JP2012506898A - ホスファチジルイノシトール−３−キナーゼ（ＰＩ３Ｋ）阻害剤とｍＴＯＲ阻害剤との併用剤 - Google Patents

ホスファチジルイノシトール−３−キナーゼ（ＰＩ３Ｋ）阻害剤とｍＴＯＲ阻害剤との併用剤 Download PDF

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JP2012506898A
JP2012506898A JP2011533721A JP2011533721A JP2012506898A JP 2012506898 A JP2012506898 A JP 2012506898A JP 2011533721 A JP2011533721 A JP 2011533721A JP 2011533721 A JP2011533721 A JP 2011533721A JP 2012506898 A JP2012506898 A JP 2012506898A
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ガルシア−エチェベリア，カルロス
マイラ，サウバー−ミシェル
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ノバルティス アーゲー
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
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  • Neurology (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
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  • Heart & Thoracic Surgery (AREA)
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  • Communicable Diseases (AREA)
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  • Hospice & Palliative Care (AREA)
  • Ophthalmology & Optometry (AREA)
  • Psychiatry (AREA)
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  • Virology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Transplantation (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2011533721A 2008-10-31 2009-10-29 ホスファチジルイノシトール−３−キナーゼ（ＰＩ３Ｋ）阻害剤とｍＴＯＲ阻害剤との併用剤 Withdrawn JP2012506898A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP08168044 2008-10-31
EP08168044.9 2008-10-31
PCT/EP2009/064274 WO2010049481A1 (en) 2008-10-31 2009-10-29 Combination of a phosphatidylinositol-3-kinase (pi3k) inhibitor and a mtor inhibitor

Related Child Applications (1)

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JP2014181069A Division JP2015013883A (ja) 2008-10-31 2014-09-05 ホスファチジルイノシトール−３−キナーゼ（ＰＩ３Ｋ）阻害剤とｍＴＯＲ阻害剤との併用剤

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JP2012506898A true JP2012506898A (ja) 2012-03-22
JP2012506898A5 JP2012506898A5 (https=) 2012-12-06

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JP2011533721A Withdrawn JP2012506898A (ja) 2008-10-31 2009-10-29 ホスファチジルイノシトール−３−キナーゼ（ＰＩ３Ｋ）阻害剤とｍＴＯＲ阻害剤との併用剤
JP2014181069A Withdrawn JP2015013883A (ja) 2008-10-31 2014-09-05 ホスファチジルイノシトール−３−キナーゼ（ＰＩ３Ｋ）阻害剤とｍＴＯＲ阻害剤との併用剤
JP2016134514A Ceased JP2017002058A (ja) 2008-10-31 2016-07-06 ホスファチジルイノシトール−３−キナーゼ（ＰＩ３Ｋ）阻害剤とｍＴＯＲ阻害剤との併用剤
JP2018136756A Pending JP2018197243A (ja) 2008-10-31 2018-07-20 ホスファチジルイノシトール−３−キナーゼ（ＰＩ３Ｋ）阻害剤とｍＴＯＲ阻害剤との併用剤

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JP2014181069A Withdrawn JP2015013883A (ja) 2008-10-31 2014-09-05 ホスファチジルイノシトール−３−キナーゼ（ＰＩ３Ｋ）阻害剤とｍＴＯＲ阻害剤との併用剤
JP2016134514A Ceased JP2017002058A (ja) 2008-10-31 2016-07-06 ホスファチジルイノシトール−３−キナーゼ（ＰＩ３Ｋ）阻害剤とｍＴＯＲ阻害剤との併用剤
JP2018136756A Pending JP2018197243A (ja) 2008-10-31 2018-07-20 ホスファチジルイノシトール−３−キナーゼ（ＰＩ３Ｋ）阻害剤とｍＴＯＲ阻害剤との併用剤

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US (3) US20110195966A1 (https=)
EP (1) EP2349275B1 (https=)
JP (4) JP2012506898A (https=)
KR (1) KR20110090911A (https=)
CN (2) CN102202668A (https=)
AU (1) AU2009309616B2 (https=)
BR (1) BRPI0921802A8 (https=)
CA (1) CA2736361C (https=)
ES (1) ES2627677T3 (https=)
MX (1) MX2011004585A (https=)
RU (2) RU2538683C2 (https=)
WO (1) WO2010049481A1 (https=)

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EP2968281B1 (en) 2013-03-13 2020-08-05 The Board of Regents of The University of Texas System Mtor inhibitors for prevention of intestinal polyp growth
EP2970240B1 (en) 2013-03-14 2018-01-10 Novartis AG 3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant idh
KR20150127720A (ko) 2013-03-14 2015-11-17 유니버시티 오브 매릴랜드, 발티모어 안드로겐 수용체 하향 조절제 및 그의 용도
WO2014144850A1 (en) 2013-03-15 2014-09-18 Genentech, Inc. Methods of treating cancer and preventing cancer drug resistance
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CN103483345B (zh) * 2013-09-25 2016-07-06 中山大学 Pi3k激酶抑制剂、包含其的药物组合物及其应用
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CN110114070A (zh) 2016-11-23 2019-08-09 诺华公司 使用依维莫司(everolimus)、达托里昔布(dactolisib)或二者增强免疫反应的方法
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CN112294967A (zh) * 2020-09-30 2021-02-02 四川大学 一种mTOR抑制剂与抗癌药物的用途

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US20160136175A1 (en) 2016-05-19
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US20110195966A1 (en) 2011-08-11
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