JP2011527675A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2011527675A5 JP2011527675A5 JP2011517424A JP2011517424A JP2011527675A5 JP 2011527675 A5 JP2011527675 A5 JP 2011527675A5 JP 2011517424 A JP2011517424 A JP 2011517424A JP 2011517424 A JP2011517424 A JP 2011517424A JP 2011527675 A5 JP2011527675 A5 JP 2011527675A5
- Authority
- JP
- Japan
- Prior art keywords
- alkoxy
- optionally substituted
- independently selected
- hydroxy
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 *C(*)(CC1)CCC1C=C[C@@]1NNC=C1 Chemical compound *C(*)(CC1)CCC1C=C[C@@]1NNC=C1 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13448508P | 2008-07-10 | 2008-07-10 | |
| US61/134,485 | 2008-07-10 | ||
| PCT/US2009/004014 WO2010005580A2 (en) | 2008-07-10 | 2009-07-09 | Methods and compositions of small molecule modulators of hepatocyte growth factor (scatter factor) activity |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015012415A Division JP2015108002A (ja) | 2008-07-10 | 2015-01-26 | 肝細胞増殖因子（分散因子）活性の低分子モジュレーターの組成物および方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011527675A JP2011527675A (ja) | 2011-11-04 |
| JP2011527675A5 true JP2011527675A5 (https=) | 2012-08-23 |
| JP5775452B2 JP5775452B2 (ja) | 2015-09-09 |
Family
ID=41507639
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011517424A Expired - Fee Related JP5775452B2 (ja) | 2008-07-10 | 2009-07-09 | 肝細胞増殖因子（分散因子）活性の低分子モジュレーターの組成物および方法 |
| JP2015012415A Pending JP2015108002A (ja) | 2008-07-10 | 2015-01-26 | 肝細胞増殖因子（分散因子）活性の低分子モジュレーターの組成物および方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015012415A Pending JP2015108002A (ja) | 2008-07-10 | 2015-01-26 | 肝細胞増殖因子（分散因子）活性の低分子モジュレーターの組成物および方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (4) | US8772326B2 (https=) |
| EP (1) | EP2313093A4 (https=) |
| JP (2) | JP5775452B2 (https=) |
| CN (1) | CN102149379A (https=) |
| CA (1) | CA2767331A1 (https=) |
| IL (1) | IL210544A (https=) |
| WO (1) | WO2010005580A2 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5775452B2 (ja) | 2008-07-10 | 2015-09-09 | アンジオン バイオメディカ コーポレイション | 肝細胞増殖因子（分散因子）活性の低分子モジュレーターの組成物および方法 |
| CN102802969A (zh) | 2009-06-12 | 2012-11-28 | 住友橡胶工业株式会社 | 车辆 |
| JP6155187B2 (ja) | 2010-03-30 | 2017-06-28 | ヴァーセオン コーポレイション | トロンビンの阻害剤としての多置換芳香族化合物 |
| JP2014509297A (ja) * | 2010-10-05 | 2014-04-17 | アンジオン バイオメディカ コーポレイション | 肝細胞増殖因子（散乱因子）活性の小分子モジュレーターの使用方法 |
| HK1214252A1 (zh) | 2013-03-15 | 2016-07-22 | Verseon Corporation | 作為凝血酶抑制劑的鹵代吡唑 |
| CN110179795A (zh) | 2013-03-15 | 2019-08-30 | 维颂公司 | 作为丝氨酸蛋白酶抑制剂的多取代芳族化合物的制药用途 |
| US10189810B2 (en) | 2014-09-17 | 2019-01-29 | Verseon Corporation | Pyrazolyl-substituted pyridone compounds as serine protease inhibitors |
| CN107405333A (zh) | 2015-02-27 | 2017-11-28 | 维颂公司 | 作为丝氨酸蛋白酶抑制剂的被取代的吡唑化合物 |
| JP6830158B2 (ja) * | 2016-12-22 | 2021-02-17 | 諾貝兒寶貝股▲ふん▼有限公司Ｎｏｒｂｅｌ Ｂａｂｙ Ｃｏ．， Ｌｔｄ． | 肝損傷を予防または治療する医薬組成物の調製における（２ｒ，４ｒ）−１，２，４−トリヒドロキシヘプタデカ−１６−インの応用 |
| CA3133803A1 (en) * | 2019-04-11 | 2020-10-15 | Angion Biomedica Corp. | Solid forms of (e)-3-[2-(2-thienyl)vinyl]-1h-pyrazole |
| EP4051271A4 (en) * | 2019-10-31 | 2023-11-29 | Angion Biomedica Corp. | IMPROVEMENT IN KIDNEY FUNCTION AFTER KIDNEY TRANSPLANT |
| CN119504599B (zh) * | 2024-11-18 | 2025-09-26 | 安徽医科大学 | 一种用于治疗肾脏纤维化的吡唑类化合物及其应用 |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE138770C (https=) | ||||
| JPS48713Y1 (https=) | 1967-12-19 | 1973-01-09 | ||
