JP2012501646A5 - - Google Patents

Download PDF

Info

Publication number
JP2012501646A5
JP2012501646A5 JP2011526037A JP2011526037A JP2012501646A5 JP 2012501646 A5 JP2012501646 A5 JP 2012501646A5 JP 2011526037 A JP2011526037 A JP 2011526037A JP 2011526037 A JP2011526037 A JP 2011526037A JP 2012501646 A5 JP2012501646 A5 JP 2012501646A5
Authority
JP
Japan
Prior art keywords
synaptic vesicle
platform
well
electrode pairs
vesicle cycling
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2011526037A
Other languages
English (en)
Japanese (ja)
Other versions
JP2012501646A (ja
JP5789513B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2009/004932 external-priority patent/WO2010027446A2/en
Publication of JP2012501646A publication Critical patent/JP2012501646A/ja
Publication of JP2012501646A5 publication Critical patent/JP2012501646A5/ja
Application granted granted Critical
Publication of JP5789513B2 publication Critical patent/JP5789513B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2011526037A 2008-09-04 2009-08-31 シナプス小胞サイクリングアッセイおよびシステム Expired - Fee Related JP5789513B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9436108P 2008-09-04 2008-09-04
US61/094,361 2008-09-04
PCT/US2009/004932 WO2010027446A2 (en) 2008-09-04 2009-08-31 Synaptic vesicle cycling assays and systems

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2015151623A Division JP6106225B2 (ja) 2008-09-04 2015-07-31 シナプス小胞サイクリングアッセイおよびシステム

Publications (3)

Publication Number Publication Date
JP2012501646A JP2012501646A (ja) 2012-01-26
JP2012501646A5 true JP2012501646A5 (cg-RX-API-DMAC7.html) 2012-10-18
JP5789513B2 JP5789513B2 (ja) 2015-10-07

Family

ID=41479300

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2011526037A Expired - Fee Related JP5789513B2 (ja) 2008-09-04 2009-08-31 シナプス小胞サイクリングアッセイおよびシステム
JP2015151623A Expired - Fee Related JP6106225B2 (ja) 2008-09-04 2015-07-31 シナプス小胞サイクリングアッセイおよびシステム

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2015151623A Expired - Fee Related JP6106225B2 (ja) 2008-09-04 2015-07-31 シナプス小胞サイクリングアッセイおよびシステム

Country Status (8)

