TW201035076A - Aryl imidazole compound - Google Patents

Aryl imidazole compound Download PDF

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Publication number
TW201035076A
TW201035076A TW099105283A TW99105283A TW201035076A TW 201035076 A TW201035076 A TW 201035076A TW 099105283 A TW099105283 A TW 099105283A TW 99105283 A TW99105283 A TW 99105283A TW 201035076 A TW201035076 A TW 201035076A
Authority
TW
Taiwan
Prior art keywords
group
compound
alkyl
reaction
formula
Prior art date
Application number
TW099105283A
Other languages
English (en)
Chinese (zh)
Inventor
Teiji Kimura
Eriko Doi
Takashi Doko
Daisuke Shinmyo
Koichi Ito
Nobuaki Sato
Minako Hashizume
Toru Watanabe
Original Assignee
Eisai R&D Man Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai R&D Man Co Ltd filed Critical Eisai R&D Man Co Ltd
Publication of TW201035076A publication Critical patent/TW201035076A/zh

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Psychiatry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
TW099105283A 2009-02-26 2010-02-24 Aryl imidazole compound TW201035076A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15577809P 2009-02-26 2009-02-26
JP2009043434A JP2012051807A (ja) 2009-02-26 2009-02-26 アリールイミダゾール化合物

Publications (1)

Publication Number Publication Date
TW201035076A true TW201035076A (en) 2010-10-01

Family

ID=42313842

Family Applications (1)

Application Number Title Priority Date Filing Date
TW099105283A TW201035076A (en) 2009-02-26 2010-02-24 Aryl imidazole compound

Country Status (4)

