JP2012516693A5 - - Google Patents
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- JP2012516693A5 JP2012516693A5 JP2011548765A JP2011548765A JP2012516693A5 JP 2012516693 A5 JP2012516693 A5 JP 2012516693A5 JP 2011548765 A JP2011548765 A JP 2011548765A JP 2011548765 A JP2011548765 A JP 2011548765A JP 2012516693 A5 JP2012516693 A5 JP 2012516693A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- sequence
- amino acids
- variant
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000765 processed proteins & peptides Proteins 0.000 claims 60
- 102000004196 processed proteins & peptides Human genes 0.000 claims 51
- 229920001184 polypeptide Polymers 0.000 claims 49
- 235000001014 amino acid Nutrition 0.000 claims 23
- 229940024606 amino acid Drugs 0.000 claims 23
- 150000001413 amino acids Chemical class 0.000 claims 23
- 239000000203 mixture Substances 0.000 claims 18
- 210000001744 T-lymphocyte Anatomy 0.000 claims 9
- 208000035285 Allergic Seasonal Rhinitis Diseases 0.000 claims 5
- 206010048908 Seasonal allergy Diseases 0.000 claims 5
- 229940046528 grass pollen Drugs 0.000 claims 5
- 201000004338 pollen allergy Diseases 0.000 claims 5
- 210000004899 c-terminal region Anatomy 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 230000002265 prevention Effects 0.000 claims 4
- 239000004475 Arginine Substances 0.000 claims 2
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 2
- 239000004472 Lysine Substances 0.000 claims 2
- 239000013566 allergen Substances 0.000 claims 2
- QWCKQJZIFLGMSD-UHFFFAOYSA-N alpha-aminobutyric acid Chemical group CCC(N)C(O)=O QWCKQJZIFLGMSD-UHFFFAOYSA-N 0.000 claims 2
- 235000009697 arginine Nutrition 0.000 claims 2
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 2
- 235000018977 lysine Nutrition 0.000 claims 2
- 235000018102 proteins Nutrition 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- JHFNSBBHKSZXKB-VKHMYHEASA-N Asp-Gly Chemical compound OC(=O)C[C@H](N)C(=O)NCC(O)=O JHFNSBBHKSZXKB-VKHMYHEASA-N 0.000 claims 1
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 claims 1
- 244000025254 Cannabis sativa Species 0.000 claims 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims 1
- 206010020751 Hypersensitivity Diseases 0.000 claims 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims 1
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 claims 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims 1
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 claims 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 1
- 230000021736 acetylation Effects 0.000 claims 1
- 238000006640 acetylation reaction Methods 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 150000007513 acids Chemical class 0.000 claims 1
- 230000007815 allergy Effects 0.000 claims 1
- 230000009435 amidation Effects 0.000 claims 1
- 238000007112 amidation reaction Methods 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
- 235000009582 asparagine Nutrition 0.000 claims 1
- 229960001230 asparagine Drugs 0.000 claims 1
- 108010047857 aspartylglycine Proteins 0.000 claims 1
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 235000013922 glutamic acid Nutrition 0.000 claims 1
- 239000004220 glutamic acid Substances 0.000 claims 1
- 230000013595 glycosylation Effects 0.000 claims 1
- 238000006206 glycosylation reaction Methods 0.000 claims 1
- 235000014304 histidine Nutrition 0.000 claims 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 125000001165 hydrophobic group Chemical group 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 238000001802 infusion Methods 0.000 claims 1
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 claims 1
- 230000004048 modification Effects 0.000 claims 1
