JP2012503026A5 - - Google Patents
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- JP2012503026A5 JP2012503026A5 JP2011528084A JP2011528084A JP2012503026A5 JP 2012503026 A5 JP2012503026 A5 JP 2012503026A5 JP 2011528084 A JP2011528084 A JP 2011528084A JP 2011528084 A JP2011528084 A JP 2011528084A JP 2012503026 A5 JP2012503026 A5 JP 2012503026A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- enhanced
- helix
- helical
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9906308P | 2008-09-22 | 2008-09-22 | |
| US61/099,063 | 2008-09-22 | ||
| PCT/US2009/057934 WO2010034034A1 (en) | 2008-09-22 | 2009-09-22 | Peptidomimetic macrocycles |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014142904A Division JP6067626B2 (ja) | 2008-09-22 | 2014-07-11 | ペプチド模倣大環状分子 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012503026A JP2012503026A (ja) | 2012-02-02 |
| JP2012503026A5 true JP2012503026A5 (https=) | 2013-05-16 |
| JP5711128B2 JP5711128B2 (ja) | 2015-04-30 |
Family
ID=41611441
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011528084A Expired - Fee Related JP5711128B2 (ja) | 2008-09-22 | 2009-09-22 | ペプチド模倣大環状分子 |
| JP2014142904A Expired - Fee Related JP6067626B2 (ja) | 2008-09-22 | 2014-07-11 | ペプチド模倣大環状分子 |
| JP2016159624A Pending JP2016190882A (ja) | 2008-09-22 | 2016-08-16 | ペプチド模倣大環状分子 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014142904A Expired - Fee Related JP6067626B2 (ja) | 2008-09-22 | 2014-07-11 | ペプチド模倣大環状分子 |
| JP2016159624A Pending JP2016190882A (ja) | 2008-09-22 | 2016-08-16 | ペプチド模倣大環状分子 |
Country Status (10)
| Country | Link |
|---|---|
| US (5) | US8524653B2 (https=) |
| EP (1) | EP2342222B1 (https=) |
| JP (3) | JP5711128B2 (https=) |
| CN (1) | CN102482336B (https=) |
| AU (1) | AU2009294877C1 (https=) |
| BR (1) | BRPI0918948A2 (https=) |
| CA (1) | CA2737922A1 (https=) |
| ES (1) | ES2666458T3 (https=) |
| IL (1) | IL211836A0 (https=) |
| WO (1) | WO2010034034A1 (https=) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7192713B1 (en) | 1999-05-18 | 2007-03-20 | President And Fellows Of Harvard College | Stabilized compounds having secondary structure motifs |
| EP1997828B1 (en) | 2003-11-05 | 2017-10-04 | Dana-Farber Cancer Institute, Inc. | Stabilized alpha helical peptides from BCL-2 and uses thereof |
| WO2005118620A2 (en) | 2004-05-27 | 2005-12-15 | New York University | Methods for preparing internally constraied peptides and peptidomimetics |
| CN105061577A (zh) * | 2006-12-14 | 2015-11-18 | 爱勒让治疗公司 | 双巯基大环化系统 |
| US7981998B2 (en) * | 2006-12-14 | 2011-07-19 | Aileron Therapeutics, Inc. | Bis-sulfhydryl macrocyclization systems |
| EP2952522B1 (en) | 2007-01-31 | 2019-10-30 | Dana-Farber Cancer Institute, Inc. | Stabilized p53 peptides and uses thereof |
| ES2398310T3 (es) | 2007-02-23 | 2013-03-15 | Aileron Therapeutics, Inc. | Péptidos macrocíclicos unidos a triazol |
| AU2008232709C1 (en) * | 2007-03-28 | 2015-01-15 | President And Fellows Of Harvard College | Stitched polypeptides |
| WO2009110952A2 (en) * | 2007-12-31 | 2009-09-11 | New York University | Control of viral-host membrane fusion with hydrogen bond surrogate-based artificial helices |
| KR20100126361A (ko) | 2008-02-08 | 2010-12-01 | 에일러론 테라퓨틱스 인코포레이티드 | 치료용 펩티드유사 거대고리 |
