JP2012510954A5 - - Google Patents
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- Publication number
- JP2012510954A5 JP2012510954A5 JP2011538838A JP2011538838A JP2012510954A5 JP 2012510954 A5 JP2012510954 A5 JP 2012510954A5 JP 2011538838 A JP2011538838 A JP 2011538838A JP 2011538838 A JP2011538838 A JP 2011538838A JP 2012510954 A5 JP2012510954 A5 JP 2012510954A5
- Authority
- JP
- Japan
- Prior art keywords
- crab
- nalmefene hydrochloride
- compound
- mixture
- aqueous solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 29
- 150000001875 compounds Chemical class 0.000 claims 18
- GYWMRGWFQPSQLK-OPHZJPRHSA-N (4r,4as,7as,12bs)-3-(cyclopropylmethyl)-7-methylidene-2,4,5,6,7a,13-hexahydro-1h-4,12-methanobenzofuro[3,2-e]isoquinoline-4a,9-diol;hydron;chloride Chemical compound Cl.N1([C@@H]2CC3=CC=C(C=4O[C@@H]5[C@](C3=4)([C@]2(CCC5=C)O)CC1)O)CC1CC1 GYWMRGWFQPSQLK-OPHZJPRHSA-N 0.000 claims 15
- 229960000677 nalmefene hydrochloride Drugs 0.000 claims 15
- 239000000203 mixture Substances 0.000 claims 11
- 239000007864 aqueous solution Substances 0.000 claims 10
- 239000008194 pharmaceutical composition Substances 0.000 claims 9
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims 6
- 239000007787 solid Substances 0.000 claims 6
- 239000013078 crystal Substances 0.000 claims 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 4
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 3
- WJBLNOPPDWQMCH-MBPVOVBZSA-N Nalmefene Chemical compound N1([C@@H]2CC3=CC=C(C=4O[C@@H]5[C@](C3=4)([C@]2(CCC5=C)O)CC1)O)CC1CC1 WJBLNOPPDWQMCH-MBPVOVBZSA-N 0.000 claims 3
- 238000010438 heat treatment Methods 0.000 claims 3
- 238000010899 nucleation Methods 0.000 claims 3
- 238000003756 stirring Methods 0.000 claims 3
- 238000001816 cooling Methods 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 238000002156 mixing Methods 0.000 claims 2
- 239000012452 mother liquor Substances 0.000 claims 2
- 229950010675 nalmefene hydrochloride dihydrate Drugs 0.000 claims 2
- 238000000634 powder X-ray diffraction Methods 0.000 claims 2
- 239000000243 solution Substances 0.000 claims 2
- 238000001228 spectrum Methods 0.000 claims 2
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 claims 1
- JWUJQDFVADABEY-UHFFFAOYSA-N 2-methyltetrahydrofuran Chemical compound CC1CCCO1 JWUJQDFVADABEY-UHFFFAOYSA-N 0.000 claims 1
- 208000007848 Alcoholism Diseases 0.000 claims 1
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 claims 1
- 201000007930 alcohol dependence Diseases 0.000 claims 1
- 239000000908 ammonium hydroxide Substances 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 239000002552 dosage form Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 150000002170 ethers Chemical class 0.000 claims 1
- 238000000605 extraction Methods 0.000 claims 1
- 150000008282 halocarbons Chemical class 0.000 claims 1
- 239000012456 homogeneous solution Substances 0.000 claims 1
- 229910000041 hydrogen chloride Inorganic materials 0.000 claims 1
- IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 claims 1
- 150000002576 ketones Chemical class 0.000 claims 1
- 150000004682 monohydrates Chemical group 0.000 claims 1
- 229960005297 nalmefene Drugs 0.000 claims 1
