JP2011527896A5 - - Google Patents

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Publication number

JP2011527896A5

JP2011527896A5 JP2011517915A JP2011517915A JP2011527896A5 JP 2011527896 A5 JP2011527896 A5 JP 2011527896A5 JP 2011517915 A JP2011517915 A JP 2011517915A JP 2011517915 A JP2011517915 A JP 2011517915A JP 2011527896 A5 JP2011527896 A5 JP 2011527896A5

Authority

JP

Japan

Prior art keywords

seq

variable region

chain variable

antibody

functional protein

Prior art date

2009-07-15

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

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• 108090000623 proteins and genes Proteins 0.000 claims 32
• 102000004169 proteins and genes Human genes 0.000 claims 30
• 125000003275 alpha amino acid group Chemical group 0.000 claims 18
• 229920001184 polypeptide Polymers 0.000 claims 16
• 102000004196 processed proteins & peptides Human genes 0.000 claims 16
• 108090000765 processed proteins & peptides Proteins 0.000 claims 16
• 238000012217 deletion Methods 0.000 claims 12
• 230000037430 deletion Effects 0.000 claims 12
• 210000003719 b-lymphocyte Anatomy 0.000 claims 9
• 210000004027 cell Anatomy 0.000 claims 7
• 238000007792 addition Methods 0.000 claims 6
• 238000006467 substitution reaction Methods 0.000 claims 6
• 150000001413 amino acids Chemical class 0.000 claims 5
• 102000006471 Fucosyltransferases Human genes 0.000 claims 4
• 108010019236 Fucosyltransferases Proteins 0.000 claims 4
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• 230000010056 antibody-dependent cellular cytotoxicity Effects 0.000 claims 3
• 230000000694 effects Effects 0.000 claims 3
• 101150023212 fut8 gene Proteins 0.000 claims 3
• 210000004962 mammalian cell Anatomy 0.000 claims 3
• 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims 2
• 208000028564 B-cell non-Hodgkin lymphoma Diseases 0.000 claims 2
• 101000795169 Homo sapiens Tumor necrosis factor receptor superfamily member 13C Proteins 0.000 claims 2
• 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 claims 2
• 206010035226 Plasma cell myeloma Diseases 0.000 claims 2
• 238000010367 cloning Methods 0.000 claims 2
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• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 208000023275 Autoimmune disease Diseases 0.000 claims 1
• 108010028006 B-Cell Activating Factor Proteins 0.000 claims 1
• 108010046304 B-Cell Activation Factor Receptor Proteins 0.000 claims 1
• 208000036170 B-Cell Marginal Zone Lymphoma Diseases 0.000 claims 1
• 208000011691 Burkitt lymphomas Diseases 0.000 claims 1
• 208000031671 Large B-Cell Diffuse Lymphoma Diseases 0.000 claims 1
• 206010025323 Lymphomas Diseases 0.000 claims 1
• 201000003791 MALT lymphoma Diseases 0.000 claims 1
• 208000025205 Mantle-Cell Lymphoma Diseases 0.000 claims 1
• 208000034578 Multiple myelomas Diseases 0.000 claims 1
• 102100036922 Tumor necrosis factor ligand superfamily member 13B Human genes 0.000 claims 1
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