JP2012502067A5 - - Google Patents

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Publication number
JP2012502067A5
JP2012502067A5 JP2011526310A JP2011526310A JP2012502067A5 JP 2012502067 A5 JP2012502067 A5 JP 2012502067A5 JP 2011526310 A JP2011526310 A JP 2011526310A JP 2011526310 A JP2011526310 A JP 2011526310A JP 2012502067 A5 JP2012502067 A5 JP 2012502067A5
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JP
Japan
Prior art keywords
group
hydrogen
halogen
alkyl
perhaloalkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2011526310A
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English (en)
Japanese (ja)
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JP2012502067A (ja
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Publication date
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Priority claimed from PCT/US2009/056519 external-priority patent/WO2010030785A2/en
Publication of JP2012502067A publication Critical patent/JP2012502067A/ja
Publication of JP2012502067A5 publication Critical patent/JP2012502067A5/ja
Pending legal-status Critical Current

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JP2011526310A 2008-09-10 2009-09-10 疾患の治療のためのヒスタミン受容体の複素環阻害剤 Pending JP2012502067A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US9582608P 2008-09-10 2008-09-10
US61/095,826 2008-09-10
US23174909P 2009-08-06 2009-08-06
US61/231,749 2009-08-06
PCT/US2009/056519 WO2010030785A2 (en) 2008-09-10 2009-09-10 Heterocyclic inhibitors of histamine receptors for the treatment of disease

Publications (2)

Publication Number Publication Date
JP2012502067A JP2012502067A (ja) 2012-01-26
JP2012502067A5 true JP2012502067A5 (cg-RX-API-DMAC7.html) 2012-11-01

Family

ID=42005738

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2011526310A Pending JP2012502067A (ja) 2008-09-10 2009-09-10 疾患の治療のためのヒスタミン受容体の複素環阻害剤

Country Status (14)

Country Link
US (2) US20100120741A1 (cg-RX-API-DMAC7.html)
EP (1) EP2324029A4 (cg-RX-API-DMAC7.html)
JP (1) JP2012502067A (cg-RX-API-DMAC7.html)
KR (1) KR20110095857A (cg-RX-API-DMAC7.html)
CN (1) CN102388044A (cg-RX-API-DMAC7.html)
AR (1) AR073574A1 (cg-RX-API-DMAC7.html)
AU (1) AU2009291719A1 (cg-RX-API-DMAC7.html)
CA (1) CA2735369A1 (cg-RX-API-DMAC7.html)
CL (1) CL2011000431A1 (cg-RX-API-DMAC7.html)
MX (1) MX2011002264A (cg-RX-API-DMAC7.html)
RU (1) RU2011113419A (cg-RX-API-DMAC7.html)
TW (1) TW201024297A (cg-RX-API-DMAC7.html)
UY (1) UY32111A (cg-RX-API-DMAC7.html)
WO (1) WO2010030785A2 (cg-RX-API-DMAC7.html)

