JP2011530525A - 新規なメチレンジオキシフェノール系化合物および疾患処置のためのそれらの使用 - Google Patents

新規なメチレンジオキシフェノール系化合物および疾患処置のためのそれらの使用 Download PDF

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JP2011530525A
JP2011530525A JP2011522226A JP2011522226A JP2011530525A JP 2011530525 A JP2011530525 A JP 2011530525A JP 2011522226 A JP2011522226 A JP 2011522226A JP 2011522226 A JP2011522226 A JP 2011522226A JP 2011530525 A JP2011530525 A JP 2011530525A
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Japan
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inv
compound
group
composition
methylenedioxy
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JP2011522226A
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Japanese (ja)
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JP2011530525A5 (enExample
Inventor
パーササラティ，サンパス
ラジャゴパラン，サンジェイ
ラジャゴパル，デシカン
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Ohio State University Research Foundation
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/385—Heterocyclic compounds having sulfur as a ring hetero atom having two or more sulfur atoms in the same ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A61K31/36—Compounds containing methylenedioxyphenyl groups, e.g. sesamin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/64—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2011522226A 2008-08-05 2009-08-05 新規なメチレンジオキシフェノール系化合物および疾患処置のためのそれらの使用 Withdrawn JP2011530525A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US8642508P 2008-08-05 2008-08-05
US61/086,425 2008-08-05
PCT/US2009/052893 WO2010017323A1 (en) 2008-08-05 2009-08-05 Novel methylenedioxy phenolic compounds and their use to treat disease

Publications (2)

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JP2011530525A true JP2011530525A (ja) 2011-12-22
JP2011530525A5 JP2011530525A5 (enExample) 2012-09-20

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ID=41172398

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JP2011522226A Withdrawn JP2011530525A (ja) 2008-08-05 2009-08-05 新規なメチレンジオキシフェノール系化合物および疾患処置のためのそれらの使用

Country Status (11)

Country Link
US (2) US8198317B2 (enExample)
EP (1) EP2324005A1 (enExample)
JP (1) JP2011530525A (enExample)
KR (1) KR20110042108A (enExample)
CN (1) CN102149702A (enExample)
AU (1) AU2009279667A1 (enExample)
BR (1) BRPI0917262A2 (enExample)
CA (1) CA2733430A1 (enExample)
IL (1) IL211076A0 (enExample)
RU (1) RU2011108587A (enExample)
WO (1) WO2010017323A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021178810A (ja) * 2020-05-11 2021-11-18 シャンシー・ユニヴァーシティ・オブ・サイエンス・アンド・テクノロジーShaanxi University Of Science And Technology 肝保護活性を有するシリビニンリポ酸エステルおよびその調製方法

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI1007600A2 (pt) * 2009-04-23 2019-09-24 Invasc Therapeutics Inc composições e métodos para tratamento de doenças cardiovasculares
CN106957298B (zh) * 2017-04-18 2019-07-16 湖南中医药大学 一种硫辛酸苯酚酯衍生物及其制备方法和应用
CN110305102B (zh) * 2019-08-13 2020-11-24 陕西中医药大学 1,3-苯并二噁茂天然多酚酸酯类化合物及其降血脂应用
CN112745291A (zh) * 2019-10-29 2021-05-04 浙江大学宁波理工学院 一种具有HMG-CoA还原酶抑制活性的化合物、药物组合物及应用
CN115047092B (zh) * 2022-04-07 2023-10-20 济宁医学院 一种血管紧张素转移酶ii抑制剂的筛选方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010031275A1 (en) * 1998-02-09 2001-10-18 Forse R Armour Sesamol inhibitor of delta-5-desaturase activity and uses therefor

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Publication number Priority date Publication date Assignee Title
EP1229034B1 (en) * 2001-01-31 2005-04-13 Pfizer Products Inc. Nicotinamide derivatives and their mimetics as inhibitors of PDE4 isozymes
KR20030070150A (ko) * 2001-01-31 2003-08-27 화이자 프로덕츠 인크. Ｐｄｅ4 이소자임 억제제로서 유용한 에테르 유도체

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010031275A1 (en) * 1998-02-09 2001-10-18 Forse R Armour Sesamol inhibitor of delta-5-desaturase activity and uses therefor

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
JPN5011011984; ＯＲＰＨＡＮＯＳ　Ｄ　Ｇ: '３，４-ＭＥＴＨＹＬＥＮＥＤＩＯＸＹ-ＡＮＤ　３，４-ＤＩＭＥＴＨＯＸＹ-５-ＡＭＩＮＯＰＨＥＮＯＬ' ＣＡＮＡＤＩＡＮ　ＪＯＵＲＮＡＬ　ＯＦ　ＣＨＥＭＩＳＴＲＹ Ｖ４４　Ｎ１５, Ｐ１８７５-１８７９ *
JPN5011011985; ＴＨＯＭＰＳＯＮ　Ｒ　Ｂ: 'ＳＯＭＥ　ＤＥＲＩＶＡＴＩＶＥＳ　ＯＦ　ＨＹＤＲＯＸＹＨＹＤＲＯＱＵＩＮＯＮＥ　ＡＳ　ＡＮＴＩＯＸＩＤＡＮＴＳ' ＪＯＵＲＮＡＬ　ＯＦ　ＴＨＥ　ＡＭＥＲＩＣＡＮ　ＯＩＬ　ＣＨＥＭＩＳＴＳ'　ＳＯＣＩＥＴＹ Ｖ３３, 1956, Ｐ４１４-４１６ *
JPN6014006450; Ｃｈｅｍｉｃａｌ　Ａｂｓｔｒａｃｔｓ　１４３：３９９７６５ *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021178810A (ja) * 2020-05-11 2021-11-18 シャンシー・ユニヴァーシティ・オブ・サイエンス・アンド・テクノロジーShaanxi University Of Science And Technology 肝保護活性を有するシリビニンリポ酸エステルおよびその調製方法
JP7118335B2 (ja) 2020-05-11 2022-08-16 シーアン・タイコメッド・ファーマシューティカル・テクノロジー・カンパニー・リミテッド 肝保護活性を有するシリビニンリポ酸エステルおよびその調製方法

Also Published As

Publication number Publication date
US20130157986A1 (en) 2013-06-20
EP2324005A1 (en) 2011-05-25
CN102149702A (zh) 2011-08-10
IL211076A0 (en) 2011-04-28
US8198317B2 (en) 2012-06-12
BRPI0917262A2 (pt) 2015-11-10
WO2010017323A1 (en) 2010-02-11
US20100035849A1 (en) 2010-02-11
CA2733430A1 (en) 2010-02-11
AU2009279667A1 (en) 2010-02-11
KR20110042108A (ko) 2011-04-22
RU2011108587A (ru) 2012-09-10

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