DE60303961T2 - Modifizierte saccharide, deren konjugate sowie deren herstellung - Google Patents
Modifizierte saccharide, deren konjugate sowie deren herstellung Download PDFInfo
- Publication number
- DE60303961T2 DE60303961T2 DE60303961T DE60303961T DE60303961T2 DE 60303961 T2 DE60303961 T2 DE 60303961T2 DE 60303961 T DE60303961 T DE 60303961T DE 60303961 T DE60303961 T DE 60303961T DE 60303961 T2 DE60303961 T2 DE 60303961T2
- Authority
- DE
- Germany
- Prior art keywords
- saccharide
- formula
- alkyl
- modified
- protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 125000005647 linker group Chemical group 0.000 abstract 4
- 150000001720 carbohydrates Chemical class 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 241000921898 Neisseria meningitidis serogroup A Species 0.000 abstract 1
- 125000003172 aldehyde group Chemical group 0.000 abstract 1
- 230000005847 immunogenicity Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/12—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by acids having the group -X-C(=X)-X-, or halides thereof, in which each X means nitrogen, oxygen, sulfur, selenium or tellurium, e.g. carbonic acid, carbamic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Saccharide Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0220198 | 2002-08-30 | ||
| GBGB0220198.6A GB0220198D0 (en) | 2002-08-30 | 2002-08-30 | Modified saccharides,conjugates thereof and their manufacture |
| PCT/IB2003/004194 WO2004019992A1 (en) | 2002-08-30 | 2003-09-01 | Modified saccharides, conjugates thereof, and their manufacture |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60303961D1 DE60303961D1 (de) | 2006-05-04 |
| DE60303961T2 true DE60303961T2 (de) | 2006-10-26 |
Family
ID=9943241
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60303961T Expired - Lifetime DE60303961T2 (de) | 2002-08-30 | 2003-09-01 | Modifizierte saccharide, deren konjugate sowie deren herstellung |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US8895516B2 (OSRAM) |
| EP (1) | EP1534342B1 (OSRAM) |
| JP (2) | JP5268222B2 (OSRAM) |
| CN (2) | CN101863998B (OSRAM) |
| AT (1) | ATE319481T1 (OSRAM) |
| AU (1) | AU2003260921B2 (OSRAM) |
| BR (1) | BR0314089A (OSRAM) |
| CA (1) | CA2497167C (OSRAM) |
| DE (1) | DE60303961T2 (OSRAM) |
| DK (1) | DK1534342T3 (OSRAM) |
| ES (1) | ES2260682T3 (OSRAM) |
| GB (1) | GB0220198D0 (OSRAM) |
| MX (1) | MXPA05002315A (OSRAM) |
| NZ (1) | NZ538703A (OSRAM) |
| RU (2) | RU2005108992A (OSRAM) |
| WO (1) | WO2004019992A1 (OSRAM) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0115176D0 (en) | 2001-06-20 | 2001-08-15 | Chiron Spa | Capular polysaccharide solubilisation and combination vaccines |
| MX339524B (es) | 2001-10-11 | 2016-05-30 | Wyeth Corp | Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica. |
| GB0220198D0 (en) * | 2002-08-30 | 2002-10-09 | Chiron Spa | Modified saccharides,conjugates thereof and their manufacture |
| JP4827726B2 (ja) * | 2003-01-30 | 2011-11-30 | ノバルティス ヴァクシンズ アンド ダイアグノスティクス エスアールエル | 複数の髄膜炎菌血清群に対する注射可能ワクチン |
| US20070258986A1 (en) * | 2003-11-19 | 2007-11-08 | Govt of the US as represented by the secretary, | Targeted Delivery System for Bioactive Agents |
| US8062641B2 (en) * | 2005-05-06 | 2011-11-22 | Novartis Ag | Immunogens for meningitidis-A vaccines |
| DK2384765T3 (en) | 2005-12-22 | 2017-01-09 | Glaxosmithkline Biologicals Sa | Vaccine against Streptococcus pneumoniae. |
| AR064642A1 (es) | 2006-12-22 | 2009-04-15 | Wyeth Corp | Polinucleotido vector que lo comprende celula recombinante que comprende el vector polipeptido , anticuerpo , composicion que comprende el polinucleotido , vector , celula recombinante polipeptido o anticuerpo , uso de la composicion y metodo para preparar la composicion misma y preparar una composi |
