JP2012512239A5 - - Google Patents
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- Publication number
- JP2012512239A5 JP2012512239A5 JP2011541613A JP2011541613A JP2012512239A5 JP 2012512239 A5 JP2012512239 A5 JP 2012512239A5 JP 2011541613 A JP2011541613 A JP 2011541613A JP 2011541613 A JP2011541613 A JP 2011541613A JP 2012512239 A5 JP2012512239 A5 JP 2012512239A5
- Authority
- JP
- Japan
- Prior art keywords
- trans
- butoxycarbonyl
- tert
- dichlorophenyl
- ethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HUP0800763 | 2008-12-17 | ||
| HU0800763A HU230067B1 (hu) | 2008-12-17 | 2008-12-17 | Új piperazin só és eljárás előállítására |
| PCT/HU2009/000108 WO2010070369A1 (en) | 2008-12-17 | 2009-12-17 | Piperazine salt and a process for the preparation thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012512239A JP2012512239A (ja) | 2012-05-31 |
| JP2012512239A5 true JP2012512239A5 (enExample) | 2013-06-13 |
| JP5735923B2 JP5735923B2 (ja) | 2015-06-17 |
Family
ID=89988672
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011541613A Active JP5735923B2 (ja) | 2008-12-17 | 2009-12-17 | ピペラジン塩およびその調製方法 |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US8569496B2 (enExample) |
| EP (1) | EP2358690B1 (enExample) |
| JP (1) | JP5735923B2 (enExample) |
| CN (1) | CN102256953B (enExample) |
| AU (1) | AU2009329294B2 (enExample) |
| BR (1) | BRPI0923007B8 (enExample) |
| CA (1) | CA2743924C (enExample) |
| DK (1) | DK2358690T3 (enExample) |
| EA (1) | EA019024B1 (enExample) |
| ES (1) | ES2573957T3 (enExample) |
| GE (1) | GEP20125711B (enExample) |
| HR (1) | HRP20160726T1 (enExample) |
| HU (2) | HU230067B1 (enExample) |
| IL (1) | IL212639A0 (enExample) |
| MX (1) | MX2011006591A (enExample) |
| NZ (1) | NZ592907A (enExample) |
| PL (1) | PL2358690T3 (enExample) |
| PT (1) | PT2358690E (enExample) |
| SI (1) | SI2358690T1 (enExample) |
| TW (1) | TWI448455B (enExample) |
| UA (1) | UA104163C2 (enExample) |
| WO (1) | WO2010070369A1 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUP0700353A2 (en) * | 2007-05-18 | 2008-12-29 | Richter Gedeon Nyrt | Metabolites of (thio)carbamoyl-cyclohexane derivatives |
| US7875610B2 (en) * | 2007-12-03 | 2011-01-25 | Richter Gedeon Nyrt. | Pyrimidinyl-piperazines useful as D3/D2 receptor ligands |
| CA2715760C (en) * | 2008-02-21 | 2017-06-13 | Mitsubishi Tanabe Pharma Corporation | Solid preparation for oral administration of cariprazine hydrochloride |
| AU2009270823B2 (en) | 2008-07-16 | 2014-07-17 | Richter Gedeon Nyrt. | Pharmaceutical formulations containing dopamine receptor ligands |
| HUP0800765A2 (en) | 2008-12-18 | 2010-11-29 | Richter Gedeon Nyrt | A new process for the preparation of piperazine derivatives and their hydrochloric salts |
| HUP0800766A2 (en) | 2008-12-18 | 2010-11-29 | Richter Gedeon Vegyeszet | Process for the preparation of piperazine derivatives |
| ITMI20131693A1 (it) * | 2013-10-14 | 2015-04-15 | Chemo Res S L | Derivati della 1,4-cicloesilammina e loro preparazione |
| CN104496854B (zh) * | 2015-01-06 | 2017-09-22 | 上海医药工业研究院 | 3‑环己基‑1,1‑二甲基脲类化合物及其制备方法和应用 |
| HU231173B1 (hu) | 2016-07-08 | 2021-06-28 | Richter Gedeon Nyrt. | Ipari eljárás cariprazine előállítására |
| US11274087B2 (en) | 2016-07-08 | 2022-03-15 | Richter Gedeon Nyrt. | Industrial process for the preparation of cariprazine |
| CN111269199B (zh) * | 2018-12-05 | 2022-04-08 | 浙江京新药业股份有限公司 | 一种卡利拉嗪的制备方法 |
| US11547707B2 (en) | 2019-04-10 | 2023-01-10 | Richter Gedeon Nyrt. | Carbamoyl cyclohexane derivatives for treating autism spectrum disorder |
