JP2012515540A5 - - Google Patents
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- Publication number
- JP2012515540A5 JP2012515540A5 JP2011546813A JP2011546813A JP2012515540A5 JP 2012515540 A5 JP2012515540 A5 JP 2012515540A5 JP 2011546813 A JP2011546813 A JP 2011546813A JP 2011546813 A JP2011546813 A JP 2011546813A JP 2012515540 A5 JP2012515540 A5 JP 2012515540A5
- Authority
- JP
- Japan
- Prior art keywords
- replaced
- region
- nucleic acid
- heavy chain
- encoding
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200900118 | 2009-01-26 | ||
| DKPA200900118 | 2009-01-26 | ||
| PCT/EP2010/050822 WO2010084197A1 (en) | 2009-01-26 | 2010-01-26 | Methods for producing mixtures of antibodies |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016052035A Division JP2016165285A (ja) | 2009-01-26 | 2016-03-16 | 抗体混合物を産生するための方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012515540A JP2012515540A (ja) | 2012-07-12 |
| JP2012515540A5 true JP2012515540A5 (https=) | 2013-03-14 |
Family
ID=42060888
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011546813A Ceased JP2012515540A (ja) | 2009-01-26 | 2010-01-26 | 抗体混合物を産生するための方法 |
| JP2016052035A Pending JP2016165285A (ja) | 2009-01-26 | 2016-03-16 | 抗体混合物を産生するための方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016052035A Pending JP2016165285A (ja) | 2009-01-26 | 2016-03-16 | 抗体混合物を産生するための方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20120020952A1 (https=) |
| EP (1) | EP2389392A1 (https=) |
| JP (2) | JP2012515540A (https=) |
| CN (2) | CN104262483A (https=) |
| SG (1) | SG172977A1 (https=) |
| WO (1) | WO2010084197A1 (https=) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2314629T4 (da) | 2002-07-18 | 2023-02-06 | Merus Nv | Rekombinant produktion af blandinger af antistoffer |
| USRE47770E1 (en) | 2002-07-18 | 2019-12-17 | Merus N.V. | Recombinant production of mixtures of antibodies |
| PE20081216A1 (es) | 2006-09-01 | 2008-09-04 | Therapeutic Human Polyclonals Inc | Expresion mejorada de la inmunoglobulina humana o humanizada en animales transgenicos no humanos |
| AU2009324092A1 (en) * | 2008-12-03 | 2011-06-23 | Genmab A/S | Antibody variants having modifications in the constant region |
| US9676845B2 (en) | 2009-06-16 | 2017-06-13 | Hoffmann-La Roche, Inc. | Bispecific antigen binding proteins |
| CN101983968B (zh) * | 2010-09-26 | 2013-03-06 | 浙江海洋学院 | 乌贼墨寡肽的酶解制备方法 |
| MX342034B (es) | 2011-02-28 | 2016-09-12 | Hoffmann La Roche | Proteinas monovalentes que se unen a antigenos. |
| AR085404A1 (es) | 2011-02-28 | 2013-09-25 | Hoffmann La Roche | Proteinas de union a antigeno |
| JP6031735B2 (ja) * | 2011-06-13 | 2016-11-24 | ソニー株式会社 | 情報処理装置、情報処理方法およびコンピュータプログラム |
| US9248181B2 (en) * | 2012-04-20 | 2016-02-02 | Merus B.V. | Methods and means for the production of Ig-like molecules |
| CN102851338A (zh) * | 2012-07-25 | 2013-01-02 | 苏州康宁杰瑞生物科技有限公司 | 利用电荷排斥作用制备同二聚体蛋白混合物的方法 |
| HUE042040T2 (hu) | 2012-09-27 | 2019-06-28 | Merus Nv | Bispecifikus IGG antitestek mint T-sejt kapcsolók |
