JP2012502938A5 - - Google Patents
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- JP2012502938A5 JP2012502938A5 JP2011527243A JP2011527243A JP2012502938A5 JP 2012502938 A5 JP2012502938 A5 JP 2012502938A5 JP 2011527243 A JP2011527243 A JP 2011527243A JP 2011527243 A JP2011527243 A JP 2011527243A JP 2012502938 A5 JP2012502938 A5 JP 2012502938A5
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- JP
- Japan
- Prior art keywords
- dsm
- cancer
- antibody
- cell
- antibody according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 210000004027 cell Anatomy 0.000 claims 19
- 206010028980 Neoplasm Diseases 0.000 claims 8
- 238000000034 method Methods 0.000 claims 7
- 201000011510 cancer Diseases 0.000 claims 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 5
- 210000004881 tumor cell Anatomy 0.000 claims 5
- 239000000427 antigen Substances 0.000 claims 4
- 102000036639 antigens Human genes 0.000 claims 4
- 108091007433 antigens Proteins 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 239000012634 fragment Substances 0.000 claims 3
- 206010006187 Breast cancer Diseases 0.000 claims 2
- 208000026310 Breast neoplasm Diseases 0.000 claims 2
- 206010008342 Cervix carcinoma Diseases 0.000 claims 2
- 206010009944 Colon cancer Diseases 0.000 claims 2
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 2
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 2
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 2
- 206010025598 Malignant hydatidiform mole Diseases 0.000 claims 2
- 206010027476 Metastases Diseases 0.000 claims 2
- 206010029260 Neuroblastoma Diseases 0.000 claims 2
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 2
- 206010033128 Ovarian cancer Diseases 0.000 claims 2
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 2
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 2
- 206010060862 Prostate cancer Diseases 0.000 claims 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 2
- 206010038389 Renal cancer Diseases 0.000 claims 2
- 208000006265 Renal cell carcinoma Diseases 0.000 claims 2
- 206010039491 Sarcoma Diseases 0.000 claims 2
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 2
- 208000024770 Thyroid neoplasm Diseases 0.000 claims 2
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 201000010881 cervical cancer Diseases 0.000 claims 2
- 208000029742 colonic neoplasm Diseases 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 201000004101 esophageal cancer Diseases 0.000 claims 2
- 206010017758 gastric cancer Diseases 0.000 claims 2
- 201000010536 head and neck cancer Diseases 0.000 claims 2
- 208000014829 head and neck neoplasm Diseases 0.000 claims 2
- 206010073071 hepatocellular carcinoma Diseases 0.000 claims 2
- 231100000844 hepatocellular carcinoma Toxicity 0.000 claims 2
- 210000004408 hybridoma Anatomy 0.000 claims 2
- 230000002163 immunogen Effects 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 230000005764 inhibitory process Effects 0.000 claims 2
- 201000010982 kidney cancer Diseases 0.000 claims 2
- 201000007270 liver cancer Diseases 0.000 claims 2
- 208000014018 liver neoplasm Diseases 0.000 claims 2
- 210000004072 lung Anatomy 0.000 claims 2
- 201000005202 lung cancer Diseases 0.000 claims 2
- 208000020816 lung neoplasm Diseases 0.000 claims 2
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 2
- 201000001441 melanoma Diseases 0.000 claims 2