- 239000003960 organic solvent Substances 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 239000007909 solid dosage form Substances 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12013208P | 2008-12-05 | 2008-12-05 | |
| DKPA200801729 | 2008-12-05 | ||
| DKPA200801729 | 2008-12-05 | ||
| US61/120,132 | 2008-12-05 | ||
| PCT/DK2009/050320 WO2010063292A1 (en) | 2008-12-05 | 2009-12-04 | Nalmefene hydrochloride dihydrate |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015028004A Division JP6591759B2 (ja) | 2008-12-05 | 2015-02-16 | ナルメフェン塩酸塩二水和物 |
| JP2016175002A Division JP6591944B2 (ja) | 2008-12-05 | 2016-09-07 | ナルメフェン塩酸塩二水和物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012510954A JP2012510954A (ja) | 2012-05-17 |
| JP2012510954A5 true JP2012510954A5 (enExample) | 2013-01-31 |
| JP6055183B2 JP6055183B2 (ja) | 2016-12-27 |
Family
ID=41571731
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011538838A Active JP6055183B2 (ja) | 2008-12-05 | 2009-12-04 | ナルメフェン塩酸塩二水和物 |
| JP2015028004A Active JP6591759B2 (ja) | 2008-12-05 | 2015-02-16 | ナルメフェン塩酸塩二水和物 |
| JP2016175002A Active JP6591944B2 (ja) | 2008-12-05 | 2016-09-07 | ナルメフェン塩酸塩二水和物 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015028004A Active JP6591759B2 (ja) | 2008-12-05 | 2015-02-16 | ナルメフェン塩酸塩二水和物 |
| JP2016175002A Active JP6591944B2 (ja) | 2008-12-05 | 2016-09-07 | ナルメフェン塩酸塩二水和物 |
Country Status (30)
| Country | Link |
|---|---|
| US (2) | US8530495B2 (enExample) |
| EP (2) | EP2300479B1 (enExample) |
| JP (3) | JP6055183B2 (enExample) |
| KR (2) | KR20110089333A (enExample) |
| CN (2) | CN104211707B (enExample) |
| AR (1) | AR074507A1 (enExample) |
| AT (1) | ATE546453T1 (enExample) |
| AU (1) | AU2009321898B2 (enExample) |
| BR (1) | BRPI0922774B8 (enExample) |
| CA (1) | CA2744932C (enExample) |
| CL (1) | CL2011001331A1 (enExample) |
| CO (1) | CO6362012A2 (enExample) |
| CY (2) | CY1112643T1 (enExample) |
| DK (2) | DK2441766T3 (enExample) |
| EA (1) | EA018948B1 (enExample) |
| ES (2) | ES2380297T3 (enExample) |
| HR (2) | HRP20120247T1 (enExample) |
| IL (1) | IL213112A (enExample) |
| MX (1) | MX2011005865A (enExample) |
| MY (1) | MY149028A (enExample) |
| NZ (1) | NZ593874A (enExample) |
| PL (2) | PL2441766T3 (enExample) |
| PT (2) | PT2300479E (enExample) |
| RS (2) | RS52255B (enExample) |
| SG (1) | SG171910A1 (enExample) |
| SI (2) | SI2441766T1 (enExample) |
| SM (2) | SMT201200014B (enExample) |
| TW (1) | TWI465450B (enExample) |
| UA (1) | UA102128C2 (enExample) |
| WO (1) | WO2010063292A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA102128C2 (en) * | 2008-12-05 | 2013-06-10 | Х. Луннбек А/С | Nalmefene hydrochloride dihydrate |
| JP2019031524A (ja) * | 2008-12-05 | 2019-02-28 | ハー・ルンドベック・アクチエゼルスカベット | ナルメフェン塩酸塩二水和物 |
| TWI560170B (en) | 2011-12-06 | 2016-12-01 | Lundbeck & Co As H | Process for recovery of nalmefene hydrochloride |
| WO2013164383A1 (en) | 2012-05-03 | 2013-11-07 | H. Lundbeck A/S | Method for the manufacturing of naltrexone |
| US20140005217A1 (en) * | 2012-06-27 | 2014-01-02 | H. Lundbeck A/S | Nalmefene for reduction of alcohol consumption in specific target populations |
| JP6479766B2 (ja) * | 2013-04-17 | 2019-03-06 | ハー・ルンドベック・アクチエゼルスカベット | 不安障害患者の治療のためのナルメフェン |