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DE102010025786A1 (de) * 2010-07-01 2012-01-05 Merck Patent Gmbh Pyrazolochinoline
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US9540379B2 (en) 2011-01-31 2017-01-10 Boehringer Ingelheim International Gmbh (1,2,4)triazolo[4,3-A]quinoxaline derivatives as inhibitors of phosphodiesterases
EA034193B1 (ru) * 2011-04-21 2020-01-15 Оригенис Гмбх Гетероциклические соединения в качестве ингибиторов киназ
US8859550B2 (en) 2011-09-12 2014-10-14 Kalypsys, Inc. Heterocyclic inhibitors of histamine receptors for the treatment of disease
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JP2014528449A (ja) * 2011-10-04 2014-10-27 ジャナス バイオセラピューティクス,インク. 新規なイミダゾールキノリン系免疫系調節剤
US20140045856A1 (en) 2012-07-31 2014-02-13 Boehringer Ingelheim International Gmbh 4-Methyl-2,3,5,9,9b-pentaaza-cyclopenta[a]naphthalenes
WO2014060113A1 (en) * 2012-10-19 2014-04-24 Origenis Gmbh Novel kinase inhibitors
WO2014087208A2 (en) * 2012-12-06 2014-06-12 Enaltec Labs Pvt. Ltd. A process of preparing alcaftadine
CN108250142B (zh) 2013-02-01 2021-01-26 维尔斯达医疗公司 具有抗炎、抗真菌、抗寄生物和抗癌活性的胺化合物
WO2014152029A2 (en) * 2013-03-15 2014-09-25 Epigenetix, Inc. Oxazolo[5,4-c]quinolin-2-one compounds as bromodomain inhibitors
KR20160034403A (ko) * 2013-07-25 2016-03-29 유니버시테트 야기엘론스키 5-ht6 길항제로서의 피롤로퀴놀린 유도체, 및 이의 제조 방법 및 용도
EP3307067B1 (en) 2015-06-11 2022-11-02 Merck Sharp & Dohme LLC Aminopyrazine compounds with a2a antagonist properties
KR102070265B1 (ko) * 2017-01-26 2020-01-28 한국화학연구원 신규한 [1,2,4]트리아졸로[4,3-a]퀴녹살린 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 BET 단백질 관련 질환의 예방 또는 치료용 약학적 조성물
WO2019177971A1 (en) * 2018-03-12 2019-09-19 Mavupharma, Inc. Ectonucleotide pyrophosphatase-phosphodiesterase 1 (enpp-1) inhibitors and uses thereof
WO2019200500A1 (zh) * 2018-04-15 2019-10-24 苏州大学张家港工业技术研究院 1,2,4-三氮唑及其制备方法
KR102822466B1 (ko) * 2018-04-27 2025-06-20 베이징 이터널 머터리얼 테크놀로지 씨오., 엘티디 유기 전계 발광 재료 및 소자
TW202021969A (zh) * 2018-05-31 2020-06-16 南韓商C&C新藥研究所 雜環衍生物及其用途
CN109705141B (zh) * 2019-02-20 2020-05-29 苏州大学 一种恶唑并喹啉类化合物及其制备方法与应用
WO2021098734A1 (zh) * 2019-11-19 2021-05-27 南京明德新药研发有限公司 作为atm抑制剂的有取代的喹啉吡咯酮类合物及其应用
US11530218B2 (en) 2020-01-20 2022-12-20 Incyte Corporation Spiro compounds as inhibitors of KRAS
US11739102B2 (en) 2020-05-13 2023-08-29 Incyte Corporation Fused pyrimidine compounds as KRAS inhibitors
WO2022047093A1 (en) 2020-08-28 2022-03-03 Incyte Corporation Vinyl imidazole compounds as inhibitors of kras
US11767320B2 (en) 2020-10-02 2023-09-26 Incyte Corporation Bicyclic dione compounds as inhibitors of KRAS
WO2022204112A1 (en) 2021-03-22 2022-09-29 Incyte Corporation Imidazole and triazole kras inhibitors
EP4067357A1 (en) * 2021-03-30 2022-10-05 JW Pharmaceutical Corporation Novel crystalline form of 1-(8-bromopyrido[2,3-e][1,2,4]triazolo[4,3-a]pyrazin-4-yl)-n-methylazetidin-3-amine hydrogen sulfate monohydrate
US12441727B2 (en) 2021-07-07 2025-10-14 Incyte Corporation Tricyclic compounds as inhibitors of KRAS
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US12030883B2 (en) 2021-09-21 2024-07-09 Incyte Corporation Hetero-tricyclic compounds as inhibitors of KRAS
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CN118613482B (zh) * 2022-09-26 2025-09-30 上海湃隆生物科技有限公司 新型prmt5抑制剂及其应用
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CN116332789A (zh) * 2023-03-10 2023-06-27 上海康鹏科技股份有限公司 一种4-氨基-2-氟苯甲酰胺的制备方法

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