Country Link
JP (1) JP2012051807A (fr)
AR (1) AR075607A1 (fr)
TW (1) TW201035076A (fr)
WO (1) WO2010098488A1 (fr)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10164139A1 (de) 2001-12-27 2003-07-10 Bayer Ag 2-Heteroarylcarbonsäureamide
KR20110113197A (ko) 2009-02-06 2011-10-14 오르토-맥닐-얀센 파마슈티칼스 인코포레이티드 감마 세크레타제 조절제로서의 신규 치환된 비사이클릭 헤테로사이클릭 화합물
NZ594776A (en) 2009-02-26 2013-05-31 Eisai R&D Man Co Ltd Nitrogen-containing fused heterocyclic compounds and their use as beta amyloid production inhibitors
EP2427453B1 (fr) 2009-05-07 2013-07-17 Janssen Pharmaceuticals, Inc. Dérivés d'indazole et d'aza-indazole substitués en tant que modulateurs de la gamma secrétase
CN102482227A (zh) * 2009-07-15 2012-05-30 杨森制药公司 作为γ分泌酶调节剂的取代的三唑和咪唑衍生物
BR112012017442A2 (pt) 2010-01-15 2016-04-19 Janssen Pharmaceuticals Inc derivados de triazol bicíclicos substituídos como moduladores de gamma secretase
US8247436B2 (en) 2010-03-19 2012-08-21 Novartis Ag Pyridine and pyrazine derivative for the treatment of CF
AR081402A1 (es) 2010-05-17 2012-08-29 Envivo Pharmaceuticals Inc Una forma cristalina de clorhidrato de (r)-7-cloro-n-(quinuclidin-3-il) benzo(b)tiofeno-2-carboxamida monohidrato
WO2011163636A2 (fr) 2010-06-24 2011-12-29 The Regents Of The University Of California Composés et leurs utilisations dans la modulation des niveaux de différentes alloformes du peptide amyloïde bêta
MX2013002511A (es) 2010-09-02 2013-07-29 Takeda Pharmaceutical Triazoles fusionados para el tratamiento o profilaxis de daño cognitivo moderado.
AU2012230348A1 (en) 2011-03-24 2013-08-29 Cellzome Limited Novel substituted triazolyl piperazine and triazolyl piperidine derivatives as gamma secretase modulators
CA2830027C (fr) 2011-03-31 2016-04-26 Pfizer Inc. Nouvelles pyridones bicycliques
CN103874702B (zh) 2011-07-15 2015-12-09 杨森制药公司 作为γ分泌酶调节剂的经取代的吲哚衍生物
AU2013259871A1 (en) 2012-05-08 2014-11-20 Forum Pharmaceuticals Inc. Methods of maintaining, treating or improving cognitive function
BR112014028395B1 (pt) 2012-05-16 2022-02-01 Janssen Pharmaceuticals, Inc. Derivados 3,4-di-hidro-2h-pirido[1,2-a]pirazina-1,6-diona substituídos úteis para o tratamento de (inter alia) doença de alzheimer e composição farmacêutica que os compreende
UA110688C2 (uk) 2012-09-21 2016-01-25 Пфайзер Інк. Біциклічні піридинони
AU2013366668B2 (en) 2012-12-20 2017-07-20 Janssen Pharmaceutica Nv Novel tricyclic 3,4-dihydro-2H-pyrido[1,2-alpha]pyrazine -1,6-dione derivatives as gamma secretase modulators
KR102171710B1 (ko) 2013-01-17 2020-10-30 얀센 파마슈티카 엔.브이. 감마 세크레타제 조절 인자로서의 신규 치환 피리도-피페라지논 유도체
WO2014165263A1 (fr) 2013-03-12 2014-10-09 The Regents Of The University Of California, A California Corporation Modulateurs de gamma-secrétase
MX2015014083A (es) * 2013-04-11 2016-07-26 Hoffmann La Roche Inhibidores de enzima de escision de proteina precursora beta-amiloide (app) en el sitio beta 1 (bace1).
US9702490B2 (en) 2013-04-30 2017-07-11 Corning Incorporated Sealing method for silicon carbide parts used at high temperatures
BR112017009010A2 (pt) 2014-10-31 2017-12-26 Massachusetts Gen Hospital moduladores potentes de gama-secretase
CN107406445B (zh) 2015-02-03 2019-12-24 辉瑞公司 新颖环丙苯并呋喃基吡啶并吡嗪二酮类
KR102512548B1 (ko) 2017-12-22 2023-03-22 삼성디스플레이 주식회사 유기 전계 발광 소자 및 유기 전계 발광 소자용 함질소 화합물
US11472781B2 (en) 2018-02-21 2022-10-18 Southern Research Institute 2-aminoaryl-5-aryloxazole analogs for the treatment of neurodegenerative diseases
WO2019222497A1 (fr) 2018-05-17 2019-11-21 Southern Research Institute Analogues du 2,5-aryl-thiazole pour le traitement de maladies neurodégénératives

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1379525B1 (fr) * 2001-02-21 2007-10-10 Nps Pharmaceuticals, Inc. Composes heteropolycycliques et leur utilisations en tant qu'antagonistes des recepteurs metabotropiques du glutamate
BRPI0410348A (pt) * 2003-05-14 2006-05-30 Torreypines Therapeutics Inc compostos e usos dos mesmos na modulação de amilóide-beta
DE102004061750A1 (de) 2004-12-22 2006-07-06 Bayer Healthcare Ag Heteroaryl-substituierte Pyrazoline
CA2643796A1 (fr) * 2006-03-09 2007-09-13 Eisai R & D Management Co., Ltd. Derive polycyclique de cinnamide
JP2009184924A (ja) 2006-05-31 2009-08-20 Eisai R & D Management Co Ltd 生物学的試薬用化合物
WO2008156580A1 (fr) * 2007-06-13 2008-12-24 Merck & Co., Inc. Dérivés du triazole destinés au traitement de la maladie d'alzheimer et d'états associés

Also Published As

Publication number Publication date
WO2010098488A1 (fr) 2010-09-02
AR075607A1 (es) 2011-04-20
JP2012051807A (ja) 2012-03-15

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