- 230000009401 metastasis Effects 0.000 claims 2
- 230000001394 metastastic effect Effects 0.000 claims 2
- 208000037819 metastatic cancer Diseases 0.000 claims 2
- 208000011575 metastatic malignant neoplasm Diseases 0.000 claims 2
- 206010061289 metastatic neoplasm Diseases 0.000 claims 2
- 201000002528 pancreatic cancer Diseases 0.000 claims 2
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 201000008824 placental choriocarcinoma Diseases 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 201000011549 stomach cancer Diseases 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 102100021334 Bcl-2-related protein A1 Human genes 0.000 claims 1
- 101000677540 Homo sapiens Acetyl-CoA carboxylase 2 Proteins 0.000 claims 1
- 101000894929 Homo sapiens Bcl-2-related protein A1 Proteins 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 230000000890 antigenic effect Effects 0.000 claims 1
- 210000001185 bone marrow Anatomy 0.000 claims 1
- 230000005757 colony formation Effects 0.000 claims 1
- 231100000433 cytotoxic Toxicity 0.000 claims 1
- 230000001472 cytotoxic effect Effects 0.000 claims 1
- 230000006806 disease prevention Effects 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000012010 growth Effects 0.000 claims 1
- 230000003053 immunization Effects 0.000 claims 1
- 230000002147 killing effect Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 201000000050 myeloid neoplasm Diseases 0.000 claims 1
- 230000017066 negative regulation of growth Effects 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 208000015347 renal cell adenocarcinoma Diseases 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 201000002510 thyroid cancer Diseases 0.000 claims 1
- 239000003053 toxin Substances 0.000 claims 1
- 231100000765 toxin Toxicity 0.000 claims 1
- 230000005909 tumor killing Effects 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9745308P | 2008-09-16 | 2008-09-16 | |
| EP08016277.9 | 2008-09-16 | ||
| US61/097,453 | 2008-09-16 | ||
| EP08016277A EP2166021A1 (en) | 2008-09-16 | 2008-09-16 | Monoclonal antibodies for treatment of cancer |
| PCT/EP2009/006704 WO2010031551A2 (en) | 2008-09-16 | 2009-09-16 | Monoclonal antibodies for treatment of cancer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012502938A JP2012502938A (ja) | 2012-02-02 |
| JP2012502938A5 true JP2012502938A5 (cg-RX-API-DMAC7.html) | 2012-10-25 |
Family
ID=40589589
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011527243A Pending JP2012502938A (ja) | 2008-09-16 | 2009-09-16 | 癌の治療のためのモノクローナル抗体 |
Country Status (27)
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1762575A1 (en) | 2005-09-12 | 2007-03-14 | Ganymed Pharmaceuticals AG | Identification of tumor-associated antigens for diagnosis and therapy |
| EP1970384A1 (en) | 2007-03-14 | 2008-09-17 | Ganymed Pharmaceuticals AG | Monoclonal antibodies for treatment of cancer |
| US9193763B2 (en) | 2007-08-17 | 2015-11-24 | Purdue Research Foundation | PSMA binding ligand-linker conjugates and methods for using |
| EP2166021A1 (en) | 2008-09-16 | 2010-03-24 | Ganymed Pharmaceuticals AG | Monoclonal antibodies for treatment of cancer |
| US9951324B2 (en) | 2010-02-25 | 2018-04-24 | Purdue Research Foundation | PSMA binding ligand-linker conjugates and methods for using |
| EP2371864A1 (en) | 2010-03-23 | 2011-10-05 | Ganymed Pharmaceuticals AG | Monoclonal antibodies for treatment of cancer |
