JP2011529467A - グリオーマの治療のためのcdk阻害剤の使用 - Google Patents
グリオーマの治療のためのcdk阻害剤の使用 Download PDFInfo
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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Abstract
Description
このアッセイにより、試験化合物を用いて得られた特定酵素のキナーゼ活性の阻害を測定できる。異なるキナーゼを並行して試験できる。
Han Wistarラットを、式(I)の化合物を60mg/kgの用量で経口投与することにより連続6日間治療した。6日目の投与の2時間および6時間後に動物を屠殺した。脳および血漿を屠殺時に採取した。血液をヘパリン処理したプラスチック管に入れ、氷水浴に保持し、次いで遠心分離した(10分間、4℃で1200g)。脳および血漿サンプルを分析時まで−80℃のフリーザーに保存した。式(I)の化合物のレベルをLC/MS/MSにより分析した。
式(I)の[14C]標識された化合物(5μCi/mgの比活性、室内で調製された。)を、6匹のオスの白色種ラット(Charles River Italyからのスプラーグ・ドーリー・ラット;投与時の体重259から273g)への単一の経口投与(マレイン酸塩として20mg/kg、約3.7MBq/kg、放射能線量として100mCi/kg)により投与した。
SF−268、SF−295、SF−539およびU251株化細胞を10%FCSおよび2mMグルタミンを添加したRPMI1640にて培養し、U−87MG株化細胞を10%FCS、2nMグルタミンおよび1%NEAAを添加したEMEMにて培養した。すべての実験に関して、前述の期間において化合物で治療した翌日に、細胞を1×104/cm2の密度にて播種し、次いで報告された時間にて回収した。
治療の72時間後に細胞を洗浄し計数した。細胞増殖を、細胞アデノシン三リン酸モニタリングシステムによって決定した。細胞増殖は、コントロール細胞と比較した。50%まで細胞増殖を阻害する濃度(IC50)を計算した。
BrdU(5−ブロモ−2’デオキシウリジン)を24時間の治療の最後に最終濃度30μMで細胞培地に添加した。細胞をPBSで洗浄し、70%エタノールで固定して、−20℃で保存した。分析時に細胞を遠心分離し、PBS中1%FCSで洗浄し、HCl 2Nにより20分間DNA変性した。Na2B4O7 0.1M pH8.5中での洗浄後、細胞をPBS+1%FCS中の0.5%Tween20の溶液で15分間温置し、次いで遠心分離した。ペレットを1:10で希釈された非抱合型アンチBrdUモノクローナル抗体(Becton Dickinson)150μl中に再懸濁し、室温で1時間温置した。PBS中での洗浄後、0.5%Tween20での温置を繰り返した;次いで二次抗体を添加した(1:50で希釈されたFITC抱合型ヤギ抗マウス免疫グロブリン(Jackson Lab.))。室温で1時間後、細胞を再びすすぎ、ヨウ化プロピジウムで一晩対比染色し(2μg/ml+12.5μg/mlDNAse−遊離RNAse)、次いでFACSで分析した。
温置の最終15分の間、アクリジンオレンジ(1μg/ml)を細胞に添加し、次いでこれを回収し、PBSで洗浄し、FACSによってこれらの蛍光発光について分析した。アクリジンオレンジは、生体膜を自由に横断するが、細胞質および核小体にあるときは明緑色および暗赤色の蛍光を発する;オートファジーによって生じる酸性空胞は明赤色に見える。
治療された細胞を、SDSサンプル緩衝液(0.125M Tris−HCI pH6.8、5%SDS)を添加することによって溶解した。サンプルを95℃に5分間加熱し、次いでUltrasonic 2000 ARTEKを用いて超音波処理した。溶解した細胞を13,000RPMで10分間遠心分離した。タンパク質の定量は、BCA緩衝液(Pierce)およびBSA標準曲線を用いて測定した。ウエルあたり20μgのタンパク質抽出物を充填し、SDS−PAGEゲル7.5から10%(PAGE−PLUS 40% concentrate AMRESCO)によって分離した。ゲルを、25mMのTrisHCI pH8.3、192mMのグリセリンおよび20%のメタノールを含有する緩衝液中、ニトロセルロースフィルタ(Hybond Amersham)上にブロットした。フィルタを0.1%Tween20(TBS−T)を含有するTBS中の5%低脂肪乳中に室温で2時間飽和させ、次いで一次モノクローナルに関して4℃で一晩温置し、続いてTBS−T中で洗浄し、二次抗マウス抗体を用いて温置した。結合を、「Super Signal West Pico」Pierceを用いて視覚化した。
Harlan(イタリア)製のBalb,Nu/Nuのオスのマウスを、紙フィルターカバー、餌、滅菌された床および酸性化水を備えたケージ中に維持した。2.5×106U251ヒトグリオーマ細胞(American Type Culture Collection製)を胸腺欠損マウスに皮下注射した。式(I)の化合物は、連続した10日間の間1日2回(BID)40mg/kgの用量にて、10ml/kgの容量で経口経路によって投与した。腫瘍成長および体重を3日毎に測定した。腫瘍成長をノギスによって評価した。2つの直径を記録し、腫瘍重量を次の式に従って計算した:長さ(mm)×幅2/2。毒性は体重減少を基準にして評価した。
