버시티 오브 옥스포드 | 콜레스테롤 수준 저하 리포좀 |
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| WO2011028779A1 (en) | 2009-09-04 | 2011-03-10 | United Therapeutics Corporation | Iminosugars and methods of treating filoviral diseases |
| KR101497194B1 (ko) | 2009-09-04 | 2015-02-27 | 유나이티드 세러퓨틱스 코오포레이션 | 오르토믹소바이러스 감염의 치료 방법 |
| CN102625801B (zh) | 2009-09-04 | 2015-09-09 | 联合治疗公司 | 治疗痘病毒感染的方法 |
-
2010
- 2010-02-22 CA CA2753195A patent/CA2753195C/en not_active Expired - Fee Related
- 2010-02-22 JP JP2011551274A patent/JP5600329B2/ja not_active Expired - Fee Related
- 2010-02-22 EP EP10744432.5A patent/EP2398321B1/en not_active Not-in-force
- 2010-02-22 US US12/656,992 patent/US8450345B2/en not_active Expired - Fee Related
- 2010-02-22 WO PCT/US2010/024920 patent/WO2010096764A1/en not_active Ceased
- 2010-02-22 KR KR1020117021770A patent/KR20120042716A/ko not_active Ceased
- 2010-02-22 CN CN201080017591.3A patent/CN102655746B/zh not_active Expired - Fee Related
- 2010-02-22 ES ES10744432.5T patent/ES2579628T3/es active Active
- 2010-02-22 CN CN201610416182.XA patent/CN106420740A/zh active Pending
- 2010-02-22 KR KR1020157006783A patent/KR101755133B1/ko not_active Expired - Fee Related
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2013
- 2013-04-25 US US13/870,341 patent/US9044470B2/en not_active Expired - Fee Related
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2014
- 2014-08-14 JP JP2014165290A patent/JP5940607B2/ja not_active Expired - Fee Related
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2015
- 2015-04-27 US US14/696,686 patent/US9579334B2/en not_active Expired - Fee Related
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2016
- 2016-05-18 JP JP2016099696A patent/JP2016175937A/ja active Pending
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2017
- 2017-01-05 US US15/399,213 patent/US9943532B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ES2579628T3 (es) | 2016-08-12 |
| EP2398321A4 (en) | 2012-01-04 |
| JP5940607B2 (ja) | 2016-06-29 |
| US20130237567A1 (en) | 2013-09-12 |
| HK1165221A1 (zh) | 2012-10-05 |
| JP2014237706A (ja) | 2014-12-18 |
| EP2398321B1 (en) | 2015-11-25 |
| EP2398321A1 (en) | 2011-12-28 |
| CN102655746B (zh) | 2016-08-03 |
| US9943532B2 (en) | 2018-04-17 |
| KR20150038684A (ko) | 2015-04-08 |
| KR20120042716A (ko) | 2012-05-03 |
| KR101755133B1 (ko) | 2017-07-06 |
| US20170304333A1 (en) | 2017-10-26 |
| JP5600329B2 (ja) | 2014-10-01 |
| US20100222383A1 (en) | 2010-09-02 |
| CN106420740A (zh) | 2017-02-22 |
| US9044470B2 (en) | 2015-06-02 |
| US9579334B2 (en) | 2017-02-28 |
| CA2753195A1 (en) | 2010-08-26 |
| US8450345B2 (en) | 2013-05-28 |
| JP2012518649A (ja) | 2012-08-16 |
| US20150224128A1 (en) | 2015-08-13 |
| CN102655746A (zh) | 2012-09-05 |
| JP2016175937A (ja) | 2016-10-06 |
| WO2010096764A1 (en) | 2010-08-26 |
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