| GB0700562D0 (en) * | 2007-01-11 | 2007-02-21 | Novartis Vaccines & Diagnostic | Modified Saccharides |
| AU2014200640B2 (en) * | 2007-01-11 | 2016-06-16 | Glaxosmithkline Biologicals Sa | Modified saccharides |
| US9475864B2 (en) | 2008-09-05 | 2016-10-25 | University Of Massachusetts | Methods, compositions and vaccines relating to Neisseria meningitidis antibodies |
| SI2445522T1 (sl) | 2009-06-22 | 2017-10-30 | Wyeth Llc | Imunogeni sestavki antigenov Staphylococcusa aureusa |
| WO2011041003A2 (en) * | 2009-06-22 | 2011-04-07 | Wyeth Llc | Compositions and methods for preparing staphylococcus aureus serotype 5 and 8 capsular polysaccharide conjugate immunogenic compositions |
| BR112012010223A2 (pt) * | 2009-10-30 | 2016-12-06 | Novartis Ag | purificação de staphylococcus aureus tipo 5 e tipo 8 sacarídeos capsulares |
| DK2608805T4 (da) | 2010-08-23 | 2025-06-30 | Wyeth Llc | STABILE FORMULERINGER AF NEISSERIA MENINGITIDIS rLP2086 ANTIGENER |
| RU2546873C2 (ru) | 2010-09-10 | 2015-04-10 | УАЙТ ЭлЭлСи | Нелипидизированные варианты антигенов neisseria meningitidis orf2086 |
| SA115360586B1 (ar) | 2012-03-09 | 2017-04-12 | فايزر انك | تركيبات لعلاج الالتهاب السحائي البكتيري وطرق لتحضيرها |
| PE20190458A1 (es) | 2012-03-09 | 2019-04-01 | Pfizer | Composiciones de neisseria meningitidis y metodos de las mismas |
| CN102861326A (zh) * | 2012-09-19 | 2013-01-09 | 天津康希诺生物技术有限公司 | 流脑多糖-蛋白质缀合疫苗及制备方法 |
| WO2014136064A2 (en) | 2013-03-08 | 2014-09-12 | Pfizer Inc. | Immunogenic fusion polypeptides |
| CA2923129C (en) | 2013-09-08 | 2020-06-09 | Pfizer Inc. | Neisseria meningitidis compositions and methods thereof |
| EP3443983B1 (en) | 2014-02-14 | 2022-07-20 | Pfizer Inc. | Immunogenic glycoprotein conjugates |
| MX391027B (es) | 2015-02-19 | 2025-03-21 | Pfizer | Composiciones de neisseria meningitidis y metodos de la misma. |
| KR102428253B1 (ko) * | 2016-03-15 | 2022-08-02 | 엠에스디 웰컴 트러스트 힐레맨 랩스 피브이티. 리미티드 | 신규한 다당류-단백질 접합체 및 이의 제조방법 |
| RS65362B1 (sr) | 2016-09-02 | 2024-04-30 | Sanofi Pasteur Inc | Vakcina protiv neisseria meningitidis |
| PE20191107A1 (es) | 2017-01-31 | 2019-08-26 | Pfizer | Composiciones de neisseria meningitidis y metodos respectivos |
| US11090374B2 (en) * | 2017-02-24 | 2021-08-17 | Merck Sharp & Dohme Corp. | Enhancing immunogenicity of Streptococcus pneumoniae polysaccharide-protein conjugates |
| US11389540B2 (en) | 2017-09-07 | 2022-07-19 | Merck Sharp & Dohme Llc | Pneumococcal polysaccharides and their use in immunogenic polysaccharide-carrier protein conjugates |
| CA3074703A1 (en) | 2017-09-07 | 2019-03-14 | Merck Sharp & Dohme Corp. | Pneumococcal polysaccharides and their use in immunogenic polysaccharide-carrier protein conjugates |
| EP3934696A1 (en) * | 2019-03-08 | 2022-01-12 | GlaxoSmithKline Biologicals S.A. | Carbocyclic derivatives and conjugated derivatives thereof, and their use in vaccines |
| CN115605222A (zh) | 2019-09-27 | 2023-01-13 | 辉瑞公司（Us） | 脑膜炎奈瑟氏菌组合物及其方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2427341A1 (fr) * | 1978-06-02 | 1979-12-28 | Delalande Sa | Nouveaux derives aminoglycosidiques hemisynthetiques, leur procede de preparation et leur application en therapeutique |
| ES2067854T3 (es) * | 1990-03-15 | 1995-04-01 | Tanabe Seiyaku Co | Polisulfato de derivado de ciclodextrina y procedimiento para preparar el mismo. |
| WO1995018144A1 (en) * | 1993-12-28 | 1995-07-06 | Pfizer Inc. | Steroidal glycosides |
| WO1995029927A2 (en) * | 1994-05-02 | 1995-11-09 | Biomira, Inc. | Process for preparation of glycosides of tumor-associated carbohydrate antigens |
