JP2012010713A5 - - Google Patents

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Publication number
JP2012010713A5
JP2012010713A5 JP2011220539A JP2011220539A JP2012010713A5 JP 2012010713 A5 JP2012010713 A5 JP 2012010713A5 JP 2011220539 A JP2011220539 A JP 2011220539A JP 2011220539 A JP2011220539 A JP 2011220539A JP 2012010713 A5 JP2012010713 A5 JP 2012010713A5
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JP
Japan
Prior art keywords
amino acid
protein
papillomavirus
acid sequence
virus
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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JP2011220539A
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English (en)
Japanese (ja)
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JP2012010713A (ja
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Priority claimed from DE19944435907 external-priority patent/DE4435907C2/de
Priority claimed from DE1995126752 external-priority patent/DE19526752C2/de
Application filed filed Critical
Publication of JP2012010713A publication Critical patent/JP2012010713A/ja
Publication of JP2012010713A5 publication Critical patent/JP2012010713A5/ja
Withdrawn legal-status Critical Current

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JP2011220539A 1994-10-07 2011-10-04 パピローマウイルス様粒子、融合タンパク質並びにそれらの製造方法 Withdrawn JP2012010713A (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DEP4435907.1 1994-10-07
DE19944435907 DE4435907C2 (de) 1994-10-07 1994-10-07 Papillomavirusähnliche Partikel und deren Anwendung
DE1995126752 DE19526752C2 (de) 1995-07-21 1995-07-21 Hocheffiziente Bildung von Papillomavirusähnlichen Partikeln
DE19526752.4 1995-07-21

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2008303257A Division JP2009102327A (ja) 1994-10-07 2008-11-27 パピローマウイルス様粒子、融合タンパク質並びにそれらの製造方法

Related Child Applications (1)

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JP2013112548A Division JP2013213034A (ja) 1994-10-07 2013-05-29 パピローマウイルス様粒子、融合タンパク質並びにそれらの製造方法

Publications (2)

Publication Number Publication Date
JP2012010713A JP2012010713A (ja) 2012-01-19
JP2012010713A5 true JP2012010713A5 (enExample) 2012-04-26

Family

ID=25940851

Family Applications (6)

Application Number Title Priority Date Filing Date
JP8512335A Withdrawn JPH11504801A (ja) 1994-10-07 1995-10-09 パピローマウイルス様粒子、融合タンパク質並びにそれらの製造方法
JP2005130613A Withdrawn JP2005270111A (ja) 1994-10-07 2005-04-27 パピローマウイルス様粒子、融合タンパク質並びにそれらの製造方法
JP2008303257A Withdrawn JP2009102327A (ja) 1994-10-07 2008-11-27 パピローマウイルス様粒子、融合タンパク質並びにそれらの製造方法
JP2011220539A Withdrawn JP2012010713A (ja) 1994-10-07 2011-10-04 パピローマウイルス様粒子、融合タンパク質並びにそれらの製造方法
JP2013112548A Withdrawn JP2013213034A (ja) 1994-10-07 2013-05-29 パピローマウイルス様粒子、融合タンパク質並びにそれらの製造方法
JP2014236222A Expired - Lifetime JP5794747B2 (ja) 1994-10-07 2014-11-21 パピローマウイルス様粒子、融合タンパク質並びにそれらの製造方法

Family Applications Before (3)

Application Number Title Priority Date Filing Date
JP8512335A Withdrawn JPH11504801A (ja) 1994-10-07 1995-10-09 パピローマウイルス様粒子、融合タンパク質並びにそれらの製造方法
JP2005130613A Withdrawn JP2005270111A (ja) 1994-10-07 2005-04-27 パピローマウイルス様粒子、融合タンパク質並びにそれらの製造方法
JP2008303257A Withdrawn JP2009102327A (ja) 1994-10-07 2008-11-27 パピローマウイルス様粒子、融合タンパク質並びにそれらの製造方法

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2013112548A Withdrawn JP2013213034A (ja) 1994-10-07 2013-05-29 パピローマウイルス様粒子、融合タンパク質並びにそれらの製造方法
JP2014236222A Expired - Lifetime JP5794747B2 (ja) 1994-10-07 2014-11-21 パピローマウイルス様粒子、融合タンパク質並びにそれらの製造方法

Country Status (13)

