JP2012509269A - 生理的条件下での高分子の凝集を低減するための方法及び製剤 - Google Patents

生理的条件下での高分子の凝集を低減するための方法及び製剤 Download PDF

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JP2012509269A
JP2012509269A JP2011536560A JP2011536560A JP2012509269A JP 2012509269 A JP2012509269 A JP 2012509269A JP 2011536560 A JP2011536560 A JP 2011536560A JP 2011536560 A JP2011536560 A JP 2011536560A JP 2012509269 A JP2012509269 A JP 2012509269A
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antibody
cyclodextrin
formulation
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humanized
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JP2012509269A5 (cg-RX-API-DMAC7.html
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ブライアン ロボ,
サブリナ ロ,
ユチャン ジョン ワン,
リタ ウォン,
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ジェネンテック, インコーポレイテッド
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40Cyclodextrins; Derivatives thereof
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    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854Immunoglobulins

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JP2011536560A 2008-11-17 2009-11-16 生理的条件下での高分子の凝集を低減するための方法及び製剤 Pending JP2012509269A (ja)

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US11544108P 2008-11-17 2008-11-17
US61/115,441 2008-11-17
PCT/US2009/064610 WO2010057107A1 (en) 2008-11-17 2009-11-16 Method and formulation for reducing aggregation of a macromolecule under physiological conditions

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JP2012509269A true JP2012509269A (ja) 2012-04-19
JP2012509269A5 JP2012509269A5 (cg-RX-API-DMAC7.html) 2012-12-27

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JP2015150264A Pending JP2016020350A (ja) 2008-11-17 2015-07-30 生理的条件下での高分子の凝集を低減するための方法及び製剤

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US (2) US20110305639A1 (cg-RX-API-DMAC7.html)
EP (1) EP2358395A4 (cg-RX-API-DMAC7.html)
JP (2) JP2012509269A (cg-RX-API-DMAC7.html)
KR (1) KR20110086705A (cg-RX-API-DMAC7.html)
CN (1) CN102281903B (cg-RX-API-DMAC7.html)
AR (1) AR074357A1 (cg-RX-API-DMAC7.html)
AU (1) AU2009313754A1 (cg-RX-API-DMAC7.html)
BR (1) BRPI0916072A2 (cg-RX-API-DMAC7.html)
CA (1) CA2742988A1 (cg-RX-API-DMAC7.html)
CL (1) CL2011001132A1 (cg-RX-API-DMAC7.html)
IL (1) IL212533A0 (cg-RX-API-DMAC7.html)
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PE (1) PE20120169A1 (cg-RX-API-DMAC7.html)
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TW (1) TW201032826A (cg-RX-API-DMAC7.html)
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JP2019512540A (ja) * 2016-03-10 2019-05-16 ユーシービー バイオファーマ エスピーアールエル 医薬製剤
JP2023523927A (ja) * 2020-04-23 2023-06-08 イーライ リリー アンド カンパニー 抗体の皮下吸収及びバイオアベイラビリティ

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ME01775B (me) 2003-11-05 2011-02-28 Glycart Biotechnology Ag Cd20 antitijela sa povećanim afinitetom vezivanja za fc receptor i efektornom funkcijom
TW201014605A (en) 2008-09-16 2010-04-16 Genentech Inc Methods for treating progressive multiple sclerosis
JP5341059B2 (ja) * 2010-11-09 2013-11-13 株式会社大塚製薬工場 幹細胞懸濁液
WO2013164837A1 (en) * 2012-03-07 2013-11-07 Cadila Healthcare Limited Pharmaceutical formulations of tnf-alpha antibodies
US8883979B2 (en) 2012-08-31 2014-11-11 Bayer Healthcare Llc Anti-prolactin receptor antibody formulations
CA2901575C (en) 2013-03-13 2022-08-30 Seattle Genetics, Inc. Cyclodextrin and antibody-drug conjugate formulations
SG11201804961UA (en) * 2015-12-30 2018-07-30 Genentech Inc Formulations with reduced degradation of polysorbate
KR102039709B1 (ko) 2017-11-03 2019-11-01 삼성전자주식회사 유기 인터포저를 포함하는 반도체 패키지
JOP20210229A1 (ar) 2019-02-18 2023-01-30 Lilly Co Eli صيغة جسم مضاد علاجي
RU2754509C1 (ru) * 2020-12-21 2021-09-02 федеральное государственное бюджетное образовательное учреждение высшего образования "Первый Санкт-Петербургский государственный медицинский университет имени академика И.П. Павлова" Министерства здравоохранения Российской Федерации Способ лечения первичной мембранозной нефропатии с нефротическим синдромом и повышенным уровнем анти-plar2

