JP2012510987A - ザレプロン胃内滞留性薬剤送達システム - Google Patents

ザレプロン胃内滞留性薬剤送達システム Download PDF

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Publication number
JP2012510987A
JP2012510987A JP2011539117A JP2011539117A JP2012510987A JP 2012510987 A JP2012510987 A JP 2012510987A JP 2011539117 A JP2011539117 A JP 2011539117A JP 2011539117 A JP2011539117 A JP 2011539117A JP 2012510987 A JP2012510987 A JP 2012510987A
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zaleplon
dosage form
gastroretentive dosage
layer
biodegradable
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Japanese (ja)
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JP2012510987A5 (OSRAM
Inventor
マスリ，サヘル
ムーア，エイタン
カーマイヤー，ダヴィデ
クルエフ，エレナ
カルニ，ギオラ
ナヴォン，ナダフ
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インテック ファーマ リミテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0065—Forms with gastric retention, e.g. floating on gastric juice, adhering to gastric mucosa, expanding to prevent passage through the pylorus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7007—Drug-containing films, membranes or sheets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2011539117A 2008-12-04 2009-10-19 ザレプロン胃内滞留性薬剤送達システム Pending JP2012510987A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12005108P 2008-12-04 2008-12-04
US61/120,051 2008-12-04
PCT/IB2009/007731 WO2010064139A2 (en) 2008-12-04 2009-10-19 Zaleplon gastroretentive drug delivery system

Related Child Applications (1)

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JP2014231788A Division JP6104873B2 (ja) 2008-12-04 2014-11-14 ザレプロン胃内滞留性薬剤送達システム

Publications (2)

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JP2012510987A true JP2012510987A (ja) 2012-05-17
JP2012510987A5 JP2012510987A5 (OSRAM) 2012-12-06

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JP2011539117A Pending JP2012510987A (ja) 2008-12-04 2009-10-19 ザレプロン胃内滞留性薬剤送達システム
JP2014231788A Expired - Fee Related JP6104873B2 (ja) 2008-12-04 2014-11-14 ザレプロン胃内滞留性薬剤送達システム

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US (2) US9693981B2 (OSRAM)
EP (1) EP2378883B1 (OSRAM)
JP (2) JP2012510987A (OSRAM)
KR (1) KR20110116004A (OSRAM)
CN (1) CN102300463B (OSRAM)
CA (1) CA2745741A1 (OSRAM)
ES (1) ES2562925T3 (OSRAM)
IL (1) IL213376A (OSRAM)
PL (1) PL2378883T3 (OSRAM)
WO (2) WO2010064139A2 (OSRAM)
ZA (1) ZA201104620B (OSRAM)

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JP2013510119A (ja) * 2009-11-04 2013-03-21 ヤンセン・アールアンドデイ・アイルランド ベンズイミダゾール−イミダゾール誘導体
JP2022525482A (ja) * 2019-03-20 2022-05-16 リンドラ セラピューティクス， インコーポレイティド 胃内滞留剤形用のコーティング
JP2022525926A (ja) * 2019-03-20 2022-05-20 リンドラ セラピューティクス， インコーポレイティド 胃内滞留剤形用のカプセル及びカプセルコーティング
JP7458317B2 (ja) 2017-10-31 2024-03-29 サムヤン、ホールディングス、コーポレーション 崩壊が改善された経口用固形製剤組成物及びその製造方法

