JP2012516845A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2012516845A5 JP2012516845A5 JP2011547981A JP2011547981A JP2012516845A5 JP 2012516845 A5 JP2012516845 A5 JP 2012516845A5 JP 2011547981 A JP2011547981 A JP 2011547981A JP 2011547981 A JP2011547981 A JP 2011547981A JP 2012516845 A5 JP2012516845 A5 JP 2012516845A5
- Authority
- JP
- Japan
- Prior art keywords
- compound according
- medicament
- manufacture
- treatment
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 20
- 239000003814 drug Substances 0.000 claims 12
- 238000004519 manufacturing process Methods 0.000 claims 12
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 3
- 201000000980 schizophrenia Diseases 0.000 claims 3
- 239000012453 solvate Substances 0.000 claims 3
- 102000003678 AMPA Receptors Human genes 0.000 claims 2
- 108090000078 AMPA Receptors Proteins 0.000 claims 2
- 239000000654 additive Substances 0.000 claims 2
- 230000000996 additive effect Effects 0.000 claims 2
- 230000007812 deficiency Effects 0.000 claims 2
- 230000002964 excitative effect Effects 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 210000000225 synapse Anatomy 0.000 claims 2
- CIXPKBCFGAGCDU-UHFFFAOYSA-N 2,1,3-benzoxadiazol-5-yl(3,7-dioxa-9-azabicyclo[3.3.1]nonan-9-yl)methanone Chemical compound C1=CC2=NON=C2C=C1C(=O)N1C2COCC1COC2 CIXPKBCFGAGCDU-UHFFFAOYSA-N 0.000 claims 1
- NWVRRDGMIWYLSO-UHFFFAOYSA-N 2,1,3-benzoxadiazol-5-yl(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)methanone Chemical compound C1=CC2=NON=C2C=C1C(=O)N1C2CCC1COC2 NWVRRDGMIWYLSO-UHFFFAOYSA-N 0.000 claims 1
- PKJCQULRFCGQCN-UHFFFAOYSA-N 2,1,3-benzoxadiazol-5-yl(3-oxa-9-azabicyclo[3.3.1]nonan-9-yl)methanone Chemical compound C1=CC2=NON=C2C=C1C(=O)N1C2CCCC1COC2 PKJCQULRFCGQCN-UHFFFAOYSA-N 0.000 claims 1
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 claims 1
- 208000036864 Attention deficit/hyperactivity disease Diseases 0.000 claims 1
- 208000020925 Bipolar disease Diseases 0.000 claims 1
- 208000028698 Cognitive impairment Diseases 0.000 claims 1
- 208000020401 Depressive disease Diseases 0.000 claims 1
- 208000001914 Fragile X syndrome Diseases 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- 208000006289 Rett Syndrome Diseases 0.000 claims 1
- 230000006399 behavior Effects 0.000 claims 1
- 208000010877 cognitive disease Diseases 0.000 claims 1
- 230000003920 cognitive function Effects 0.000 claims 1
- 230000001054 cortical effect Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000001771 impaired effect Effects 0.000 claims 1
- 230000000241 respiratory effect Effects 0.000 claims 1
- 201000002859 sleep apnea Diseases 0.000 claims 1
- 208000019116 sleep disease Diseases 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20664209P | 2009-02-02 | 2009-02-02 | |
| US61/206,642 | 2009-02-02 | ||
| PCT/US2010/000255 WO2010087981A2 (en) | 2009-02-02 | 2010-01-29 | Bicyclic amide derivatives for enhancing glutamatergic synaptic responses |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012516845A JP2012516845A (ja) | 2012-07-26 |
| JP2012516845A5 true JP2012516845A5 (enExample) | 2013-03-14 |
Family
ID=42396261
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011547981A Pending JP2012516845A (ja) | 2009-02-02 | 2010-01-29 | グルタミン酸作動性シナプス反応を増強するための二環式アミド誘導体 |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP2391621A4 (enExample) |
| JP (1) | JP2012516845A (enExample) |
| KR (1) | KR20110115139A (enExample) |
| CN (1) | CN102369201A (enExample) |
| AU (1) | AU2010208646A1 (enExample) |
| BR (1) | BRPI1005316A2 (enExample) |
| CA (1) | CA2751285A1 (enExample) |
| EA (1) | EA018994B1 (enExample) |
| IL (1) | IL214392A0 (enExample) |
