JP2012510953A5 - - Google Patents

Download PDF

Info

Publication number
JP2012510953A5
JP2012510953A5 JP2011525203A JP2011525203A JP2012510953A5 JP 2012510953 A5 JP2012510953 A5 JP 2012510953A5 JP 2011525203 A JP2011525203 A JP 2011525203A JP 2011525203 A JP2011525203 A JP 2011525203A JP 2012510953 A5 JP2012510953 A5 JP 2012510953A5
Authority
JP
Japan
Prior art keywords
alkyl
independently
aryl
monocyclic
alkenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2011525203A
Other languages
English (en)
Japanese (ja)
Other versions
JP2012510953A (ja
Filing date
Publication date
Priority claimed from PCT/US2008/074444 external-priority patent/WO2009105123A1/en
Application filed filed Critical
Priority claimed from PCT/US2009/055221 external-priority patent/WO2010025272A1/en
Publication of JP2012510953A publication Critical patent/JP2012510953A/ja
Publication of JP2012510953A5 publication Critical patent/JP2012510953A5/ja
Pending legal-status Critical Current

Links

JP2011525203A 2008-08-27 2009-08-27 毒性を減少し、そして疾病を治療又は予防するための化合物、組成物及び方法 Pending JP2012510953A (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US9229108P 2008-08-27 2008-08-27
US61/092,291 2008-08-27
PCT/US2008/074444 WO2009105123A1 (en) 2008-02-22 2008-08-27 Compounds, compositions and methods for treating or preventing diseases
USUS08/74444 2008-08-27
US12226808P 2008-12-12 2008-12-12
US61/122,268 2008-12-12
US22808309P 2009-07-23 2009-07-23
US61/228,083 2009-07-23
PCT/US2009/055221 WO2010025272A1 (en) 2008-08-27 2009-08-27 Compounds, compositions and methods for reducing toxicity and treating or preventing diseases

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2014141096A Division JP5822991B2 (ja) 2008-08-27 2014-07-09 毒性を減少し、そして疾病を治療又は予防するための化合物、組成物及び方法

Publications (2)

Publication Number Publication Date
JP2012510953A JP2012510953A (ja) 2012-05-17
JP2012510953A5 true JP2012510953A5 (https=) 2013-03-14

Family

ID=43971169

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2011525203A Pending JP2012510953A (ja) 2008-08-27 2009-08-27 毒性を減少し、そして疾病を治療又は予防するための化合物、組成物及び方法
JP2014141096A Expired - Fee Related JP5822991B2 (ja) 2008-08-27 2014-07-09 毒性を減少し、そして疾病を治療又は予防するための化合物、組成物及び方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2014141096A Expired - Fee Related JP5822991B2 (ja) 2008-08-27 2014-07-09 毒性を減少し、そして疾病を治療又は予防するための化合物、組成物及び方法

Country Status (6)