- 238000012986 modification Methods 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 230000026731 phosphorylation Effects 0.000 claims 1
- 238000006366 phosphorylation reaction Methods 0.000 claims 1
- 125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 claims 1
- 241000894007 species Species 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- 238000011200 topical administration Methods 0.000 claims 1
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0901927.4A GB0901927D0 (en) | 2009-02-05 | 2009-02-05 | Peptide for IL10 production |
| GB0901927.4 | 2009-02-05 | ||
| GB0901928A GB0901928D0 (en) | 2009-02-05 | 2009-02-05 | Peptides for vaccine |
| GB0901928.2 | 2009-02-05 | ||
| GB0912578A GB0912578D0 (en) | 2009-07-20 | 2009-07-20 | Peptide for IL-10 production |
| GB0912578.2 | 2009-07-20 | ||
| GBPCT/GB2009/01995 | 2009-08-14 | ||
| PCT/GB2009/001995 WO2010018384A1 (en) | 2008-08-15 | 2009-08-14 | T-cell antigen peptide from allergen for stimulation of il-10 production |
| GB0917871A GB0917871D0 (en) | 2009-10-12 | 2009-10-12 | Peptides for vaccine |
| GB0917871.6 | 2009-10-12 | ||
| PCT/GB2010/000198 WO2010089554A1 (en) | 2009-02-05 | 2010-02-05 | Peptides for vaccine |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015094636A Division JP6215252B2 (ja) | 2009-02-05 | 2015-05-07 | ワクチン用ペプチド |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012516693A JP2012516693A (ja) | 2012-07-26 |
| JP2012516693A5 true JP2012516693A5 (enExample) | 2013-03-21 |
| JP5746053B2 JP5746053B2 (ja) | 2015-07-08 |
Family
ID=42082585
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011548765A Expired - Fee Related JP5746053B2 (ja) | 2009-02-05 | 2010-02-05 | ワクチン用ペプチド |
| JP2015094636A Expired - Fee Related JP6215252B2 (ja) | 2009-02-05 | 2015-05-07 | ワクチン用ペプチド |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015094636A Expired - Fee Related JP6215252B2 (ja) | 2009-02-05 | 2015-05-07 | ワクチン用ペプチド |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US8753644B2 (enExample) |
| EP (2) | EP2891662A1 (enExample) |
| JP (2) | JP5746053B2 (enExample) |
| KR (1) | KR20110111307A (enExample) |
| CN (2) | CN103784952B (enExample) |
| AU (1) | AU2010212193B2 (enExample) |
| BR (1) | BRPI1008802A2 (enExample) |
| CA (1) | CA2751500A1 (enExample) |
| DK (1) | DK2393830T3 (enExample) |
| EA (1) | EA020792B1 (enExample) |
| ES (1) | ES2532759T3 (enExample) |
| GB (1) | GB2469894B (enExample) |
| HK (1) | HK1212358A1 (enExample) |
| HR (1) | HRP20150317T1 (enExample) |
| IL (1) | IL214257A (enExample) |
| MX (1) | MX2011008179A (enExample) |
| NZ (1) | NZ594268A (enExample) |
| PL (1) | PL2393830T3 (enExample) |
| PT (1) | PT2393830E (enExample) |
| SG (1) | SG173523A1 (enExample) |
| SI (1) | SI2393830T1 (enExample) |
| WO (1) | WO2010089554A1 (enExample) |
| ZA (1) | ZA201105436B (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103784952B (zh) * | 2009-02-05 | 2016-08-17 | 切尔卡西亚有限公司 | 用于疫苗的草肽 |
| CN103501812A (zh) | 2011-04-29 | 2014-01-08 | 西莱克塔生物科技公司 | 用于过敏症治疗的致耐受性合成纳米载体 |
| CA2910584A1 (en) | 2013-05-03 | 2014-11-06 | Selecta Biosciences, Inc. | Use of immunosuppressants attached to synthetic nanocarriers to enhance levels of cd4+ regulatory t cells |
| WO2016037163A1 (en) | 2014-09-07 | 2016-03-10 | Selecta Biosciences, Inc. | Methods and compositions for attenuating gene therapy anti-viral transfer vector immune responses |
| US11013781B2 (en) | 2015-07-01 | 2021-05-25 | Alk-Abelló As | Peptide combinations and uses thereof for treating grass allergy |
| EP3592389B1 (en) | 2017-03-11 | 2025-05-07 | Cartesian Therapeutics, Inc. | Methods and compositions related to combined treatment with anti-inflammatories and synthetic nanocarriers comprising an immunosuppressant |