| CN103459424B (zh) * | 2011-01-19 | 2017-11-10 | 坎塔吉亚有限责任公司 | 抗il1rap抗体及其治疗人类的用途 |
| US20130236890A1 (en) * | 2012-03-08 | 2013-09-12 | HI-STEM Heidelberg Institute for Stem Cell Technology and Experimental Medicine gGmbH | Novel method for analyzing circulating tumor cells of a patient for the presence of metastasis-initiating cells |
| KR101471253B1 (ko) * | 2012-10-29 | 2014-12-10 | 인제대학교 산학협력단 | 암 표적 항체 및 이를 포함하는 암 예방 또는 치료용 조성물 |
| EP3858341A1 (en) | 2012-11-15 | 2021-08-04 | Endocyte, Inc. | Psma ligand-containing conjugates for the treatment of prostate cancer |
| KR101947053B1 (ko) | 2013-10-18 | 2019-02-12 | 도이체스 크렙스포르슝스첸트룸 | 전립선 특이적 막 항원（ｐｓｍａ）의 표지된 억제제, 조영제로서의 이의 용도 및 전립선암 치료용 약제 |
| EP3533473A3 (en) | 2013-11-14 | 2019-12-18 | Endocyte, Inc. | Compounds for positron emission tomography |
| JP2017521998A (ja) * | 2014-05-12 | 2017-08-10 | ヌマブ アクチェンゲゼルシャフト | 新規多重特異性分子及びかかる多重特異性分子に基づく新規治療方法 |
| US10188759B2 (en) | 2015-01-07 | 2019-01-29 | Endocyte, Inc. | Conjugates for imaging |
| WO2016161410A2 (en) * | 2015-04-03 | 2016-10-06 | Xoma Technology Ltd. | Treatment of cancer using inhibitors of tgf-beta and pd-1 |
| CA2992091A1 (en) * | 2015-07-14 | 2017-01-19 | Medimmune, Llc | Compositions and methods for treating cancer |
| EP3344278A4 (en) * | 2015-09-04 | 2019-01-23 | The California Institute for Biomedical Research | INSULIN-IMMUNOGLOBULIN FUSION PROTEINS |
| WO2017093447A1 (en) * | 2015-12-01 | 2017-06-08 | Genmab B.V. | Anti-death receptor antibodies and methods of use thereof |
| BR112019008010A2 (pt) * | 2016-10-20 | 2019-07-09 | I Mab | anticorpo monoclonal isolado ou fragmento imunologicamente ativo do mesmo, anticorpo monoclonal biespecífico isolado, composição farmacêutica, método para tratamento de uma doença em um sujeito humano em necessidade do mesmo, proteína de fusão, epítopo imunodominante codificado pelo gene cd47, e, molécula biológica |
| EP4467565A3 (en) | 2016-12-21 | 2025-03-12 | Amgen Inc. | Anti-tnf alpha antibody formulations |
| CN106632661A (zh) * | 2017-01-10 | 2017-05-10 | 天津东亚生物技术有限公司 | 利用hla‑g分子及其抗原片段制备预防肿瘤和病毒病的广谱疫苗及其应用 |
| CN108124445B (zh) * | 2017-03-15 | 2021-05-04 | 苏州银河生物医药有限公司 | Ctla4抗体、其药物组合物及其用途 |
| CN107556369A (zh) * | 2017-08-23 | 2018-01-09 | 天津国际生物医药联合研究院 | 一种抗原肽和用于检测肿瘤细胞的抗体制备方法及其应用 |
| CA3097381A1 (en) | 2018-04-17 | 2019-10-24 | Endocyte, Inc. | Methods of treating cancer |
| CN109402064B (zh) * | 2018-11-05 | 2021-05-14 | 湖南省肿瘤医院 | 杂交瘤细胞株及其产生的单克隆抗体和应用 |
| EP3972627A4 (en) | 2019-05-20 | 2023-06-21 | Endocyte, Inc. | Methods for preparing psma conjugates |
| KR102266418B1 (ko) * | 2019-07-30 | 2021-06-16 | 한국생명공학연구원 | 영여자 추출물을 유효성분으로 함유하는 전립선 질환의 예방 및 치료용 조성물 |
Family Cites Families (52)
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| US4475196A (en) | 1981-03-06 | 1984-10-02 | Zor Clair G | Instrument for locating faults in aircraft passenger reading light and attendant call control system |
| US4447233A (en) | 1981-04-10 | 1984-05-08 | Parker-Hannifin Corporation | Medication infusion pump |
| US4474893A (en) | 1981-07-01 | 1984-10-02 | The University of Texas System Cancer Center | Recombinant monoclonal antibodies |
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| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| US4447224A (en) | 1982-09-20 | 1984-05-08 | Infusaid Corporation | Variable flow implantable infusion apparatus |