| US20110144303A1 (en) * | 2008-04-08 | 2011-06-16 | Aileron Therapeutics, Inc. | Biologically Active Peptidomimetic Macrocycles |
| WO2010011313A2 (en) * | 2008-07-23 | 2010-01-28 | President And Fellows Of Harvard College | Ligation of stapled polypeptides |
| ES2666458T3 (es) | 2008-09-22 | 2018-05-04 | Aileron Therapeutics, Inc. | Macrociclos peptidomiméticos |
| CN102203126A (zh) | 2008-09-22 | 2011-09-28 | 爱勒让治疗公司 | 用于制备纯化的多肽组合物的方法 |
| EP2352507A4 (en) | 2008-11-24 | 2012-04-25 | Aileron Therapeutics Inc | PEPTIDOMIMETIC MACROCYCLES WITH IMPROVED PROPERTIES |
| WO2010083347A2 (en) | 2009-01-14 | 2010-07-22 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
| JP2012532929A (ja) | 2009-07-13 | 2012-12-20 | プレジデント アンド フェロウズ オブ ハーバード カレッジ | 二機能性のステープリングされたポリペプチドおよびそれらの使用 |
| US20130072439A1 (en) | 2009-09-22 | 2013-03-21 | Huw M. Nash | Peptidomimetic macrocycles |
| US20110223149A1 (en) * | 2009-10-14 | 2011-09-15 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
| KR20170058446A (ko) | 2010-08-13 | 2017-05-26 | 에일러론 테라퓨틱스 인코포레이티드 | 펩티도미메틱 거대고리 |
| WO2012040459A2 (en) | 2010-09-22 | 2012-03-29 | President And Fellows Of Harvard College | Beta-catenin targeting peptides and uses thereof |
| US9169295B2 (en) | 2010-10-13 | 2015-10-27 | Bristol-Myers Squibb Company | Macrocycles and macrocycle stabilized peptides |
| JP2014502152A (ja) | 2010-11-12 | 2014-01-30 | ダナ ファーバー キャンサー インスティテュート,インコーポレイテッド | 癌の治療及び診断 |
| US9029332B2 (en) | 2010-12-15 | 2015-05-12 | The Research Foundation For The State University Of New York | Cross-linked peptides and proteins, methods of making same, and uses thereof |
| WO2012174423A1 (en) | 2011-06-17 | 2012-12-20 | President And Fellows Of Harvard College | Stabilized polypeptides as regulators of rab gtpase function |
| EP2721061A4 (en) * | 2011-06-17 | 2014-11-05 | Harvard College | VARIANT STABILIZED MAML-PEPTIDES AND USES THEREOF |
| US20130123196A1 (en) * | 2011-08-31 | 2013-05-16 | New York University | Thioether-, ether-, and alkylamine-linked hydrogen bond surrogate peptidomimetics |
| AR088392A1 (es) | 2011-10-18 | 2014-05-28 | Aileron Therapeutics Inc | Macrociclos peptidomimeticos |
| HK1205454A1 (en) | 2012-02-15 | 2015-12-18 | Aileron Therapeutics, Inc. | Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles |
| CA2862038C (en) | 2012-02-15 | 2021-05-25 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
| ES2874525T3 (es) | 2012-09-26 | 2021-11-05 | Harvard College | Péptidos grapados bloqueados con prolina y usos de los mismos |
| BR112015009470A2 (pt) | 2012-11-01 | 2019-12-17 | Aileron Therapeutics Inc | aminoácidos dissubstituídos e seus métodos de preparação e uso |
| WO2014113792A1 (en) * | 2013-01-19 | 2014-07-24 | New York University | Hydrogen-bond surrogate peptides and peptidomimetics for p53 reactivation |
| KR20150131244A (ko) | 2013-03-13 | 2015-11-24 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 스테이플드 및 스티치드 폴리펩티드 및 그의 용도 |
| CA2915354A1 (en) | 2013-06-14 | 2014-12-18 | President And Fellows Of Harvard College | Stabilized polypeptide insulin receptor modulators |
| CN105792851B (zh) | 2013-09-13 | 2023-10-10 | 斯克利普斯研究所 | 修饰的治疗剂及其组合物 |
