JP2012017342A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2012017342A5 JP2012017342A5 JP2011228229A JP2011228229A JP2012017342A5 JP 2012017342 A5 JP2012017342 A5 JP 2012017342A5 JP 2011228229 A JP2011228229 A JP 2011228229A JP 2011228229 A JP2011228229 A JP 2011228229A JP 2012017342 A5 JP2012017342 A5 JP 2012017342A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- composition according
- capsular saccharide
- formula
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 48
- 150000001720 carbohydrates Chemical class 0.000 claims 15
- 125000000217 alkyl group Chemical group 0.000 claims 9
- 125000000753 cycloalkyl group Chemical group 0.000 claims 8
- 201000010099 disease Diseases 0.000 claims 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 5
- 125000003118 aryl group Chemical group 0.000 claims 4
- 239000003937 drug carrier Substances 0.000 claims 4
- 231100000699 Bacterial toxin Toxicity 0.000 claims 3
- 241000588650 Neisseria meningitidis Species 0.000 claims 3
- 239000000688 bacterial toxin Substances 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 241000894006 Bacteria Species 0.000 claims 2
- 206010027202 Meningitis bacterial Diseases 0.000 claims 2
- 125000002947 alkylene group Chemical group 0.000 claims 2
- 230000005875 antibody response Effects 0.000 claims 2
- 201000009904 bacterial meningitis Diseases 0.000 claims 2
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 108090000623 proteins and genes Chemical group 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 125000006539 C12 alkyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 102000016607 Diphtheria Toxin Human genes 0.000 claims 1
- 108010053187 Diphtheria Toxin Proteins 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 241000921898 Neisseria meningitidis serogroup A Species 0.000 claims 1
- 125000003172 aldehyde group Chemical group 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 claims 1
- 239000012646 vaccine adjuvant Substances 0.000 claims 1
- 229940124931 vaccine adjuvant Drugs 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0220198.6 | 2002-08-30 | ||
| GBGB0220198.6A GB0220198D0 (en) | 2002-08-30 | 2002-08-30 | Modified saccharides,conjugates thereof and their manufacture |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004532625A Division JP5268222B2 (ja) | 2002-08-30 | 2003-09-01 | 改変された糖類、それらの結合体、およびそられの製造 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012017342A JP2012017342A (ja) | 2012-01-26 |
| JP2012017342A5 true JP2012017342A5 (OSRAM) | 2013-05-30 |
| JP5314745B2 JP5314745B2 (ja) | 2013-10-16 |
Family
ID=9943241
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004532625A Expired - Fee Related JP5268222B2 (ja) | 2002-08-30 | 2003-09-01 | 改変された糖類、それらの結合体、およびそられの製造 |
| JP2011228229A Expired - Fee Related JP5314745B2 (ja) | 2002-08-30 | 2011-10-17 | 改変された糖類、それらの結合体、およびそられの製造 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004532625A Expired - Fee Related JP5268222B2 (ja) | 2002-08-30 | 2003-09-01 | 改変された糖類、それらの結合体、およびそられの製造 |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US8895516B2 (OSRAM) |