| US11524019B2 (en) | 2017-08-21 | 2022-12-13 | Glycom A/S | Synthetic composition for reducing allergy symptoms |
| CN108802216B (zh) * | 2018-05-23 | 2021-04-16 | 山东出入境检验检疫局检验检疫技术中心 | 一种使用区域敏感性蛋白组和/或多肽组鉴别刺参产地的方法 |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1340729C (en) | 1988-03-23 | 1999-09-07 | Mohan Bir Singh | Ryegrass pollen allergen |
| US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
| US5399346A (en) | 1989-06-14 | 1995-03-21 | The United States Of America As Represented By The Department Of Health And Human Services | Gene therapy |
| DE69128039T2 (de) | 1990-08-17 | 1998-03-05 | Penelope Smith | Allergene aus roggenspreupollen |
| WO1992016554A1 (en) | 1991-03-14 | 1992-10-01 | The University Of Melbourne | Protein allergens of the species cynodon dactylon |
| WO1994001560A1 (en) | 1991-07-12 | 1994-01-20 | Immulogic Pharmaceutical Corporation | Allergenic proteins and peptides from japanese cedar pollen |
| NZ243956A (en) | 1991-08-16 | 1997-05-26 | Univ Melbourne | Ryegrass pollen antigen (lol p ib), nucleic acid encoding it, host cells, vectors, monoclonal antibodies and pharmaceutical for treating ryegrass allergy |
| EP0668915A1 (en) | 1991-11-15 | 1995-08-30 | The University Of Melbourne | Protein allergens of the species cynodon dactylon |
| US6441157B1 (en) | 1991-11-15 | 2002-08-27 | University Of Melbourne | Nucleic acid sequences encoding protein allergens of the species Cynodon dactylon |
| NZ328940A (en) | 1992-08-14 | 1999-05-28 | Univ Melbourne | Methods and use t cell epitopes of lol p v ryegrass pollen antigens |
| US6214358B1 (en) | 1992-10-30 | 2001-04-10 | Immulogic Pharamaceutical Corp. | Protein allergens of the species Cynodon dactylon |
| US5480972A (en) | 1992-10-30 | 1996-01-02 | The University Of Melbourne | Allergenic proteins from Johnson grass pollen |
| FI954269A0 (fi) | 1993-03-12 | 1995-09-12 | Immunologic Pharma Corp | Raiheinäsiitepölyallergeenin T-soluepitoopit |
| JPH09504167A (ja) * | 1993-08-13 | 1997-04-28 | イミュロジック ファーマスーティカル コーポレイション | ドクムギ花粉アレルゲンのｔ細胞エピトープ |
| US5820862A (en) | 1994-04-14 | 1998-10-13 | Immulogic Pharmaceutical Corporation | T cell epitopes of the major allergens from dermatophagoides (house dust mite) |
| GB9412714D0 (en) | 1994-06-24 | 1994-08-17 | Lewin Ian V | T cill epitopes |
| WO1996003106A2 (en) * | 1994-07-26 | 1996-02-08 | University Of Manitoba | Allergenic peptides derived from poa pratensis |
| US7112333B1 (en) * | 1994-08-05 | 2006-09-26 | Heska Corporation | T cell epitopes of ryegrass pollen allergen |
| IL115744A (en) | 1994-10-27 | 2000-07-16 | Akzo Nobel Nv | Peptides comprising a subsequence of human cartilage glycoprotein - 39 |
| AT402505B (de) | 1995-08-02 | 1997-06-25 | Biomay Prod & Handel | Rekombinantes 60 kda pflanzliches panallergen (kofaktor-unabhängige phosphoglyceratmutase; e.c. 5.4.2.1.) |
| JP2002500198A (ja) | 1998-01-09 | 2002-01-08 | サーカシア リミテッド | 脱感作のための方法及び組成物 |
| DE19823097A1 (de) * | 1998-05-22 | 1999-11-25 | Max Planck Gesellschaft | Mittel gegen saisonale Typ-I-Allergien und bakterielle Infektionen |
| US6989146B2 (en) | 2000-08-09 | 2006-01-24 | The Regents Of The University Of California | Stress proteins and peptides and methods of use thereof |
| AUPR775401A0 (en) * | 2001-09-18 | 2001-10-11 | Monash University | Novel Epitopes and Uses Thereof |
| JP4874522B2 (ja) | 2001-12-05 | 2012-02-15 | サーカッシア リミテッド | 免疫療法および系 |
| AUPS148202A0 (en) * | 2002-04-02 | 2002-05-09 | Monash University | Immunotherapeutic and immunoprophylactic reagents |
| AU2003228133A1 (en) | 2002-04-22 | 2003-11-03 | Umc Utrecht Holding B.V. | Reduction of unwanted immune reactions |
| GB0210741D0 (en) | 2002-05-10 | 2002-06-19 | Medical Res Council | Methods of therapy |
| GB0308988D0 (en) | 2003-04-17 | 2003-05-28 | Univ Singapore | Molecule |