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US20130078290A1 (en) * 2010-06-01 2013-03-28 Rubicon Research Private Limited Gastroretentive Dosage Forms Of GABA Analogs
HUE038653T2 (hu) * 2011-03-01 2018-11-28 Pharnext Neurológiai rendellenességek baclofen és acamprosate alapú terápiája
US9248111B2 (en) 2011-03-01 2016-02-02 Pharnext Therapeutic approaches for treating parkinson's disease
US9180108B2 (en) 2011-10-27 2015-11-10 Medtronic, Inc. Baclofen formulations and methods for making same
US20130143867A1 (en) 2011-12-02 2013-06-06 Sychroneuron Inc. Acamprosate formulations, methods of using the same, and combinations comprising the same
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EP3878445A3 (en) 2013-06-05 2021-10-27 Synchroneuron Inc. Acamprosate formulations, methods of using the same, and combinations comprising the same
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FR3014692B1 (fr) * 2013-12-18 2016-01-29 Ethypharm Sa Compositions pharmaceutiques orales a retention gastrique.
FI3725357T3 (fi) 2014-06-11 2024-12-13 Massachusetts Inst Technology Pidättyviä rakenteita ja niihin liittyviä menetelmiä
US20170266112A1 (en) 2014-06-11 2017-09-21 Massachusetts Institute Of Technology Residence structures and related methods
US10881619B2 (en) * 2014-12-29 2021-01-05 Boston Scientific Scimed, Inc. Compositions, devices and methods for multi-stage release of chemotherapeutics
US10300032B2 (en) 2015-02-20 2019-05-28 Osmotica Kereskedelmi Es Szolgaltato Kft Controlled release dosage form
US10987328B2 (en) 2015-02-20 2021-04-27 Osmotica Kereskedelmi Es Szolgaltato Kft Controlled release dosage form
US9579289B2 (en) 2015-02-20 2017-02-28 Osmotica Kereskedelmi Es Szolgaltato Kft Controlled release dosage form
US10172800B2 (en) 2015-02-20 2019-01-08 Osmotica Kereskedelmi Es Szolgaltato Kft Controlled release dosage form with enhanced pharmacokinetics
AU2016342374B2 (en) 2015-10-23 2022-08-04 Lyndra Therapeutics, Inc. Gastric residence systems for sustained release of therapeutic agents and methods of use thereof
US9849125B1 (en) 2015-11-03 2017-12-26 Banner Lifie Sciences LLC Anti-overingestion dosage forms
CN108697649A (zh) 2015-12-08 2018-10-23 林德拉有限公司 用于胃驻留系统的几何构型
JP7189772B2 (ja) 2016-05-27 2022-12-14 リンドラ セラピューティクス， インコーポレイティド 胃内滞留システムのための材料構造物
US20190224118A1 (en) * 2016-07-11 2019-07-25 Intec Pharma Ltd. Oral gastroretentive formulations and uses thereof
CN118766834A (zh) 2016-09-30 2024-10-15 林德拉治疗公司 用于金刚烷类药物缓释的胃驻留系统
EP3612196A4 (en) * 2017-04-18 2021-01-13 Actorius Innovations and Research Pvt. Ltd. Polymer based formulation for release of drugs and bioactives at specific git sites
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US10792262B1 (en) * 2019-07-29 2020-10-06 Saol International Limited Stabilized formulations of 4-amino-3-substituted butanoic acid derivatives
US11654124B2 (en) 2019-07-29 2023-05-23 Amneal Pharmaceuticals Llc Stabilized formulations of 4-amino-3-substituted butanoic acid derivatives
WO2021138495A1 (en) * 2019-12-30 2021-07-08 Fraunhofer Usa, Inc. Particles for multi-dose delivery
US11491125B1 (en) 2021-09-29 2022-11-08 Amneal Pharmaceuticals Llc Baclofen formulations and methods of minimizing patient exposure to metabolite variations
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JP2003503340A (ja) * 1999-06-28 2003-01-28 サノフィ−サンテラボ 短時間型催眠薬またはその塩からなる二重持効性剤形
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WO2008110577A1 (en) * 2007-03-15 2008-09-18 Polichem S.A. Time- specific delayed/pulsatile release dosage forms

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013510119A (ja) * 2009-11-04 2013-03-21 ヤンセン・アールアンドデイ・アイルランド ベンズイミダゾール−イミダゾール誘導体
JP7458317B2 (ja) 2017-10-31 2024-03-29 サムヤン、ホールディングス、コーポレーション 崩壊が改善された経口用固形製剤組成物及びその製造方法
JP2022525482A (ja) * 2019-03-20 2022-05-16 リンドラ セラピューティクス， インコーポレイティド 胃内滞留剤形用のコーティング
JP2022525926A (ja) * 2019-03-20 2022-05-20 リンドラ セラピューティクス， インコーポレイティド 胃内滞留剤形用のカプセル及びカプセルコーティング
US12447130B2 (en) 2019-03-20 2025-10-21 Lyndra Therapeutics, Inc. Capsules and capsule coatings for gastric residence dosage forms

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Publication number Publication date
US20110091542A1 (en) 2011-04-21
ZA201104620B (en) 2012-03-28
WO2010064139A3 (en) 2010-09-10
KR20110116004A (ko) 2011-10-24
WO2010064139A2 (en) 2010-06-10
IL213376A0 (en) 2011-07-31
JP2015028094A (ja) 2015-02-12
EP2378883A2 (en) 2011-10-26
WO2010064100A1 (en) 2010-06-10
EP2378883A4 (en) 2014-03-05
CN102300463B (zh) 2015-03-25
US9693981B2 (en) 2017-07-04
CA2745741A1 (en) 2010-06-10
CN102300463A (zh) 2011-12-28
EP2378883B1 (en) 2015-12-23
ES2562925T3 (es) 2016-03-09
PL2378883T3 (pl) 2016-06-30
JP6104873B2 (ja) 2017-03-29
US20120021051A1 (en) 2012-01-26
IL213376A (en) 2015-06-30

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