Country Link
US (2) US20120053084A1 (cg-RX-API-DMAC7.html)
EP (1) EP2329275A2 (cg-RX-API-DMAC7.html)
JP (2) JP5789513B2 (cg-RX-API-DMAC7.html)
KR (1) KR20110073494A (cg-RX-API-DMAC7.html)
CN (1) CN102203622A (cg-RX-API-DMAC7.html)
AU (2) AU2009288657A1 (cg-RX-API-DMAC7.html)
CA (1) CA2744804C (cg-RX-API-DMAC7.html)
WO (1) WO2010027446A2 (cg-RX-API-DMAC7.html)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2254458A1 (en) * 2008-02-04 2010-12-01 Bayer HealthCare, LLC Semiconductor based analyte sensors and methods
US9217155B2 (en) 2008-05-28 2015-12-22 University Of Massachusetts Isolation of novel AAV'S and uses thereof
US8734809B2 (en) 2009-05-28 2014-05-27 University Of Massachusetts AAV's and uses thereof
CN103168236B (zh) 2010-08-23 2016-01-20 哈佛大学管理委员会 用于膜电位测定的光遗传学探针
US9207237B2 (en) 2010-08-23 2015-12-08 President And Fellows Of Harvard College Systems, methods, and workflows for optogenetics analysis
US9488637B2 (en) * 2011-01-26 2016-11-08 The Curators Of The University Of Missouri Combination of single-cell electroporation and electrical recording using the same electrode
CA2870511C (en) 2011-04-21 2023-08-08 University Of Massachusetts Raav-based compositions and methods for treating alpha-1 anti-trypsin deficiencies
WO2013078347A2 (en) * 2011-11-23 2013-05-30 President And Fellows Of Harvard College Systems and methods for imaging at high spatial and/or temporal precision
US9696275B2 (en) 2012-10-12 2017-07-04 The Curators Of The University Of Missouri Addressable electrode arrays in multiple fluidic compartments and uses thereof
EP2913391B1 (en) * 2012-10-25 2020-07-01 Hamamatsu Photonics K.K. Cell observation device, and cell observation method
US9778189B2 (en) 2012-10-25 2017-10-03 Hamamatsu Photonics K.K. Cell observation device, electrical stimulation device, and cell observation method
JP6370544B2 (ja) * 2013-11-11 2018-08-08 浜松ホトニクス株式会社 細胞観察装置及び細胞観察方法
US10415010B2 (en) 2014-01-16 2019-09-17 Hamamatsu Photonics K.K. Cell observation device, electrostimulation device, and cell observation method
WO2015127128A2 (en) 2014-02-19 2015-08-27 University Of Massachusetts Recombinant aavs having useful transcytosis properties
EP4410805A3 (en) 2014-03-18 2024-11-27 University of Massachusetts Raav-based compositions and methods for treating amyotrophic lateral sclerosis
US9594075B2 (en) 2014-04-22 2017-03-14 Q-State Biosciences, Inc. Diagnostic methods for neural disorders
EP3134522B1 (en) 2014-04-25 2021-10-06 University of Massachusetts Recombinant aav vectors useful for reducing immunity against transgene products
US9518103B2 (en) 2014-06-18 2016-12-13 President And Fellows Of Harvard College Optogenetic probes for measuring membrane potential
SG11201701540PA (en) 2014-08-28 2017-03-30 Stemonix Inc Method of fabricating cell arrays and uses thereof
WO2016054554A1 (en) 2014-10-03 2016-04-07 University Of Massachusetts Heterologous targeting peptide grafted aavs
JP6842410B2 (ja) 2014-10-03 2021-03-17 ユニバーシティ オブ マサチューセッツ 新規の高効率ライブラリーにより同定されるａａｖベクター
RU2738421C2 (ru) 2014-10-21 2020-12-14 Юниверсити Оф Массачусетс Варианты рекомбинантных aav и их применения
WO2016115333A1 (en) 2015-01-15 2016-07-21 President And Fellows Of Harvard College Optical selection of cells
EP3256170B1 (en) 2015-02-13 2020-09-23 University of Massachusetts Compositions and methods for transient delivery of nucleases
US10048275B2 (en) 2015-03-13 2018-08-14 Q-State Biosciences, Inc. Cardiotoxicity screening methods
CA3019315A1 (en) 2015-04-23 2016-10-27 University Of Massachusetts Modulation of aav vector transgene expression
US11046955B2 (en) 2015-04-24 2021-06-29 University Of Massachusetts Modified AAV constructs and uses thereof
US11248212B2 (en) 2015-06-30 2022-02-15 StemoniX Inc. Surface energy directed cell self assembly
US10760053B2 (en) 2015-10-15 2020-09-01 StemoniX Inc. Method of manufacturing or differentiating mammalian pluripotent stem cells or progenitor cells using a hollow fiber bioreactor
WO2017070516A1 (en) 2015-10-22 2017-04-27 University Of Massachusetts Prostate-targeting adeno-associated virus serotype vectors
EP3364997B1 (en) 2015-10-22 2024-01-17 University of Massachusetts Aspartoacylase gene therapy in the treatment of canavan disease
US11826433B2 (en) 2016-02-02 2023-11-28 University Of Massachusetts Method to enhance the efficiency of systemic AAV gene delivery to the central nervous system
EP3413928B1 (en) 2016-02-12 2022-04-20 University of Massachusetts Anti-angiogenic mirna therapeutics for inhibiting corneal neovascularization
EP3225279B1 (en) * 2016-03-31 2023-12-20 Université de Rennes Brain tissue stimulation apparatus and computer program
US11207426B2 (en) 2016-04-05 2021-12-28 University Of Massachusetts Compositions and methods for selective inhibition of grainyhead-like protein expression
US11413356B2 (en) 2016-04-15 2022-08-16 University Of Massachusetts Methods and compositions for treating metabolic imbalance
US11882815B2 (en) 2016-06-15 2024-01-30 University Of Massachusetts Recombinant adeno-associated viruses for delivering gene editing molecules to embryonic cells
US10457940B2 (en) 2016-09-22 2019-10-29 University Of Massachusetts AAV treatment of Huntington's disease
WO2018071831A1 (en) 2016-10-13 2018-04-19 University Of Massachusetts Aav capsid designs
WO2018208972A1 (en) 2017-05-09 2018-11-15 University Of Massachusetts Methods of treating amyotrophic lateral sclerosis (als)
EP3684937A4 (en) 2017-09-22 2021-06-02 University of Massachusetts NEW DUAL SOD1 EXPRESSION VECTORS AND RELATED USES
CA3096102A1 (en) 2018-04-13 2019-10-17 University Of Massachusetts Bicistronic aav vectors encoding hexosaminidase alpha and beta-subunits and uses thereof
JP7065433B2 (ja) * 2018-08-14 2022-05-12 日本電信電話株式会社 電極及びその製造方法、並びに積層体
JP7709201B2 (ja) 2018-10-05 2025-07-16 ユニバーシティ オブ マサチューセッツ ＧＭ１ガングリオシドーシスおよびＧＭ２ガングリオシドーシスの処置のためのｒＡＡＶベクター
AU2020314729B2 (en) * 2019-07-16 2023-07-06 Meso Scale Technologies, Llc. Assay apparatuses, methods and reagents
JP2024501849A (ja) * 2020-12-31 2024-01-16 キュー－ステート バイオサイエンシーズ， インコーポレイテッド 光学プレートコントローラおよびリーダ
EP4271978A4 (en) 2020-12-31 2024-12-18 Q-State Biosciences, Inc. MICROSCOPE WITH SPATIAL IMAGING AND BEAM HOMOGENIZER
WO2022146981A1 (en) * 2020-12-31 2022-07-07 Q-State Biosciences, Inc. Plate imager
EP4271994A4 (en) 2020-12-31 2024-11-27 Q-State Biosciences, Inc. Calibrating and normalizing imager for optogenetics
JP2024516303A (ja) * 2021-05-04 2024-04-12 キュー－ステート バイオサイエンシーズ， インコーポレイテッド 薬物フィンガプリンティング
WO2023278672A1 (en) 2021-06-30 2023-01-05 Q-State Biosciences, Inc. Multiplex optical stimulus and readout
JPWO2023210585A1 (cg-RX-API-DMAC7.html) * 2022-04-25 2023-11-02
WO2025084395A1 (ja) * 2023-10-19 2025-04-24 株式会社Jiksak Bioengineering 抗シナプトタグミン２抗体
WO2025089346A1 (ja) * 2023-10-25 2025-05-01 株式会社Jiksak Bioengineering 抗シナプトフィジン抗体