| EP (1) | EP1534342B1 (OSRAM) |
| JP (2) | JP5268222B2 (OSRAM) |
| CN (2) | CN101863998B (OSRAM) |
| AT (1) | ATE319481T1 (OSRAM) |
| AU (1) | AU2003260921B2 (OSRAM) |
| BR (1) | BR0314089A (OSRAM) |
| CA (1) | CA2497167C (OSRAM) |
| DE (1) | DE60303961T2 (OSRAM) |
| DK (1) | DK1534342T3 (OSRAM) |
| ES (1) | ES2260682T3 (OSRAM) |
| GB (1) | GB0220198D0 (OSRAM) |
| MX (1) | MXPA05002315A (OSRAM) |
| NZ (1) | NZ538703A (OSRAM) |
| RU (2) | RU2005108992A (OSRAM) |
| WO (1) | WO2004019992A1 (OSRAM) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0115176D0 (en) | 2001-06-20 | 2001-08-15 | Chiron Spa | Capular polysaccharide solubilisation and combination vaccines |
| MX339524B (es) | 2001-10-11 | 2016-05-30 | Wyeth Corp | Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica. |
| GB0220198D0 (en) * | 2002-08-30 | 2002-10-09 | Chiron Spa | Modified saccharides,conjugates thereof and their manufacture |
| CN101926988B (zh) * | 2003-01-30 | 2014-06-04 | 诺华疫苗和诊断有限公司 | 抗多种脑膜炎球菌血清组的可注射性疫苗 |
| US20070258986A1 (en) * | 2003-11-19 | 2007-11-08 | Govt of the US as represented by the secretary, | Targeted Delivery System for Bioactive Agents |
| ES2533248T3 (es) * | 2005-05-06 | 2015-04-08 | Novartis Ag | Inmunógenos para vacunas contra Meningitidis A |
| PT1973564T (pt) | 2005-12-22 | 2017-01-24 | Glaxosmithkline Biologicals Sa | Vacina compreendendo conjugados polissacarídicos capsulares de streptococcus pneumoniae |
| AR064642A1 (es) | 2006-12-22 | 2009-04-15 | Wyeth Corp | Polinucleotido vector que lo comprende celula recombinante que comprende el vector polipeptido , anticuerpo , composicion que comprende el polinucleotido , vector , celula recombinante polipeptido o anticuerpo , uso de la composicion y metodo para preparar la composicion misma y preparar una composi |
| GB0700562D0 (en) * | 2007-01-11 | 2007-02-21 | Novartis Vaccines & Diagnostic | Modified Saccharides |
| AU2014200640B2 (en) * | 2007-01-11 | 2016-06-16 | Glaxosmithkline Biologicals Sa | Modified saccharides |
| US9475864B2 (en) | 2008-09-05 | 2016-10-25 | University Of Massachusetts | Methods, compositions and vaccines relating to Neisseria meningitidis antibodies |
| CN102481352A (zh) | 2009-06-22 | 2012-05-30 | 惠氏有限责任公司 | 金黄色葡萄球菌抗原的免疫原性组合物 |
| SG177310A1 (en) | 2009-06-22 | 2012-02-28 | Wyeth Llc | Compositions and methods for preparing staphylococcus aureus serotype 5 and 8 capsular polysaccharide conjugate immunogenic compositions |
| BR112012010223A2 (pt) * | 2009-10-30 | 2016-12-06 | Novartis Ag | purificação de staphylococcus aureus tipo 5 e tipo 8 sacarídeos capsulares |
| MX350142B (es) | 2010-08-23 | 2017-08-28 | Wyeth Llc * | Formulaciones estables de antigenos rlp2086 de neisseria meningitidis. |
| SG187912A1 (en) | 2010-09-10 | 2013-04-30 | Wyeth Llc | Non-lipidated variants of neisseria meningitidis orf2086 antigens |
| KR101763625B1 (ko) | 2012-03-09 | 2017-08-01 | 화이자 인코포레이티드 | 수막염균 조성물 및 이의 사용 방법 |
| SA115360586B1 (ar) | 2012-03-09 | 2017-04-12 | فايزر انك | تركيبات لعلاج الالتهاب السحائي البكتيري وطرق لتحضيرها |