| CN111892556A (zh) * | 2019-05-06 | 2020-11-06 | 北京万全德众医药生物技术有限公司 | 新的卡利拉嗪制备方法 |
| CN110372557B (zh) * | 2019-08-06 | 2021-05-18 | 上海勋和医药科技有限公司 | 环己烷胺类d3/d2受体部分激动剂 |
| CN114539185B (zh) * | 2020-11-24 | 2024-12-24 | 上海新礼泰药业有限公司 | 一种卡利拉嗪及其中间体的制备方法 |
| HUP2100108A1 (hu) | 2021-03-12 | 2022-09-28 | Richter Gedeon Nyrt | Eljárás és berendezés gyógyászatilag alkalmazható piperazin származékok folyamatos áramú, áramlásos konszekutív redukálással történõ elõállítására |
| CN119874636B (zh) * | 2025-01-16 | 2026-07-28 | 鲁南制药集团股份有限公司 | 一种卡利拉嗪的制备方法 |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4957921A (en) | 1989-12-06 | 1990-09-18 | Warner-Lambert Company | Substituted cyclohexanols as central nervous system agents |
| US5047406A (en) | 1989-12-06 | 1991-09-10 | Warner-Lambert Co. | Substituted cyclohexanols as central nervous system agents |
| US6334997B1 (en) | 1994-03-25 | 2002-01-01 | Isotechnika, Inc. | Method of using deuterated calcium channel blockers |
| KR100477070B1 (ko) | 1994-03-25 | 2006-04-21 | 이소테크니카 인코포레이티드 | 중수소화작용에의한의약품의효능강화법 |
| US5977110A (en) | 1995-09-22 | 1999-11-02 | Warner-Lambert Company | Substituted cyclohexylamines as central nervous systems agents |
| KR100672186B1 (ko) | 1998-03-31 | 2007-01-19 | 아카디아 파마슈티칼스 인코포레이티드 | 무스카린 수용체에 대해 활성을 갖는 화합물 |
| US6528529B1 (en) | 1998-03-31 | 2003-03-04 | Acadia Pharmaceuticals Inc. | Compounds with activity on muscarinic receptors |
| SE9802208D0 (sv) | 1998-06-22 | 1998-06-22 | Astra Pharma Inc | Novel compounds |
| JP2000191570A (ja) * | 1998-12-24 | 2000-07-11 | Sumitomo Chem Co Ltd | ヒドロキシフェニルプロパノール類の製造法 |
| US6489341B1 (en) | 1999-06-02 | 2002-12-03 | Sepracor Inc. | Methods for the treatment of neuroleptic and related disorders using sertindole derivatives |
| DE60223506T2 (de) | 2001-02-27 | 2008-09-18 | Ortho-Mcneil Pharmaceutical, Inc. | Carbamatverbindungen zur vorbeugung oder behandlung bipolarer erkrankungen |
| US6566550B2 (en) | 2001-06-21 | 2003-05-20 | Pfizer Inc | Substituted aromatic ethers as inhibitors of glycine transport |
| HU227543B1 (en) * | 2001-09-28 | 2011-08-29 | Richter Gedeon Nyrt | N-[4-(2-piperazin- and 2-piperidin-1-yl-ethyl)-cyclohexyl]-sulfon- and sulfamides, process for their preparation, their use and pharmaceutical compositions containing them |
| SE0200301D0 (sv) | 2002-02-01 | 2002-02-01 | Axon Biochemicals Bv | Thio-carbostyril derivative |
| US6833459B2 (en) * | 2002-04-26 | 2004-12-21 | Orchid Chemicals & Pharmaceuticals Limited | Process for the preparation of thiazole intermediate |
| US6919342B2 (en) | 2003-06-05 | 2005-07-19 | Abbott Gmbh & Co. Kg | Triazole compounds suitable for treating disorders that respond to modulation of the dopamine D3 receptor |
| HU227534B1 (en) | 2003-08-04 | 2011-08-29 | Richter Gedeon Nyrt | (thio)carbamoyl-cyclohexane derivatives, process for producing them and pharmaceutical compositions containing them |
| DE102004047517A1 (de) | 2004-09-28 | 2006-03-30 | Merck Patent Gmbh | Neuartige Kristallform von (3-Cyan-1H-indol-7-yl)-[4-(4-fluorphenethyl)-piperazin-1-yl]-methanon, Hydrochlorid |
| HUP0500170A3 (en) | 2005-02-03 | 2007-11-28 | Richter Gedeon Nyrt | Piperazine derivatives, process for producing them and pharmaceutical compositions containing them |
| GT200600414A (es) | 2005-09-12 | 2007-09-20 | Sal de glucuranato de compuesto de piperazine | |
| JP2008001633A (ja) * | 2006-06-22 | 2008-01-10 | Showa Denko Kk | テトラヒドロピランを溶媒とする塩化アルミニウム存在下での水素化ホウ素化合物による還元反応 |