外科手術を受けた動物を、上述のプロトコルの1つに従って麻酔する、即ちケタミン80から100mg/kg i.p.+Xilazin:10mg/kg i.p.;イソフルオラン:1.5から2%。6から8週齢の胸腺欠損のオスのヌードマウスを麻酔し、定位固定装置に置き、イヤーバーを用い、ヘッドホルダーに優しく固定した。頭部の皮膚を縦方向(耳に対して平行)に切断し、マウスの頭蓋骨を見出す。装置のXおよびY軸コントローラを用いて、ブレグマ(大脳核に注射を行うための正中矢状と前側冠状縫合との交叉点)およびラムダ(小脳に注射を行うための正中矢状縫合と後側冠状縫合との交叉点)をポイント0として同定した。次の座標を装置に設定し、注射ポイントを同定した。ミクロドリルを用いて小さい穴を所望のポイントにあけた。注射直前にハミルトン注射器(通常2から5ml)を用いて細胞を吸引した(吸引の前に細胞のショートミックスを行い細胞の沈降を回避した。)。穴にポイントを付けることによって、Z軸を0に固定し、注射器を右座標(−3.0mmの深さ)に到達するまで脳内に優しく挿入した。U251細胞を毎分1μlの速度で注射した。注射器をさらに5分間穴に放置した後、細胞吸引を避けるために取り除いた。ボーンワックスを用いて穴を塞ぎ、創傷を無菌のオートクリップで閉じた。手術の終了後、完全に目覚めるまでの回復に関してマウスをモニターした。
Claims (8)
- 悪性グリオーマがグリオブラストーマである、請求項1に記載の化合物。
- 悪性グリオーマを治療するための方法に使用するための、請求項1に定義される式(I)の化合物および(b)細胞毒性または細胞分裂阻害性の化学剤および電離放射線から成る群から選択される1またはこれ以上の抗悪性腫瘍剤とを含む治療の組み合わせ。
- 化学剤がテモゾロミドである、請求項3に記載の治療の組み合わせ。
- 悪性グリオーマがグリオブラストーマである、請求項3および4のいずれか一項に記載の治療の組み合わせ。
- 悪性グリオーマの治療に使用するための、医薬的に許容される担体、希釈剤または賦形剤と混合されて請求項1に定義される式(I)の化合物を含む医薬組成物。
- 悪性グリオーマを治療するための方法に使用するための、細胞毒性または細胞分裂阻害性の化学剤および電離放射線から成る群から選択される1またはこれ以上の抗悪性腫瘍剤をさらに含む、請求項6に記載の医薬組成物。
- 化学剤がテモゾロミドである、請求項7に記載の医薬組成物。
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Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2012525345A (ja) * | 2009-04-29 | 2012-10-22 | ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ | Cdk阻害物質の塩 |
JP2016505588A (ja) * | 2012-12-20 | 2016-02-25 | ラントメネン・アーエス−ファクトール・アーベー | 膠芽腫処置における抗分泌性因子(af)の使用 |
JP2020530491A (ja) * | 2017-08-11 | 2020-10-22 | 晟科薬業(江蘇)有限公司Shengke Pharmaceuticals (Jiangsu) Ltd. | プロテインキナーゼ阻害剤としての1h−ピラゾロ[4,3−h]キナゾリン系化合物 |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RS53350B (en) | 2008-09-22 | 2014-10-31 | Array Biopharma, Inc. | SUBSTITUTED COMPOUNDS OF IMIDASO [1,2-B] PYRIDASINE AS INK KINASE INHIBITORS |
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JP2022515197A (ja) | 2018-12-19 | 2022-02-17 | アレイ バイオファーマ インコーポレイテッド | がんを治療するためのfgfr阻害剤としての7-((3,5-ジメトキシフェニル)アミノ)キノキサリン誘導体 |
EP3898626A1 (en) | 2018-12-19 | 2021-10-27 | Array Biopharma, Inc. | Substituted pyrazolo[1,5-a]pyridine compounds as inhibitors of fgfr tyrosine kinases |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004104007A1 (en) * | 2003-05-22 | 2004-12-02 | Pharmacia Italia S.P.A. | Pyrazolo-quinazoline derivatives,process for their preparation and their use as kinase inhibitors |
WO2007090794A1 (en) * | 2006-02-10 | 2007-08-16 | Nerviano Medical Sciences S.R.L. | Combinations comprising a cdk inhibitor and a growth factor antibody or anti-mitotic |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010012777A1 (en) * | 2008-07-29 | 2010-02-04 | Nerviano Medical Sciences S.R.L. | THERAPEUTIC COMBINATION COMPRISING A CDKs INHIBITOR AND AN ANTINEOPLASTIC AGENT |
