JP2012503981A5 - - Google Patents
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- JP2012503981A5 JP2012503981A5 JP2011529064A JP2011529064A JP2012503981A5 JP 2012503981 A5 JP2012503981 A5 JP 2012503981A5 JP 2011529064 A JP2011529064 A JP 2011529064A JP 2011529064 A JP2011529064 A JP 2011529064A JP 2012503981 A5 JP2012503981 A5 JP 2012503981A5
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- 239000000203 mixture Substances 0.000 claims 17
- 108090000790 Enzymes Proteins 0.000 claims 7
- 102000004190 Enzymes Human genes 0.000 claims 7
- 229920000642 polymer Polymers 0.000 claims 6
- 239000004971 Cross linker Substances 0.000 claims 5
- 239000002202 Polyethylene glycol Substances 0.000 claims 4
- 229920001223 polyethylene glycol Polymers 0.000 claims 4
- 229920002521 Macromolecule Polymers 0.000 claims 3
- 108010046334 Urease Proteins 0.000 claims 3
- 230000002255 enzymatic Effects 0.000 claims 3
- 108010093096 Immobilized Enzymes Proteins 0.000 claims 2
- 230000024881 catalytic activity Effects 0.000 claims 2
- 239000007795 chemical reaction product Substances 0.000 claims 2
- 239000003431 cross linking reagent Substances 0.000 claims 2
- 125000000524 functional group Chemical group 0.000 claims 2
- 239000008247 solid mixture Substances 0.000 claims 2
- KGIGUEBEKRSTEW-UHFFFAOYSA-N 2-Vinylpyridine Chemical compound C=CC1=CC=CC=N1 KGIGUEBEKRSTEW-UHFFFAOYSA-N 0.000 claims 1
- PNEYBMLMFCGWSK-UHFFFAOYSA-N AI2O3 Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 claims 1
- 239000004593 Epoxy Substances 0.000 claims 1
- 229920002873 Polyethylenimine Polymers 0.000 claims 1
- NIXOWILDQLNWCW-UHFFFAOYSA-M acrylate group Chemical group C(C=C)(=O)[O-] NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 238000004132 cross linking Methods 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 125000003700 epoxy group Chemical group 0.000 claims 1
- 238000005755 formation reaction Methods 0.000 claims 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims 1
- 125000001475 halogen functional group Chemical group 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 229920000729 poly(L-lysine) polymer Polymers 0.000 claims 1
- 229920002006 poly(N-vinylimidazole) polymer Polymers 0.000 claims 1
- 229920000083 poly(allylamine) Polymers 0.000 claims 1
- 229920000333 poly(propyleneimine) Polymers 0.000 claims 1
- 229920000768 polyamine Polymers 0.000 claims 1
Claims (10)
- 共有結合的に固定化した酵素を含み、酵素活性を有する、乾燥した固体組成物であって、共有結合した巨大分子の形成体中に（ｉ）少なくとも１つの酵素と、（ｉｉ）少なくとも１つのポリマーと、（ｉｉｉ）少なくとも１つの架橋剤との反応生成物を含み、酵素が乾燥状態、周囲温度及び圧力で、少なくとも９０日間保存される場合、製造時の酵素活性と比較して９０％を超える酵素活性を保持する、組成物。
- ポリマーがポリ（エチレンイミン）、ポリ（プロピレンイミン）、ポリ（アリルアミン）、ポリ（ビニルピリジン）、ポリ（ビニルイミダゾール）、ポリ（ｌ−リジン）、又はそれらの組合せを含み、かつ、架橋剤がヘテロ二官能性ポリエチレングリコール、ホモ二官能性ポリエチレングリコール、又はそれらの組合せを含む、請求項１に記載の組成物。
- 架橋剤が１つ又は複数のエポキシ官能基、１つ又は複数のアクリレート官能基、１つ又は複数のハロゲン官能基、１つ又は複数のカルボキシル官能基、１つ又は複数のアルデヒド官能基、又はそれらの組合せを含む、請求項１に記載の組成物。
- 酵素がウレアーゼである、請求項１に記載の組成物。
- 酵素が架橋剤及びポリマーと共有結合する、請求項１に記載の組成物。
- 共有結合した巨大分子の形成体中に固定化ウレアーゼと、少なくとも１つのポリマーと、少なくとも１つの架橋剤とを含む、請求項１に記載の組成物。
- 共有結合的に固定化した酵素を含み、酵素活性を有する、乾燥した固体組成物であって、該組成物が共有結合した巨大分子の形成体中に（ｉ）少なくとも１つの酵素と、（ｉｉ）少なくとも１つのポリマーと、（ｉｉｉ）少なくとも１つの架橋剤との反応生成物を含み、該ポリマーがポリアミンを含み、該架橋剤がヘテロ二官能性ポリエチレングリコール、ホモ二官能性ポリエチレングリコール、又はそれらの組合せを含み、該酵素がウレアーゼであり、前記組成物が４０％未満の架橋密度を有し、該酵素が乾燥状態、周囲温度及び圧力で、少なくとも３０日間保存される場合、製造時の酵素活性と比較して８０％を超える酵素活性を保持する、請求項１に記載の組成物。
- 組成物が４０％未満の架橋密度を有する、請求項１に記載の組成物。
- 吸着カートリッジ中に層として請求項１に記載の組成物を含む、吸着カートリッジ。
- 組成物に隣接したアルミナの存在を排除する、請求項９に記載の吸着カートリッジ。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10130208P | 2008-09-30 | 2008-09-30 | |
| US61/101,302 | 2008-09-30 | ||
| PCT/US2009/055647 WO2010039384A2 (en) | 2008-09-30 | 2009-09-02 | Covalently immobilized enzyme and method to make the same |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012503981A JP2012503981A (ja) | 2012-02-16 |
| JP2012503981A5 true JP2012503981A5 (ja) | 2012-10-04 |
| JP5848128B2 JP5848128B2 (ja) | 2016-01-27 |
Family
ID=41301245
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011529064A Active JP5848128B2 (ja) | 2008-09-30 | 2009-09-02 | 共有結合的に固定化した酵素及びその製造方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US8497107B2 (ja) |
| EP (1) | EP2331688B1 (ja) |
| JP (1) | JP5848128B2 (ja) |
| AU (1) | AU2009300187B2 (ja) |
| CA (2) | CA3076044A1 (ja) |
| WO (1) | WO2010039384A2 (ja) |
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2009
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- 2009-09-02 CA CA3076044A patent/CA3076044A1/en not_active Abandoned
- 2009-09-02 US US12/552,332 patent/US8497107B2/en active Active
- 2009-09-02 CA CA2735452A patent/CA2735452C/en active Active
- 2009-09-02 EP EP09792142.3A patent/EP2331688B1/en active Active
- 2009-09-02 AU AU2009300187A patent/AU2009300187B2/en active Active
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2013
- 2013-03-18 US US13/846,255 patent/US9187744B2/en not_active Expired - Fee Related
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