| MX (1) | MX2011008060A (enExample) |
| SG (1) | SG173168A1 (enExample) |
| WO (2) | WO2010087980A2 (enExample) |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69331761T2 (de) * | 1992-07-24 | 2002-09-12 | The Regents Of The University Of California, Oakland | Arzneimittel, die den durch ampa rezeptoren vermittelten synaptischen respons erhöhen |
| US20020099050A1 (en) * | 1993-07-23 | 2002-07-25 | Lynch Gary S. | Drugs that enhance synaptic responses mediated by AMPA receptors |
| US6110935A (en) * | 1997-02-13 | 2000-08-29 | The Regents Of The University Of California | Benzofurazan compounds for enhancing glutamatergic synaptic responses |
| US6166008A (en) * | 1997-10-27 | 2000-12-26 | Cortex Pharmaceuticals, Inc. | Treatment of schizophrenia with ampakines and neuroleptics |
| JP5694765B2 (ja) * | 2007-05-17 | 2015-04-01 | コーテックス ファーマシューティカルズ， インコーポレイテッド | グルタミン酸作動性シナプス反応を増強するための二置換アミド |
| ES2560095T3 (es) * | 2007-08-10 | 2016-02-17 | Cortex Pharmaceuticals, Inc. | Amidas bicíclicas para mejorar las respuestas sinápticas glutamatérgicas |
-
2010
- 2010-01-29 WO PCT/US2010/000254 patent/WO2010087980A2/en not_active Ceased
- 2010-01-29 WO PCT/US2010/000255 patent/WO2010087981A2/en not_active Ceased
- 2010-01-29 EA EA201101162A patent/EA018994B1/ru not_active IP Right Cessation
- 2010-01-29 CA CA2751285A patent/CA2751285A1/en not_active Abandoned
- 2010-01-29 SG SG2011054376A patent/SG173168A1/en unknown
- 2010-01-29 KR KR1020117019461A patent/KR20110115139A/ko not_active Withdrawn
- 2010-01-29 EP EP10736150A patent/EP2391621A4/en not_active Withdrawn
- 2010-01-29 JP JP2011547981A patent/JP2012516845A/ja active Pending
- 2010-01-29 AU AU2010208646A patent/AU2010208646A1/en not_active Abandoned
- 2010-01-29 MX MX2011008060A patent/MX2011008060A/es active IP Right Grant
- 2010-01-29 BR BRPI1005316-6A patent/BRPI1005316A2/pt not_active IP Right Cessation
- 2010-01-29 CN CN2010800154033A patent/CN102369201A/zh active Pending
-
2011
- 2011-08-01 IL IL214392A patent/IL214392A0/en unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2010535858A5 (enExample) | ||
| MX2013004588A (es) | Derivados de triazol y su uso para trastornos neurologicos. | |
| PH12014502341A1 (en) | Amino-indolyl-substituted imidazolyl-pyrimidines and their use as medicaments | |
| MX2011011489A (es) | Derivados de isoxazol-piridina. | |
| MX2013001614A (es) | Compuestos heterociclico. | |
| JP2014518266A5 (enExample) | ||
| TWI455938B (zh) | 碳酸啶衍生物及其醫藥組成物 | |
| MX2011007774A (es) | Derivados de isoxazol-isoxazol e isoxazol-isotiazol. | |
| UA107112C2 (uk) | Активатори розчинної гуанілатциклази | |
| JP2012515720A5 (enExample) | ||
| JP2012255026A5 (enExample) | ||
| UA99309C2 (ru) | Замещенные пиперидинодигидротиенопиримидины | |
| JP2017504635A5 (enExample) | ||
| JP2014503593A5 (enExample) | ||
| ES2968840T3 (es) | Compuestos de aminocarbonilcarbamato y su uso en el tratamiento de trastornos hipercinéticos tales como el TDAH | |
| GEP20166483B (en) | Phenyl-3-aza-bicyclo[3.1.0] hex-3-yl-methanones and the use thereof as medicament | |
| MX2011011273A (es) | Derivados de isoxazol-pirazol. | |
| TW200901986A (en) | New combination | |
| JP2014505107A5 (enExample) | ||
| JP2012504560A5 (enExample) | ||
| JP2014534197A5 (enExample) | ||
| EA201792071A2 (ru) | Производные глутаримидов, их применение, фармацевтическая композиция на их основе, способы их получения | |
| HRP20110970T1 (hr) | 3-supstituirani-[1,2,3]-benzotriazinonski spoj za poboljšanje glutamatergičnih sinaptičkih odgovora | |
| MX2011011303A (es) | Derivados de isoxazol. | |
| EP2535329A3 (en) | Spiro-piperidine derivatives |