JP2011529942A5 - - Google Patents
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- Publication number
- JP2011529942A5 JP2011529942A5 JP2011521561A JP2011521561A JP2011529942A5 JP 2011529942 A5 JP2011529942 A5 JP 2011529942A5 JP 2011521561 A JP2011521561 A JP 2011521561A JP 2011521561 A JP2011521561 A JP 2011521561A JP 2011529942 A5 JP2011529942 A5 JP 2011529942A5
- Authority
- JP
- Japan
- Prior art keywords
- crystalline form
- compound
- formula
- methylbenzenesulfonate
- xrpd
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 238000000634 powder X-ray diffraction Methods 0.000 claims 6
- 150000001875 compounds Chemical class 0.000 claims 5
- JOXIMZWYDAKGHI-UHFFFAOYSA-M toluene-4-sulfonate Chemical compound CC1=CC=C(S([O-])(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-M 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical class CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 claims 3
- 239000012453 solvate Substances 0.000 claims 2
- 208000019901 Anxiety disease Diseases 0.000 claims 1
- 229940126062 Compound A Drugs 0.000 claims 1
- NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 claims 1
- 208000019022 Mood disease Diseases 0.000 claims 1
- 208000028017 Psychotic disease Diseases 0.000 claims 1
- 230000036506 anxiety Effects 0.000 claims 1
- 229940126214 compound 3 Drugs 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000001747 exhibiting effect Effects 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 208000019116 sleep disease Diseases 0.000 claims 1
- 208000011117 substance-related disease Diseases 0.000 claims 1
Claims (9)
- 結晶形態である、式（Ｉ）の化合物の４−メチルベンゼンスルホン酸塩またはその溶媒和物。
- 結晶形態が無水型である、結晶形態の式（Ｉ）の化合物の４−メチルベンゼンスルホン酸塩。
- 結晶形態が水和物である、結晶形態の式（Ｉ）の化合物の４−メチルベンゼンスルホン酸塩。
- 結晶形態が図１に示す粉末X線回折（ＸＲＰＤ）パターンと実質的に同じパターンを示すことを特徴とする無水結晶形態１である、請求項１または２に記載の結晶形態の式（Ｉ）の化合物の４−メチルベンゼンスルホン酸塩。
- 結晶形態が図３に示す粉末X線回折（ＸＲＰＤ）パターンと実質的に同じパターンを示すことを特徴とする無水結晶形態２である、請求項１または２に記載の結晶形態の式（Ｉ）の化合物の４−メチルベンゼンスルホン酸塩。
- 結晶形態が図５に示す粉末X線回折（ＸＲＰＤ）パターンと実質的に同じパターンを示すことを特徴とする水和物１である、請求項１または３に記載の結晶形態の式（Ｉ）の化合物の４−メチルベンゼンスルホン酸塩。
- 請求項１〜６のいずれか一項に記載の結晶形態の式（Ｉ）の化合物の４−メチルベンゼンスルホン酸塩またはその溶媒和物を含んでなる、医薬組成物。
- １種以上の薬学上許容される担体または希釈剤を更に含んでなる、請求項７に記載の医薬組成物。
- 精神病性障害、うつ病、気分障害、不安、睡眠障害、および物質関連障害の治療または予防のために用いられる、請求項７または８に記載の医薬組成物。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0814340.6A GB0814340D0 (en) | 2008-08-05 | 2008-08-05 | Anhydrous crystol form fo a pyridine derivative |
| GB0814340.6 | 2008-08-05 | ||
| PCT/EP2009/060089 WO2010015626A1 (en) | 2008-08-05 | 2009-08-04 | Crystalline forms of a pyridine derivative |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011529942A JP2011529942A (ja) | 2011-12-15 |
| JP2011529942A5 true JP2011529942A5 (ja) | 2012-09-27 |
Family
ID=39767571
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011521561A Withdrawn JP2011529942A (ja) | 2008-08-05 | 2009-08-04 | ピリジン誘導体の結晶体 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US8093242B2 (ja) |
| EP (1) | EP2321324A1 (ja) |
| JP (1) | JP2011529942A (ja) |
