JP2012511558A5 - - Google Patents
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- Publication number
- JP2012511558A5 JP2012511558A5 JP2011540193A JP2011540193A JP2012511558A5 JP 2012511558 A5 JP2012511558 A5 JP 2012511558A5 JP 2011540193 A JP2011540193 A JP 2011540193A JP 2011540193 A JP2011540193 A JP 2011540193A JP 2012511558 A5 JP2012511558 A5 JP 2012511558A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- unsubstituted
- compound
- halogen
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 6
- 125000000217 alkyl group Chemical group 0.000 claims 4
- 229910052736 halogen Inorganic materials 0.000 claims 4
- 150000002367 halogens Chemical class 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 239000011780 sodium chloride Substances 0.000 claims 4
- 150000002431 hydrogen Chemical class 0.000 claims 3
- 229910052739 hydrogen Inorganic materials 0.000 claims 3
- 239000001257 hydrogen Substances 0.000 claims 3
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 150000001408 amides Chemical class 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
Claims (7)
- 一般式（ＩＩＩ）
の化合物、またはその塩。 - Ｒ９およびＲ１３の少なくとも１つがハロゲンまたは置換もしくは非置換Ｃ１−４アルキルである請求項１に記載の化合物。
- Ｒ１０およびＲ１２の少なくとも１つが、水素、ハロゲンおよび置換または非置換アルキルから成る群より選択される請求項１または２に記載の化合物。
- Ｒ１１が水素、ハロゲン、置換または非置換アルキル、置換または非置換アルコキシ、および置換または非置換フェニルから成る群より選択される請求項１〜３のいずれか１項に記載の化合物。
- 式：
- 治療的有効量の請求項１〜５のいずれか１項に記載の化合物またはその塩と、製薬学的に許容可能なビヒクルとを含む医薬組成物。
- 疼痛の治療に使用するための、請求項１〜５のいずれか１項に記載の化合物もしくはその塩、または請求項６に記載の医薬組成物。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0822486.7A GB0822486D0 (en) | 2008-12-10 | 2008-12-10 | Compounds for use in the treatment of pain |
| GB0822486.7 | 2008-12-10 | ||
| PCT/GB2009/002850 WO2010067069A1 (en) | 2008-12-10 | 2009-12-09 | Compounds for use in the treatment of pain |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012511558A JP2012511558A (ja) | 2012-05-24 |
| JP2012511558A5 true JP2012511558A5 (ja) | 2013-01-31 |
| JP5732400B2 JP5732400B2 (ja) | 2015-06-10 |
Family
ID=40289770
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011540193A Active JP5732400B2 (ja) | 2008-12-10 | 2009-12-09 | 疼痛の治療で使用するための化合物 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US8507724B2 (ja) |
| EP (1) | EP2373605B1 (ja) |
| JP (1) | JP5732400B2 (ja) |
| CN (1) | CN102307836B (ja) |
| AU (1) | AU2009326261B2 (ja) |
| CA (1) | CA2747232C (ja) |
| GB (1) | GB0822486D0 (ja) |
| WO (1) | WO2010067069A1 (ja) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2522651B1 (en) * | 2011-05-12 | 2013-11-20 | Siegfried AG | Process for the purification of 2,6-diisopropyl phenol |
| US9045684B2 (en) * | 2012-07-30 | 2015-06-02 | Jnc Corporation | Liquid crystal composition, antioxidant and liquid crystal display device |
| GB201322905D0 (en) | 2013-12-23 | 2014-02-12 | Univ Liverpool | Pharmacologically active compounds |
| EP3189834B1 (en) | 2014-09-04 | 2024-01-17 | Haisco Innovative Pharmaceutical PTE. LTD. | Use of gabaa receptor reinforcing agent in preparation of sedative and anesthetic medicament |
| WO2017120507A1 (en) * | 2016-01-06 | 2017-07-13 | The Board Of Trustees Of The University Of Illinois | Novel compounds which activate estrogen receptors and compositions and methods of using the same |
| US10449198B2 (en) | 2016-07-01 | 2019-10-22 | The University Of Liverpool | Method for treating pain |
| CN116554127A (zh) * | 2022-01-28 | 2023-08-08 | 成都麻沸散医药科技有限公司 | 哌嗪取代苯酚类衍生物及其用途 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3498853B2 (ja) | 1993-09-27 | 2004-02-23 | 小野薬品工業株式会社 | ビフェニル誘導体 |
| US6121271A (en) * | 1998-05-12 | 2000-09-19 | American Home Products Corporation | Naphtho[2,3-B]heteroar-4-yl derivatives |
| AU3979199A (en) | 1998-05-12 | 1999-11-29 | American Home Products Corporation | 11-aryl-benzo{b}naphtho{2,3-d}furans and 11-aryl-benzo{b}naphtho{2,3-d}thiophenes useful in the treatment of insulin resistance and hyperglycemia |
| IL139132A0 (en) | 1998-05-12 | 2001-11-25 | American Home Prod | Benzothiophenes, benzofurans and indoles useful in the treatment of insulin resistance and hyperglycemia |
| TWI292316B (en) * | 1999-10-11 | 2008-01-11 | Sod Conseils Rech Applic | Pharmaceutical composition of thiazole derivatives intended to inhibit mao and/or lipidic peroxidation and/or to act as modulators of sodium channels and the use thereof |
| JP2002093609A (ja) * | 2000-09-14 | 2002-03-29 | Univ Waseda | ラジカル高分子化合物からなる磁性素子 |
| AU2005212834A1 (en) * | 2004-02-16 | 2005-08-25 | Laboratorios Del Dr. Esteve S.A. | Substituted azetidine compounds as cyclooxygenase-1-cyclooxygenase-2 inhibitors, and their preparation and use as medicaments |
| JP2005234086A (ja) * | 2004-02-18 | 2005-09-02 | Konica Minolta Medical & Graphic Inc | 光熱写真画像形成材料 |
| WO2006089120A2 (en) * | 2005-02-18 | 2006-08-24 | Abraxis Bioscience, Inc | Compositions, methods of use and preparation of 2,6-diisopropyl phenol and analogs for ischemic injury |
| CA2632561C (en) * | 2005-12-19 | 2015-01-27 | The University Of Liverpool | Substituted propofol derivatives as analgesics |
| CN1907954B (zh) * | 2006-08-16 | 2011-11-23 | 重庆医科大学医药研究所 | 麻醉药2,6-二异丙基苯酚的水溶性衍生物及其制备方法 |
-
2008
- 2008-12-10 GB GBGB0822486.7A patent/GB0822486D0/en not_active Ceased
-
2009
- 2009-12-09 JP JP2011540193A patent/JP5732400B2/ja active Active
- 2009-12-09 EP EP09793566.2A patent/EP2373605B1/en not_active Not-in-force
- 2009-12-09 US US13/133,569 patent/US8507724B2/en not_active Expired - Fee Related
- 2009-12-09 AU AU2009326261A patent/AU2009326261B2/en not_active Ceased
- 2009-12-09 CN CN200980156008.4A patent/CN102307836B/zh not_active Expired - Fee Related
- 2009-12-09 WO PCT/GB2009/002850 patent/WO2010067069A1/en active Application Filing
- 2009-12-09 CA CA2747232A patent/CA2747232C/en not_active Expired - Fee Related