HK1165221A1 - 亞胺糖和治療病毒疾病的方法 - Google Patents

亞胺糖和治療病毒疾病的方法

Info

Publication number
HK1165221A1
HK1165221A1 HK12106325.9A HK12106325A HK1165221A1 HK 1165221 A1 HK1165221 A1 HK 1165221A1 HK 12106325 A HK12106325 A HK 12106325A HK 1165221 A1 HK1165221 A1 HK 1165221A1
Authority
HK
Hong Kong
Prior art keywords
iminosugars
methods
viral diseases
treating viral
treating
Prior art date
Application number
HK12106325.9A
Other languages
English (en)
Inventor
Urban Ramstedt
Brennan Klose
Nicole Zitzmann
Raymond A Dwek
Terry D Butters
Original Assignee
United Therapeutics Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by United Therapeutics Corp filed Critical United Therapeutics Corp
Publication of HK1165221A1 publication Critical patent/HK1165221A1/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/665—Phosphorus compounds having oxygen as a ring hetero atom, e.g. fosfomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
HK12106325.9A 2009-02-23 2012-06-28 亞胺糖和治療病毒疾病的方法 HK1165221A1 (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US20236709P 2009-02-23 2009-02-23
US27225509P 2009-09-04 2009-09-04
PCT/US2010/024920 WO2010096764A1 (en) 2009-02-23 2010-02-22 Iminosugars and methods of treating viral diseases

Publications (1)

Publication Number Publication Date
HK1165221A1 true HK1165221A1 (zh) 2012-10-05

Family

ID=42634239

Family Applications (1)

Application Number Title Priority Date Filing Date
HK12106325.9A HK1165221A1 (zh) 2009-02-23 2012-06-28 亞胺糖和治療病毒疾病的方法

Country Status (9)

Country Link
US (4) US8450345B2 (zh)
EP (1) EP2398321B1 (zh)
JP (3) JP5600329B2 (zh)
KR (2) KR20120042716A (zh)
CN (2) CN102655746B (zh)
CA (1) CA2753195C (zh)
ES (1) ES2579628T3 (zh)
HK (1) HK1165221A1 (zh)
WO (1) WO2010096764A1 (zh)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20150035767A (ko) 2012-06-06 2015-04-07 유니터 바이롤로지, 엘엘씨 신규 이미노당 및 그의 용도
EP2968300A4 (en) * 2013-03-15 2016-09-28 Unither Virology Llc ANTIBACTERIAL COMPOUNDS
WO2015039010A2 (en) 2013-09-16 2015-03-19 Unither Virology, Llc Deoxynojirimycin derivatives and methods of their using
WO2016073652A1 (en) 2014-11-05 2016-05-12 Unither Virology, Llc Iminosugars useful for the treatment of viral diseases
US20190282558A1 (en) * 2016-05-16 2019-09-19 Emergent Virology Llc Methods of Treating Zika Virus Infection
KR101942757B1 (ko) 2017-08-23 2019-01-28 주식회사 유앤아이미트 마이크로웨이브를 이용한 n-노닐데옥시노지리마이신의 제조방법
CN113425720A (zh) * 2020-04-03 2021-09-24 深圳前海诺贝尔奖科学家技术转移转化有限公司 亚胺糖化合物在制备抗SARS-CoV-2病毒的药物中的用途

