JP2012517971A - キナーゼ阻害薬としての［１，２，４］トリアゾロ［１，５−ａ］ピリジン類 - Google Patents
キナーゼ阻害薬としての［１，２，４］トリアゾロ［１，５−ａ］ピリジン類 Download PDFInfo
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- JP2012517971A JP2012517971A JP2011549537A JP2011549537A JP2012517971A JP 2012517971 A JP2012517971 A JP 2012517971A JP 2011549537 A JP2011549537 A JP 2011549537A JP 2011549537 A JP2011549537 A JP 2011549537A JP 2012517971 A JP2012517971 A JP 2012517971A
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- Prior art keywords
- triazolo
- pyridin
- chloro
- phenyl
- phenylamino
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- 229940043355 kinase inhibitor Drugs 0.000 title abstract description 9
- 239000003757 phosphotransferase inhibitor Substances 0.000 title abstract description 9
- 150000008527 [1,2,4]triazolo-[1,5-a]pyridines Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract description 140
- -1 C 1 -C 4 alkyl Chemical group 0.000 claims description 17
- 125000003118 aryl group Chemical group 0.000 claims description 11
- 125000001072 heteroaryl group Chemical group 0.000 claims description 11
- 239000001257 hydrogen Substances 0.000 claims description 11
- 229910052739 hydrogen Inorganic materials 0.000 claims description 11
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims description 10
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims description 9
- 150000003839 salts Chemical class 0.000 claims description 8
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 7
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 claims description 6
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims description 6
- 229910052736 halogen Inorganic materials 0.000 claims description 6
- 239000012453 solvate Substances 0.000 claims description 6
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 5
- BARSDANYGJRCIS-UHFFFAOYSA-N 1-[4-[[6-(2-chloro-5-hydroxyphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]amino]phenyl]-3-(2-pyrrolidin-1-ylethyl)imidazolidin-2-one Chemical compound OC1=CC=C(Cl)C(C2=CN3N=C(NC=4C=CC(=CC=4)N4C(N(CCN5CCCC5)CC4)=O)N=C3C=C2)=C1 BARSDANYGJRCIS-UHFFFAOYSA-N 0.000 claims description 4
- 229910052799 carbon Inorganic materials 0.000 claims description 4
- 150000004677 hydrates Chemical class 0.000 claims description 4
- 229910052757 nitrogen Inorganic materials 0.000 claims description 4
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 3
- 150000002367 halogens Chemical class 0.000 claims description 3
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims description 3
- PLJUZHRXSVGDPZ-UHFFFAOYSA-N 1-[4-[[6-(2-chloro-5-hydroxyphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]amino]phenyl]-3-(2-methoxyethyl)imidazolidin-2-one Chemical compound O=C1N(CCOC)CCN1C(C=C1)=CC=C1NC1=NN2C=C(C=3C(=CC=C(O)C=3)Cl)C=CC2=N1 PLJUZHRXSVGDPZ-UHFFFAOYSA-N 0.000 claims description 2
- WJEJGIVUBFILHU-UHFFFAOYSA-N 1-[4-[[6-(2-chloro-5-hydroxyphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]amino]phenyl]-3-(2-pyrrolidin-1-ylethyl)urea Chemical compound OC1=CC=C(Cl)C(C2=CN3N=C(NC=4C=CC(NC(=O)NCCN5CCCC5)=CC=4)N=C3C=C2)=C1 WJEJGIVUBFILHU-UHFFFAOYSA-N 0.000 claims description 2
- YCRZYLWMKQNAPY-UHFFFAOYSA-N 1-[4-[[6-(2-chloro-5-hydroxyphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]amino]phenyl]imidazolidin-2-one Chemical compound OC1=CC=C(Cl)C(C2=CN3N=C(NC=4C=CC(=CC=4)N4C(NCC4)=O)N=C3C=C2)=C1 YCRZYLWMKQNAPY-UHFFFAOYSA-N 0.000 claims description 2
- DSPDRCOCBFODME-FSRHSHDFSA-N 2-[4-[[6-(2-chloro-5-hydroxyphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]amino]phenoxy]-1-[(3r)-3-(dimethylamino)pyrrolidin-1-yl]ethanone;hydrochloride Chemical compound Cl.C1[C@H](N(C)C)CCN1C(=O)COC(C=C1)=CC=C1NC1=NN2C=C(C=3C(=CC=C(O)C=3)Cl)C=CC2=N1 DSPDRCOCBFODME-FSRHSHDFSA-N 0.000 claims description 2