| CN102861326A (zh) * | 2012-09-19 | 2013-01-09 | 天津康希诺生物技术有限公司 | 流脑多糖-蛋白质缀合疫苗及制备方法 |
| WO2014136064A2 (en) | 2013-03-08 | 2014-09-12 | Pfizer Inc. | Immunogenic fusion polypeptides |
| CA2923129C (en) | 2013-09-08 | 2020-06-09 | Pfizer Inc. | Neisseria meningitidis compositions and methods thereof |
| ES2701169T3 (es) * | 2014-02-14 | 2019-02-21 | Pfizer | Conjugados glucoproteicos inmunogénicos |
| CN107249626A (zh) | 2015-02-19 | 2017-10-13 | 辉瑞大药厂 | 脑膜炎奈瑟球菌组合物及其方法 |
| KR102428253B1 (ko) * | 2016-03-15 | 2022-08-02 | 엠에스디 웰컴 트러스트 힐레맨 랩스 피브이티. 리미티드 | 신규한 다당류-단백질 접합체 및 이의 제조방법 |
| PL3506935T3 (pl) | 2016-09-02 | 2024-06-10 | Sanofi Pasteur, Inc. | Szczepionka przeciwko Neisseria meningitidis |
| PE20191107A1 (es) | 2017-01-31 | 2019-08-26 | Pfizer | Composiciones de neisseria meningitidis y metodos respectivos |
| EP3589314A4 (en) * | 2017-02-24 | 2021-04-21 | Merck Sharp & Dohme Corp. | INCREASED IMMUNOGENICITY OF STREPTOCOCCUS PNEUMONIAE POLYSACCHARIDE PROTEIN CONJUGATES |
| CN117018172A (zh) | 2017-09-07 | 2023-11-10 | 默沙东有限责任公司 | 肺炎球菌多糖及其在免疫原性多糖-载体蛋白缀合物中的用途 |
| BR112020004471A8 (pt) | 2017-09-07 | 2022-11-01 | Merck Sharp & Dohme | Polissacarídeos pneumocócicos e uso dos mesmos em conjugados imunogênicos polissacarídeo-proteína carreadora |
| US20220152183A1 (en) * | 2019-03-08 | 2022-05-19 | Glaxosmithkline Biologicals Sa | Carbocyclic derivatives and conjugated derivatives thereof, and their use in vaccines |
| CA3155669A1 (en) | 2019-09-27 | 2021-04-01 | Pfizer Inc. | Neisseria meningitidis compositions and methods thereof |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2427341A1 (fr) * | 1978-06-02 | 1979-12-28 | Delalande Sa | Nouveaux derives aminoglycosidiques hemisynthetiques, leur procede de preparation et leur application en therapeutique |
| EP0447171B1 (en) * | 1990-03-15 | 1994-11-02 | Tanabe Seiyaku Co., Ltd. | Polysulfate of cyclodextrin derivative and process for preparing the same |
| AU7948494A (en) * | 1993-12-28 | 1995-07-17 | Pfizer Inc. | Steroidal glycosides |
| WO1995029927A2 (en) * | 1994-05-02 | 1995-11-09 | Biomira, Inc. | Process for preparation of glycosides of tumor-associated carbohydrate antigens |
| CA2246760C (en) * | 1997-01-21 | 2012-01-10 | Pasteur Merieux Serums & Vaccins | Polysaccharide-peptide-conjugates |
| US5929049A (en) * | 1997-08-08 | 1999-07-27 | Dade Behring Marburg Gmbh | Polysaccharide conjugates of biomolecules |
| CA2266718C (en) * | 1997-08-08 | 2007-05-22 | Behringwerke Aktiengesellschaft | Polysaccharide conjugates of biomolecules |
| US5952454A (en) * | 1997-12-12 | 1999-09-14 | The United States Of America As Represented By The Department Of Health And Human Services | Linking compounds useful for coupling carbohydrates to amine-containing carriers |
| NZ535968A (en) * | 2002-03-26 | 2006-08-31 | Chiron S | Modified saccharides having improved stability in water |
| GB0220198D0 (en) * | 2002-08-30 | 2002-10-09 | Chiron Spa | Modified saccharides,conjugates thereof and their manufacture |
-
2002