| KR (1) | KR20110052686A (ja) |
| CN (1) | CN102171219A (ja) |
| AU (1) | AU2009279135B2 (ja) |
| BR (1) | BRPI0917224A2 (ja) |
| CA (1) | CA2733235A1 (ja) |
| EA (1) | EA201170300A1 (ja) |
| GB (1) | GB0814340D0 (ja) |
| IL (1) | IL210777A0 (ja) |
| MX (1) | MX2011001414A (ja) |
| WO (1) | WO2010015626A1 (ja) |
| ZA (1) | ZA201100426B (ja) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2012002369A (es) * | 2009-08-27 | 2012-03-29 | Glaxosmithkline Llc | Formas de anhidrato de un derivado de piridina. |
| RU2743206C2 (ru) * | 2015-05-18 | 2021-02-16 | Кэнди Терапьютикс Лимитед | Двойные антагонисты рецептора нейрокинин-1/нейрокинин-3 для лечения заболеваний, зависимых от половых гормонов |
| MX2020009438A (es) | 2018-03-14 | 2022-05-11 | Kandy Therapeutics Ltd | Formulacion farmaceutica novedosa que comprende antagonistas del receptor dual nk-1/nk-3. |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69728883T2 (de) | 1996-07-17 | 2005-04-07 | Merck & Co., Inc. | Änderung des zirkadischen rhythmus mit nicht-peptidischen neurokinin-1 rezeptor antagonisten |
| PT1394150E (pt) | 1999-02-24 | 2011-02-17 | Hoffmann La Roche | Derivados de 4-fenilpiridina e a sua utilização como antagonistas dos receptores de nc-1 |
| WO2001030348A1 (en) | 1999-10-25 | 2001-05-03 | Janssen Pharmaceutica N.V. | Use of substance p antagonists for influencing the circadian timing system |
| GB0203022D0 (en) | 2002-02-08 | 2002-03-27 | Glaxo Group Ltd | Chemical compounds |
| GB0203020D0 (en) | 2002-02-08 | 2002-03-27 | Glaxo Group Ltd | Chemical compounds |
| TW200403058A (en) | 2002-04-19 | 2004-03-01 | Bristol Myers Squibb Co | Heterocyclo inhibitors of potassium channel function |
| BRPI0412291A (pt) | 2003-07-03 | 2006-09-19 | Hoffmann La Roche | antagonistas duplos de nka/nk3 para o tratamento de esquizofrenia |
| SI1928886T1 (sl) * | 2005-09-09 | 2011-08-31 | Glaxosmithkline Llc | Derivati piridina in njihova uporaba pri zdravljenju psihotiäśnih motenj |
-
2008
- 2008-08-05 GB GBGB0814340.6A patent/GB0814340D0/en not_active Ceased
-
2009
- 2009-08-04 JP JP2011521561A patent/JP2011529942A/ja not_active Withdrawn
- 2009-08-04 EP EP09781468A patent/EP2321324A1/en not_active Withdrawn
- 2009-08-04 US US13/056,775 patent/US8093242B2/en active Active
- 2009-08-04 CA CA2733235A patent/CA2733235A1/en not_active Abandoned
- 2009-08-04 EA EA201170300A patent/EA201170300A1/ru unknown
- 2009-08-04 AU AU2009279135A patent/AU2009279135B2/en not_active Ceased
- 2009-08-04 WO PCT/EP2009/060089 patent/WO2010015626A1/en active Application Filing
- 2009-08-04 BR BRPI0917224A patent/BRPI0917224A2/pt not_active IP Right Cessation
- 2009-08-04 MX MX2011001414A patent/MX2011001414A/es unknown
- 2009-08-04 CN CN2009801393221A patent/CN102171219A/zh active Pending
- 2009-08-04 KR KR1020117005159A patent/KR20110052686A/ko not_active Application Discontinuation
-
2011
- 2011-01-17 ZA ZA2011/00426A patent/ZA201100426B/en unknown
- 2011-01-20 IL IL210777A patent/IL210777A0/en unknown