JP2012509659A5 - - Google Patents

Info

Publication number

JP2012509659A5

JP2012509659A5 JP2011536895A JP2011536895A JP2012509659A5 JP 2012509659 A5 JP2012509659 A5 JP 2012509659A5 JP 2011536895 A JP2011536895 A JP 2011536895A JP 2011536895 A JP2011536895 A JP 2011536895A JP 2012509659 A5 JP2012509659 A5 JP 2012509659A5

Authority

JP

Japan

Prior art keywords

chain

tcr

nucleic acid

encoding

vector

Prior art date

2009-11-24

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 150000007523 nucleic acids Chemical class 0.000 claims 13
• 108020004707 nucleic acids Proteins 0.000 claims 7
• 102000039446 nucleic acids Human genes 0.000 claims 7
• 239000013598 vector Substances 0.000 claims 7
• 108091028043 Nucleic acid sequence Proteins 0.000 claims 6
• 150000001413 amino acids Chemical class 0.000 claims 6
• 206010028980 Neoplasm Diseases 0.000 claims 5
• 239000000427 antigen Substances 0.000 claims 5
• 102000036639 antigens Human genes 0.000 claims 5
• 108091007433 antigens Proteins 0.000 claims 5
• 210000004027 cell Anatomy 0.000 claims 5
• 125000003275 alpha amino acid group Chemical group 0.000 claims 3
• 239000008194 pharmaceutical composition Substances 0.000 claims 3
• 108060003951 Immunoglobulin Proteins 0.000 claims 2
• 210000001744 T-lymphocyte Anatomy 0.000 claims 2
• 102000003425 Tyrosinase Human genes 0.000 claims 2
• 108060008724 Tyrosinase Proteins 0.000 claims 2
• 238000007792 addition Methods 0.000 claims 2
• 239000003795 chemical substances by application Substances 0.000 claims 2
• 238000012217 deletion Methods 0.000 claims 2
• 230000037430 deletion Effects 0.000 claims 2
• 201000010099 disease Diseases 0.000 claims 2
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
• 239000012634 fragment Substances 0.000 claims 2
• 102000018358 immunoglobulin Human genes 0.000 claims 2
• 238000006467 substitution reaction Methods 0.000 claims 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 108020004705 Codon Proteins 0.000 claims 1
• 208000032612 Glial tumor Diseases 0.000 claims 1
• 206010018338 Glioma Diseases 0.000 claims 1
• 208000037323 Rare tumor Diseases 0.000 claims 1
• 238000011467 adoptive cell therapy Methods 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 210000003981 ectoderm Anatomy 0.000 claims 1
• 239000013604 expression vector Substances 0.000 claims 1
• 108020001507 fusion proteins Proteins 0.000 claims 1
• 102000037865 fusion proteins Human genes 0.000 claims 1
• 238000001415 gene therapy Methods 0.000 claims 1
• 208000005017 glioblastoma Diseases 0.000 claims 1
• 238000001802 infusion Methods 0.000 claims 1
• 238000002347 injection Methods 0.000 claims 1
• 239000007924 injection Substances 0.000 claims 1
• 210000000265 leukocyte Anatomy 0.000 claims 1
• 230000003211 malignant effect Effects 0.000 claims 1
• 201000001441 melanoma Diseases 0.000 claims 1
• 238000005457 optimization Methods 0.000 claims 1
• 239000002245 particle Substances 0.000 claims 1
• 239000013612 plasmid Substances 0.000 claims 1
• 230000001177 retroviral effect Effects 0.000 claims 1
• 239000013605 shuttle vector Substances 0.000 claims 1