JP2012072157A5 - - Google Patents

Info

Publication number

JP2012072157A5

JP2012072157A5 JP2011242133A JP2011242133A JP2012072157A5 JP 2012072157 A5 JP2012072157 A5 JP 2012072157A5 JP 2011242133 A JP2011242133 A JP 2011242133A JP 2011242133 A JP2011242133 A JP 2011242133A JP 2012072157 A5 JP2012072157 A5 JP 2012072157A5

Authority

JP

Japan

Prior art keywords

composition

immunostimulatory complex

dextran

deae

composition according

Prior art date

2011-11-04

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 239000000203 mixture Substances 0.000 claims 21
• 230000002163 immunogen Effects 0.000 claims 9
• 230000003308 immunostimulating effect Effects 0.000 claims 9
• 229920002307 Dextran Polymers 0.000 claims 6
• 239000002671 adjuvant Substances 0.000 claims 4
• 150000004676 glycans Chemical class 0.000 claims 4
• 229920001282 polysaccharide Polymers 0.000 claims 4
• 239000005017 polysaccharide Substances 0.000 claims 4
• HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 2
• 229960003983 diphtheria toxoid Drugs 0.000 claims 2
• 230000028993 immune response Effects 0.000 claims 2
• 239000001397 quillaja saponaria molina bark Substances 0.000 claims 2
• 229930182490 saponin Natural products 0.000 claims 2
• 150000007949 saponins Chemical class 0.000 claims 2
• 101000904173 Homo sapiens Progonadoliberin-1 Proteins 0.000 claims 1
• 102100024028 Progonadoliberin-1 Human genes 0.000 claims 1
• 101000996723 Sus scrofa Gonadotropin-releasing hormone receptor Proteins 0.000 claims 1
• UZQJVUCHXGYFLQ-AYDHOLPZSA-N [(2s,3r,4s,5r,6r)-4-[(2s,3r,4s,5r,6r)-4-[(2r,3r,4s,5r,6r)-4-[(2s,3r,4s,5r,6r)-3,5-dihydroxy-6-(hydroxymethyl)-4-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3,5-dihydroxy-6-(hy Chemical compound O([C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O)O[C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O)O[C@H]1CC[C@]2(C)[C@H]3CC=C4[C@@]([C@@]3(CC[C@H]2[C@@]1(C=O)C)C)(C)CC(O)[C@]1(CCC(CC14)(C)C)C(=O)O[C@H]1[C@@H]([C@@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O[C@H]4[C@@H]([C@@H](O[C@H]5[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O5)O)[C@H](O)[C@@H](CO)O4)O)[C@H](O)[C@@H](CO)O3)O)[C@H](O)[C@@H](CO)O2)O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UZQJVUCHXGYFLQ-AYDHOLPZSA-N 0.000 claims 1
• 235000012000 cholesterol Nutrition 0.000 claims 1
• 239000003085 diluting agent Substances 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• XLXSAKCOAKORKW-UHFFFAOYSA-N gonadorelin Chemical compound C1CCC(C(=O)NCC(N)=O)N1C(=O)C(CCCN=C(N)N)NC(=O)C(CC(C)C)NC(=O)CNC(=O)C(NC(=O)C(CO)NC(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C(CC=1NC=NC=1)NC(=O)C1NC(=O)CC1)CC1=CC=C(O)C=C1 XLXSAKCOAKORKW-UHFFFAOYSA-N 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 238000000034 method Methods 0.000 claims 1
• 239000008194 pharmaceutical composition Substances 0.000 claims 1
• 150000003904 phospholipids Chemical class 0.000 claims 1