| JP6419780B2 (ja) * | 2013-04-17 | 2018-11-07 | ハー・ルンドベック・アクチエゼルスカベット | 睡眠障害患者の治療のためのナルメフェン |
| AR096851A1 (es) | 2013-07-11 | 2016-02-03 | H Lundbeck As | Sales que no forman hidratos ni solvatos de nalmefeno |
| MX2016013889A (es) | 2014-04-22 | 2017-03-09 | Otsuka Pharma Co Ltd | Medicamento. |
| TWI681954B (zh) | 2014-06-12 | 2020-01-11 | 美商西爾拉癌症醫學公司 | Ｎ-（氰基甲基）-４-（２-（４-𠰌啉基苯基胺基）嘧啶-４-基）苯甲醯胺 |
| CN105646508B (zh) * | 2016-02-17 | 2018-02-27 | 南京卓康医药科技有限公司 | 一种盐酸纳美芬一水合物的制备方法 |
| WO2019022274A1 (ko) * | 2017-07-28 | 2019-01-31 | 동아대학교 산학협력단 | Pauf 단백질에 특이적으로 결합하는 항체 및 이의 용도 |
| US10927121B1 (en) | 2019-12-20 | 2021-02-23 | Southwest Research Institute | Technologies for removing residual solvent from nalmefene hydrochloride and producing crystalline nalmefene hydrochloride monohydrate, monosolvate, or crystalline nalmefene hydrochloride dihydrate |
| CN111875530A (zh) * | 2020-08-17 | 2020-11-03 | 浙江朗华制药有限公司 | 一种普拉西坦水合物晶体及其制备方法 |
| WO2022165040A1 (en) | 2021-01-28 | 2022-08-04 | Rhodes Technologies | Process for crystallizing nalmefene hydrochloride |
| CN113354652A (zh) * | 2021-06-24 | 2021-09-07 | 无锡济煜山禾药业股份有限公司 | 一种盐酸纳美芬合成方法 |
| CN117843650A (zh) * | 2023-12-27 | 2024-04-09 | 南京海纳医药科技股份有限公司 | 一种盐酸纳美芬的精制方法 |
| CN117986261B (zh) * | 2024-04-02 | 2024-06-18 | 成都瑞尔医药科技有限公司 | 一种盐酸纳美芬母液的回收套用方法 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4535157A (en) | 1983-11-01 | 1985-08-13 | Key Pharmaceuticals, Inc. | Process for making 6-desoxy-6-methylenenaloxone and 6-desoxy-6-methylenenaltrexone |
| US4751307A (en) | 1985-01-17 | 1988-06-14 | Mallinckrodt, Inc. | Wittig-reaction processes |
| JPH07206857A (ja) * | 1993-12-28 | 1995-08-08 | Synthelabo Sa | アルフゾシン塩酸塩の二水和物 |
| US6262067B1 (en) * | 1999-06-22 | 2001-07-17 | Pfizer Inc. | Polymorphs of a crystalline azo-bicyclo 2,2,2 OCT-3-yl amine dihydrochloride and their pharmaceutical compositions |
| ES2177373B1 (es) * | 1999-11-26 | 2003-11-01 | Astur Pharma Sa | Preparacion de azitromicina en su forma no cristalina |
| CH693586A8 (de) * | 2002-10-14 | 2003-12-15 | Roche Consumer Health Ag | Darreichungsform von Ibuprofen-Natrium. |
| FR2861299B1 (fr) * | 2003-10-28 | 2006-01-27 | Pf Medicament | Compositions pharmaceutiques a base de derives d'idasoxan sous formes polymorphes |
| PL1708690T3 (pl) * | 2003-11-17 | 2017-01-31 | Biomarin Pharmaceutical Inc. | Leczenie fenyloketonurii za pomocą BH4 |
| MY139797A (en) * | 2004-11-29 | 2009-10-30 | Kowa Co | (s)-(-)-1-(4-fluoroisoquinolin-5-yl)sulfonyl-2-methyl-1, 4-homopiperazine hydrochloride dihydrate |
| CN100536848C (zh) * | 2005-07-13 | 2009-09-09 | 北京易明康元医药科技有限公司 | 稳定的盐酸纳美芬注射液及其制备方法 |
| GB2447016A (en) | 2007-03-01 | 2008-09-03 | Reckitt Benckiser Healthcare | Buprenorphine/naloxone compositions |
| GB2447013A (en) * | 2007-03-01 | 2008-09-03 | Reckitt Benckiser Healthcare | Analgesic composition containing buprenorphone and nalmefene |
| AU2008223328B2 (en) * | 2007-03-06 | 2012-10-11 | SpecGx LLC | Process for the preparation of quaternary N-alkyl morphinan alkaloid salts |
| WO2008127618A1 (en) * | 2007-04-12 | 2008-10-23 | Mallinckrodt Inc. | Crystalline and amorphous forms of naltrexone hydrochloride |