JP2012509859A (ja) * | 2008-11-24 | 2012-04-26 | ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ | 中皮腫の治療のためのcdk阻害物質 |
-
2009
- 2009-07-28 EP EP09781195.4A patent/EP2323664B1/en active Active
- 2009-07-28 WO PCT/EP2009/059747 patent/WO2010012733A1/en active Application Filing
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-
2011
- 2011-08-08 HK HK11108251.4A patent/HK1153938A1/xx unknown
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004104007A1 (en) * | 2003-05-22 | 2004-12-02 | Pharmacia Italia S.P.A. | Pyrazolo-quinazoline derivatives,process for their preparation and their use as kinase inhibitors |
WO2007090794A1 (en) * | 2006-02-10 | 2007-08-16 | Nerviano Medical Sciences S.R.L. | Combinations comprising a cdk inhibitor and a growth factor antibody or anti-mitotic |
Non-Patent Citations (8)
Title |
---|
CSNC200901116027; 日本臨牀 Vol.54(4) p.141-146 (1996) * |
JPN6013064314; 日本臨牀 Vol.54(4) p.141-146 (1996) * |
JPN6013064316; Crit Rev in Oncol/Hematol, vol.60, p.181-193 (2006) * |
JPN6013064318; Update on Cancer Ther, vol.3, p.49-79 (2007.12.31) * |
JPN6013064321; Cancer Lett, vol.261 p.26-36 (2008 March) * |
JPN6013064324; J Med Chem, vol.47, p.3367-3380 (2004) * |
JPN6013064327; J Natl Cancer Inst, vol.99, p.936-948 (2007) * |
JPN6013064330; British J Pharm, vol.169, p.156-166 (2013) * |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2012525345A (ja) * | 2009-04-29 | 2012-10-22 | ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ | Cdk阻害物質の塩 |
JP2016505588A (ja) * | 2012-12-20 | 2016-02-25 | ラントメネン・アーエス−ファクトール・アーベー | 膠芽腫処置における抗分泌性因子(af)の使用 |
JP2020530491A (ja) * | 2017-08-11 | 2020-10-22 | 晟科薬業(江蘇)有限公司Shengke Pharmaceuticals (Jiangsu) Ltd. | プロテインキナーゼ阻害剤としての1h−ピラゾロ[4,3−h]キナゾリン系化合物 |
JP7233743B2 (ja) | 2017-08-11 | 2023-03-07 | 晟科薬業(江蘇)有限公司 | プロテインキナーゼ阻害剤としての1h-ピラゾロ[4,3-h]キナゾリン系化合物 |
US11993604B2 (en) | 2017-08-11 | 2024-05-28 | Shengke Pharmaceuticals (Jiangsu) Ltd. | Substituted pyrazolo[4,3-H]quinazolines as protein kinase inhibitors |
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US8946226B2 (en) | 2015-02-03 |
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US20110190311A1 (en) | 2011-08-04 |
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HK1153938A1 (en) | 2012-04-13 |
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