JP2011530537A5 - - Google Patents
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- JP2011530537A5 JP2011530537A5 JP2011522303A JP2011522303A JP2011530537A5 JP 2011530537 A5 JP2011530537 A5 JP 2011530537A5 JP 2011522303 A JP2011522303 A JP 2011522303A JP 2011522303 A JP2011522303 A JP 2011522303A JP 2011530537 A5 JP2011530537 A5 JP 2011530537A5
- Authority
- JP
- Japan
- Prior art keywords
- sequence
- cap03
- another embodiment
- dna
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 108020004414 DNA Proteins 0.000 description 7
- 239000000412 dendrimer Substances 0.000 description 6
- 229920000736 dendritic polymer Polymers 0.000 description 6
- 108091081021 Sense strand Proteins 0.000 description 3
- 102000053602 DNA Human genes 0.000 description 2
- 108091028043 Nucleic acid sequence Proteins 0.000 description 2
- 230000000692 anti-sense effect Effects 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 150000007523 nucleic acids Chemical group 0.000 description 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 1
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 1
- 108020004459 Small interfering RNA Proteins 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18831808P | 2008-08-08 | 2008-08-08 | |
| US61/188,318 | 2008-08-08 | ||
| PCT/US2009/053264 WO2010017544A2 (en) | 2008-08-08 | 2009-08-10 | Long-acting dna dendrimers and methods thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011530537A JP2011530537A (ja) | 2011-12-22 |
| JP2011530537A5 true JP2011530537A5 (enExample) | 2012-03-15 |
| JP5583667B2 JP5583667B2 (ja) | 2014-09-03 |
Family
ID=41664237
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011522303A Active JP5583667B2 (ja) | 2008-08-08 | 2009-08-10 | 長時間作用型ｄｎａデンドリマーおよびその方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20120122800A1 (enExample) |
| EP (2) | EP2657342B1 (enExample) |
| JP (1) | JP5583667B2 (enExample) |
| AU (1) | AU2009279458B2 (enExample) |
| CA (1) | CA2731521C (enExample) |
| IL (1) | IL210841A (enExample) |
| WO (1) | WO2010017544A2 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110206611A1 (en) | 2010-02-24 | 2011-08-25 | Genisphere, Llc | DNA Dendrimers as Thermal Ablation Devices |
| US20140228234A1 (en) | 2011-06-15 | 2014-08-14 | Naomi B. Zak | Target-recognition compositions comprising novel synthetic conjugates for trapping and diagnosis of a target molecule |
| HK1201486A1 (en) * | 2011-10-25 | 2015-09-04 | Arch Personal Care Products, L.P. | Composition containing an extract of a sequential or simultaneous fermentation |
| US9651549B2 (en) * | 2012-07-13 | 2017-05-16 | Genisphere, Llc | Lateral flow assays using DNA dendrimers |
| CN105073141A (zh) * | 2013-02-01 | 2015-11-18 | 詹尼斯费尔公司 | 用于将基因递送到细胞的功能化dna树状聚合物 |
| EP2976109B1 (en) | 2013-03-21 | 2018-07-25 | Genisphere, LLC | Cellular delivery of dna intercalating agents |
| EP3289084B1 (en) * | 2015-04-17 | 2020-09-16 | Genisphere, LLC | siRNA INHIBITION OF HUMAN ANTIGEN R EXPRESSION FOR TREATMENT OF CANCER |
| JP7366541B2 (ja) * | 2016-02-19 | 2023-10-23 | コード バイオセラピューティクス インコーポレイテッド | 核酸キャリア及び治療上の使用方法 |
| EP3416691A4 (en) * | 2016-02-19 | 2020-02-26 | Genisphere, LLC | SUPPORTS OF NUCLEIC ACIDS AND THEIR THERAPEUTIC METHODS OF USE |