| UA102128C2 (en) * | 2008-12-05 | 2013-06-10 | Х. Луннбек А/С | Nalmefene hydrochloride dihydrate |
-
2009
- 2009-04-12 UA UAA201108231A patent/UA102128C2/ru unknown
- 2009-12-04 AT AT09771286T patent/ATE546453T1/de active
- 2009-12-04 AU AU2009321898A patent/AU2009321898B2/en not_active Ceased
- 2009-12-04 PL PL12150266T patent/PL2441766T3/pl unknown
- 2009-12-04 US US13/132,494 patent/US8530495B2/en active Active
- 2009-12-04 MY MYPI2011002518A patent/MY149028A/en unknown
- 2009-12-04 SI SI200930985T patent/SI2441766T1/sl unknown
- 2009-12-04 KR KR1020117012659A patent/KR20110089333A/ko not_active Ceased
- 2009-12-04 ES ES09771286T patent/ES2380297T3/es active Active
- 2009-12-04 JP JP2011538838A patent/JP6055183B2/ja active Active
- 2009-12-04 SI SI200930215T patent/SI2300479T1/sl unknown
- 2009-12-04 NZ NZ593874A patent/NZ593874A/xx not_active IP Right Cessation
- 2009-12-04 KR KR1020177001191A patent/KR20170008893A/ko not_active Ceased
- 2009-12-04 RS RS20120126A patent/RS52255B/sr unknown
- 2009-12-04 CA CA2744932A patent/CA2744932C/en active Active
- 2009-12-04 EP EP09771286A patent/EP2300479B1/en active Active
- 2009-12-04 DK DK12150266.0T patent/DK2441766T3/da active
- 2009-12-04 PT PT09771286T patent/PT2300479E/pt unknown
- 2009-12-04 EA EA201170753A patent/EA018948B1/ru not_active IP Right Cessation
- 2009-12-04 SG SG2011040102A patent/SG171910A1/en unknown
- 2009-12-04 ES ES12150266.0T patent/ES2488165T3/es active Active
- 2009-12-04 CN CN201410323051.8A patent/CN104211707B/zh not_active Expired - Fee Related
- 2009-12-04 CN CN200980156373.5A patent/CN102325778B/zh not_active Expired - Fee Related
- 2009-12-04 RS RS20140376A patent/RS53415B/sr unknown
- 2009-12-04 PL PL09771286T patent/PL2300479T3/pl unknown
- 2009-12-04 PT PT121502660T patent/PT2441766E/pt unknown
- 2009-12-04 DK DK09771286.3T patent/DK2300479T3/da active
- 2009-12-04 HR HRP20120247AT patent/HRP20120247T1/hr unknown
- 2009-12-04 WO PCT/DK2009/050320 patent/WO2010063292A1/en not_active Ceased
- 2009-12-04 EP EP12150266.0A patent/EP2441766B1/en active Active
- 2009-12-04 MX MX2011005865A patent/MX2011005865A/es active IP Right Grant
- 2009-12-04 BR BRPI0922774A patent/BRPI0922774B8/pt not_active IP Right Cessation
- 2009-12-07 TW TW098141677A patent/TWI465450B/zh not_active IP Right Cessation
- 2009-12-07 AR ARP090104739A patent/AR074507A1/es unknown
-
2011
- 2011-05-24 IL IL213112A patent/IL213112A/en active IP Right Grant
- 2011-06-01 CO CO11067790A patent/CO6362012A2/es not_active Application Discontinuation
- 2011-06-03 CL CL2011001331A patent/CL2011001331A1/es unknown
-
2012
- 2012-03-15 CY CY20121100278T patent/CY1112643T1/el unknown
- 2012-04-04 SM SM201200014T patent/SMT201200014B/it unknown
-
2013
- 2013-06-25 US US13/926,427 patent/US8754217B2/en active Active
-
2014
- 2014-07-08 HR HRP20140648AT patent/HRP20140648T1/hr unknown
- 2014-07-25 CY CY20141100563T patent/CY1115381T1/el unknown
- 2014-08-18 SM SM201400113T patent/SMT201400113B/xx unknown
-
2015
- 2015-02-16 JP JP2015028004A patent/JP6591759B2/ja active Active
-
2016
- 2016-09-07 JP JP2016175002A patent/JP6591944B2/ja active Active
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