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- ZBDPZYTWLRKACH-UHFFFAOYSA-N 1-[4-[4-[[6-(2-chloro-5-hydroxyphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]amino]phenyl]piperazin-1-yl]-2-methoxyethanone Chemical compound C1CN(C(=O)COC)CCN1C(C=C1)=CC=C1NC1=NN2C=C(C=3C(=CC=C(O)C=3)Cl)C=CC2=N1 ZBDPZYTWLRKACH-UHFFFAOYSA-N 0.000 claims 1
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- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Ophthalmology & Optometry (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| EP09360013.8 | 2009-02-13 | ||
| EP09360013 | 2009-02-13 | ||
| PCT/EP2010/051556 WO2010092041A1 (en) | 2009-02-13 | 2010-02-09 | [1, 2, 4] triazolo [1, 5 -a] pyridines as kinase inhibitors |
Publications (2)
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| JP2012517971A true JP2012517971A (ja) | 2012-08-09 |
| JP2012517971A5 JP2012517971A5 (enExample) | 2013-05-02 |
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| EP (1) | EP2396324A1 (enExample) |
| JP (1) | JP2012517971A (enExample) |
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| CN (1) | CN102317288A (enExample) |
| AR (1) | AR075411A1 (enExample) |
| BR (1) | BRPI1008850A2 (enExample) |
| CA (1) | CA2751517A1 (enExample) |
| CL (1) | CL2011001947A1 (enExample) |
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| CR (1) | CR20110386A (enExample) |
| DO (1) | DOP2011000248A (enExample) |
| EA (1) | EA201101188A1 (enExample) |
| EC (1) | ECSP11011250A (enExample) |
| HN (1) | HN2011002095A (enExample) |
| IL (1) | IL214426A0 (enExample) |
| MX (1) | MX2011008549A (enExample) |
| NI (1) | NI201100151A (enExample) |
| NZ (1) | NZ594508A (enExample) |
| PE (1) | PE20120110A1 (enExample) |
| SG (1) | SG173610A1 (enExample) |
| TN (1) | TN2011000379A1 (enExample) |
| WO (1) | WO2010092041A1 (enExample) |
| ZA (1) | ZA201105896B (enExample) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013512264A (ja) * | 2009-11-30 | 2013-04-11 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | トリアゾロピリジン |
| JP2013512268A (ja) * | 2009-11-30 | 2013-04-11 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | トリアゾロピリジン誘導体 |
| JP2013532147A (ja) * | 2010-06-16 | 2013-08-15 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 置換トリアゾロピリジン |
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| KR20120044966A (ko) | 2009-06-05 | 2012-05-08 | 세파론, 인코포레이티드 | 1,2,4-트리아졸로〔1,5ａ〕 피리딘 유도체의 제조 및 용도 |
| EP2343294A1 (en) | 2009-11-30 | 2011-07-13 | Bayer Schering Pharma AG | Substituted triazolopyridines |
| AR081960A1 (es) * | 2010-06-22 | 2012-10-31 | Fovea Pharmaceuticals Sa | Compuestos heterociclicos, su preparacion y su aplicacion terapeutica |
| MA35049B1 (fr) | 2011-04-21 | 2014-04-03 | Bayer Ip Gmbh | Triazolopyridines |
| WO2012160029A1 (en) | 2011-05-23 | 2012-11-29 | Bayer Intellectual Property Gmbh | Substituted triazolopyridines |
| UA112096C2 (uk) | 2011-12-12 | 2016-07-25 | Байєр Інтеллектуал Проперті Гмбх | Заміщені триазолопіридини та їх застосування як інгібіторів ttk |
| KR20130091464A (ko) | 2012-02-08 | 2013-08-19 | 한미약품 주식회사 | 타이로신 카이네이즈 억제 활성을 갖는 트리아졸로피리딘 유도체 |
| WO2013135612A1 (en) | 2012-03-14 | 2013-09-19 | Bayer Intellectual Property Gmbh | Substituted imidazopyridazines |
| CN104603136B (zh) | 2012-07-10 | 2017-06-27 | 拜耳医药股份有限公司 | 制备取代的三唑并吡啶的方法 |
| WO2014020043A1 (en) | 2012-08-02 | 2014-02-06 | Bayer Pharma Aktiengesellschaft | Combinations for the treatment of cancer |
| LT3008062T (lt) | 2013-06-11 | 2017-06-12 | Bayer Pharma Aktiengesellschaft | Pakeistųjų triazolpiridinų provaistų dariniai |
| EP4063371A1 (en) * | 2019-11-22 | 2022-09-28 | Medshine Discovery Inc. | Pyrimidopyrrole spiro compounds and derivatives thereof as dna-pk inhibitors |