| MA45328A (fr) | 2016-04-01 | 2019-02-06 | Avidity Biosciences Llc | Compositions acide nucléique-polypeptide et utilisations de celles-ci |
| CN118667812A (zh) | 2017-12-06 | 2024-09-20 | 艾维迪提生物科学公司 | 治疗肌萎缩和强直性肌营养不良的组合物和方法 |
| US20190269728A1 (en) | 2018-03-02 | 2019-09-05 | Sixfold Bioscience Ltd. | Compositions for delivery of cargo to cells |
| KR102544292B1 (ko) * | 2018-05-11 | 2023-06-15 | 주고꾸 도료 가부시키가이샤 | 방오 도료 조성물, 방오 도막, 방오 도막 부착 기재 및 방오 방법 |
| US20230183746A1 (en) | 2019-08-30 | 2023-06-15 | Sixfold Bioscience Ltd. | Compositions for transfer of cargo to cells |
| IL289295B2 (en) * | 2019-12-23 | 2025-07-01 | Illumina Cambridge Ltd | A nanoparticle with a single site for attaching a polynucleotide template |
| EP4121063A4 (en) | 2020-03-19 | 2024-07-03 | Avidity Biosciences, Inc. | COMPOSITIONS AND METHODS FOR TREATING FACIO-SCAPULO-HUMERAL MUSCULAR DYSTROPHY |
| EP4143316A2 (en) | 2020-04-27 | 2023-03-08 | Sixfold Bioscience Ltd. | Compositions containing nucleic acid nanoparticles with modular functionality |
| CN115916967A (zh) | 2020-05-12 | 2023-04-04 | 伊鲁米纳公司 | 使用重组末端脱氧核苷酸转移酶生成具有经修饰的碱基的核酸 |
| AU2021355846A1 (en) * | 2020-10-09 | 2023-06-08 | Sumitomo Pharma Co., Ltd. | Oligonucleic acid conjugate |
| KR20240055874A (ko) | 2021-09-16 | 2024-04-29 | 어비디티 바이오사이언시스 인크. | 안면견갑상완 근이영양증을 치료하는 조성물 및 방법 |
Family Cites Families (34)
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|---|---|---|---|---|
| NL154600B (nl) | 1971-02-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen. |
| NL154598B (nl) | 1970-11-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking. |
| NL154599B (nl) | 1970-12-28 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen, alsmede testverpakking. |
| US3901654A (en) | 1971-06-21 | 1975-08-26 | Biological Developments | Receptor assays of biologically active compounds employing biologically specific receptors |
| US3853987A (en) | 1971-09-01 | 1974-12-10 | W Dreyer | Immunological reagent and radioimmuno assay |
| US3867517A (en) | 1971-12-21 | 1975-02-18 | Abbott Lab | Direct radioimmunoassay for antigens and their antibodies |
| NL171930C (nl) | 1972-05-11 | 1983-06-01 | Akzo Nv | Werkwijze voor het aantonen en bepalen van haptenen, alsmede testverpakkingen. |
| US3850578A (en) | 1973-03-12 | 1974-11-26 | H Mcconnell | Process for assaying for biologically active molecules |
| US3935074A (en) | 1973-12-17 | 1976-01-27 | Syva Company | Antibody steric hindrance immunoassay with two antibodies |
| US3996345A (en) | 1974-08-12 | 1976-12-07 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
| US4034074A (en) | 1974-09-19 | 1977-07-05 | The Board Of Trustees Of Leland Stanford Junior University | Universal reagent 2-site immunoradiometric assay using labelled anti (IgG) |
| US3984533A (en) | 1975-11-13 | 1976-10-05 | General Electric Company | Electrophoretic method of detecting antigen-antibody reaction |
| US4098876A (en) | 1976-10-26 | 1978-07-04 | Corning Glass Works | Reverse sandwich immunoassay |
| US4879219A (en) | 1980-09-19 | 1989-11-07 | General Hospital Corporation | Immunoassay utilizing monoclonal high affinity IgM antibodies |
