TW201035076A - Aryl imidazole compound - Google Patents

Aryl imidazole compound Download PDF

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Publication number
TW201035076A
TW201035076A TW099105283A TW99105283A TW201035076A TW 201035076 A TW201035076 A TW 201035076A TW 099105283 A TW099105283 A TW 099105283A TW 99105283 A TW99105283 A TW 99105283A TW 201035076 A TW201035076 A TW 201035076A
Authority
TW
Taiwan
Prior art keywords
group
compound
alkyl
reaction
formula
Prior art date
Application number
TW099105283A
Other languages
English (en)
Chinese (zh)
Inventor
Teiji Kimura
Eriko Doi
Takashi Doko
Daisuke Shinmyo
Koichi Ito
Nobuaki Sato
Minako Hashizume
Toru Watanabe
Original Assignee
Eisai R&D Man Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai R&D Man Co Ltd filed Critical Eisai R&D Man Co Ltd
Publication of TW201035076A publication Critical patent/TW201035076A/zh

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Psychiatry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
TW099105283A 2009-02-26 2010-02-24 Aryl imidazole compound TW201035076A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15577809P 2009-02-26 2009-02-26
JP2009043434A JP2012051807A (ja) 2009-02-26 2009-02-26 アリールイミダゾール化合物

Publications (1)

Publication Number Publication Date
TW201035076A true TW201035076A (en) 2010-10-01

Family

ID=42313842

Family Applications (1)

Application Number Title Priority Date Filing Date
TW099105283A TW201035076A (en) 2009-02-26 2010-02-24 Aryl imidazole compound

Country Status (4)

Country Link
JP (1) JP2012051807A (fr)
AR (1) AR075607A1 (fr)
TW (1) TW201035076A (fr)
WO (1) WO2010098488A1 (fr)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10164139A1 (de) 2001-12-27 2003-07-10 Bayer Ag 2-Heteroarylcarbonsäureamide
MX2011008335A (es) 2009-02-06 2011-09-06 Ortho Mcneil Janssen Pharm Novedosos compuestos heterociclicos biciclicos sustituidos como moduladores de la gamma secretasa.
TW201035101A (en) 2009-02-26 2010-10-01 Eisai R&D Man Co Ltd Nitrogen-containing fused heterocyclic compound
JP5559309B2 (ja) 2009-05-07 2014-07-23 ジヤンセン・フアーマシユーチカルズ・インコーポレーテツド γ分泌酵素調節物質としての新規置換インダゾールおよびアザインダゾール誘導体
SG177644A1 (en) 2009-07-15 2012-03-29 Janssen Pharmaceuticals Inc Substituted triazole and imidazole derivatives as gamma secretase modulators
US9079886B2 (en) 2010-01-15 2015-07-14 Janssen Pharmaceuticals, Inc. Substituted triazole derivatives as gamma secretase modulators
US8247436B2 (en) 2010-03-19 2012-08-21 Novartis Ag Pyridine and pyrazine derivative for the treatment of CF
CN105837566B (zh) 2010-05-17 2018-02-06 富瑞姆制药公司 (R)‑7‑氯‑N‑(奎宁环‑3‑基)苯并[b]噻吩‑2‑甲酰胺盐酸盐单水合物的晶型
WO2011163636A2 (fr) 2010-06-24 2011-12-29 The Regents Of The University Of California Composés et leurs utilisations dans la modulation des niveaux de différentes alloformes du peptide amyloïde bêta
CA2809779A1 (fr) 2010-09-02 2012-03-08 Takeda Pharmaceutical Company Limited Triazoles fusionnes pour le traitement ou la prophylaxie du trouble cognitif leger
US8987276B2 (en) 2011-03-24 2015-03-24 Janssen Pharmaceuticals, Inc. Substituted triazolyl piperazine and triazolyl piperidine derivatives as gamma secretase modulators
WO2012131539A1 (fr) 2011-03-31 2012-10-04 Pfizer Inc. Nouvelles pyridones bicycliques
TWI567079B (zh) 2011-07-15 2017-01-21 健生醫藥公司 作為伽瑪分泌酶調節劑之新穎的經取代的吲哚衍生物
EP2846796A4 (fr) 2012-05-08 2015-10-21 Forum Pharmaceuticals Inc Procédés de maintien, de traitement ou d'amélioration de la fonction cognitive
BR112014028395B1 (pt) 2012-05-16 2022-02-01 Janssen Pharmaceuticals, Inc. Derivados 3,4-di-hidro-2h-pirido[1,2-a]pirazina-1,6-diona substituídos úteis para o tratamento de (inter alia) doença de alzheimer e composição farmacêutica que os compreende
UA110688C2 (uk) 2012-09-21 2016-01-25 Пфайзер Інк. Біциклічні піридинони
CN104918938B (zh) 2012-12-20 2017-08-15 詹森药业有限公司 新颖的作为γ分泌酶调节剂的三环3，4‑二氢‑2H‑吡啶并[1，2‑a]吡嗪‑1，6‑二酮衍生物
WO2014111457A1 (fr) 2013-01-17 2014-07-24 Janssen Pharmaceutica Nv Dérivés substitués de pyrido-pipérazinone d'un nouveau type en tant que modulateurs de la gamma-sécrétase
EP2968296B1 (fr) 2013-03-12 2020-09-02 The Regents of the University of California Modulateurs de gamma-secrétase
MA38556A1 (fr) 2013-04-11 2017-09-29 Hoffmann La Roche Inhibiteurs de bace1
US9702490B2 (en) 2013-04-30 2017-07-11 Corning Incorporated Sealing method for silicon carbide parts used at high temperatures
AU2015338946B2 (en) * 2014-10-31 2020-06-11 The General Hospital Corporation Potent gamma-secretase modulators
EP3253755B1 (fr) 2015-02-03 2020-08-26 Pfizer Inc Nouveaux pyridopyrazinediones cyclopropabenzofuranyl
KR102512548B1 (ko) 2017-12-22 2023-03-22 삼성디스플레이 주식회사 유기 전계 발광 소자 및 유기 전계 발광 소자용 함질소 화합물
US11472781B2 (en) 2018-02-21 2022-10-18 Southern Research Institute 2-aminoaryl-5-aryloxazole analogs for the treatment of neurodegenerative diseases
WO2019222497A1 (fr) 2018-05-17 2019-11-21 Southern Research Institute Analogues du 2,5-aryl-thiazole pour le traitement de maladies neurodégénératives

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL369598A1 (en) * 2001-02-21 2005-05-02 Nps Pharmaceuticals, Inc. Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
JP4847868B2 (ja) * 2003-05-14 2011-12-28 ニューロジェネティック ファーマシューティカルズ、 インコーポレイテッド 化合物、及び、アミロイドベータの調節におけるその使用
DE102004061750A1 (de) 2004-12-22 2006-07-06 Bayer Healthcare Ag Heteroaryl-substituierte Pyrazoline
WO2007102580A1 (fr) * 2006-03-09 2007-09-13 Eisai R & D Management Co., Ltd. Dérivé polycyclique de cinnamide
JP2009184924A (ja) 2006-05-31 2009-08-20 Eisai R & D Management Co Ltd 生物学的試薬用化合物
WO2008156580A1 (fr) * 2007-06-13 2008-12-24 Merck & Co., Inc. Dérivés du triazole destinés au traitement de la maladie d'alzheimer et d'états associés

Also Published As

Publication number Publication date
AR075607A1 (es) 2011-04-20
WO2010098488A1 (fr) 2010-09-02
JP2012051807A (ja) 2012-03-15

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