| US4487603A (en) | 1982-11-26 | 1984-12-11 | Cordis Corporation | Implantable microinfusion pump system |
| US4486194A (en) | 1983-06-08 | 1984-12-04 | James Ferrara | Therapeutic device for administering medicaments through the skin |
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| EP1762575A1 (en) | 2005-09-12 | 2007-03-14 | Ganymed Pharmaceuticals AG | Identification of tumor-associated antigens for diagnosis and therapy |
| EP1970384A1 (en) * | 2007-03-14 | 2008-09-17 | Ganymed Pharmaceuticals AG | Monoclonal antibodies for treatment of cancer |
| EP2166021A1 (en) | 2008-09-16 | 2010-03-24 | Ganymed Pharmaceuticals AG | Monoclonal antibodies for treatment of cancer |
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-
2008
- 2008-09-16 EP EP08016277A patent/EP2166021A1/en not_active Withdrawn
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2009
- 2009-09-16 MX MX2015005367A patent/MX357010B/es unknown
- 2009-09-16 KR KR1020117007149A patent/KR101818741B1/ko not_active Expired - Fee Related
- 2009-09-16 LT LTEP09778564.6T patent/LT2342234T/lt unknown
- 2009-09-16 TR TR2018/02090T patent/TR201802090T4/tr unknown
- 2009-09-16 NO NO09778564A patent/NO2342234T3/no unknown
- 2009-09-16 MX MX2011002856A patent/MX2011002856A/es active IP Right Grant
- 2009-09-16 WO PCT/EP2009/006704 patent/WO2010031551A2/en not_active Ceased
- 2009-09-16 HR HRP20180262TT patent/HRP20180262T1/hr unknown
- 2009-09-16 NZ NZ596490A patent/NZ596490A/xx not_active IP Right Cessation
- 2009-09-16 SI SI200931801T patent/SI2342234T1/en unknown
- 2009-09-16 SM SM20180079T patent/SMT201800079T1/it unknown
- 2009-09-16 DK DK09778564.6T patent/DK2342234T3/en active
- 2009-09-16 PL PL09778564T patent/PL2342234T3/pl unknown
- 2009-09-16 CA CA2732594A patent/CA2732594C/en not_active Expired - Fee Related
- 2009-09-16 CN CN201510373379.5A patent/CN105753988A/zh active Pending
- 2009-09-16 EP EP17201134.8A patent/EP3312198A1/en not_active Withdrawn
- 2009-09-16 CN CN200980136101.9A patent/CN102164963B/zh not_active Expired - Fee Related
- 2009-09-16 US US13/119,027 patent/US8946388B2/en not_active Expired - Fee Related
- 2009-09-16 EP EP09778564.6A patent/EP2342234B1/en active Active
- 2009-09-16 BR BRPI0918178A patent/BRPI0918178B8/pt not_active IP Right Cessation
- 2009-09-16 RS RS20180160A patent/RS56937B1/sr unknown
- 2009-09-16 PT PT97785646T patent/PT2342234T/pt unknown
- 2009-09-16 NZ NZ591004A patent/NZ591004A/en not_active IP Right Cessation
- 2009-09-16 HU HUE09778564A patent/HUE036477T2/hu unknown
- 2009-09-16 AU AU2009294896A patent/AU2009294896B2/en not_active Ceased
- 2009-09-16 JP JP2011527243A patent/JP2012502938A/ja active Pending
- 2009-09-16 ES ES09778564.6T patent/ES2659718T3/es active Active
- 2009-09-16 CN CN201410649373.1A patent/CN104628858B/zh not_active Expired - Fee Related
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2011
- 2011-02-01 ZA ZA2011/00835A patent/ZA201100835B/en unknown
- 2011-02-02 IL IL211010A patent/IL211010A/en not_active IP Right Cessation
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2015
- 2015-10-22 IL IL242204A patent/IL242204B/en active IP Right Grant
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2018
- 2018-02-15 CY CY20181100189T patent/CY1119956T1/el unknown
- 2018-10-08 HK HK18112784.5A patent/HK1253579A1/en unknown