| AU2014364589B2 (en) | 2013-12-18 | 2020-02-27 | The California Institute For Biomedical Research | Modified therapeutic agents, stapled peptide lipid conjugates, and compositions thereof |
| CN114805527A (zh) | 2014-05-21 | 2022-07-29 | 哈佛大学的校长及成员们 | Ras抑制肽和其用途 |
| SG11201702175YA (en) | 2014-09-24 | 2017-04-27 | Aileron Therapeutics Inc | Peptidomimetic macrocycles and formulations thereof |
| WO2016049359A1 (en) * | 2014-09-24 | 2016-03-31 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and uses thereof |
| US10253067B2 (en) | 2015-03-20 | 2019-04-09 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and uses thereof |
| KR102665898B1 (ko) * | 2015-06-25 | 2024-05-14 | 에이지씨 가부시키가이샤 | 발수제 조성물, 발수제 조성물의 제조 방법 및 물품 |
| US10059741B2 (en) | 2015-07-01 | 2018-08-28 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
| JP2018528217A (ja) | 2015-09-10 | 2018-09-27 | エルロン・セラピューティクス・インコーポレイテッドAileron Therapeutics,Inc. | Mcl−1のモジュレーターとしてのペプチド模倣大環状分子 |
| EP3389668A4 (en) | 2015-12-15 | 2019-08-21 | Glycom A/S | MIXTURE OF HMOS |
| CN109414470A (zh) * | 2016-03-21 | 2019-03-01 | 艾瑞朗医疗公司 | 用于拟肽大环化合物的伴随诊断工具 |
| US12059413B2 (en) | 2016-11-02 | 2024-08-13 | The Research Foundation For The State University Of New York | Methods of inhibiting viruses using compositions targeting TSG101-ubiquitin interaction |
| EA202090513A1 (ru) | 2017-09-07 | 2020-08-24 | Фог Фармасьютикалз, Инк. | Агенты, модулирующие функции бета-катенина, и связанные способы |
| US20200354413A1 (en) | 2017-12-15 | 2020-11-12 | Dana-Farber Cancer Institute, Inc. | Stabilized peptide-mediated targeted protein degradation |
| WO2019157131A1 (en) | 2018-02-07 | 2019-08-15 | Dana-Farber Cancer Institute, Inc. | Cell-permeable stapled peptide modules for cellular delivery |
| WO2020023502A1 (en) | 2018-07-23 | 2020-01-30 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and uses thereof |
| AU2020397917A1 (en) | 2019-12-04 | 2022-06-23 | The Scripps Research Institute | GLP2 receptor agonists and methods of use |
| AU2021360898A1 (en) | 2020-10-14 | 2023-03-23 | Dana-Farber Cancer Institute, Inc. | Chimeric conjugates for degradation of viral and host proteins and methods of use |
| US20240360186A1 (en) * | 2021-01-28 | 2024-10-31 | Institute For Cancer Research D/B/A The Research Institute Of Fox Chase Cancer Center | Treatment Of Integrin-Related Disorders With Stapled Peptides |
| MX2023014771A (es) | 2021-06-09 | 2024-03-19 | Scripps Research Inst | Conjugados peptidicos duales gip/glp-1 de accion prolongada y metodos de uso. |
Family Cites Families (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5811515A (en) | 1995-06-12 | 1998-09-22 | California Institute Of Technology | Synthesis of conformationally restricted amino acids, peptides, and peptidomimetics by catalytic ring closing metathesis |
| JP2003503008A (ja) | 1999-03-01 | 2003-01-28 | バリアジェニックス インコーポレーテッド | Rna分子をターゲティングする方法 |
| US7192713B1 (en) | 1999-05-18 | 2007-03-20 | President And Fellows Of Harvard College | Stabilized compounds having secondary structure motifs |
| JP4879020B2 (ja) * | 2003-05-01 | 2012-02-15 | コーネル リサーチ ファウンデイション インコーポレイテッド | 細胞に分子を送達する方法及び担体複合体 |