Family Cites Families (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1555654A (en) 1977-06-25 1979-11-14 Exxon Research Engineering Co Agricultural burner apparatus
NO154918C (no) 1977-08-27 1987-01-14 Bayer Ag Analogifremgangsmaate til fremstilling av terapeutisk aktive derivater av 3,4,5-trihydroksypiperidin.
DE2834122A1 (de) 1978-08-03 1980-02-14 Bayer Ag Verfahren zur herstellung von 6-amino-6-desoxy-l-sorbose
DE2839309A1 (de) 1978-09-09 1980-03-27 Bayer Ag 3,4,5-trihydroxypiperidin-derivate
DE2853573A1 (de) 1978-12-12 1980-07-03 Bayer Ag Herstellung von n-substituierten derivaten des l-desoxynojirimycins
DE3038901A1 (de) 1980-10-15 1982-05-06 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von n-substituierten derivaten des 1-desoxynojirimycins
DE3611841A1 (de) 1986-04-09 1987-10-15 Bayer Ag Verfahren zur herstellung von 1-desoxynojirimycin und dessen n-derivaten
US5043273A (en) 1989-08-17 1991-08-27 Monsanto Company Phosphorylated glycosidase inhibitor prodrugs
US5103008A (en) 1989-08-17 1992-04-07 Monsanto Company Compound, N-butyl-deoxynojirimycin-6-phosphate
US4994572A (en) 1989-10-12 1991-02-19 Monsanto Company Synthesis of nojirimycin derivatives
US5030638A (en) 1990-02-26 1991-07-09 G. D. Searle & Co. Method of antiviral enhancement
US5200523A (en) 1990-10-10 1993-04-06 Monsanto Company Synthesis of nojirimycin derivatives
US5206251A (en) 1992-04-01 1993-04-27 G. D. Searle & Co. 2- and 3- amino and azido derivatives of 1,5-iminosugars
US5399567A (en) 1993-05-13 1995-03-21 Monsanto Company Method of treating cholera
AU1876095A (en) 1994-02-25 1995-09-11 G.D. Searle & Co. Use of 1-deoxynojirimycin and its derivatives for treating mammals infected with respiratory syncytial virus
AU761748B2 (en) 1997-12-11 2003-06-12 Chancellor, Masters And Scholars Of The University Of Oxford, The Inhibition of membrane-associated viral replication
KR20010040937A (ko) 1998-02-12 2001-05-15 윌리암스 로저 에이 간염 바이러스 감염의 치료를 위한 ｎ-치환된1,5-디데옥시-1,5-이미노-ｄ-글루시톨 화합물의 용도
US6689759B1 (en) 1998-02-12 2004-02-10 G. D. Searle & Co. Methods of Treating hepatitis virus infections with N-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds in combination therapy
EP1714676A3 (en) 1998-02-12 2006-11-15 G.D. Searle LLC. Use of N-substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds for treating hepatitis virus infections
US6610703B1 (en) 1998-12-10 2003-08-26 G.D. Searle & Co. Method for treatment of glycolipid storage diseases
GB9828474D0 (en) 1998-12-24 1999-02-17 British Aerospace Surface topology inspection
US6545021B1 (en) 1999-02-12 2003-04-08 G.D. Searle & Co. Use of substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds for treating hepatitis virus infections
GB0100889D0 (en) 2001-01-12 2001-02-21 Oxford Glycosciences Uk Ltd Compounds
JP2003505430A (ja) 1999-07-26 2003-02-12 ジー・ディー・サール・アンド・カンパニー デオキシノジリマイシンの長鎖ｎ−アルキル誘導体およびグルコセレブロシダーゼ酵素の糖脂質異常蓄積疾患の治療用の薬剤の製造のための使用
US7256005B2 (en) 1999-08-10 2007-08-14 The Chancellor, Masters And Scholars Of The University Of Oxford Methods for identifying iminosugar derivatives that inhibit HCV p7 ion channel activity
CA2500940A1 (en) * 2002-09-23 2004-06-10 The Chancellor, Masters And Scholars Of The University Of Oxford Use of iminosugar derivatives to inhibit ion channel activity
CA2814774C (en) 2003-01-31 2016-03-22 Mount Sinai School Of Medicine Of New York University Combination therapy for treating protein deficiency disorders
US7446098B2 (en) 2003-02-18 2008-11-04 Mount Sinai School Of Medicine Of New York University Combination therapy for treating protein deficiencies
US20060211752A1 (en) * 2004-03-16 2006-09-21 Kohn Leonard D Use of phenylmethimazoles, methimazole derivatives, and tautomeric cyclic thiones for the treatment of autoimmune/inflammatory diseases associated with toll-like receptor overexpression
US20050256168A1 (en) 2004-04-28 2005-11-17 Block Timothy M Compositions for oral administration for the treatment of interferon-responsive disorders
US7524829B2 (en) 2004-11-01 2009-04-28 Avi Biopharma, Inc. Antisense antiviral compounds and methods for treating a filovirus infection
GB0501352D0 (en) 2005-01-21 2005-03-02 Slingsby Jason H Use of glycosylation modulators in combination with membrane fusion inhibitors for treatment of infections caused by viruses bearing glycosylated envelope
US7638488B2 (en) 2005-03-08 2009-12-29 Intermune, Inc. Use of alpha-glucosidase inhibitors to treat alphavirus infections
JP2008533175A (ja) 2005-03-16 2008-08-21 ユニバーシティ・オブ・オックスフォード Ｈｉｖ−１のためのマンノース免疫原
EP3782655A1 (en) 2005-05-17 2021-02-24 Amicus Therapeutics, Inc. A method for the treatment of pompe disease using 1-deoxynojirimycin and derivatives
KR20080033463A (ko) 2005-07-27 2008-04-16 유니버시티 오브 플로리다 리서치 파운데이션, 아이엔씨. 단백질 미스폴딩을 보정하는 작은 화합물 및 그의 용도
NZ565954A (en) 2005-07-27 2012-03-30 Univ Florida Use of heat shock inducing compound and an agent that increases stem cell mobilization int he manufacture of a medicament to treat ocular disease
US20070244184A1 (en) 2006-01-09 2007-10-18 Simon Fraser University Glycosidase inhibitors and methods of synthesizing same
JP2009538276A (ja) 2006-04-24 2009-11-05 アカデミッシュ メディシュ セントラム 嚢胞性線維症の改良型治療
JP5241709B2 (ja) * 2006-05-24 2013-07-17 ユナイテッド セラピューティクス コーポレーション デオキシノジリマイシンおよびｄ−アラビニトールのアナログおよび使用方法
EP2399587A1 (en) 2006-08-02 2011-12-28 The University of Oxford Liposome treatment of viral infections
CA2666814A1 (en) 2006-08-21 2008-05-29 United Therapeutics Corporation Combination therapy for treatment of viral infections
WO2008068548A1 (en) 2006-12-08 2008-06-12 Institut Necker Use of inhibitors of the glycosylation process for the prevention and treatment of genetic diseases
US8097728B2 (en) * 2007-04-30 2012-01-17 Philadelphia Health & Education Corporation Iminosugar compounds with antiflavirus activity
EP2282723A2 (en) 2008-03-26 2011-02-16 University of Oxford Endoplasmic reticulum targeting liposomes
CN102625660B (zh) 2009-02-24 2015-03-11 联合治疗公司 亚氨基糖以及治疗沙粒病毒感染的方法
EP2410989A2 (en) 2009-03-27 2012-02-01 The Chancellor, Masters and Scholars of the University of Oxford Cholesterol level lowering liposomes
ES2524361T3 (es) 2009-06-12 2014-12-05 United Therapeutics Corporation Iminoazúcares para su uso en el tratamiento de enfermedades por bunyavirus y togavirus
KR20120081990A (ko) 2009-09-04 2012-07-20 더 챈슬러 마스터즈 앤드 스칼라스 오브 더 유니버시티 오브 옥스포드 이미노당 및 필로바이러스 질환의 치료 방법
CN102625801B (zh) 2009-09-04 2015-09-09 联合治疗公司 治疗痘病毒感染的方法
BR112012004676A2 (pt) 2009-09-04 2019-09-24 United Therapeutics Corp método de tratar infecções orotomixovirais.

