JP2012051807A - アリールイミダゾール化合物 - Google Patents

アリールイミダゾール化合物 Download PDF

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Publication number
JP2012051807A
JP2012051807A JP2009043434A JP2009043434A JP2012051807A JP 2012051807 A JP2012051807 A JP 2012051807A JP 2009043434 A JP2009043434 A JP 2009043434A JP 2009043434 A JP2009043434 A JP 2009043434A JP 2012051807 A JP2012051807 A JP 2012051807A
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JP
Japan
Prior art keywords
group
compound
reaction
alkyl
ester
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2009043434A
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English (en)
Japanese (ja)
Inventor
Teiji Kimura
禎治 木村
Eriko Doi
江梨子 土井
Takashi Doko
隆司 土幸
Daisuke Shinmyo
大輔 新明
Koichi Ito
康一 伊藤
Nobuaki Sato
信明 佐藤
Minako Hashizume
みな子 橋爪
Toru Watanabe
亨 渡邉
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eisai R&D Management Co Ltd
Original Assignee
Eisai R&D Management Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai R&D Management Co Ltd filed Critical Eisai R&D Management Co Ltd
Priority to JP2009043434A priority Critical patent/JP2012051807A/ja
Priority to PCT/JP2010/053370 priority patent/WO2010098488A1/fr
Priority to TW099105283A priority patent/TW201035076A/zh
Priority to ARP100100549A priority patent/AR075607A1/es
Publication of JP2012051807A publication Critical patent/JP2012051807A/ja
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Psychiatry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2009043434A 2009-02-26 2009-02-26 アリールイミダゾール化合物 Pending JP2012051807A (ja)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2009043434A JP2012051807A (ja) 2009-02-26 2009-02-26 アリールイミダゾール化合物
PCT/JP2010/053370 WO2010098488A1 (fr) 2009-02-26 2010-02-24 Composé arylimidazole et leur utilisation en tant qu'inhibiteurs de production de la protéine amyloïde bêta
TW099105283A TW201035076A (en) 2009-02-26 2010-02-24 Aryl imidazole compound
ARP100100549A AR075607A1 (es) 2009-02-26 2010-02-25 Compuestos de aril imidazol

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2009043434A JP2012051807A (ja) 2009-02-26 2009-02-26 アリールイミダゾール化合物

Publications (1)

Publication Number Publication Date
JP2012051807A true JP2012051807A (ja) 2012-03-15

Family

ID=42313842

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2009043434A Pending JP2012051807A (ja) 2009-02-26 2009-02-26 アリールイミダゾール化合物

Country Status (4)

Country Link
JP (1) JP2012051807A (fr)
AR (1) AR075607A1 (fr)
TW (1) TW201035076A (fr)
WO (1) WO2010098488A1 (fr)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012532912A (ja) * 2009-07-15 2012-12-20 ジヤンセン・フアーマシユーチカルズ・インコーポレーテツド ガンマセクレターゼモジュレーターとしての置換されたトリアゾールおよびイミダゾール誘導体
US9702490B2 (en) 2013-04-30 2017-07-11 Corning Incorporated Sealing method for silicon carbide parts used at high temperatures
JP2017533237A (ja) * 2014-10-31 2017-11-09 ザ ジェネラル ホスピタル コーポレイション 強力なγ−セクレターゼモジュレータ
JP2019031532A (ja) * 2013-04-11 2019-02-28 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ Ｂａｃｅ１阻害剤
US11718593B2 (en) 2018-05-17 2023-08-08 Southern Research Institute 2,5-aryl-thiazole analogs for the treatment of neurodegenerative diseases
US11905258B2 (en) 2018-02-21 2024-02-20 Southern Research Institute 2-aminoaryl-5-aryloxazole analogs for the treatment of neurodegenerative diseases