| DD138770A1 (de) | 1978-09-20 | 1979-11-21 | Juergen Liebscher | Verfahren zur herstellung von 5-styryl-pyrazolen und ihren vinylogen |
| US4806535A (en) | 1987-07-22 | 1989-02-21 | Rorer Pharmaceutical Corporation | Imidazolylphenyl and 1,2,4-triazolylphenyl benzopyridazinone and pyridopyridazinone compounds and their use for increasing cardiatonic contractility |
| JPH02193994A (ja) | 1989-01-23 | 1990-07-31 | Kyowa Hakko Kogyo Co Ltd | ピリダジノン誘導体 |
| US6566098B1 (en) | 1990-09-14 | 2003-05-20 | The United States Of America As Represented By The Department Of Health And Human Services | DNA encoding truncated hepatocyte growth factor variants |
| JP3680114B2 (ja) | 1993-09-17 | 2005-08-10 | 敏一 中村 | 脳神経障害治療剤 |
| US5837676A (en) | 1993-10-18 | 1998-11-17 | Long Island Jewish Medical Center | Use of scatter factor to enhance angiogenesis |
| US6498144B1 (en) | 1993-10-18 | 2002-12-24 | North Shore - Long Island Jewish Research Institute | Use of scatter factor to enhance angiogenesis |
| JP3818322B2 (ja) | 1994-04-28 | 2006-09-06 | 敏一 中村 | コラーゲン分解促進剤 |
| KR100765687B1 (ko) | 1995-08-29 | 2007-10-11 | 안제스에무지 가부시키가이샤 | Ｈｇｆ 유전자를 함유하는 약제 |
| US5830879A (en) | 1995-10-02 | 1998-11-03 | St. Elizabeth's Medical Center Of Boston, Inc. | Treatment of vascular injury using vascular endothelial growth factor |
| JPH11288112A (ja) | 1998-04-06 | 1999-10-19 | Mitsubishi Paper Mills Ltd | 電子写真感光体 |
| US6677333B1 (en) | 1999-01-26 | 2004-01-13 | Ono Pharmaceutical Co., Ltd. | 2H-phthalazin-1-one derivatives and drug containing its derivatives as active ingredient |
| PE20010306A1 (es) | 1999-07-02 | 2001-03-29 | Agouron Pharma | Compuestos de indazol y composiciones farmaceuticas que los contienen utiles para la inhibicion de proteina kinasa |
| US6437006B1 (en) * | 1999-09-27 | 2002-08-20 | American Cyanamid Company | Pharmaceutical carrier formulation |
| US7459536B1 (en) | 1999-11-09 | 2008-12-02 | The United States Of America As Represented By The Secretary, Department Of Health And Human Services | HGF-SF monoclonal antibody combinations |
| EP2206720A1 (en) | 2000-04-12 | 2010-07-14 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| EP1355921A2 (en) | 2000-06-29 | 2003-10-29 | North Shore-Long Island Jewish Health System | Modulators of cellular proliferation and angiogenesis, methods for use and identification thereof |
| DE10047486A1 (de) * | 2000-09-26 | 2002-04-11 | Bayer Ag | Phenoxyphenyl Alkansulfonate |
| US7151102B2 (en) | 2000-10-30 | 2006-12-19 | Kudos Pharmaceuticals Limited | Phthalazinone derivatives |
| US6610726B2 (en) | 2001-06-29 | 2003-08-26 | North Shore-Long Island Jewish Research Institute | Compositions and agents for modulating cellular proliferation and angiogenesis |
| US6589997B2 (en) * | 2001-06-29 | 2003-07-08 | North Shore-Long Island Jewish Health System | Small-molecule modulators of hepatocyte growth factor/scatter factor activities |
| US20030073692A1 (en) | 2001-08-07 | 2003-04-17 | Pharmacia & Upjohn S.P.A. | Amino-phthalazinone derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions containing them |
| CA2662899A1 (en) | 2002-02-22 | 2003-09-04 | Schering Corporation | Pharmaceutical formulations of antineoplastic agents, in particular temozolomide, processes of making and using the same |
| AU2002313690A1 (en) | 2002-07-19 | 2004-02-09 | Targacept, Inc. | Five-membered heteroaromatic olefinic azacyclic compounds, pharmaceutical compositions containing them and their use as inhibitors of ncotinic cholinergic receptors |