Country Link
US (6) US6066324A (enExample)
EP (2) EP1728800A1 (enExample)
JP (6) JPH11504801A (enExample)
AT (1) ATE325875T1 (enExample)
AU (2) AU4270196A (enExample)
CA (1) CA2202090C (enExample)
DE (3) DE59511047D1 (enExample)
DK (1) DK0809700T3 (enExample)
ES (1) ES2264563T3 (enExample)
LU (2) LU91390I2 (enExample)
NL (2) NL300323I2 (enExample)
PT (1) PT809700E (enExample)
WO (1) WO1996011272A2 (enExample)

Families Citing this family (89)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020164350A1 (en) 1992-09-03 2002-11-07 Lowy Douglas R. Chimeric papillomavirus-like particles
US8062642B1 (en) 1993-03-09 2011-11-22 University Of Rochester Production of papillomavirus capsid protein and virus-like particles
AU4270196A (en) * 1994-10-07 1996-05-02 Lutz Gissmann Papilloma virus-like particles, fusion proteins and process for producing the same
CA2257822A1 (en) 1996-07-17 1998-01-22 The Government Of The United States Of America, Represented By The Secre Tary, Department Of Health And Human Services Infectious papillomavirus pseudoviral particles
DE19631357A1 (de) * 1996-08-02 1998-02-05 Deutsches Krebsforsch Vektor zur Aktivierung des Immunsystems gegen mit Papillomviren bzw. Sequenzen davon assoziierten Zellen
GB9621091D0 (en) 1996-10-09 1996-11-27 Fondation Pour Le Perfectionem Attenuated microorganisms strains and their uses
ATE341339T1 (de) * 1996-12-20 2006-10-15 Merck & Co Inc Zusammensetzungen von rekombinanten papillomavirus vakzinen
WO1999001557A1 (en) * 1997-07-03 1999-01-14 University Of Colorado, University Technology Corporation Homogeneous human papilloma virus capsomere containing compositions, methods for manufacture, and the use thereof as diagnostic, prophylactic or therapy
US7351533B2 (en) * 1997-09-05 2008-04-01 Medimmune, Inc. In vitro method for disassmbly/reassembly of papillomavirus virus-like particles (VLPs). Homogeneous VLP and cavsomere compositions produced by said methods: use thereof as vehicle for improved purification, and delivery of active agents
US6228368B1 (en) 1997-10-06 2001-05-08 Loyola University Of Chicago Papilloma virus capsomere formulations and method of use
AU2003200653B2 (en) * 1997-10-06 2007-01-18 Loyola University Of Chicago Papilloma virus capsomere vaccine formulations and methods of use
US7182947B2 (en) 1998-02-20 2007-02-27 Medigene Ag Papillomavirus truncated L1 protein and fusion protein constructs
US7494658B2 (en) * 1998-02-20 2009-02-24 Medigene Ag Papilloma virus truncated L1 protein and fusion protein constructs
US20020039584A1 (en) 1998-02-20 2002-04-04 Medigene Ag Papilloma virus capsomere vaccine formulations and methods of use
CA2229955C (en) 1998-02-20 2003-12-09 Medigene Gmbh Papilloma virus capsomere vaccine formulations and methods of use
DE19812940A1 (de) * 1998-03-24 1999-10-07 Medigene Ag Formulierung mit Papillomavirus-spezifischem Protein, seine Herstellung und Verwendung
US6926897B1 (en) * 1998-03-24 2005-08-09 Medigene Aktiengesellschaft Medicament for the avoidance or treatment of papillomavirus-specific tumour
GB9806666D0 (en) * 1998-03-27 1998-05-27 Stanley Margaret Antigen preparation and use
US6991795B1 (en) * 1998-08-14 2006-01-31 Merck & Co., Inc. Protein delivery system using human papillomavirus virus-like particles
JP4563582B2 (ja) * 1998-08-14 2010-10-13 メルク・シャープ・エンド・ドーム・コーポレイション ヒトパピローマウイルスのウイルス様粒子を使用するタンパク質送達系
EP1797896A1 (en) 1998-10-16 2007-06-20 GlaxoSmithKline Biologicals SA Adjuvant systems and vaccines
SE514982C2 (sv) * 1999-09-30 2001-05-28 Active Biotech Ab Bärare innehållande ett huvudkapsidprotein L1 från humant papillomavirus samt dess användning
DE19925199A1 (de) 1999-06-01 2000-12-07 Medigene Ag Zytotoxische T-Zellepitope des Papillomavirus L1-Proteins und ihre Verwendung in Diagnostik und Therapie
DE19925235A1 (de) 1999-06-01 2000-12-07 Medigene Ag Zytotoxische T-Zellepitope des Papillomavirus L1-Proteins und ihre Verwendung in Diagnostik und Therapie