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WO2005065717A2 (de) * 2003-12-24 2005-07-21 Boehringer Ingelheim International Gmbh Flüssigformulierungen von antikörperkonjugaten
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JPH11500404A (ja) * 1988-10-05 1999-01-12 カイロン コーポレイション ポリペプチド、特にタンパク質の可溶化および安定化のための方法および組成物
JP2000226336A (ja) * 1998-11-30 2000-08-15 Sankyo Co Ltd 免疫グロブリン製剤
JP2003510368A (ja) * 1999-10-04 2003-03-18 カイロン コーポレイション 安定化された液体のポリペプチド含有薬学的組成物
JP2004522803A (ja) * 2001-06-29 2004-07-29 マキシゲン・エイピーエス インターフェロン製剤
JP2005534671A (ja) * 2002-06-24 2005-11-17 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング オリゴペプチドとエーテル化シクロデキストリンを含む液体製剤
JP2006517540A (ja) * 2003-01-14 2006-07-27 テバ ファーマシューティカル インダストリーズ リミティド 全身性エリテマトーデスの治療のためのペプチドの非経口製剤
JP2007524602A (ja) * 2003-04-04 2007-08-30 ジェネンテック・インコーポレーテッド 高濃度抗体及びタンパク質製剤
WO2005065717A2 (de) * 2003-12-24 2005-07-21 Boehringer Ingelheim International Gmbh Flüssigformulierungen von antikörperkonjugaten
JP2008529499A (ja) * 2005-02-07 2008-08-07 ジェネンテック・インコーポレーテッド 抗体変異体とその使用
WO2007019232A2 (en) * 2005-08-03 2007-02-15 Immunogen, Inc. Immunoconjugate formulations
WO2008071394A1 (en) * 2006-12-11 2008-06-19 F. Hoffmann-La Roche Ag Abeta antibody parenteral formulation

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019512540A (ja) * 2016-03-10 2019-05-16 ユーシービー バイオファーマ エスピーアールエル 医薬製剤
JP2022062014A (ja) * 2016-03-10 2022-04-19 ユーシービー バイオファーマ エスピーアールエル 医薬製剤
JP7539761B2 (ja) 2016-03-10 2024-08-26 ユーシービー バイオファーマ エスアールエル 医薬製剤
JP2023523927A (ja) * 2020-04-23 2023-06-08 イーライ リリー アンド カンパニー 抗体の皮下吸収及びバイオアベイラビリティ

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ZA201103006B (en) 2012-07-25
CL2011001132A1 (es) 2012-07-20
CA2742988A1 (en) 2010-05-20
KR20110086705A (ko) 2011-07-29
RU2011124550A (ru) 2012-12-27
EP2358395A1 (en) 2011-08-24
CN102281903A (zh) 2011-12-14
TW201032826A (en) 2010-09-16
US20110305639A1 (en) 2011-12-15
WO2010057107A1 (en) 2010-05-20
IL212533A0 (en) 2011-06-30
MX2011005051A (es) 2011-06-01
PE20120169A1 (es) 2012-02-29
BRPI0916072A2 (pt) 2015-11-10
US20140093493A1 (en) 2014-04-03
AR074357A1 (es) 2011-01-12
CN102281903B (zh) 2013-11-13
EP2358395A4 (en) 2013-11-20
AU2009313754A1 (en) 2010-05-20
RU2563823C2 (ru) 2015-09-20
JP2016020350A (ja) 2016-02-04

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