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10164139A1 (de) 2001-12-27 2003-07-10 Bayer Ag 2-Heteroarylcarbonsäureamide
KR20110113197A (ko) 2009-02-06 2011-10-14 오르토-맥닐-얀센 파마슈티칼스 인코포레이티드 감마 세크레타제 조절제로서의 신규 치환된 비사이클릭 헤테로사이클릭 화합물
NZ594776A (en) 2009-02-26 2013-05-31 Eisai R&D Man Co Ltd Nitrogen-containing fused heterocyclic compounds and their use as beta amyloid production inhibitors
EP2427453B1 (fr) 2009-05-07 2013-07-17 Janssen Pharmaceuticals, Inc. Dérivés d'indazole et d'aza-indazole substitués en tant que modulateurs de la gamma secrétase
BR112012017442A2 (pt) 2010-01-15 2016-04-19 Janssen Pharmaceuticals Inc derivados de triazol bicíclicos substituídos como moduladores de gamma secretase
US8247436B2 (en) 2010-03-19 2012-08-21 Novartis Ag Pyridine and pyrazine derivative for the treatment of CF
AR081402A1 (es) 2010-05-17 2012-08-29 Envivo Pharmaceuticals Inc Una forma cristalina de clorhidrato de (r)-7-cloro-n-(quinuclidin-3-il) benzo(b)tiofeno-2-carboxamida monohidrato
WO2011163636A2 (fr) 2010-06-24 2011-12-29 The Regents Of The University Of California Composés et leurs utilisations dans la modulation des niveaux de différentes alloformes du peptide amyloïde bêta
MX2013002511A (es) 2010-09-02 2013-07-29 Takeda Pharmaceutical Triazoles fusionados para el tratamiento o profilaxis de daño cognitivo moderado.
AU2012230348A1 (en) 2011-03-24 2013-08-29 Cellzome Limited Novel substituted triazolyl piperazine and triazolyl piperidine derivatives as gamma secretase modulators
CA2830027C (fr) 2011-03-31 2016-04-26 Pfizer Inc. Nouvelles pyridones bicycliques
CN103874702B (zh) 2011-07-15 2015-12-09 杨森制药公司 作为γ分泌酶调节剂的经取代的吲哚衍生物
AU2013259871A1 (en) 2012-05-08 2014-11-20 Forum Pharmaceuticals Inc. Methods of maintaining, treating or improving cognitive function
BR112014028395B1 (pt) 2012-05-16 2022-02-01 Janssen Pharmaceuticals, Inc. Derivados 3,4-di-hidro-2h-pirido[1,2-a]pirazina-1,6-diona substituídos úteis para o tratamento de (inter alia) doença de alzheimer e composição farmacêutica que os compreende
UA110688C2 (uk) 2012-09-21 2016-01-25 Пфайзер Інк. Біциклічні піридинони
AU2013366668B2 (en) 2012-12-20 2017-07-20 Janssen Pharmaceutica Nv Novel tricyclic 3,4-dihydro-2H-pyrido[1,2-alpha]pyrazine -1,6-dione derivatives as gamma secretase modulators
KR102171710B1 (ko) 2013-01-17 2020-10-30 얀센 파마슈티카 엔.브이. 감마 세크레타제 조절 인자로서의 신규 치환 피리도-피페라지논 유도체
WO2014165263A1 (fr) 2013-03-12 2014-10-09 The Regents Of The University Of California, A California Corporation Modulateurs de gamma-secrétase
CN107406445B (zh) 2015-02-03 2019-12-24 辉瑞公司 新颖环丙苯并呋喃基吡啶并吡嗪二酮类
KR102512548B1 (ko) 2017-12-22 2023-03-22 삼성디스플레이 주식회사 유기 전계 발광 소자 및 유기 전계 발광 소자용 함질소 화합물

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1379525B1 (fr) * 2001-02-21 2007-10-10 Nps Pharmaceuticals, Inc. Composes heteropolycycliques et leur utilisations en tant qu'antagonistes des recepteurs metabotropiques du glutamate
BRPI0410348A (pt) * 2003-05-14 2006-05-30 Torreypines Therapeutics Inc compostos e usos dos mesmos na modulação de amilóide-beta
DE102004061750A1 (de) 2004-12-22 2006-07-06 Bayer Healthcare Ag Heteroaryl-substituierte Pyrazoline
CA2643796A1 (fr) * 2006-03-09 2007-09-13 Eisai R & D Management Co., Ltd. Derive polycyclique de cinnamide
JP2009184924A (ja) 2006-05-31 2009-08-20 Eisai R & D Management Co Ltd 生物学的試薬用化合物
WO2008156580A1 (fr) * 2007-06-13 2008-12-24 Merck & Co., Inc. Dérivés du triazole destinés au traitement de la maladie d'alzheimer et d'états associés

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012532912A (ja) * 2009-07-15 2012-12-20 ジヤンセン・フアーマシユーチカルズ・インコーポレーテツド ガンマセクレターゼモジュレーターとしての置換されたトリアゾールおよびイミダゾール誘導体
JP2015129147A (ja) * 2009-07-15 2015-07-16 ジヤンセン・フアーマシユーチカルズ・インコーポレーテツド ガンマセクレターゼモジュレーターとしての置換されたトリアゾールおよびイミダゾール誘導体
JP2019031532A (ja) * 2013-04-11 2019-02-28 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ Ｂａｃｅ１阻害剤
US9702490B2 (en) 2013-04-30 2017-07-11 Corning Incorporated Sealing method for silicon carbide parts used at high temperatures
JP2017533237A (ja) * 2014-10-31 2017-11-09 ザ ジェネラル ホスピタル コーポレイション 強力なγ−セクレターゼモジュレータ
US11117884B2 (en) 2014-10-31 2021-09-14 The General Hospital Corporation Potent gamma-secretase modulators
US11905258B2 (en) 2018-02-21 2024-02-20 Southern Research Institute 2-aminoaryl-5-aryloxazole analogs for the treatment of neurodegenerative diseases
US11718593B2 (en) 2018-05-17 2023-08-08 Southern Research Institute 2,5-aryl-thiazole analogs for the treatment of neurodegenerative diseases

Also Published As

Publication number Publication date
TW201035076A (en) 2010-10-01
WO2010098488A1 (fr) 2010-09-02
AR075607A1 (es) 2011-04-20

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