- 2002-08-30 GB GBGB0220198.6A patent/GB0220198D0/en not_active Ceased
-
2003
- 2003-09-01 BR BR0314089-0A patent/BR0314089A/pt not_active Application Discontinuation
- 2003-09-01 WO PCT/IB2003/004194 patent/WO2004019992A1/en not_active Ceased
- 2003-09-01 CN CN2010101825535A patent/CN101863998B/zh not_active Expired - Fee Related
- 2003-09-01 NZ NZ538703A patent/NZ538703A/en not_active IP Right Cessation
- 2003-09-01 RU RU2005108992/04A patent/RU2005108992A/ru unknown
- 2003-09-01 MX MXPA05002315A patent/MXPA05002315A/es active IP Right Grant
- 2003-09-01 EP EP03791149A patent/EP1534342B1/en not_active Expired - Lifetime
- 2003-09-01 CN CN038237245A patent/CN1688343B/zh not_active Expired - Fee Related
- 2003-09-01 CA CA2497167A patent/CA2497167C/en not_active Expired - Fee Related
- 2003-09-01 AT AT03791149T patent/ATE319481T1/de active
- 2003-09-01 DE DE60303961T patent/DE60303961T2/de not_active Expired - Lifetime
- 2003-09-01 JP JP2004532625A patent/JP5268222B2/ja not_active Expired - Fee Related
- 2003-09-01 ES ES03791149T patent/ES2260682T3/es not_active Expired - Lifetime
- 2003-09-01 AU AU2003260921A patent/AU2003260921B2/en not_active Ceased
- 2003-09-01 US US10/526,124 patent/US8895516B2/en not_active Expired - Fee Related
- 2003-09-01 DK DK03791149T patent/DK1534342T3/da active
-
2008
- 2008-12-19 RU RU2008150551/13A patent/RU2531909C2/ru not_active IP Right Cessation
-
2011
- 2011-10-17 JP JP2011228229A patent/JP5314745B2/ja not_active Expired - Fee Related
-
2014
- 2014-10-23 US US14/521,761 patent/US20150166593A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2012017342A5 (OSRAM) | ||
| AU2008227128B2 (en) | Conjugates of synthetic TLR agonists and uses therefor | |
| JP2013136639A5 (OSRAM) | ||
| JP2010132925A5 (OSRAM) | ||
| JP2010515718A5 (OSRAM) | ||
| TWI633112B (zh) | 醣類－醣脂類結合性疫苗 | |
| JP2022068303A (ja) | 多価肺炎球菌多糖体－タンパク質複合体組成物 | |
| JP2014218516A5 (OSRAM) | ||
| EA023725B1 (ru) | Соединения (липопептиды на основе цистеина) и композиции в качестве агонистов tlr2, применяемые для лечения инфекционных, воспалительных, респираторных и других заболеваний | |
| WO2009095226A3 (en) | NUCLEIC ACIDS COMPRISING FORMULA (NuGlXmGnNv)a AND DERIVATIVES THEREOF AS AN IMMUNOSTIMULATING AGENTS /ADJUVANTS | |
| JP2007507487A5 (OSRAM) | ||
| JP2008526939A5 (OSRAM) | ||
| JP2011528710A5 (OSRAM) | ||
| RU2007145219A (ru) | Иммуногены для вакцин против менингита а | |
| JP2017532321A (ja) | 肺炎連鎖球菌血清型８に対するワクチン | |
| CN110302375A (zh) | 一种糖缀合物及其用途 | |
| Mat Rani et al. | Outer membrane vesicles as biomimetic vaccine carriers against infections and cancers | |
| JP6630440B2 (ja) | ストレプトコッカス ニューモニアエ（Ｓｔｒｅｐｔｏｃｏｃｃｕｓ ｐｎｅｕｍｏｎｉａｅ）血清型２に対する合成ワクチン | |
| WO2012145626A1 (en) | Synthetic oligosaccharides for staphylococcus vaccine | |
| JP5249041B2 (ja) | ビスアシルオキシプロピルシステイン複合体に基づく新規なアジュバント及び誘導体並びに医薬組成物におけるその使用 | |
| WO2013178236A1 (en) | Carbohydrate-glycolipid conjugate vaccines | |
| JP2008231343A (ja) | ワクチン剤 | |
| JP2011527340A5 (OSRAM) | ||
| JP2007518732A5 (OSRAM) | ||
| WO2024238735A1 (en) | Compounds and formulations useful as vaccine adjuvants |