JP2012509292A - 重症の集中治療患者への人工栄養のための脂肪乳剤 - Google Patents
重症の集中治療患者への人工栄養のための脂肪乳剤 Download PDFInfo
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Abstract
Description
[式中、基R1、R2またはR3のうち少なくとも1個は、独立して、5〜15個の奇数の炭素原子を有するアルカノイル基である]
で示される少なくとも1個のトリグリセリド(A)を含有する脂肪乳剤を含む、CIPおよび/またはCIMの予防または治療のための医薬製剤に関するものである。
[式中、基R1、R2またはR3のうち少なくとも1個は、5〜15個の奇数の炭素原子を有するアルカノイル基である]
で示されるトリグリセリド(A)を含み、(A)とは異なる、そして、カプリル酸、カプリン酸またはラウリン酸を包含する中鎖脂肪酸、ミリスチン酸、パルミチン酸またはステアリン酸を包含する長鎖飽和脂肪酸、パルミトレイン酸またはオレイン酸を包含するモノ不飽和脂肪酸、ならびに、エイコサペンタエン酸、ドコサヘキサエン酸、リノール酸およびγ−リノレン酸を包含するオメガ−3およびオメガ−6型多価不飽和脂肪酸より成る群から選ばれる少なくとも1個の脂肪酸残基を有する少なくとも1個のさらなるトリグリセリド(B)を含む、等張性脂肪乳剤に関するものである。
[式中、基R1、R2またはR3のうち少なくとも1個は、独立して、5〜15個の奇数の炭素原子を有するアルカノイル基である]
で示される少なくとも1個のトリグリセリド(A)、および(A)とは異なる少なくとも1個の別のトリグリセリド(B)を含む医薬に関するものである。好ましくは該医薬は本発明の等張性脂肪乳剤を含む。
Claims (17)
- 脂肪乳剤が、(A)とは異なる、そして、カプリル酸、カプリン酸またはラウリン酸を包含する中鎖脂肪酸、ミリスチン酸、パルミチン酸またはステアリン酸を包含する長鎖飽和脂肪酸、パルミトレイン酸またはオレイン酸を包含するモノ不飽和脂肪酸、ならびに、エイコサペンタエン酸、ドコサヘキサエン酸、リノール酸およびγ−リノレン酸を包含するオメガ−3およびオメガ−6型多価不飽和脂肪酸より成る群から選ばれる少なくとも1個の脂肪酸残基を有する少なくとも1個のさらなるトリグリセリド(B)を含むことを特徴とする、請求項1に記載の医薬製剤。
- トリグリセリド(A)が、ランダム化されたまたは化学的に定義された構造トリグリセリドの形態であることを特徴とする、請求項1または2に記載の医薬製剤。
- トリグリセリド(A)中の基R1、R2またはR3のうち少なくとも1個が、独立して、5〜9個の炭素原子の鎖長を有することを特徴とする、請求項1〜3のいずれか1項に記載の医薬製剤。
- トリグリセリド(A)中の基R1、R2またはR3のうち少なくとも1個が、独立してn−ヘプタノイルであることを特徴とする、請求項1〜4のいずれか1項に記載の医薬製剤。
- トリグリセリド(A)がトリヘプタノインであることを特徴とする、請求項1〜5のいずれか1項に記載の医薬製剤。
- トリグリセリドの量が医薬製剤総量を基準として5〜30%(重量)であることを特徴とする、請求項1〜6のいずれか1項に記載の医薬製剤。
- トリグリセリドの量が医薬製剤総量を基準として10〜20%(重量)であることを特徴とする、請求項7に記載の医薬製剤。
- トリグリセリド(A)の量が乳剤中の全トリグリセリド総量を基準として50〜80%(重量)であることを特徴とする、請求項1〜8のいずれか1項に記載の医薬製剤。
- トリグリセリド(A)の量が乳剤中の全トリグリセリド総量を基準として60〜70%(重量)であることを特徴とする、請求項1〜9のいずれか1項に記載の医薬製剤。
- 式(I):
[式中、基R1、R2またはR3のうち少なくとも1個は、5〜15個の奇数の炭素原子を有するアルカノイル基である]
で示されるトリグリセリド(A)を含み、(A)とは異なる、そして、カプリル酸、カプリン酸またはラウリン酸を包含する中鎖脂肪酸、ミリスチン酸、パルミチン酸またはステアリン酸を包含する長鎖飽和脂肪酸、パルミトレイン酸またはオレイン酸を包含するモノ不飽和脂肪酸、ならびに、エイコサペンタエン酸、ドコサヘキサエン酸、リノール酸およびγ−リノレン酸を包含するオメガ−3およびオメガ−6型多価不飽和脂肪酸より成る群から選ばれる少なくとも1個の脂肪酸残基を有する少なくとも1個のさらなるトリグリセリド(B)を含む、等張性脂肪乳剤。 - 食餌製品としての請求項11に記載の等張性脂肪乳剤の使用。
- 経腸栄養のための請求項12に記載の使用。
- 請求項11に記載の等張性脂肪乳剤を含むことを特徴とする、請求項14に記載の医薬。
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DE102008057867.3 | 2008-11-18 | ||
DE102008057867A DE102008057867A1 (de) | 2008-11-18 | 2008-11-18 | Fettemulsion zur künstlichen Ernährung von schwerkranken Intensivpatienten |
PCT/EP2009/064839 WO2010057804A1 (de) | 2008-11-18 | 2009-11-09 | Fettemulsion zur künstlichen ernährung von schwerkranken intensivpatienten |
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US (2) | US20110207819A1 (ja) |
EP (1) | EP2355813B1 (ja) |
JP (1) | JP2012509292A (ja) |
KR (1) | KR20110084513A (ja) |
