JP2012514499A - 薬学的投薬量送達システム - Google Patents
薬学的投薬量送達システム Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/07—Endoradiosondes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1468—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means
- A61B5/1473—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means invasive, e.g. introduced into the body by a catheter
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/48—Other medical applications
- A61B5/4836—Diagnosis combined with treatment in closed-loop systems or methods
- A61B5/4839—Diagnosis combined with treatment in closed-loop systems or methods combined with drug delivery
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0097—Micromachined devices; Microelectromechanical systems [MEMS]; Devices obtained by lithographic treatment of silicon; Devices comprising chips
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
- A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
- A61J3/071—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use into the form of telescopically engaged two-piece capsules
Abstract
Description
本出願は、米国特許法第119条第(e)項に基づき、2009年1月6日に出願した米国仮特許出願第61/142,861号の出願日に優先権を主張するものであり、その開示が、参照により本明細書に援用される。
Claims (25)
- 送達パラメータを追跡するための薬学的送達システムであって、
閉口端部および開口端部を有し、空洞を画定するキャリアハウジングと、
前記キャリアハウジングの前記空洞内に配置されている薬学的薬剤と、
上端部と、前記薬学的薬剤を収容している前記空洞を密封するために、前記キャリアハウジングの前記開口端部と物理的に連通している密封部分を含む下端部とを備える蓋と、
前記システムに関連し、情報を伝達するために識別可能な電流シグネチャを発生する、デバイスと、を備える、システム。 - 前記デバイスは、前記キャリアハウジングが周辺環境と接触する際に、前記デバイスが周辺環境と接触できるように、前記蓋の上部部分に固定される、請求項1に記載のシステム。
- 前記密封部分は、前記蓋が前記キャリアハウジングの前記開口端部内に押圧によって嵌入されるようにする少なくとも1つのチャネルを画定する、請求項1に記載のシステム。
- 前記デバイスは、前記システムが摂取されて、前記蓋がキャリアハウジングから分離した後に、前記周辺環境と接触するように前記下端部に固定される、請求項1に記載のシステム。
- 前記密封部分は、接着剤を使用して前記キャリアハウジングの開口端部に固定される、請求項1に記載のシステム。
- 前記デバイスは、
フレームと、
前記情報を表す前記識別可能な電流シグネチャを発生するために、前記フレーム内に固定される導電制御モジュールと、
前記フレームに固定され、前記導電制御モジュールに電気的に結合される、第1の材料と、
前記フレームに固定され、前記導電制御モジュールに電気的に結合される、第2の材料と、を備え、
前記第1の材料および前記第2の材料は、非導電性の材料によって分離され、導電性流体に接触すると電圧電位を生成するように選択される、請求項1に記載のシステム。 - 開口端部および閉口端部を有し、空洞を画定するハウジングと、
前記キャリアの浮力を変更するために、前記ハウジングの前記空洞内に配置される、装置と、
上端部と、前記空洞の内容物を密封するために、前記ハウジングの前記開口端部に前記蓋を嵌入させるための少なくとも1つのチャネルを画定する下端部とを備える蓋と、
前記蓋に固定され、一意の電流シグネチャを発生するための電流制御デバイスと、を備え、前記電流制御デバイスは、
識別可能な電流シグネチャを発生するために、フレーム内に固定される、導電制御モジュールと、