| HUP0600809A3 (en) * | 2006-10-27 | 2008-09-29 | Richter Gedeon Nyrt | New phenylsulfamoyl-benzamide derivatives as bradykinin antagonists, process and intermediates for their preparation and pharmaceutical compositions containing them |
| MY148643A (en) | 2007-05-11 | 2013-05-15 | Richter Gedeon Nyrt | Solvate and crystalline forms of carbamoyl-cyclohexane derivatives |
| HU230748B1 (hu) | 2007-05-11 | 2018-02-28 | Richter Gedeon Nyrt | Új piperazin só és előállítási eljárása |
| HUP0700353A2 (en) * | 2007-05-18 | 2008-12-29 | Richter Gedeon Nyrt | Metabolites of (thio)carbamoyl-cyclohexane derivatives |
| HUP0700369A2 (en) | 2007-05-24 | 2009-04-28 | Richter Gedeon Nyrt | Use of (thio)-carbamoyl-cyclohexane derivatives in the manufacture of a medicament for the treatment in the manufacture of a medicament for the treatment of schizophrenia |
| HUP0700370A2 (en) | 2007-05-24 | 2009-04-28 | Richter Gedeon Nyrt | Use of (thio)-carbamoyl-cyclohexane derivatives in the manufacture of a medicament for the treatment of acute mania |
| CN101790374A (zh) | 2007-08-01 | 2010-07-28 | H.隆德贝克有限公司 | Kcnq钾通道开放剂用于减轻多巴胺能系统受到干扰的障碍或病症的症状或治疗这种障碍或病症的用途 |
| US7875610B2 (en) | 2007-12-03 | 2011-01-25 | Richter Gedeon Nyrt. | Pyrimidinyl-piperazines useful as D3/D2 receptor ligands |
| CA2715760C (en) | 2008-02-21 | 2017-06-13 | Mitsubishi Tanabe Pharma Corporation | Solid preparation for oral administration of cariprazine hydrochloride |
| AU2009270823B2 (en) | 2008-07-16 | 2014-07-17 | Richter Gedeon Nyrt. | Pharmaceutical formulations containing dopamine receptor ligands |
| HUP0800765A2 (en) | 2008-12-18 | 2010-11-29 | Richter Gedeon Nyrt | A new process for the preparation of piperazine derivatives and their hydrochloric salts |
| HUP0800766A2 (en) | 2008-12-18 | 2010-11-29 | Richter Gedeon Vegyeszet | Process for the preparation of piperazine derivatives |
-
2008
- 2008-12-17 HU HU0800763A patent/HU230067B1/hu not_active IP Right Cessation
-
2009
- 2009-12-15 TW TW098142934A patent/TWI448455B/zh active
- 2009-12-17 HU HUE09797145A patent/HUE029667T2/en unknown
- 2009-12-17 GE GEAP200912300A patent/GEP20125711B/en unknown
- 2009-12-17 MX MX2011006591A patent/MX2011006591A/es active IP Right Grant
- 2009-12-17 DK DK09797145.1T patent/DK2358690T3/en active
- 2009-12-17 US US13/140,232 patent/US8569496B2/en active Active
- 2009-12-17 CA CA2743924A patent/CA2743924C/en not_active Expired - Fee Related
- 2009-12-17 WO PCT/HU2009/000108 patent/WO2010070369A1/en not_active Ceased
- 2009-12-17 NZ NZ592907A patent/NZ592907A/xx unknown
- 2009-12-17 SI SI200931453A patent/SI2358690T1/sl unknown
- 2009-12-17 AU AU2009329294A patent/AU2009329294B2/en active Active
- 2009-12-17 JP JP2011541613A patent/JP5735923B2/ja active Active
- 2009-12-17 UA UAA201109013A patent/UA104163C2/ru unknown
- 2009-12-17 ES ES09797145.1T patent/ES2573957T3/es active Active
- 2009-12-17 BR BRPI0923007A patent/BRPI0923007B8/pt active IP Right Grant
- 2009-12-17 HR HRP20160726TT patent/HRP20160726T1/hr unknown
- 2009-12-17 CN CN200980150465.2A patent/CN102256953B/zh active Active
- 2009-12-17 EP EP09797145.1A patent/EP2358690B1/en active Active
- 2009-12-17 PT PT09797145T patent/PT2358690E/pt unknown
- 2009-12-17 PL PL09797145.1T patent/PL2358690T3/pl unknown
- 2009-12-17 EA EA201170810A patent/EA019024B1/ru unknown
-
2011
- 2011-05-03 IL IL212639A patent/IL212639A0/en active IP Right Grant
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