| EP1997828B1 (en) | 2003-11-05 | 2017-10-04 | Dana-Farber Cancer Institute, Inc. | Stabilized alpha helical peptides from BCL-2 and uses thereof |
| AU2005224027B2 (en) | 2004-03-17 | 2011-05-26 | 7Tm Pharma A/S | Y2/Y4 selective receptor agonists for therapeutic interventions |
| WO2005090388A1 (en) | 2004-03-19 | 2005-09-29 | The University Of Queensland | Alpha helical mimics, their uses and methods for their production |
| WO2005118620A2 (en) | 2004-05-27 | 2005-12-15 | New York University | Methods for preparing internally constraied peptides and peptidomimetics |
| US7084248B2 (en) | 2004-07-14 | 2006-08-01 | Gene Tools, Llc | Peptide composition and method for delivering substances into the cytosol of cells |
| WO2006103666A2 (en) | 2005-03-28 | 2006-10-05 | Yeda Research And Development Co. Ltd. | Isolated bid polypeptides, polynucleotides encoding same and antibodies directed thereagainst and methods of using same for inducing cell cycle arrest or apoptosis |
| WO2008061192A2 (en) * | 2006-11-15 | 2008-05-22 | Dana-Farber Cancer Institute, Inc. | Stabilized maml peptides and uses thereof |
| CN105061577A (zh) | 2006-12-14 | 2015-11-18 | 爱勒让治疗公司 | 双巯基大环化系统 |
| US7981998B2 (en) | 2006-12-14 | 2011-07-19 | Aileron Therapeutics, Inc. | Bis-sulfhydryl macrocyclization systems |
| EP2952522B1 (en) | 2007-01-31 | 2019-10-30 | Dana-Farber Cancer Institute, Inc. | Stabilized p53 peptides and uses thereof |
| ES2398310T3 (es) | 2007-02-23 | 2013-03-15 | Aileron Therapeutics, Inc. | Péptidos macrocíclicos unidos a triazol |
| AU2008232709C1 (en) | 2007-03-28 | 2015-01-15 | President And Fellows Of Harvard College | Stitched polypeptides |
| JP5883220B2 (ja) | 2007-05-02 | 2016-03-09 | デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド | 細胞のホメオスタシス経路および細胞の生存を調節する方法 |
| WO2009110952A2 (en) | 2007-12-31 | 2009-09-11 | New York University | Control of viral-host membrane fusion with hydrogen bond surrogate-based artificial helices |
| JP5788178B2 (ja) | 2008-01-23 | 2015-09-30 | ダナ ファーバー キャンサー インスティテュート インコーポレイテッド | ウィルス感染症の治療のための組成物及び方法 |
| KR20100126361A (ko) * | 2008-02-08 | 2010-12-01 | 에일러론 테라퓨틱스 인코포레이티드 | 치료용 펩티드유사 거대고리 |
| WO2009126292A2 (en) | 2008-04-08 | 2009-10-15 | Aileron Therapeutics, Inc. | Biologically active peptidomimetic macrocycles |
| US20110144303A1 (en) | 2008-04-08 | 2011-06-16 | Aileron Therapeutics, Inc. | Biologically Active Peptidomimetic Macrocycles |
| WO2009149214A2 (en) | 2008-06-03 | 2009-12-10 | Aileron Therapeutics, Inc. | Compositions and methods for enhancing cellular transport of biomolecules |
| WO2010011313A2 (en) | 2008-07-23 | 2010-01-28 | President And Fellows Of Harvard College | Ligation of stapled polypeptides |
| US9399666B2 (en) | 2008-09-18 | 2016-07-26 | New York University | Inhibiting interaction between the HIF-1ALPHA and p300/CBP with hydrogen bond surrogate-based helices |
| CN102884074A (zh) | 2008-09-22 | 2013-01-16 | 爱勒让治疗公司 | 拟肽大环化合物 |
| EP2329015A1 (en) | 2008-09-22 | 2011-06-08 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
| AU2009294871A1 (en) | 2008-09-22 | 2010-03-25 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
| CN102203126A (zh) | 2008-09-22 | 2011-09-28 | 爱勒让治疗公司 | 用于制备纯化的多肽组合物的方法 |