互いに絶縁された第1の材料および第2の材料を備える部分的電源と、を備え、前記第1の材料および前記第2の材料のそれぞれは、前記導電制御モジュールに電気的に結合される、であって、前記第1の材料および前記第2の材料は前記フレームに固定される薬学的キャリア。 - 前記電流制御デバイスの前記部分的電源は、前記第1の材料および前記第2の材料が、それらと接触している導電性流体を通して電気的に結合されると、電圧電位を発生し、前記電圧電位は、前記識別可能な電流シグネチャを発生するように前記導電制御モジュールを作動するために使用される、請求項7に記載のキャリア。
- 前記電流制御デバイスは、前記ハウジングが前記導電性流体に接触するのとほぼ同時に、前記電流制御デバイスが前記導電性流体に接触し、したがって、前記電流制御デバイスは、前記導電性流体との接触によって作動するように、前記蓋の前記上端部に固定される、請求項8に記載のキャリア。
- 前記電流制御デバイスは、前記蓋の前記上端部に固定され、前記キャリアは、前記蓋の前記上端部上に配置される外蓋をさらに備え、前記外蓋が、前記外蓋が溶解するまで前記導電性流体の前記電流制御デバイスとの接触を防ぐようにし、前記環境への前記キャリアの導入の時間と、前記導電制御モジュールの作動の時間との間を遅延させ、それにより、前記識別可能な電流シグネチャの生成を遅延させる、請求項8に記載のキャリア。
- 前記電流制御デバイスは、前記蓋が前記ハウジングから分離された後に、前記電流制御デバイスが前記周辺環境と接触し、それにより、前記電流制御デバイスが前記識別可能な電流シグネチャを発生するのを遅延させるように、前記蓋の前記下端部に固定される、請求項8に記載のキャリア。
- 前記蓋は前記下端部に先細部分を含み、前記ハウジングは前記開口端部に先細部分を含み、前記先細部分が雄雌型の対となって互いに組み合わされるようにし、それにより、前記蓋は前記ハウジングの前記開口端部内に固定されて前記空洞を密封する、請求項7に記載のキャリア。
- 前記蓋は、前記ハウジングの前記空洞を密封するために、前記ハウジングの前記開口端部に機械的に嵌合される、請求項7に記載のキャリア。
- 前記ハウジングの前記空洞内に配置される、薬学的薬剤をさらに備える、請求項7に記載のキャリア。
- 前記装置は、胃液よりも高い密度を前記デバイスに付与する組成物を有する、請求項7に記載のキャリア。
- 薬学的製品の摂取に関連づけられた情報を提供するための、摂取可能なキャリアであって、
開口端部および閉口端部を有し、空洞を画定する溶解可能なケーシングと、
固定部分を含む上端部および下端部を備え蓋と、
前記薬学的製品の摂取に関連づけられた情報を表す電流シグネチャを発生するための前記キャリアに関連づけられた電流シグネチャ発生デバイスと、を備え、前記ケーシングが該ケーシングによって画定される前記空洞内に前記薬学的製品を配置可能にし、前記固定部分は、前記蓋の、前記ケーシングの前記開口端部への挿入を可能にする複数のチャネルを画定し、ケーシング前記電流シグネチャ発生デバイスは、
フレームと、
前記情報を表す前記電流シグネチャを発生するために、前記フレームに固定される、導電制御モジュールと、
前記導電制御モジュールにそれぞれ電気的に結合される、第1の材料および第2の材料を備える、部分的電源と、を有し、前記第1の材料および前記第2の材料は前記フレームに固定され、非導電性の材料によって分離され、前記部分的電源は、前記第1の材料および前記第2の材料がそれらに接触している導電性流体を通して、電気的に結合されると、電圧電位を発生し、前記電圧電位は、前記導電制御モジュール、したがって前記デバイスを作動させる、を備える、キャリア。 - 前記デバイスは、前記ケーシングが前記導電性流体に接触するのとほぼ同時に、前記デバイスが前記導電性流体に接触するように、前記蓋の前記上端部に固定される、請求項16に記載のキャリア。
- 前記デバイスは、前記蓋の前記上端部に配置され、前記キャリアは、前記蓋の周りに配置され、前記蓋に固定される外蓋をさらに備え、それにより、前記外蓋は、前記デバイスと前記導電性流体との間の接触を遅延させることによって、前記デバイスの作動を遅延させ、したがって、電流シグネチャの発生を遅延させる、請求項16に記載のキャリア。
- 前記デバイスは、前記蓋が解放される段階まで前記ケーシングが溶解した後に、前記デバイスが前記導電性流体に接触し、それにより、前記電流シグネチャの発生を遅延させるように、固定端部の底部に固定される、請求項16に記載のキャリア。
- 前記デバイスは、前記ケーシングによって画定される前記空洞内に配置される、請求項16に記載のキャリア。
- 前記キャリアは、前記ケーシングによって画定される前記空洞内の前記薬学的製品および前記デバイスの移動を防止するために、前記ケーシングによって画定される前記空洞内に配置される、充填剤組成物をさらに備える、請求項16に記載のキャリア。
- 前記ケーシングによって画定される前記空洞内に配置される、浮力変更装置をさらに備える、請求項16に記載のキャリア。
- 前記固定部分は、前記ケーシングの前記開口端部内に接着される、請求項16に記載のキャリア。
- 前記固定部分は、前記ケーシングの前記開口端部に機械的に固定される、請求項16に記載のキャリア。