Also Published As

Publication number Publication date
CA2753195C (en) 2015-06-02
US8450345B2 (en) 2013-05-28
KR20150038684A (ko) 2015-04-08
EP2398321B1 (en) 2015-11-25
JP2016175937A (ja) 2016-10-06
CN102655746A (zh) 2012-09-05
CA2753195A1 (en) 2010-08-26
JP2012518649A (ja) 2012-08-16
KR20120042716A (ko) 2012-05-03
JP5600329B2 (ja) 2014-10-01
JP2014237706A (ja) 2014-12-18
US20130237567A1 (en) 2013-09-12
CN106420740A (zh) 2017-02-22
US20150224128A1 (en) 2015-08-13
WO2010096764A1 (en) 2010-08-26
US9579334B2 (en) 2017-02-28
KR101755133B1 (ko) 2017-07-06
ES2579628T3 (es) 2016-08-12
US9044470B2 (en) 2015-06-02
EP2398321A4 (en) 2012-01-04
US20100222383A1 (en) 2010-09-02
US20170304333A1 (en) 2017-10-26
EP2398321A1 (en) 2011-12-28
US9943532B2 (en) 2018-04-17
JP5940607B2 (ja) 2016-06-29
CN102655746B (zh) 2016-08-03

Similar Documents

Publication Publication Date Title
EP2485751A4 (en) METHOD FOR THE TREATMENT OF DEPRESSIONS AND OTHER DISORDERS THEREOF
EP2493479A4 (en) METHOD FOR THE TREATMENT OF VIRUS DISEASES
HK1217763A1 (zh) 用於治療疾病的方法
HK1173654A1 (zh) 治療化合物及相關的使用方法
ZA201106730B (en) Methods of treatment using combination therapy
EP2521724A4 (en) ACTIVE AGENTS AND METHODS FOR TREATING ISCHEMIC AND OTHER DISEASES
EP2509596A4 (en) COMPOUNDS AND METHOD FOR THE TREATMENT OF EYE DISEASES
IL218212A0 (en) Therapeutic methods and compositions
EP2440205A4 (en) IMINO SUGAR UDN METHOD FOR THE TREATMENT OF BUNYAVIRAL AND TOGAVIRAL DISEASES
GB2503066B (en) Combination pharmaceutical composition and methods of treating and preventing the infectious diseases
PT2429524T (pt) Formulação de ac220 seca por atomização
HK1165221A1 (zh) 亞胺糖和治療病毒疾病的方法
ZA201109449B (en) Methods and products for treatment of diseases
EP2473046A4 (en) IMINOSUCRES AND METHODS OF TREATING FILOVIRAL DISEASES
EP2585828A4 (en) METHOD FOR THE TREATMENT OF PATIENTS WITH IMMUNE SYSTEM DISEASES
EP2521554A4 (en) SUBSTANCES AND METHODS FOR THE PREVENTION AND TREATMENT OF VIRAL INFECTIONS
IL216000A0 (en) Methods of treating hiv patients with anti-fibrotics
HK1165675A1 (zh) 治療沙粒病毒感染的亞氨糖類和方法
EP2710017A4 (en) MACROCYCLIC THERAPEUTIC AGENTS AND METHODS OF TREATMENT
EP2461870A4 (en) THERAPEUTIC COMPOSITIONS AND METHOD
ZA201207226B (en) Compositions and methods for treating viral diseases
EP2462131A4 (en) COMPOSITIONS AND METHODS FOR TREATING DISEASES ASSOCIATED WITH BETA-AMYLOID
EP2440238A4 (en) Methods of Treatment
GB0803515D0 (en) Medicament and method of treatment
HK1174620A1 (zh) 吲唑基取代的二氫異噁唑並吡啶及其使用方法

Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20200224