CN (1) | CN102215839B (ja) |
BR (1) | BRPI0921917B8 (ja) |
CA (1) | CA2739390C (ja) |
DE (1) | DE102008057867A1 (ja) |
ES (1) | ES2561207T3 (ja) |
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DE102009013914B4 (de) * | 2009-03-19 | 2011-05-05 | Bruker Daltonik Gmbh | Kalibriersubstanzen für Atmosphärendruck-Ionenquellen |
EP2671578A4 (en) * | 2011-01-31 | 2014-04-02 | Nippon Zoki Pharmaceutical Co | PROPHYLACTIC OR THERAPEUTIC MEDICINE FOR PERIPHERAL NEUROPATHY CAUSED BY AN ANTICANCER AGENT |
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US8168611B1 (en) | 2011-09-29 | 2012-05-01 | Chemo S.A. France | Compositions, kits and methods for nutrition supplementation |
CN106900888B (zh) * | 2015-12-23 | 2021-12-24 | 丰益(上海)生物技术研发中心有限公司 | 含有奇数碳脂肪酸结构脂的油脂组合物及其应用 |
CA3026152A1 (en) | 2016-06-08 | 2017-12-14 | Sunregen Healthcare Ag | Lipids with odd number of carbon atoms and their use as pharmaceutical composition or nutritional supplement |
CN109602704A (zh) * | 2019-01-23 | 2019-04-12 | 广东嘉博制药有限公司 | 丁酸氯维地平脂肪乳注射液及其制备工艺 |
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- 2009-11-09 RU RU2011124887/15A patent/RU2528108C2/ru active
- 2009-11-09 MX MX2011005201A patent/MX338223B/es active IP Right Grant
- 2009-11-09 CA CA2739390A patent/CA2739390C/en active Active
- 2009-11-09 KR KR1020117010418A patent/KR20110084513A/ko not_active Application Discontinuation
- 2009-11-09 WO PCT/EP2009/064839 patent/WO2010057804A1/de active Application Filing
- 2009-11-09 BR BRPI0921917A patent/BRPI0921917B8/pt active IP Right Grant
- 2009-11-09 JP JP2011536823A patent/JP2012509292A/ja active Pending
- 2009-11-09 ES ES09760502.6T patent/ES2561207T3/es active Active
- 2009-11-09 CN CN200980145702.6A patent/CN102215839B/zh not_active Ceased
- 2009-11-09 EP EP09760502.6A patent/EP2355813B1/de active Active
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2015
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RU2011124887A (ru) | 2012-12-27 |
EP2355813B1 (de) | 2015-11-04 |
BRPI0921917B8 (pt) | 2021-05-25 |
BRPI0921917A2 (pt) | 2015-12-29 |
CN102215839B (zh) | 2016-08-24 |
US20110207819A1 (en) | 2011-08-25 |
ES2561207T3 (es) | 2016-02-25 |
RU2528108C2 (ru) | 2014-09-10 |
WO2010057804A1 (de) | 2010-05-27 |
EP2355813A1 (de) | 2011-08-17 |
US20160051506A1 (en) | 2016-02-25 |
DE102008057867A1 (de) | 2010-05-20 |
CA2739390C (en) | 2016-05-03 |
BRPI0921917B1 (pt) | 2020-08-25 |
MX2011005201A (es) | 2011-06-01 |
KR20110084513A (ko) | 2011-07-25 |
MX338223B (es) | 2016-04-08 |
CN102215839A (zh) | 2011-10-12 |
CA2739390A1 (en) | 2010-05-27 |
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