| US7192976B2 (en) | 2002-12-21 | 2007-03-20 | Angion Biomedica Corporation | Small molecule modulators of hepatocyte growth factor (scatter factor) activity |
| FR2868519B1 (fr) * | 2004-03-30 | 2006-06-16 | Christian Muller | Generateur thermique a materiau magneto-calorique et procede de generation de thermies |
| GB0419072D0 (en) | 2004-08-26 | 2004-09-29 | Kudos Pharm Ltd | Phthalazinone derivatives |
| EP1799651A2 (en) | 2004-09-28 | 2007-06-27 | Angion Biomedica Corp. | Small molecule modulators of cytokine activity |
| US20110230407A1 (en) | 2005-03-14 | 2011-09-22 | Alexander Yuzhakov | Hepatocyte growth factor pathway activators in demyelinating diseases and central nervous system trauma |
| US7879898B1 (en) | 2006-02-14 | 2011-02-01 | Angion Biomedica Corp. | Hepatocyte growth factor pathway activators in chronic obstructive pulmonary disease |
| US8299256B2 (en) | 2007-03-08 | 2012-10-30 | Janssen Pharmaceutica Nv | Quinolinone derivatives as PARP and TANK inhibitors |
| US8193177B2 (en) | 2007-11-13 | 2012-06-05 | Angion Biomedica Corp. | Hepatocyte growth factor pathway activators in fibrotic connective tissue diseases |
| JP5775452B2 (ja) | 2008-07-10 | 2015-09-09 | アンジオン バイオメディカ コーポレイション | 肝細胞増殖因子（分散因子）活性の低分子モジュレーターの組成物および方法 |
| US20110098304A1 (en) | 2008-10-22 | 2011-04-28 | Bijoy Panicker | Small molecule inhibitors of PARP activity |
| WO2011019400A2 (en) | 2009-08-12 | 2011-02-17 | Angion Biomedica Corp. | Enhancement of cellular transplantation using small molecule modulators hepatocyte growth factor (scatter factor) activity |
| JP2014509297A (ja) | 2010-10-05 | 2014-04-17 | アンジオン バイオメディカ コーポレイション | 肝細胞増殖因子（散乱因子）活性の小分子モジュレーターの使用方法 |
-
2009
- 2009-07-09 JP JP2011517424A patent/JP5775452B2/ja not_active Expired - Fee Related
- 2009-07-09 US US13/003,514 patent/US8772326B2/en active Active
- 2009-07-09 CA CA2767331A patent/CA2767331A1/en not_active Abandoned
- 2009-07-09 EP EP09794828A patent/EP2313093A4/en not_active Withdrawn
- 2009-07-09 CN CN2009801353421A patent/CN102149379A/zh active Pending
- 2009-07-09 WO PCT/US2009/004014 patent/WO2010005580A2/en not_active Ceased
-
2011
- 2011-01-10 IL IL210544A patent/IL210544A/en not_active IP Right Cessation
-
2014
- 2014-05-25 US US14/287,039 patent/US20140256727A1/en not_active Abandoned
-
2015
- 2015-01-26 JP JP2015012415A patent/JP2015108002A/ja active Pending
-
2017
- 2017-02-23 US US15/440,398 patent/US20180009793A1/en not_active Abandoned
-
2019
- 2019-01-04 US US16/239,836 patent/US10899750B2/en not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2011527675A5 (https=) | ||
| JP2012529486A5 (https=) | ||
| JP5775452B2 (ja) | 肝細胞増殖因子（分散因子）活性の低分子モジュレーターの組成物および方法 | |
| RU2469042C2 (ru) | Терапевтически активные триазолы и их использование | |
| US11667630B2 (en) | Nitrogen-containing 6-membered cyclic compound | |
| JP5643213B2 (ja) | 肥大性心筋症治療用のホスホジエステラーゼタイプＩＩＩ（ＰＤＥＩＩＩ）インヒビターまたはＣａ２＋感作剤 | |
| JPH11228410A (ja) | イミダゾールアンジオテンシン−ｉｉ受容体拮抗薬からなる慢性腎不全治療剤 | |
| CN107530352A (zh) | 使用茚满乙酸衍生物治疗肝病的方法 | |
| JP2006513221A5 (https=) | ||
| KR20140056250A (ko) | 좌심실 확장 기능 개선제 | |
| JP4011114B2 (ja) | 脳浮腫抑制剤 | |
| JP2014509297A5 (https=) | ||
| CA2813719A1 (en) | Methods of use of small molecule modulators of hepatocyte growth factor (scatter factor) activity | |
| JPWO1999040919A1 (ja) | 心拡張障害治療剤 | |
| JPWO2022178420A5 (https=) | ||
| JP2009286712A (ja) | スピロキノン化合物及び医薬組成物 | |
| JPH08165239A (ja) | 抗動脈硬化剤 | |
| JPWO2023166203A5 (https=) |