US20040146531A1 (en) * 1999-09-30 2004-07-29 Active Biotech Ab Virus-like particles devoid of HPV 16 type-specific antibody epitopes as carriers of peptides for introduction into cells
US6908613B2 (en) * 2000-06-21 2005-06-21 Medimmune, Inc. Chimeric human papillomavirus (HPV) L1 molecules and uses therefor
WO2002004007A2 (en) * 2000-07-06 2002-01-17 Georgetown University Stable (fixed) forms of viral capsid proteins, fusion proteins and uses thereof
GB0109297D0 (en) 2001-04-12 2001-05-30 Glaxosmithkline Biolog Sa Vaccine
DE10137102A1 (de) * 2001-07-30 2003-02-27 Deutsches Krebsforsch Polyvalente Vakzine gegen durch Papillomaviren verursachte Erkrankungen, Verfahren zu deren Herstellung und deren Verwendung
GB0206360D0 (en) * 2002-03-18 2002-05-01 Glaxosmithkline Biolog Sa Viral antigens
PT1506222E (pt) * 2002-05-17 2009-06-12 Univ Cape Town Proteínas l1 quiméricas do papilomavírus humano 16 incluindo um péptido l2, partículas semelhantes a vírus preparadas a partir daquelas e um método de preparação das partículas
WO2004042001A2 (en) * 2002-05-17 2004-05-21 Emory University Virus-like particles, methods of preparation, and immonogenic compositions
US9045727B2 (en) * 2002-05-17 2015-06-02 Emory University Virus-like particles, methods of preparation, and immunogenic compositions
US7858098B2 (en) * 2002-12-20 2010-12-28 Glaxosmithkline Biologicals, S.A. Vaccine
US20080160040A1 (en) * 2004-04-15 2008-07-03 Ghim Shin-Je Plant-produced compositions for treating papillomavirus infection and related methods
US7732166B2 (en) * 2005-11-15 2010-06-08 Oncohealth Corporation Detection method for human pappilomavirus (HPV) and its application in cervical cancer
US7972776B2 (en) * 2005-11-15 2011-07-05 Oncohealth Corporation Protein chips for HPV detection
TWI457133B (zh) 2005-12-13 2014-10-21 Glaxosmithkline Biolog Sa 新穎組合物
US8778351B2 (en) 2006-08-30 2014-07-15 University Of Rochester Combined human papillomavirus VLP/gene delivery system and use thereof as a vaccine for prophylaxis and immunotherapy of infectious diseases and tumors
CN101148661B (zh) * 2006-09-18 2013-01-02 中国医学科学院基础医学研究所 人乳头瘤病毒16型外壳蛋白病毒样颗粒及其制备方法和用途
US20090181078A1 (en) 2006-09-26 2009-07-16 Infectious Disease Research Institute Vaccine composition containing synthetic adjuvant
LT2486938T (lt) 2006-09-26 2018-06-25 Infectious Disease Research Institute Vakcinos kompozicija, turinti sintetinio adjuvanto
US8968995B2 (en) * 2008-11-12 2015-03-03 Oncohealth Corp. Detection, screening, and diagnosis of HPV-associated cancers
US8859218B2 (en) * 2008-06-13 2014-10-14 Oncohealth Corp. In situ detection of early stages and late stages HPV infection
US8916342B2 (en) 2006-11-13 2014-12-23 Oncohealth Corp. Identification of high grade or ≧ CIN2 for early stages and late stages detection, screening, and diagnosis of human papillomavirus (HPV) and HPV-associated cancers
WO2008115631A2 (en) * 2007-02-08 2008-09-25 University Of Louisville Research Foundation, Inc. Plant-produced compositions for treating papillomavirus infection and related methods
EA021391B1 (ru) 2007-03-02 2015-06-30 Глаксосмитклайн Байолоджикалс С.А. Способ индукции иммунного ответа, вакцинная композиция, ее применение и набор
US9364529B2 (en) 2007-04-29 2016-06-14 Beijing Wantai Biological Pharmacy Enterprise Co., Ltd. Truncated L1 protein of human papillomavirus type 18
EP2154147B1 (en) 2007-04-29 2015-10-07 Beijing Wantai Biological Pharmacy Enterprise Co., Ltd. A truncated l1 protein of human papillomavirus 16
DK2154149T3 (da) * 2007-05-29 2019-10-14 Univ Xiamen En trunkeret l1-protein af human papillomavirus 6
US20100260792A1 (en) * 2007-10-22 2010-10-14 University Of Rochester Respiratory syncytial virus vaccine based on chimeric papillomavirus virus-like particles or capsomeres