| KR100593466B1 (ko) * | 1997-01-21 | 2007-04-25 | 파스퇴르 메리오 세룸 에 박신 | 다당류-펩타이드접합체 |
| US5929049A (en) | 1997-08-08 | 1999-07-27 | Dade Behring Marburg Gmbh | Polysaccharide conjugates of biomolecules |
| DE69737298T2 (de) * | 1997-08-08 | 2007-06-28 | Dade Behring Marburg Gmbh | Konjugate von polysacchariden und biomolekülen |
| US5952454A (en) * | 1997-12-12 | 1999-09-14 | The United States Of America As Represented By The Department Of Health And Human Services | Linking compounds useful for coupling carbohydrates to amine-containing carriers |
| ES2318117T3 (es) | 2002-03-26 | 2009-05-01 | Novartis Vaccines And Diagnostics S.R.L. | Sacaridos modificados que tienen una estabilidad mejorada en agua. |
| GB0220198D0 (en) * | 2002-08-30 | 2002-10-09 | Chiron Spa | Modified saccharides,conjugates thereof and their manufacture |
-
2002
- 2002-08-30 GB GBGB0220198.6A patent/GB0220198D0/en not_active Ceased
-
2003
- 2003-09-01 NZ NZ538703A patent/NZ538703A/en not_active IP Right Cessation
- 2003-09-01 BR BR0314089-0A patent/BR0314089A/pt not_active Application Discontinuation
- 2003-09-01 ES ES03791149T patent/ES2260682T3/es not_active Expired - Lifetime
- 2003-09-01 CA CA2497167A patent/CA2497167C/en not_active Expired - Fee Related
- 2003-09-01 AU AU2003260921A patent/AU2003260921B2/en not_active Ceased
- 2003-09-01 MX MXPA05002315A patent/MXPA05002315A/es active IP Right Grant
- 2003-09-01 CN CN2010101825535A patent/CN101863998B/zh not_active Expired - Fee Related
- 2003-09-01 WO PCT/IB2003/004194 patent/WO2004019992A1/en not_active Ceased
- 2003-09-01 US US10/526,124 patent/US8895516B2/en not_active Expired - Fee Related
- 2003-09-01 DK DK03791149T patent/DK1534342T3/da active
- 2003-09-01 DE DE60303961T patent/DE60303961T2/de not_active Expired - Lifetime
- 2003-09-01 JP JP2004532625A patent/JP5268222B2/ja not_active Expired - Fee Related
- 2003-09-01 RU RU2005108992/04A patent/RU2005108992A/ru unknown
- 2003-09-01 AT AT03791149T patent/ATE319481T1/de active
- 2003-09-01 EP EP03791149A patent/EP1534342B1/en not_active Expired - Lifetime
- 2003-09-01 CN CN038237245A patent/CN1688343B/zh not_active Expired - Fee Related
-
2008
- 2008-12-19 RU RU2008150551/13A patent/RU2531909C2/ru not_active IP Right Cessation
-
2011
- 2011-10-17 JP JP2011228229A patent/JP5314745B2/ja not_active Expired - Fee Related
-
2014
- 2014-10-23 US US14/521,761 patent/US20150166593A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20150166593A1 (en) | 2015-06-18 |
| CN101863998A (zh) | 2010-10-20 |
| MXPA05002315A (es) | 2005-06-08 |
| RU2008150551A (ru) | 2010-06-27 |
| JP5314745B2 (ja) | 2013-10-16 |
| EP1534342A1 (en) | 2005-06-01 |
| AU2003260921B2 (en) | 2008-03-06 |
| CA2497167A1 (en) | 2004-03-11 |
| CA2497167C (en) | 2011-07-12 |
| DK1534342T3 (da) | 2006-07-10 |
| GB0220198D0 (en) | 2002-10-09 |
| RU2531909C2 (ru) | 2014-10-27 |
| CN1688343B (zh) | 2010-09-08 |
| CN1688343A (zh) | 2005-10-26 |
| AU2003260921A1 (en) | 2004-03-19 |
| JP2006511465A (ja) | 2006-04-06 |
| EP1534342B1 (en) | 2006-03-08 |
| BR0314089A (pt) | 2005-11-16 |
| NZ538703A (en) | 2006-09-29 |
| JP2012017342A (ja) | 2012-01-26 |
| RU2005108992A (ru) | 2005-11-10 |
| JP5268222B2 (ja) | 2013-08-21 |
| WO2004019992A1 (en) | 2004-03-11 |
| DE60303961D1 (de) | 2006-05-04 |
| US8895516B2 (en) | 2014-11-25 |
| ATE319481T1 (de) | 2006-03-15 |
| ES2260682T3 (es) | 2006-11-01 |
| CN101863998B (zh) | 2012-08-29 |
| US20060263390A1 (en) | 2006-11-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8327 | Change in the person/name/address of the patent owner |
Owner name: NOVARTIS VACCINES AND DIAGNOSTICS S.R.L., SIEN, IT |