| ES2666458T3 (es) | 2008-09-22 | 2018-05-04 | Aileron Therapeutics, Inc. | Macrociclos peptidomiméticos |
| EP2331567A1 (en) | 2008-09-22 | 2011-06-15 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
| EP2352507A4 (en) | 2008-11-24 | 2012-04-25 | Aileron Therapeutics Inc | PEPTIDOMIMETIC MACROCYCLES WITH IMPROVED PROPERTIES |
| WO2010083347A2 (en) | 2009-01-14 | 2010-07-22 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
| JP2012532929A (ja) | 2009-07-13 | 2012-12-20 | プレジデント アンド フェロウズ オブ ハーバード カレッジ | 二機能性のステープリングされたポリペプチドおよびそれらの使用 |
| US20130072439A1 (en) | 2009-09-22 | 2013-03-21 | Huw M. Nash | Peptidomimetic macrocycles |
| US20110223149A1 (en) | 2009-10-14 | 2011-09-15 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
| KR20170058446A (ko) | 2010-08-13 | 2017-05-26 | 에일러론 테라퓨틱스 인코포레이티드 | 펩티도미메틱 거대고리 |
| JP6239979B2 (ja) | 2011-03-04 | 2017-11-29 | ニューヨーク・ユニバーシティ | Rasの調節因子としての水素結合代替大環状分子 |
| WO2012173846A2 (en) | 2011-06-06 | 2012-12-20 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
| US20130123196A1 (en) | 2011-08-31 | 2013-05-16 | New York University | Thioether-, ether-, and alkylamine-linked hydrogen bond surrogate peptidomimetics |
| AR088392A1 (es) | 2011-10-18 | 2014-05-28 | Aileron Therapeutics Inc | Macrociclos peptidomimeticos |
| WO2013059530A2 (en) | 2011-10-18 | 2013-04-25 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
| CA2862038C (en) | 2012-02-15 | 2021-05-25 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
| HK1205454A1 (en) | 2012-02-15 | 2015-12-18 | Aileron Therapeutics, Inc. | Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles |
| BR112015009470A2 (pt) | 2012-11-01 | 2019-12-17 | Aileron Therapeutics Inc | aminoácidos dissubstituídos e seus métodos de preparação e uso |
| WO2014138429A2 (en) | 2013-03-06 | 2014-09-12 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and use thereof in regulating hif1alpha |
-
2009
- 2009-09-22 ES ES09736335.2T patent/ES2666458T3/es active Active
- 2009-09-22 EP EP09736335.2A patent/EP2342222B1/en not_active Not-in-force
- 2009-09-22 CA CA2737922A patent/CA2737922A1/en not_active Abandoned
- 2009-09-22 WO PCT/US2009/057934 patent/WO2010034034A1/en not_active Ceased
- 2009-09-22 AU AU2009294877A patent/AU2009294877C1/en not_active Ceased
- 2009-09-22 CN CN200980142223.9A patent/CN102482336B/zh not_active Expired - Fee Related
- 2009-09-22 JP JP2011528084A patent/JP5711128B2/ja not_active Expired - Fee Related
- 2009-09-22 US US12/564,910 patent/US8524653B2/en not_active Expired - Fee Related
- 2009-09-22 BR BRPI0918948A patent/BRPI0918948A2/pt not_active Application Discontinuation
-
2011
- 2011-03-21 IL IL211836A patent/IL211836A0/en active IP Right Grant
-
2012
- 2012-02-03 US US13/366,113 patent/US8399405B2/en not_active Expired - Fee Related
-
2013
- 2013-08-02 US US13/957,667 patent/US9175045B2/en not_active Expired - Fee Related
-
2014
- 2014-07-11 JP JP2014142904A patent/JP6067626B2/ja not_active Expired - Fee Related
-
2015
- 2015-09-25 US US14/866,445 patent/US20160096873A1/en not_active Abandoned
-
2016
- 2016-08-16 JP JP2016159624A patent/JP2016190882A/ja active Pending
- 2016-09-06 US US15/257,807 patent/US20170299576A1/en not_active Abandoned
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