| US5011771A (en) | 1984-04-12 | 1991-04-30 | The General Hospital Corporation | Multiepitopic immunometric assay |
| US4666828A (en) | 1984-08-15 | 1987-05-19 | The General Hospital Corporation | Test for Huntington's disease |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4801531A (en) | 1985-04-17 | 1989-01-31 | Biotechnology Research Partners, Ltd. | Apo AI/CIII genomic polymorphisms predictive of atherosclerosis |
| US5175270A (en) | 1986-09-10 | 1992-12-29 | Polyprobe, Inc. | Reagents for detecting and assaying nucleic acid sequences |
| US5272057A (en) | 1988-10-14 | 1993-12-21 | Georgetown University | Method of detecting a predisposition to cancer by the use of restriction fragment length polymorphism of the gene for human poly (ADP-ribose) polymerase |
| US5192659A (en) | 1989-08-25 | 1993-03-09 | Genetype Ag | Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes |
| US5281521A (en) | 1992-07-20 | 1994-01-25 | The Trustees Of The University Of Pennsylvania | Modified avidin-biotin technique |
| US6117631A (en) | 1996-10-29 | 2000-09-12 | Polyprobe, Inc. | Detection of antigens via oligonucleotide antibody conjugates |
| EP1005573B1 (en) | 1997-07-29 | 2006-05-24 | Polyprobe, Inc. | Dendritic nucleic acids exhibiting maximal self-assembly |
| US20070173473A1 (en) * | 2001-05-18 | 2007-07-26 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of proprotein convertase subtilisin Kexin 9 (PCSK9) gene expression using short interfering nucleic acid (siNA) |
| US20040023248A1 (en) * | 2001-12-07 | 2004-02-05 | Whitehead Institiute For Biomedical Research | Methods and reagents for improving nucleic acid detection |
| EP1530581A4 (en) * | 2002-06-12 | 2006-08-30 | Datascope Investment Corp | POLYMERIC MARKING MOLECULES |
| US7223544B2 (en) * | 2003-06-27 | 2007-05-29 | Cornell Research Foundation, Inc. | Nucleic acid-engineered materials |
| KR101147147B1 (ko) * | 2004-04-01 | 2012-05-25 | 머크 샤프 앤드 돔 코포레이션 | Ｒｎａ 간섭의 오프 타겟 효과 감소를 위한 변형된폴리뉴클레오타이드 |
| WO2005113571A2 (en) * | 2004-05-13 | 2005-12-01 | The University Of North Carolina At Chapel Hill | Methods for the delivery of oligomeric compounds |
| US8067572B2 (en) * | 2005-05-25 | 2011-11-29 | The University Of York | Hybrid interfering RNA |
| US20100136614A1 (en) * | 2005-10-18 | 2010-06-03 | Dan Luo | Dendrimer-like modular delivery vector |
| WO2008147526A1 (en) * | 2007-05-23 | 2008-12-04 | The Trustees Of The University Of Pennsylvania | Targeted carriers for intracellular drug delivery |
| US9029524B2 (en) * | 2007-12-10 | 2015-05-12 | California Institute Of Technology | Signal activated RNA interference |
-
2009
- 2009-08-10 EP EP13178199.9A patent/EP2657342B1/en active Active
- 2009-08-10 EP EP09805654.2A patent/EP2320953B1/en active Active
- 2009-08-10 US US13/058,123 patent/US20120122800A1/en not_active Abandoned
- 2009-08-10 JP JP2011522303A patent/JP5583667B2/ja active Active
- 2009-08-10 CA CA2731521A patent/CA2731521C/en active Active
- 2009-08-10 WO PCT/US2009/053264 patent/WO2010017544A2/en not_active Ceased
- 2009-08-10 AU AU2009279458A patent/AU2009279458B2/en active Active
-
2011
- 2011-01-24 IL IL210841A patent/IL210841A/en active IP Right Grant