RU2494106C2 (ru) * 2007-11-23 2013-09-27 Шанхай Зеран Биотекнолоджи Ко., Лтд. Гены, кодирующие главный капсидный белок l1 вируса папилломы человека, и их применение
GB0815872D0 (en) 2008-09-01 2008-10-08 Pasteur Institut Novel method and compositions
GB0820822D0 (en) 2008-11-13 2008-12-24 Inst Catala D Oncologia Novel product and processes
JP5830015B2 (ja) 2009-06-05 2015-12-09 インフェクシャス ディズィーズ リサーチ インスティチュート 合成グルコピラノシル脂質アジュバント
EP2521914A4 (en) 2010-01-08 2013-07-10 Oncohealth Corp CELL-BASED HPV IMMUNOTESTS HAVE A HIGH PERFORMANCE FOR DIAGNOSIS AND SCANNING OF HPV ASSOCIATED CANCER
CN103596586A (zh) 2011-04-08 2014-02-19 免疫设计公司 免疫原性组合物及使用所述组合物诱导体液和细胞免疫反应的方法
CN103732250A (zh) * 2011-06-14 2014-04-16 全球免疫股份有限公司 基于酵母的治疗或预防丁型肝炎病毒感染的组合物和方法
RU2610174C2 (ru) 2011-06-24 2017-02-08 Мерк Шарп И Доум Корп. Вакцинные составы против вируса папилломы человека (hpv), содержащие алюминиевый адъювант, и способы их получения
CA2847604A1 (en) 2011-09-08 2013-03-14 Uniqure Ip B.V. Removal of contaminating viruses from aav preparations
US11510875B2 (en) 2012-02-07 2022-11-29 Access To Advanced Health Institute Adjuvant formulations comprising TLR4 agonists and methods of using the same
CA2866582A1 (en) 2012-03-18 2013-09-26 Brigitte Desiree Alberte Colau Method of vaccination against human papillomavirus
HUE039215T2 (hu) 2012-05-16 2018-12-28 Immune Design Corp Vakcinák HSV-2-höz
EA032326B1 (ru) 2013-04-18 2019-05-31 Иммьюн Дизайн Корп. Монотерапия gla для применения в лечении рака
US9463198B2 (en) 2013-06-04 2016-10-11 Infectious Disease Research Institute Compositions and methods for reducing or preventing metastasis
CN104231060B (zh) * 2013-06-05 2018-05-15 厦门大学 人乳头瘤病毒l1l2衣壳蛋白相互作用位点及其应用
IL310015B1 (en) 2013-12-31 2025-10-01 Access To Advanced Health Inst Single vial formulation
JP7195148B2 (ja) 2016-05-16 2022-12-23 アクセス ツー アドバンスト ヘルス インスティチュート Tlrアゴニストを含有する製剤及び使用方法
JP7195147B2 (ja) 2016-05-16 2022-12-23 アクセス ツー アドバンスト ヘルス インスティチュート Peg化リポソームおよび使用方法
KR102472026B1 (ko) 2016-06-01 2022-11-30 액세스 투 어드밴스드 헬스 인스티튜트 사이징제를 함유하는 나노명반 입자
IL271384B2 (en) 2017-06-15 2025-02-01 Access To Advanced Health Inst Nanostructured lipid carriers and stable emulsions and their uses
KR102755593B1 (ko) 2017-09-08 2025-01-20 액세스 투 어드밴스드 헬스 인스티튜트 사포닌을 포함하는 리포솜 제형 및 사용 방법
JP7491932B2 (ja) * 2018-12-28 2024-05-28 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー 操作されたb型肝炎コアポリペプチド
CA3141577A1 (en) 2019-05-25 2020-12-03 Infectious Disease Research Institute Composition and method for spray drying an adjuvant vaccine emulsion
CN114127295B (zh) * 2019-07-19 2024-05-14 神州细胞工程有限公司 嵌合的人乳头瘤病毒16型l1蛋白
CN114127099B (zh) * 2019-07-19 2024-04-19 神州细胞工程有限公司 嵌合的人乳头瘤病毒6型l1蛋白
CA3147850A1 (en) 2019-07-19 2021-01-28 Sinocelltech Ltd. Chimeric papillomavirus l1 protein
AU2020317321B2 (en) 2019-07-19 2023-07-27 Sinocelltech Ltd. Polyvalent immunogenicity composition for human papillomavirus
CN114127097B (zh) * 2019-07-19 2024-09-17 神州细胞工程有限公司 嵌合的人乳头瘤病毒56型l1蛋白
CR20220395A (es) 2020-02-14 2022-10-27 Merck Sharp & Dome Llc Vacuna contra hpv
AU2021337493A1 (en) 2020-09-04 2023-05-18 Access To Advanced Health Institute Co-lyophilized rna and nanostructured lipid carrier
CN114539365B (zh) * 2020-11-26 2023-12-01 中国医学科学院基础医学研究所 一种改造的人乳头瘤病毒52型l1蛋白及其用途
CN114539363B (zh) * 2020-11-26 2023-12-01 中国医学科学院基础医学研究所 一种c端改造的人乳头瘤病毒11型l1蛋白及其用途
MX2023009456A (es) 2021-02-11 2023-08-28 Glaxosmithkline Biologicals Sa Preparacion de la vacuna contra el vph.
US20240287545A1 (en) 2021-06-21 2024-08-29 Uniqure Biopharma B.V. Improved lysis procedures
TW202313658A (zh) 2021-08-06 2023-04-01 美商默沙東有限責任公司 Hpv疫苗
JP2024532127A (ja) 2021-08-19 2024-09-05 メルク・シャープ・アンド・ドーム・エルエルシー 熱安定性脂質ナノ粒子およびその使用方法
IL319329A (en) 2022-09-09 2025-05-01 Access To Advanced Health Inst Immunogenic vaccine composition incorporating saponin
AR132886A1 (es) 2023-06-09 2025-08-06 Merck Sharp & Dohme Llc Composiciones adyuvantes en nanoemulsión para vacunas contra el papilomavirus humano