| BR112016006929A2 (pt) | 2013-10-11 | 2017-09-19 | Hoffmann La Roche | Anticorpo, ácido nucleico, vetor de expressão, célula hospedeira, métodos de preparação de anticorpo, de tratamento de pacientes e de geração de um anticorpo, composição farmacêutica e uso do anticorpo |
| TW201609805A (zh) | 2013-12-23 | 2016-03-16 | 美國禮來大藥廠 | 結合ｅｇｆｒ及ｍｅｔ之多功能抗體 |
| JP6771385B2 (ja) | 2014-02-28 | 2020-10-21 | メルス ナムローゼ フェンノートシャップ | 二重特異性抗体および医薬組成物 |
| WO2015130173A1 (en) | 2014-02-28 | 2015-09-03 | Merus B.V. | Antibody that binds erbb-2 and erbb-3 |
| ES2833230T3 (es) | 2014-05-13 | 2021-06-14 | Univ Pennsylvania | Composiciones que comprenden AVV que expresan construcciones y usos de doble anticuerpo del mismo |
| CN110655582B (zh) | 2015-01-08 | 2022-12-16 | 江苏康宁杰瑞生物制药有限公司 | 具有共同轻链的双特异性抗体或抗体混合物 |
| US9914777B2 (en) | 2015-07-10 | 2018-03-13 | Merus N.V. | Human CD3 binding antibody |
| SMT202100230T1 (it) | 2015-10-23 | 2021-07-12 | Fundacio Inst De Recerca Biomedica Irb Barcelona | Molecole di legame che inibiscono la crescita tumorale |
| CN109475627B (zh) * | 2016-05-26 | 2023-01-06 | 齐鲁普吉湾生物治疗公司 | 抗体混合物 |
| IL269656B2 (en) | 2017-03-31 | 2024-06-01 | Merus Nv | Bispecific antibodies that bind ERBB-2 and ERBB3 for use in the treatment of cells with NRG1 fusion gene |
| JP7296891B2 (ja) | 2017-05-17 | 2023-06-23 | メルス ナムローゼ フェンノートシャップ | 乳癌のためのＥｒｂＢ－２／ＥｒｂＢ－３二重特異性抗体と内分泌療法との組み合わせ |
| SG11202001050PA (en) | 2017-08-09 | 2020-03-30 | Merus Nv | Antibodies that bind egfr and cmet |
| WO2025228542A1 (en) | 2024-05-03 | 2025-11-06 | Genmab B.V. | Method for co-expression of a plurality of antibodies |
| EP4644413A1 (en) | 2024-05-03 | 2025-11-05 | Genmab B.V. | Binding agents having altered fc-mediated effector functions |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003217912A1 (en) * | 2002-03-01 | 2003-09-16 | Xencor | Antibody optimization |
| DK2314629T4 (da) * | 2002-07-18 | 2023-02-06 | Merus Nv | Rekombinant produktion af blandinger af antistoffer |
| JP2006501856A (ja) * | 2002-10-09 | 2006-01-19 | インテグリジェン， インコーポレイテッド | 組換え触媒ポリペプチドおよびその使用 |
| WO2004106375A1 (en) * | 2003-05-30 | 2004-12-09 | Merus Biopharmaceuticals B.V. I.O. | Fab library for the preparation of anti vegf and anti rabies virus fabs |
| JP5511654B2 (ja) * | 2007-05-31 | 2014-06-04 | ゲンマブ エー／エス | 分子操作により得られた組換え非グリコシル化一価半抗体 |
| JP6157046B2 (ja) * | 2008-01-07 | 2017-07-05 | アムジェン インコーポレイテッド | 静電的ステアリング（ｅｌｅｃｔｒｏｓｔａｔｉｃｓｔｅｅｒｉｎｇ）効果を用いた抗体Ｆｃヘテロ二量体分子を作製するための方法 |
-
2010
- 2010-01-26 CN CN201410421605.8A patent/CN104262483A/zh active Pending
- 2010-01-26 CN CN2010800137659A patent/CN102365296A/zh active Pending
- 2010-01-26 SG SG2011050903A patent/SG172977A1/en unknown
- 2010-01-26 EP EP10701360A patent/EP2389392A1/en not_active Withdrawn
- 2010-01-26 JP JP2011546813A patent/JP2012515540A/ja not_active Ceased
- 2010-01-26 US US13/146,297 patent/US20120020952A1/en not_active Abandoned
- 2010-01-26 WO PCT/EP2010/050822 patent/WO2010084197A1/en not_active Ceased
-
2016
- 2016-03-16 JP JP2016052035A patent/JP2016165285A/ja active Pending
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