Country Link
US (1) US8859615B2 (https=)
EP (1) EP2331093A4 (https=)
JP (2) JP2012510953A (https=)
KR (1) KR101496508B1 (https=)
CN (1) CN102215840B (https=)
WO (1) WO2010025272A1 (https=)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102146369A (zh) * 2010-12-24 2011-08-10 吉林大学 一种基于配位作用的固相介质提取dna的方法
CN102743795A (zh) * 2012-05-11 2012-10-24 天津大学 虎杖甙填充胶原支架及其制备方法和应用
WO2014089177A2 (en) 2012-12-04 2014-06-12 Massachusetts Institute Of Technology Compounds, conjugates and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines
WO2014113635A1 (en) * 2013-01-18 2014-07-24 Sloan-Kettering Institute For Cancer Research Reduction of toxicities by synthetic panaxytriol analogs
US9868730B2 (en) 2013-02-18 2018-01-16 The Trustees Of Columbia University In The City Of New York Kappa opioid receptor selective compounds, compositions, and uses thereof
US10201623B2 (en) 2013-03-15 2019-02-12 Memorial Sloan Kettering Cancer Center HSP90-targeted cardiac imaging and therapy
CA2961894C (en) 2014-09-19 2023-12-12 Memorial Sloan-Kettering Cancer Center Methods for treating brain metastatis using gap junction inhibitors
US10918627B2 (en) 2016-05-11 2021-02-16 Massachusetts Institute Of Technology Convergent and enantioselective total synthesis of Communesin analogs
CN106831366A (zh) * 2017-01-20 2017-06-13 山西大学 一种共轭二炔一醇类化合物及其制备方法和应用
CN106748827B (zh) * 2017-01-20 2019-04-02 山西大学 一种8-胺基-4,6-二炔-1-醇类化合物及其制备方法和应用
WO2018209239A1 (en) 2017-05-11 2018-11-15 Massachusetts Institute Of Technology Potent agelastatin derivatives as modulators for cancer invasion and metastasis
US10640508B2 (en) 2017-10-13 2020-05-05 Massachusetts Institute Of Technology Diazene directed modular synthesis of compounds with quaternary carbon centers
CN109704926B (zh) * 2019-01-29 2022-02-08 南京工业大学 抗癌活性分子骨架1,4-烯炔类化合物及其制备方法与应用
US11535634B2 (en) 2019-06-05 2022-12-27 Massachusetts Institute Of Technology Compounds, conjugates, and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines and uses thereof
CN111467347A (zh) * 2020-04-30 2020-07-31 河北医科大学第二医院 苯并菲啶生物碱类化合物用于制备ano1 编码的钙激活氯离子通道阻断剂的用途
WO2022182415A1 (en) 2021-02-24 2022-09-01 Massachusetts Institute Of Technology Himastatin derivatives, and processes of preparation thereof, and uses thereof
CN113372355B (zh) * 2021-05-13 2023-02-17 山东大学 六氢苯并菲啶类生物碱及其制备方法和应用
WO2023143988A1 (en) * 2022-01-26 2023-08-03 Eth Zurich New compounds and their use as anti-aging agent or as exercise enhancer
CN120987853B (zh) * 2025-07-22 2026-04-17 中国科学技术大学 一种NQO1响应性的mRNA翻译掩蔽剂及其应用、产品和方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07103024B2 (ja) * 1986-03-07 1995-11-08 理化学研究所 ジイン化合物を含む制癌剤
JP2720176B2 (ja) * 1988-09-08 1998-02-25 理化学研究所 パナキサコール類の製造方法
JPH03200736A (ja) * 1989-12-28 1991-09-02 Tsumura & Co 新規ポリアセチレン系化合物類およびポリアセチレン系化合物類を有効成分とする抗腫瘍剤
JPH05163202A (ja) * 1991-02-26 1993-06-29 Tsumura & Co 新規ポリアセチレン系化合物類およびポリアセチレン系化合物類を有効成分とする５−リポキシゲナーゼ阻害剤
CA2307393A1 (en) * 2000-05-01 2001-11-01 The University Of British Columbia Ginsenoside chemotherapy
US20030092638A1 (en) * 2001-09-21 2003-05-15 Dong Huang Protopanaxadiol and protopanaxatriol and their use as anti-cancer agents
US20070065526A1 (en) * 2005-09-19 2007-03-22 Gow Robert T Methods and compositions comprising Panax species
US7419689B2 (en) * 2005-11-15 2008-09-02 Access Business Group International Llc. Plant-based formulations for improving liver health

Similar Documents

Publication Publication Date Title
JP2012510953A5 (https=)
JP2014237656A5 (https=)
AU2023204318A1 (en) Combination therapy for cancer treatment
US12121510B2 (en) Compounds and methods to sensitize cancer cells to cisplatin
JP5822991B2 (ja) 毒性を減少し、そして疾病を治療又は予防するための化合物、組成物及び方法
EP3750545B1 (en) Phospholipid ether analogs as cancer-targeting drug vehicles
JP5598775B2 (ja) 癌の介入治療および根絶のためのｉｔｅとその類似体を含む医薬組成物
US20220304977A1 (en) Combination cancer therapy with pentaaza macrocyclic ring complex and ascorbate compound
Cheng et al. Rational incorporation of selenium into temozolomide elicits superior antitumor activity associated with both apoptotic and autophagic cell death
JP7045985B2 (ja) Ｅｚｈ２阻害剤を用いた髄芽腫の処置方法
Zhang et al. Determination of maximum tolerated dose and toxicity of Inauhzin in mice
US20170007588A1 (en) Small molecule inhibitors of xbp1 splicing
JP2021512110A (ja) ペンタアザ大環状環複合体および白金を基にした抗癌剤による組み合わせ癌療法
US20110288177A1 (en) Methods for Preventing or Reducing Colon Carcinogenesis
KR20150042231A (ko) 소세포폐암을 치료하기 위한 벤조디아제핀
CN112423743A (zh) 未折叠蛋白反应的激活剂
CN1681489A (zh) 增加抗肿瘤活性的化疗药物的联用
JP5440985B2 (ja) メラノーマの治療
JP2021105005A (ja) 癌治療
JP2007509955A5 (https=)
CA2992033A1 (en) Fucosidase inhibitors
US20180169123A1 (en) Combination therapy with a flavagline and 2-deoxyglucose
TWI862414B (zh) 難治性癌症之預防或治療用之醫藥組合物
US20250387406A1 (en) Therapy for reduced ototoxicity from chemotherapeutic agent with pentaaza macrocyclic ring complex
US9890106B2 (en) Anti-cancer lead molecule