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2010
- 2010-02-09 CA CA2751517A patent/CA2751517A1/en not_active Abandoned
- 2010-02-09 NZ NZ594508A patent/NZ594508A/en not_active IP Right Cessation
- 2010-02-09 BR BRPI1008850A patent/BRPI1008850A2/pt not_active IP Right Cessation
- 2010-02-09 SG SG2011057247A patent/SG173610A1/en unknown
- 2010-02-09 KR KR1020117018592A patent/KR20110116160A/ko not_active Withdrawn
- 2010-02-09 CN CN2010800077376A patent/CN102317288A/zh active Pending
- 2010-02-09 WO PCT/EP2010/051556 patent/WO2010092041A1/en not_active Ceased
- 2010-02-09 EP EP10706180A patent/EP2396324A1/en not_active Withdrawn
- 2010-02-09 US US13/201,165 patent/US20120041195A1/en not_active Abandoned
- 2010-02-09 EA EA201101188A patent/EA201101188A1/ru unknown
- 2010-02-09 JP JP2011549537A patent/JP2012517971A/ja active Pending
- 2010-02-09 MX MX2011008549A patent/MX2011008549A/es not_active Application Discontinuation
- 2010-02-09 PE PE2011001470A patent/PE20120110A1/es not_active Application Discontinuation
- 2010-02-12 AR ARP100100400A patent/AR075411A1/es not_active Application Discontinuation
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2011
- 2011-07-15 CR CR20110386A patent/CR20110386A/es unknown
- 2011-07-28 NI NI201100151A patent/NI201100151A/es unknown
- 2011-07-29 HN HN2011002095A patent/HN2011002095A/es unknown
- 2011-07-29 DO DO2011000248A patent/DOP2011000248A/es unknown
- 2011-08-03 TN TN2011000379A patent/TN2011000379A1/fr unknown
- 2011-08-03 IL IL214426A patent/IL214426A0/en unknown
- 2011-08-09 EC EC2011011250A patent/ECSP11011250A/es unknown
- 2011-08-11 ZA ZA2011/05896A patent/ZA201105896B/en unknown
- 2011-08-11 CL CL2011001947A patent/CL2011001947A1/es unknown
- 2011-08-11 CO CO11102097A patent/CO6420343A2/es not_active Application Discontinuation
Patent Citations (6)
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| WO2004058769A2 (en) * | 2002-12-18 | 2004-07-15 | Vertex Pharmaceuticals Incorporated | Triazolopyridazines as protein kinases inhibitors |
| WO2005037843A1 (en) * | 2003-10-14 | 2005-04-28 | Vertex Pharmaceuticals Incorporated | Compositions useful as inhibitors of protein kinases |
| WO2007067537A1 (en) * | 2005-12-07 | 2007-06-14 | Osi Pharmaceuticals, Inc. | Pyrrolopyridine kinase inhibiting compounds |
| WO2008025821A1 (en) * | 2006-08-30 | 2008-03-06 | Cellzome Limited | Triazole derivatives as kinase inhibitors |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013512264A (ja) * | 2009-11-30 | 2013-04-11 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | トリアゾロピリジン |
| JP2013512268A (ja) * | 2009-11-30 | 2013-04-11 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | トリアゾロピリジン誘導体 |
| JP2013532147A (ja) * | 2010-06-16 | 2013-08-15 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 置換トリアゾロピリジン |
Also Published As
| Publication number | Publication date |
|---|---|
| CO6420343A2 (es) | 2012-04-16 |
| IL214426A0 (en) | 2011-09-27 |
| NZ594508A (en) | 2013-12-20 |
| ECSP11011250A (es) | 2011-10-31 |
| BRPI1008850A2 (pt) | 2016-03-15 |
| SG173610A1 (en) | 2011-09-29 |
| CN102317288A (zh) | 2012-01-11 |
| KR20110116160A (ko) | 2011-10-25 |
| HN2011002095A (es) | 2014-01-06 |
| CL2011001947A1 (es) | 2012-03-16 |
| NI201100151A (es) | 2012-10-03 |
| US20120041195A1 (en) | 2012-02-16 |
| EA201101188A1 (ru) | 2012-04-30 |
| EP2396324A1 (en) | 2011-12-21 |
| DOP2011000248A (es) | 2011-10-31 |
| AR075411A1 (es) | 2011-03-30 |
| MX2011008549A (es) | 2011-12-06 |
| CR20110386A (es) | 2011-12-02 |
| ZA201105896B (en) | 2012-03-28 |
| PE20120110A1 (es) | 2012-02-20 |
| WO2010092041A1 (en) | 2010-08-19 |
| CA2751517A1 (en) | 2010-08-19 |
| TN2011000379A1 (en) | 2013-03-27 |
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