| DE102004035337A1 (de) * | 2004-07-21 | 2006-03-16 | Merck Patent Gmbh | Varianten der Gruppe 1-Allergene aus Poaceae mit reduzierter Allergenität und erhaltener T-Zellreaktivität |
| WO2006075253A2 (en) | 2005-01-11 | 2006-07-20 | Commissariat A L'energie Atomique | Peptides for desensitizing subjects allergic to dog hair and dander and compositions containing said peptides. |
| US20090130130A1 (en) | 2005-06-10 | 2009-05-21 | National University Of Singapore | Mutant allergen(s) |
| DE202005009990U1 (de) * | 2005-06-25 | 2006-11-02 | Hengst Gmbh & Co.Kg | Vorrichtung zum Abscheiden von Ölteilchen aus dem Kurbelgehäuseentlüftungsgas einer Brennkraftmaschine |
| US20070092532A1 (en) | 2005-10-25 | 2007-04-26 | Board Of Trustees Operating Michigan State University | Arthritis vaccines and methods |
| ES2405552T3 (es) | 2005-11-29 | 2013-05-31 | Actogenix N.V. | Inducción de tolerancia mucosa a antiantígenos de células beta de islotes pancreáticos |
| AT503690A1 (de) * | 2006-06-09 | 2007-12-15 | Biomay Ag | Hypoallergene moleküle |
| EP2156183B1 (en) | 2007-05-09 | 2013-08-07 | Circassia Limited | Prognostic assay for determining t cell response to hla antigens and use thereof in field of tissue transplantation |
| GB0710529D0 (en) | 2007-06-01 | 2007-07-11 | Circassia Ltd | Vaccine |
| ES2402956T3 (es) | 2007-08-15 | 2013-05-10 | Circassia Limited | Péptido con formación de dímeros reducida |
| EP2042193A1 (en) | 2007-09-28 | 2009-04-01 | Biomay AG | RNA Vaccines |
| EP2331124A1 (en) | 2008-08-15 | 2011-06-15 | Circassia Limited | T-cell antigen peptide from allergen for stimulation of il-10 production |
| CN103784952B (zh) * | 2009-02-05 | 2016-08-17 | 切尔卡西亚有限公司 | 用于疫苗的草肽 |
-
2010
- 2010-02-05 CN CN201410056647.6A patent/CN103784952B/zh not_active Expired - Fee Related
- 2010-02-05 GB GB1001954A patent/GB2469894B/en not_active Expired - Fee Related
- 2010-02-05 EP EP15152164.8A patent/EP2891662A1/en not_active Withdrawn
- 2010-02-05 JP JP2011548765A patent/JP5746053B2/ja not_active Expired - Fee Related
- 2010-02-05 HR HRP20150317TT patent/HRP20150317T1/hr unknown
- 2010-02-05 KR KR1020117019157A patent/KR20110111307A/ko not_active Ceased
- 2010-02-05 ES ES10704399.4T patent/ES2532759T3/es active Active
- 2010-02-05 US US13/148,024 patent/US8753644B2/en active Active
- 2010-02-05 DK DK10704399T patent/DK2393830T3/en active
- 2010-02-05 MX MX2011008179A patent/MX2011008179A/es active IP Right Grant
- 2010-02-05 NZ NZ594268A patent/NZ594268A/xx not_active IP Right Cessation
- 2010-02-05 SG SG2011055951A patent/SG173523A1/en unknown
- 2010-02-05 EA EA201171001A patent/EA020792B1/ru not_active IP Right Cessation
- 2010-02-05 EP EP10704399.4A patent/EP2393830B8/en not_active Not-in-force
- 2010-02-05 WO PCT/GB2010/000198 patent/WO2010089554A1/en not_active Ceased
- 2010-02-05 CA CA2751500A patent/CA2751500A1/en not_active Abandoned
- 2010-02-05 SI SI201030898T patent/SI2393830T1/sl unknown
- 2010-02-05 BR BRPI1008802A patent/BRPI1008802A2/pt not_active IP Right Cessation
- 2010-02-05 PL PL10704399T patent/PL2393830T3/pl unknown
- 2010-02-05 CN CN201080006665.3A patent/CN102307893B/zh not_active Expired - Fee Related
- 2010-02-05 AU AU2010212193A patent/AU2010212193B2/en not_active Ceased
- 2010-02-05 PT PT107043994T patent/PT2393830E/pt unknown
-
2011
- 2011-07-22 ZA ZA2011/05436A patent/ZA201105436B/en unknown
- 2011-07-24 IL IL214257A patent/IL214257A/en not_active IP Right Cessation
-
2012
- 2012-01-10 HK HK16100075.0A patent/HK1212358A1/en unknown
-
2014
- 2014-05-19 US US14/281,089 patent/US20140302071A1/en not_active Abandoned
-
2015
- 2015-05-07 JP JP2015094636A patent/JP6215252B2/ja not_active Expired - Fee Related
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