- 前記固定部分は、前記ケーシングの前記開口端部に押圧によって嵌合される、請求項16に記載のキャリア。
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US14286109P | 2009-01-06 | 2009-01-06 | |
US61/142,861 | 2009-01-06 | ||
PCT/US2010/020140 WO2010080764A2 (en) | 2009-01-06 | 2010-01-05 | Pharmaceutical dosages delivery system |
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JP2015111894A Division JP2015177999A (ja) | 2009-01-06 | 2015-06-02 | 薬学的投薬量送達システム |
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JP2012514499A true JP2012514499A (ja) | 2012-06-28 |
JP5785097B2 JP5785097B2 (ja) | 2015-09-24 |
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JP2011544658A Active JP5785097B2 (ja) | 2009-01-06 | 2010-01-05 | 薬学的投薬量送達システム |
JP2015111894A Pending JP2015177999A (ja) | 2009-01-06 | 2015-06-02 | 薬学的投薬量送達システム |
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US (2) | US8597186B2 (ja) |
EP (2) | EP3395333A1 (ja) |
JP (2) | JP5785097B2 (ja) |
KR (1) | KR20110104079A (ja) |
CN (1) | CN102365084B (ja) |
AU (1) | AU2010203737B2 (ja) |
CA (1) | CA2750148C (ja) |
HK (2) | HK1165272A1 (ja) |
IL (1) | IL213687A (ja) |
MY (1) | MY153758A (ja) |
SG (1) | SG172847A1 (ja) |
TW (2) | TWI544917B (ja) |
WO (1) | WO2010080764A2 (ja) |
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SG172847A1 (en) | 2011-08-29 |
JP2015177999A (ja) | 2015-10-08 |
EP2385827A4 (en) | 2012-06-27 |
IL213687A0 (en) | 2011-07-31 |
EP2385827A2 (en) | 2011-11-16 |
CN102365084A (zh) | 2012-02-29 |
WO2010080764A3 (en) | 2010-10-21 |
AU2010203737A1 (en) | 2011-07-21 |
CN102365084B (zh) | 2014-04-30 |
TW201603805A (zh) | 2016-02-01 |
TWI544917B (zh) | 2016-08-11 |
HK1165272A1 (en) | 2012-10-05 |
US20110306852A1 (en) | 2011-12-15 |
WO2010080764A2 (en) | 2010-07-15 |
CA2750148A1 (en) | 2010-07-15 |
US8597186B2 (en) | 2013-12-03 |
EP2385827B1 (en) | 2018-07-04 |
AU2010203737B2 (en) | 2016-09-15 |
TWI602561B (zh) | 2017-10-21 |
US20140046147A1 (en) | 2014-02-13 |
HK1258442A1 (zh) | 2019-11-15 |
MY153758A (en) | 2015-03-13 |
US8951234B2 (en) | 2015-02-10 |
EP3395333A1 (en) | 2018-10-31 |
CA2750148C (en) | 2017-02-07 |
JP5785097B2 (ja) | 2015-09-24 |
KR20110104079A (ko) | 2011-09-21 |
IL213687A (en) | 2015-07-30 |
TW201028140A (en) | 2010-08-01 |
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