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1403645B1 (en) 1998-07-17 2007-09-12 Vertex Pharmaceuticals (San Diego) LLC Detector and screening device for ion channels
US6686193B2 (en) * 2000-07-10 2004-02-03 Vertex Pharmaceuticals, Inc. High throughput method and system for screening candidate compounds for activity against target ion channels
US7615356B2 (en) * 2000-07-10 2009-11-10 Vertex Pharmaceuticals (San Diego) Llc Ion channel assay methods
EP1425065A4 (en) * 2001-07-12 2004-12-15 Merck & Co Inc ELECTRIC FIELD STIMULATION WITH EUKARYONTIC CELLS
US7221981B2 (en) * 2002-03-28 2007-05-22 Northstar Neuroscience, Inc. Electrode geometries for efficient neural stimulation
US20070274923A1 (en) 2005-01-11 2007-11-29 Philippe Brulet Non-invasive real-time in vivo bioluminescence imaging of local Ca2+ dynamics in living organisms

Similar Documents

Publication Publication Date Title
JP2012501646A5 (cg-RX-API-DMAC7.html)
Ravnik-Glavač et al. Circulating RNAs as potential biomarkers in amyotrophic lateral sclerosis
Ligon et al. The ins and outs of Mycobacterium tuberculosis protein export
Greco et al. The impact of mass spectrometry–based proteomics on fundamental discoveries in virology
EP2629855A4 (en) CONTINUOUS SUPPORT DEVICE WITH INTEGRATED TILT SENSOR
RU2015130611A (ru) Способ диагностики рака с применением выдыхаемого воздуха
JP2014521089A5 (cg-RX-API-DMAC7.html)
Palrasu et al. Role of bacterial and viral pathogens in gastric carcinogenesis
FR2969916B1 (fr) Systeme et procede pour detecter la sensibilite d'une personne a une ou plusieurs substances possiblement allergisantes
Grassadonia et al. Role of hydroxamate-based histone deacetylase inhibitors (Hb-HDACIs) in the treatment of solid malignancies
JP2011177182A5 (cg-RX-API-DMAC7.html)
EP2797513A4 (en) X-RAY DETECTOR WITH FAST SWITCHING, IMAGING DEVICE AND METHOD THEREFORE
JP2013514073A5 (cg-RX-API-DMAC7.html)
JP2013545093A5 (cg-RX-API-DMAC7.html)
JP2012053056A5 (cg-RX-API-DMAC7.html)
EP2260928A4 (en) MEMBRANE DISCONNECTING DEVICE AND MEMBRANE ASSASSET
JP2010161740A5 (cg-RX-API-DMAC7.html)
Du et al. Insights into the molecular basis of tick-borne encephalitis from multiplatform metabolomics
JP2018528441A5 (cg-RX-API-DMAC7.html)
JP2011515672A5 (cg-RX-API-DMAC7.html)
Leng et al. mTOR activation induces endolysosomal remodeling and nonclassical secretion of IL-32 via exosomes in inflammatory reactive astrocytes
JP2015521728A5 (cg-RX-API-DMAC7.html)
EP1832862A4 (en) MEASURING DEVICE
EP2114251A4 (en) DEVICE SUPPORTING THE DETERMINATION OF THE QUANTITY EFFICIENCY
Li et al. An update on the mutual impact between SARS-CoV-2 infection and gut microbiota