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9113809D0 (en) * 1991-06-26 1991-08-14 Cancer Res Campaign Tech Papillomavirus l2 protein
EP1359156B1 (en) * 1991-07-19 2007-03-07 University of Queensland Vaccine against Human Papillomavirus (Type 18)
GB9207701D0 (en) 1992-04-08 1992-05-27 Cancer Res Campaign Tech Papillomavirus e7 protein
AU2462392A (en) * 1992-04-14 1993-11-18 British Biotech Pharmaceuticals Limited Induction of CTL responses
DE69334192T2 (de) 1992-06-25 2008-12-04 Georgetown University Papillomavirus vakzine
US5618536A (en) * 1992-09-03 1997-04-08 The United States Of America As Represented By The Department Of Health And Human Services Chimeric papillomavirus-like particles
US5437951A (en) * 1992-09-03 1995-08-01 The United States Of America As Represented By The Department Of Health And Human Services Self-assembling recombinant papillomavirus capsid proteins
DE05075369T1 (de) * 1993-03-09 2006-11-16 The University Of Rochester Herstellung von menschlichem Papilloma-Virus-Capsid-Protein und virusähnlichen Teilchen
US6153201A (en) * 1993-03-09 2000-11-28 University Of Rochester Oral immunization with papillomavirus virus-like particles
AU4270196A (en) * 1994-10-07 1996-05-02 Lutz Gissmann Papilloma virus-like particles, fusion proteins and process for producing the same
AU4727296A (en) * 1995-02-24 1996-09-11 Cantab Pharmaceuticals Research Limited Polypeptides useful as immunotherapeutic agents and methods of polypeptide preparation
US5874089A (en) * 1995-10-02 1999-02-23 Georgetown University School Of Medicine Protecting against canine oral papillomavirus (copy)
US6228368B1 (en) * 1997-10-06 2001-05-08 Loyola University Of Chicago Papilloma virus capsomere formulations and method of use

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